Omental implantation of BOECs in hemophilia dogs results in circulating FVIII antigen and a complex immune response

Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant

(2013) J. McIntosh et al.   BLOOD

The polygenic nature of inhibitors in hemophilia A: results from the Hemophilia Inhibitor Genetics Study (HIGS) Combined Cohort

(2012) J. Astermark et al.   BLOOD

A major determinant of the immunogenicity of factor VIII in a murine model is independent of its procoagulant function

(2012) S. L. Meeks et al.   BLOOD

Bioengineering of coagulation factor VIII for efficient expression through elimination of a dispensable disulfide loop

(2011) S. R. SELVARAJ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A

(2011) Hideto Matsui et al.   MOLECULAR THERAPY

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

(2011) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function

(2010) J. Lu et al.   BLOOD

Codon optimization of human factor VIII cDNAs leads to high-level expression

(2010) N. J. Ward et al.   BLOOD

Trp2313-His2315of Factor VIII C2 Domain Is Involved in Membrane Binding

(2010) Zhuo Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for thrombin in the initiation of the immune response to therapeutic factor VIII

(2009) J. Skupsky et al.   BLOOD

Haemophilia gene therapy: the patients’ perspective

(2009) I. COSTEA et al.   HAEMOPHILIA

Kinetic parameters of monoclonal antibodies ESH2, ESH4, ESH5, and ESH8 on coagulation factor VIII and their influence on factor VIII activity

(2009) C. Egler et al.   JOURNAL OF MOLECULAR RECOGNITION

Antioxidants reduce endoplasmic reticulum stress and improve protein secretion

(2008) J. D. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA