Pharmacologic inhibition of PKC  and PKC  prevents GVHD while preserving GVL activity in mice

Prevention of GVHD while sparing GVL effect by targeting Th1 and Th17 transcription factor T-bet and ROR t in mice

(2011) Y. Yu et al.   BLOOD

Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new

(2011) J. M. Coghill et al.   BLOOD

PKC-θ: hitting the bull's eye

(2011) Michael L Dustin   NATURE IMMUNOLOGY

PKC-θ function at the immunological synapse: prospects for therapeutic targeting

(2011) Alexandra Zanin-Zhorov et al.   TRENDS IN IMMUNOLOGY

Sotrastaurin, a Novel Small Molecule Inhibiting Protein Kinase C: First Clinical Results in Renal-Transplant Recipients

(2010) K. Budde et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

PKC inhibitors: potential in T cell-dependent immune diseases

(2009) Gottfried Baier et al.   CURRENT OPINION IN CELL BIOLOGY

PKC-α controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells

(2009) Christelle Langlet et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice

(2009) Javier O. Valenzuela et al.   JOURNAL OF CLINICAL INVESTIGATION

PKCθ cooperates with PKCα in alloimmune responses of T cells in vivo

(2009) Thomas Gruber et al.   MOLECULAR IMMUNOLOGY

PKC-  selectively controls the adhesion-stimulating molecule Rap1

(2008) T. Letschka et al.   BLOOD

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

(2008) Hans Skvara et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential requirement of PKC-θ in the development and function of natural regulatory T cells

(2008) Sonal Gupta et al.   MOLECULAR IMMUNOLOGY

2 integrins separate graft-versus-host disease and graft-versus-leukemia effects

(2007) Y. Liang et al.   BLOOD