Article
Neurosciences
Mattia Camera, Isabella Russo, Valentina Zamboni, Alessandra Ammoni, Simona Rando, Alessandro Morellato, Irene Cimino, Costanza Angelini, Paolo Giacobini, Roberto Oleari, Federica Amoruso, Anna Cariboni, Isabelle Franceschini, Emilia Turco, Paola Defilippi, Giorgio R. Merlo
Summary: The absence of the p140Cap gene in mice leads to abnormalities in fertility, puberty development, and hormone secretion. This may be due to its role in the development of the hypothalamic gonadotropic system and modulation of glutamatergic signaling.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Mor Kishner, Libat Habaz, Lana Meshnik, Tomer Dvir Meidan, Alexandra Polonsky, Anat Ben-Zvi
Summary: This study found that GnRH receptors in Caenorhabditis elegans regulate protein homeostasis in different somatic tissues during the transition to adulthood. They modulate the activity of transcription factors and affect reproductive capacity. This suggests that GnRH-like signaling plays a crucial regulatory role in controlling reproduction and quality control.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Gunter Emons, Carsten Gruendker
Summary: Endometrial cancer expresses GnRH and its receptor, which can regulate proliferation, the cell cycle, and apoptosis. GnRH agonists are used in fertility preserving therapy for early EC, but show limited activity in advanced or recurrent EC. Further clinical trials exploring the GnRH-system in EC may be beneficial.
Article
Biology
Chirine Toufaily, Jerome Fortin, Carlos A. Alonso, Evelyne Lapointe, Xiang Zhou, Yorgui Santiago-Andres, Yeu-Farn Lin, Yiming Cui, Ying Wang, Dominic Devost, Ferdinand Roelfsema, Frederik Steyn, Aylin C. Hanyaloglu, Terence E. Hebert, Tatiana Fiordelisio, Derek Boerboom, Daniel J. Bernard
Summary: Gonadotropin-releasing hormone (GnRH) controls reproduction by stimulating FSH and LH synthesis via its receptor GnRHR, but the lack of Ctail in mammalian GnRHR may not provide an advantage for LH surge generation. In transgenic mice, addition of Ctail resulted in reduced FSH production and fertility, suggesting a potential role of Ctail in normal reproductive function.
Review
Cell Biology
Carsten Gruendker, Guenter Emons
Summary: The HPG axis regulates the female menstrual cycle through GnRH, which can impact ovarian cancer either indirectly through the HPG axis or directly through receptors on the surface of tumor cells.
Article
Developmental Biology
Xinyi Li, Jiaxin Shi, Weijie Zhao, Xixi Huang, Liyuan Cui, Lu Liu, Xueling Jin, Djin Li, Xuan Zhang, Meirong Du
Summary: This study found that DSCs promote invasion and survival of trophoblastic cells through the WNT16/AKT/beta-catenin pathway at the maternal-fetal interface in human early pregnancy. The disruption of this crosstalk between DSCs and trophoblasts may lead to pregnancy failure.
Article
Immunology
Ai-Mei Chang, Chen-Chih Chen, Ding-Liang Hou, Guan-Ming Ke, Jai-Wei Lee
Summary: The study revealed that GnRH vaccine can reduce hormone concentrations, lead to testicular atrophy and decreased sperm quality, and have an impact on animal mating and reproductive abilities.
Review
Chemistry, Medicinal
Yi-Fu Liu, Sheng-Qiang Fu, Yu-Chang Yan, Bin-Bin Gong, Wen-Jie Xie, Xiao-Rong Yang, Ting Sun, Ming Ma
Summary: This review discusses the usage, administration, and impact on serum testosterone levels of GnRH receptor agonists and antagonists, focusing on the mechanism of action of the antagonists and their development in clinical studies.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Tracy A. Burnett, Augusto M. L. Madureira, Janet W. Bauer, Ronaldo L. A. Cerri
Summary: This study found that administration of GnRH at the time of artificial insemination can improve fertility in cows with reduced estrous expression, but increased ovulation rate does not seem to be the direct mechanism behind this relationship.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Lisa-Marie Sattler, Hanna A. Schniewind, Waldemar B. Minich, Christoph W. Haudum, Petra Niklowitz, Julia Muenzker, Gabor L. Kovacs, Thomas Reinehr, Barbara Obermayer-Pietsch, Lutz Schomburg
Summary: In European adult control groups and PCOS patients, only a very small fraction have natural GnRH-R-aAb. Our results do not support the hypothesis that GnRH-R is a significant autoantigen in PCOS.
Article
Cell Biology
Zilong Deng, Wenjuan Yan, Xingzhu Dai, Ming Chen, Qian Qu, Buling Wu, Wanghong Zhao
Summary: N-cadherin acts as a negative regulator by regulating beta-catenin activity during odontogenic differentiation of DPSCs, helping guide DPSC behavior through tuning these interactions, with implications for pulp regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Ying Liu, Xiao-Ya Ren, Ya-Guang Peng, Shao-Ke Chen, Xin-Ran Cheng, Miao Qin, Xiao-Ling Wang, Yan-Ning Song, Li-Jun Fan, Chun-Xiu Gong
Summary: The study demonstrated that hCG/hMG therapy is feasible and effective for treating male adolescents with CHH, with the initial 3 months of treatment showing the strongest effects. Results from the extended time-period also showed positive outcomes at the 1-year mark, indicating the potential of hCG/hMG regimen, although further research is needed to assess its long-term effectiveness and limitations.
CHINESE MEDICAL JOURNAL
(2021)
Article
Physiology
Aihua Lu, Min Pu, Shiqi Mo, Jiahui Su, Jiajia Hu, Chunling Li, Weidong Wang, Tianxin Yang
Summary: This study identified a novel role of (pro)renin receptor (PRR) in mediating the phosphaturic response to phosphate treatment. Activation of PRR promotes the production of FGF23, which in turn downregulates the expression of renal Na/Pi-IIa and enhances phosphate excretion.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Reproductive Biology
Faten AbdelHafez, Christian Klausen, Hua Zhu, Peter C. K. Leung
Summary: This study found that myostatin can increase trophoblast cell invasion by upregulating N-cadherin, and this effect is mediated by the SMAD2/3-SMAD4 signaling pathway.
BIOLOGY OF REPRODUCTION
(2022)
Article
Agriculture, Dairy & Animal Science
M. H. C. Pereira, B. I. Cappellozza, R. L. A. Cerri, C. P. Sanches Jr, T. G. Guida, L. F. S. P. Barbosa, J. E. P. Santos, J. L. M. Vasconcelos
Summary: This study evaluated the use of a second PGF(2 alpha) treatment in improving pregnancy rates of lactating Holstein cows undergoing timed embryo transfer. The results showed that the use of a second PGF(2 alpha) treatment increased estrus expression and ovulation rates, but did not affect pregnancy rates.
JOURNAL OF DAIRY SCIENCE
(2023)
Article
Cell Biology
Xinyi Zhang, Bo Liang, Jun Zhang, Xinyao Hao, Xiaoyan Xu, Hsun-Ming Chang, Peter C. K. Leung, Jichun Tan
Summary: Raman spectroscopy combined with machine-learning algorithms can detect changes in the metabolic profiles of PCOS patients, aiding in diagnosis and characterization.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Duan Li, Xiaoyan Wang, Yujie Dang, Xinyue Zhang, Shidou Zhao, Gang Lu, Wai-Yee Chan, Peter C. K. Leung, Yingying Qin
Summary: The lncRNA GCAT1 is downregulated in granulosa cells from patients with biochemical POI, and its downregulation inhibits cell proliferation by PTBP1-dependent p27 regulation. This suggests a novel form of lncRNA-mediated epigenetic regulation of GC function in the pathogenesis of POI.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Endocrinology & Metabolism
Yuanyuan Man, Rusong Zhao, Xueying Gao, Yue Liu, Shigang Zhao, Gang Lu, Wai-Yee Chan, Peter C. K. Leung, Yuehong Bian
Summary: TOX3 overexpression stimulates estrogen synthesis in ovarian granulosa cells, leading to increased cell viability and decreased apoptosis. Transcriptome analysis revealed that TOX3 overexpression affects the ovarian steroidogenesis pathway.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Cell Biology
Jiali You, Wei Wang, Hsun-Ming Chang, Yuyin Yi, Hongjin Zhao, Hua Zhu, Yu Sun, Minyue Tang, Chunyan Wang, Yimiao Sang, Guofang Feng, Shaobing Cheng, Peter C. K. Leung, Yi-Min Zhu
Summary: Embryo implantation and trophoblast invasion are critical for establishing pregnancy, with BMP2 playing a significant role in regulating these processes by influencing gene expression and promoting the development and invasion of embryo and trophoblast cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, General & Internal
Yanting Wu, Isabelle Marc, Luigi Bouchard, Fengxiu Ouyang, Zhong-Cheng Luo, Jianxia Fan, Lise Dubois, Benoit Masse, Jun Zhang, Peter C. K. Leung, Xiang Peng Liao, C. M. Herba, Linda Booij, Jian Shen, Antoine Lewin, Hong Jiang, Liping Wang, Jian Xu, Weibin Wu, Wenguang Sun, Jiahao Wu, Hong Li, Chen Lei, Anita Kozyrskyj, Sonia Semenic, N. Chaillet, Isabel Fortier, Louise Masse, Janelle Zhan, Catherine Allard, Bartha Knoppers, Ma'n Zawati, Jean-Patrice Baillargeon, Maria P. Velez, Hanqiu Zhang, Yamei Yu, Wen Yu, Yan Ding, Caroline Vaillancourt, Han Liu, Amelie Tetu, Wenli Fang, Rong Zhang, Xinzhi Zhao, Yan Jin, Xin-Mei Liu, Huijuan Zhang, Zhirou Chen, Xi Yang, Yan-Hui Hao, Nadia Abdelouahab, William Fraser, He-Feng Huang
Summary: The SCHeLTI trial in Shanghai, China aims to evaluate the effectiveness of a multifaceted health promotion intervention on childhood overweight and obesity as well as non-communicable diseases risk.
Article
Reproductive Biology
Sai-Jiao Li, Hsun-Ming Chang, Jeremy H. Wang, Jing Yang, Peter C. K. Leung
Summary: IL-6 trans-signaling modulates progesterone production by activating the phosphorylation of JAK2 and STAT3 in human granulosa-lutein cells.
BIOLOGY OF REPRODUCTION
(2022)
Article
Reproductive Biology
Faten AbdelHafez, Christian Klausen, Hua Zhu, Peter C. K. Leung
Summary: This study found that myostatin can increase trophoblast cell invasion by upregulating N-cadherin, and this effect is mediated by the SMAD2/3-SMAD4 signaling pathway.
BIOLOGY OF REPRODUCTION
(2022)
Article
Reproductive Biology
Shen Tian, Han Zhang, Hsun-Ming Chang, Christian Klausen, He-Feng Huang, Min Jin, Peter C. K. Leung
Summary: Activin A increases the production of hyaluronan and the expression of versican in human granulosa-lutein cells, possibly through the mediation of the ALK4/SMAD2/SMAD3-SMAD4 signaling pathway.
BIOLOGY OF REPRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhang, Hsun-Ming Chang, Hua Zhu, Peter C. K. Leung
Summary: BMP2 suppresses PTX3 production through a canonical ALK2/3-mediated SMAD1/5-SMAD4-dependent signaling pathway, potentially regulating the process of endometrial decidualization in humans.
Article
Endocrinology & Metabolism
Hsun-Ming Chang, Long Bai, Yi-Min Zhu, Peter C. K. Leung
Summary: In this study, we found that BMP2 can promote the production of hyaluronan in human granulosa cells by upregulating the expression of hyaluronan synthase 2 (HAS2). This effect is mediated by the connective tissue growth factor (CTGF) through the ALK2/ALK3-mediated SMAD-dependent signaling pathway.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Li Dong, Xin Xin, Hsun-Ming Chang, Peter C. K. Leung, Chen Yu, Fang Lian, Haicui Wu
Summary: This study compared the expression profiles of lncRNA and mRNA in ovarian granulosa cells (OGCs) between patients with normal ovarian reserve (NOR) and diminished ovarian reserve (DOR) using RNA sequencing. The identified lncRNAs and mRNAs may serve as novel diagnostic biomarkers for patients with DOR.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Cell Biology
Hui Li, Hsun-Ming Chang, Saijiao Li, Christian Klausen, Zhendan Shi, Peter C. K. Leung
Summary: This study provides important insights into the molecular mechanisms by which AREG and TGF-β1 differentially regulate VE-cadherin expression and angiogenesis. AREG promotes microvascular-like formation through the EGFR-ERK1/2 signaling pathway, while TGF-β1 suppresses microvascular-like formation through the ALK5-SMAD2/3/4 signaling pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qi Jiang, Ruolan Miao, Yuhuan Wang, Wenqi Wang, Dingying Zhao, Yue Niu, Qiaoqiao Ding, Yan Li, Peter C. K. Leung, Daimin Wei, Zi-Jiang Chen
Summary: Polycystic ovary syndrome (PCOS) is a common and heterogeneous endocrine disorder, which is the main cause of ovulatory obstacle associated with abnormal folliculogenesis. Dysfunction of ovarian granulosa cells (GCs) is recognized as a major factor that underlies abnormal follicle maturation. The expression of angiopoietin-like 4 (ANGPTL4) in GCs differs between patients with and without PCOS. In this study, ANGPTL4 was found to be upregulated in patients with PCOS and its overexpression inhibited the proliferation of GCs through the EGFR/JAK1/STAT3-mediated induction of p21, providing a novel epigenetic mechanism for the pathogenesis of PCOS.
Article
Genetics & Heredity
Xin Xin, Hsun-Ming Chang, Peter C. K. Leung, Li Dong, Jiaxi Li, Fang Lian, Haicui Wu
Summary: This study aimed to investigate the expression of PTX3 in granulosa lutein cells derived from women with PCOS and explore the potential regulation of BMP6 on PTX3 expression in hGL cells. The results showed that the levels of BMP6 were negatively correlated with oocyte maturation and embryo quality in PCOS, while the levels of PTX3 were positively correlated with oocyte maturation. In vitro experiments also confirmed that BMP6 inhibited the expression of PTX3 in KGN cells. Further analysis revealed that the ALK2/ALK3 type I receptors and BMPR2/ACVR2A type II receptors, as well as the SMAD1/5-SMAD4 signaling pathway, were involved in the suppressive effect of BMP6 on PTX3 in granulosa cells. These findings provide new insights into the pathogenesis of PCOS-related ovulatory disorders.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Article
Obstetrics & Gynecology
Daimin Wei, Yaxin Su, Peter C. K. Leung, Yan Li, Zi-Jiang Chen
Summary: This review summarizes the current knowledge on the pathophysiological roles of BMPs and their underlying molecular mechanisms in regulating human endometrial proliferation and decidualization, aiming to promote the development of innovative strategies for diagnosing, treating, and preventing infertility and adverse pregnancy complications associated with dysregulated human endometrial remodeling.
HUMAN REPRODUCTION UPDATE
(2023)