Article
Cardiac & Cardiovascular Systems
Alexander Witte, Anne-Katrin Rohlfing, Benjamin Dannenmann, Valerie Dicenta, Masoud Nasri, Kyra Kolb, Jessica Sudmann, Tatsiana Castor, Dominik Rath, Oliver Borst, Julia Skokowa, Meinrad Gawaz
Summary: This study reveals that CXCL14 is a novel platelet-derived chemokine involved in thrombus formation and platelet migration, with CXCR4 identified as the principal receptor for CXCL14, promoting platelet migration.
CARDIOVASCULAR RESEARCH
(2021)
Article
Hematology
Larissa Doll, Narges Aghaallaei, Advaita M. Dick, Karl Welte, Julia Skokowa, Baubak Bajoghli
Summary: Research showed that knockdown of zebrafish hax1 impairs neutrophil development and the reduced neutrophil numbers can be reversed by granulocyte colony-stimulating factor. This study opens up new avenues for developing tailored therapeutic strategies for patients with congenital neutropenia.
Article
Hematology
Malte Ritter, Maksim Klimiankou, Olga Klimenkova, Axel Schambach, Dirk Hoffmann, Amy Schmidt, Lothar Kanz, Daniel C. Link, Karl Welte, Julia Skokowa
ANNALS OF HEMATOLOGY
(2020)
Article
Hematology
Christoph Schurch, Thorsten Schaefer, Joelle S. Muller, Pauline Hanns, Marlon Arnone, Alain Dumlin, Jonas Scharer, Irmgard Sinning, Klemens Wild, Julia Skokowa, Karl Welte, Raphael Carapito, Seiamak Bahram, Martina Konantz, Claudia Lengerke
Summary: Variants of SRP54 gene play a critical role in the development of congenital neutropenia, with knockout zebrafish serving as an in vivo model for the disease. The study reveals that SRP54 is crucial for tissue development, with neutrophils being particularly sensitive to its loss, suggesting potential therapeutic targets in patients with different phenotypes ranging from mild CN to SDS-like disease.
Letter
Hematology
Ekaterina Deordieva, Oksana Shvets, Kirill Voronin, Alexei Maschan, Karl Welte, Julia Skokowa, Galina Novichkova, Anna Shcherbina
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Birte Hernandez Alvarez, Julia Skokowa, Murray Coles, Perihan Mir, Masoud Nasri, Kateryna Maksymenko, Laura Weidmann, Katherine W. Rogers, Karl Welte, Andrei N. Lupas, Patrick Muller, Mohammad ElGamacy
Article
Cell & Tissue Engineering
Yun Xu, Masoud Nasri, Benjamin Dannenmann, Perihan Mir, Azadeh Zahabi, Karl Welte, Tatsuya Morishima, Julia Skokowa
Summary: The study demonstrates the essential role of the NAMPT/SIRT2/p53/p21 signaling axis in the maintenance and hematopoietic differentiation of iPS cells.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cell & Tissue Engineering
Benjamin Dannenmann, Maksim Klimiankou, Benedikt Oswald, Anna Solovyeva, Jehan Mardan, Masoud Nasri, Malte Ritter, Azadeh Zahabi, Patricia Arreba-Tutusaus, Perihan Mir, Frederic Stein, Siarhei Kandabarau, Nico Lachmann, Thomas Moritz, Tatsuya Morishima, Martina Konantz, Claudia Lengerke, Tim Ripperger, Doris Steinemann, Miriam Erlacher, Charlotte M. Niemeyer, Cornelia Zeidler, Karl Welte, Julia Skokowa
Summary: By editing CN patient-derived iPSCs using CRISPR-Cas9, this study established a model of stepwise leukemogenesis in CN/AML and identified the upregulation of BAALC and phosphorylation of MK2a as key events in leukemogenesis. Deleting BAALC or using a selective inhibitor of MK2a phosphorylation, CMPD1, can prevent cell proliferation and induce differentiation of CN/AML cells.
Editorial Material
Medicine, General & Internal
Julia Skokowa
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Pediatrics
Cornelia Zeidler, Julia Skokowa
Summary: Mature neutrophil granulocytes play a crucial role in defending against bacterial infections. While a decrease in neutrophil numbers, known as neutropenia, typically increases the risk of infections, autoimmune neutropenia in infancy tends to be self-limiting and does not usually lead to severe infections. Severe congenital neutropenia, on the other hand, was previously untreatable and often led to fatal outcomes before the introduction of hematopoietic growth factors in the late 1980s.
MONATSSCHRIFT KINDERHEILKUNDE
(2021)
Editorial Material
Hematology
Maksim Klimiankou, Julia Skokowa
Summary: The study demonstrates that disulfiram inhibits the excessive formation of neutrophil extracellular traps during sepsis by targeting gasdermin D.
Article
Multidisciplinary Sciences
Julia Skokowa, Birte Hernandez Alvarez, Murray Coles, Malte Ritter, Masoud Nasri, Jeremy Haaf, Narges Aghaallaei, Yun Xu, Perihan Mir, Ann-Christin Krahl, Katherine W. Rogers, Kateryna Maksymenko, Baubak Bajoghli, Karl Welte, Andrei N. Lupas, Patrick Muller, Mohammad ElGamacy
Summary: Skokowa et al. demonstrate the successful design of novel granulopoietic proteins with therapeutic potential through topological refactoring. These proteins possess de novo fold, high stability, and high activity, effectively addressing challenges commonly faced by protein therapeutics. The designs show specific and significant activity in differentiating stem cells and hold promise for treating neutropenia disorders.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Kshama Gupta, Jeremy C. Jones, Virginea De Araujo Farias, Yuri Mackeyev, Pankaj K. Singh, Alfredo Quinones-Hinojosa, Sunil Krishnan
Summary: Treatment resistance is common in advanced cancers, including colorectal adenocarcinoma (COAD). A study found that targeting the DDR1/BCR-ABL signaling axis with EGFR-ERBB2 could be a potential strategy for treating chemotherapy and radiotherapy-resistant COAD and glioblastoma (GBM) tumors driven by the KRAS mutation.
FRONTIERS IN ONCOLOGY
(2022)
Correction
Cell & Tissue Engineering
Yun Xu, Masoud Nasri, Benjamin Dannenmann, Perihan Mir, Azadeh Zahabi, Karl Welte, Tatsuya Morishima, Julia Skokowa
STEM CELL RESEARCH & THERAPY
(2023)
Meeting Abstract
Hematology
Julia Skokowa, Mohammad Elgamacy, Patrick Muller