Aurora and IKK kinases cooperatively interact to protect multiple myeloma cells from Apo2L/TRAIL

Bone Marrow Stroma Confers Resistance to Apo2 Ligand/TRAIL in Multiple Myeloma in Part by Regulating c-FLIP

(2014) L. E. Perez et al.   JOURNAL OF IMMUNOLOGY

Aurora B confers cancer cell resistance to TRAIL-induced apoptosis via phosphorylation of survivin

(2011) Mi Jin Yoon et al.   CARCINOGENESIS

Crosstalk in NF-κB signaling pathways

(2011) Andrea Oeckinghaus et al.   NATURE IMMUNOLOGY

A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma

(2010) G. Gorgun et al.   BLOOD

Classical and/or alternative NF- B pathway activation in multiple myeloma

(2010) Y. N. Demchenko et al.   BLOOD

Death Receptor Agonists as a Targeted Therapy for Cancer

(2010) J. Wiezorek et al.   CLINICAL CANCER RESEARCH

Phase I Dose-Escalation Study of Recombinant Human Apo2L/TRAIL, a Dual Proapoptotic Receptor Agonist, in Patients With Advanced Cancer

(2010) Roy S. Herbst et al.   JOURNAL OF CLINICAL ONCOLOGY

Inhibition of aurora kinases for tailored risk-adapted treatment of multiple myeloma

(2009) D. Hose et al.   BLOOD

Biologic sequelae of I B kinase (IKK) inhibition in multiple myeloma: therapeutic implications

(2009) T. Hideshima et al.   BLOOD

Bortezomib restores stroma-mediated APO2L/TRAIL apoptosis resistance in multiple myeloma

(2009) Lia E. Perez et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Phorbol ester-induced PKC  down-modulation sensitizes AML cells to TRAIL-induced apoptosis and cell differentiation

(2008) G. Gobbi et al.   BLOOD

Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways

(2008) P. Lunghi et al.   BLOOD

Inhibition of Aurora B kinase sensitizes a subset of human glioma cells to TRAIL concomitant with induction of TRAIL-R2

(2008) J Li et al.   CELL DEATH AND DIFFERENTIATION

NF-??B in the pathogenesis and treatment of multiple myeloma

(2008) Zhi-Wei Li et al.   CURRENT OPINION IN HEMATOLOGY

TRAIL receptor-targeted therapeutics: Resistance mechanisms and strategies to avoid them

(2008) A THORBURN et al.   DRUG RESISTANCE UPDATES

To kill a tumor cell: the potential of proapoptotic receptor agonists

(2008) Avi Ashkenazi et al.   JOURNAL OF CLINICAL INVESTIGATION

Compensatory IKK  activation of classical NF- B signaling during IKK  inhibition identified by an RNA interference sensitization screen

(2008) L. T. Lam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem-Cell Transplantation for Multiple Myeloma in the Era of Novel Drugs

(2007) William Bensinger   JOURNAL OF CLINICAL ONCOLOGY