NOTCH2 and FLT3 gene mis-splicings are common events in patients with acute myeloid leukemia (AML): new potential targets in AML

Acute Myeloid Leukemia

(2017) Margaret R. O'Donnell et al.   Journal of the National Comprehensive Cancer Network

A Genome-Wide Aberrant RNA Splicing in Patients with Acute Myeloid Leukemia Identifies Novel Potential Disease Markers and Therapeutic Targets

(2013) Sophia Adamia et al.   CLINICAL CANCER RESEARCH

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

(2013) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch activation inhibits AML growth and survival: a potential therapeutic approach

(2013) Sankaranarayanan Kannan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing

(2012) A. Dolnik et al.   BLOOD

Alternative splicing of RAGE: roles in biology and disease

(2011) Anastasia et al.   Frontiers in Bioscience-Landmark

Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript

(2011) Z. Kote-Jarai et al.   HUMAN GENETICS

Involvement of Dominant-negative Spliced Variants of the Intermediate Conductance Ca2+-activated K+Channel, KCa3.1, in Immune Function of Lymphoid Cells

(2011) Susumu Ohya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression

(2011) Rhonda L. Brown et al.   JOURNAL OF CLINICAL INVESTIGATION

CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing

(2011) Sanjeev Shukla et al.   NATURE

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

(2011) Timothy A Graubert et al.   NATURE GENETICS

Novel splice variants of human IKKε negatively regulate IKKε-induced IRF3 and NF-kB activation

(2010) Anja Koop et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A novel exon in AML1-ETO negatively influences the clonogenic potential of the t(8;21) in acute myeloid leukemia

(2010) D Mannari et al.   LEUKEMIA

Editorial on alternative splicing and disease

(2010) Andrea Barta et al.   RNA Biology

Aberrant splicing of folylpolyglutamate synthetase as a novel mechanism of antifolate resistance in leukemia

(2009) M. Stark et al.   BLOOD

Aberrant Splicing of Hugl-1 Is Associated with Hepatocellular Carcinoma Progression

(2009) X. Lu et al.   CLINICAL CANCER RESEARCH

Persistent altered fusion transcript splicing identifiesRUNX1-RUNX1T1+ AML patients likely to relapse

(2009) Hans B. Ommen et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Growth factor independent 1b (Gfi1b) and a new splice variant of Gfi1b are highly expressed in patients with acute and chronic leukemia

(2009) Lothar Vassen et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis

(2009) X Liu et al.   LEUKEMIA

Inactivation of SHIP1 in T-cell acute lymphoblastic leukemia due to mutation and extensive alternative splicing

(2009) Tony C.T. Lo et al.   LEUKEMIA RESEARCH

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glycogen synthase kinase 3  missplicing contributes to leukemia stem cell generation

(2009) A. E. Abrahamsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative splicing and disease

(2008) Jamal Tazi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

CD96 Interaction with CD155 via Its First Ig-like Domain Is Modulated by Alternative Splicing or Mutations in Distal Ig-like Domains

(2008) Dorothee Meyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY