Journal
BLOOD CELLS MOLECULES AND DISEASES
Volume 42, Issue 1, Pages 38-43Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2008.07.003
Keywords
Platelets; Hypertension; Ca2+ signaling; Reactive oxygen species; Nitric oxide
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Platelets from hypertensive patients show increased sensitivity to agonists and have high intracellular free Ca2+ concentration. Furthermore, in hypertension, platelets show enhanced endogenous production of reactive oxygen species and a reduced antioxidant status which increases protein tyrosine phosphorylation, enhances Ca2+ mobilization and attenuates NO bioavailability. The study of the abnormalities in platelet function in hypertensive patients can lead to the development of new pharmacological strategies to prevent and/or palliate hypertension-derived complications associated to platelet hyperactivity. (C) 2008 Elsevier Inc. All rights reserved.
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