JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation

Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes

(2012) C. Pecquet et al.   BLOOD

JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis

(2012) Claire Harrison et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacious Intermittent Dosing of a Novel JAK2 Inhibitor in Mouse Models of Polycythemia Vera

(2012) Manfred Kraus et al.   PLoS One

New mutations and pathogenesis of myeloproliferative neoplasms

(2011) W. Vainchenker et al.   BLOOD

How I treat essential thrombocythemia

(2010) P. A. Beer et al.   BLOOD

Screening forMPLmutations in essential thrombocythemia and primary myelofibrosis: normal Mpl expression and absence of constitutive STAT3 and STAT5 activation inMPLW515L-positive platelets

(2010) Ana C. Glembotsky et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Mouse Monoclonal Antibodies Against Human c-Mpl and Characterization for Flow Cytometry Applications

(2010) Christina Abbott et al.   HYBRIDOMA

Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1

(2010) A Tefferi   LEUKEMIA

Megakaryopoiesis

(2010) Amy E. Geddis   SEMINARS IN HEMATOLOGY

A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation

(2010) Rodolphe Besancenot et al.   PLOS BIOLOGY

ERK and cell death: Mechanisms of ERK-induced cell death - apoptosis, autophagy and senescence

(2009) Sebastien Cagnol et al.   FEBS Journal

Ras/MAPK signaling from endomembranes

(2009) Nicole Fehrenbacher et al.   Molecular Oncology

Myeloproliferative neoplasms: contemporary diagnosis using histology and genetics

(2009) Ayalew Tefferi et al.   Nature Reviews Clinical Oncology

Incomplete restoration of Mpl expression in the mpl-/- mouse produces partial correction of the stem cell-repopulating defect and paradoxical thrombocytosis

(2008) B. J. Lannutti et al.   BLOOD

Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes

(2008) R. Tiedt et al.   BLOOD