Image-guided intrathymic injection of multipotent stem cells supports lifelong T-cell immunity and facilitates targeted immunotherapy

Intrathymic progenitor cell transplantation across histocompatibility barriers results in the persistence of early thymic progenitors and T-cell differentiation

(2013) S. C. de Barros et al.   BLOOD

Quantitative assessment of T cell repertoire recovery after hematopoietic stem cell transplantation

(2013) Jeroen W J van Heijst et al.   NATURE MEDICINE

Early T-cell progenitors are the major granulocyte precursors in the adult mouse thymus

(2012) M. E. De Obaldia et al.   BLOOD

High levels of IL-7 cause dysregulation of thymocyte development

(2012) N. El-Kassar et al.   INTERNATIONAL IMMUNOLOGY

Thymocytes may persist and differentiate without any input from bone marrow progenitors

(2012) Laetitia Peaudecerf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thymus-autonomous T cell development in the absence of progenitor import

(2012) Vera C. Martins et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential

(2012) Sidinh Luc et al.   NATURE IMMUNOLOGY

Interleukin-22 Drives Endogenous Thymic Regeneration in Mice

(2012) J. A. Dudakov et al.   SCIENCE

Changes in primary lymphoid organs with aging

(2012) Ivan K. Chinn et al.   SEMINARS IN IMMUNOLOGY

Comparison of Different Suicide-Gene Strategies for the Safety Improvement of Genetically Manipulated T Cells

(2012) Virna Marin et al.   Human Gene Therapy Methods

How do CARs work?

(2012) Marco L. Davila et al.   OncoImmunology

Delivery of progenitors to the thymus limits T-lineage reconstitution after bone marrow transplantation

(2011) D. A. Zlotoff et al.   BLOOD

Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

(2011) C. U. Louis et al.   BLOOD

Thymic fatness and approaches to enhance thymopoietic fitness in aging

(2010) Vishwa Deep Dixit   CURRENT OPINION IN IMMUNOLOGY

Emerging strategies to boost thymic function

(2010) Georg A Holländer et al.   CURRENT OPINION IN PHARMACOLOGY

Stem-Cell Gene Therapy for the Wiskott–Aldrich Syndrome

(2010) Kaan Boztug et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intrathymic transplantation of bone marrow-derived progenitors provides long-term thymopoiesis

(2009) R. Vicente et al.   BLOOD

Multiple extrathymic precursors contribute to T-cell development with different kinetics

(2009) N. Saran et al.   BLOOD

Cytokines, leptin, and stress-induced thymic atrophy

(2008) Amanda L. Gruver et al.   JOURNAL OF LEUKOCYTE BIOLOGY