Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia

Cord Blood T Cells Retain Early Differentiation Phenotype Suitable for Immunotherapy After TCR Gene Transfer to Confer EBV Specificity

(2012) G. Frumento et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma

(2012) H. Nishikawa et al.   BLOOD

Impact of graft-versus-host disease on outcomes after allogeneic hematopoietic cell transplantation for adult T-cell leukemia: a retrospective cohort study

(2012) J. Kanda et al.   BLOOD

Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study

(2012) Takashi Ishida et al.   JOURNAL OF CLINICAL ONCOLOGY

A Promising Vector for TCR Gene Therapy: Differential Effect of siRNA, 2A Peptide, and Disulfide Bond on the Introduced TCR Expression

(2012) Sachiko Okamoto et al.   Molecular Therapy-Nucleic Acids

Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity

(2011) K. Nagai et al.   BLOOD

Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety

(2011) T. Ochi et al.   BLOOD

hTERT mRNA dendritic cell vaccination: complete response in a pancreatic cancer patient associated with response against several hTERT epitopes

(2011) Else M. Inderberg Suso et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting Regulatory T Cells in Cancer

(2011) W. L. Byrne et al.   CANCER RESEARCH

Requisite considerations for successful adoptive immunotherapy with engineered T-lymphocytes using tumor antigen-specific T-cell receptor gene transfer

(2011) Toshiki Ochi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

(2011) Paul F. Robbins et al.   JOURNAL OF CLINICAL ONCOLOGY

T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

(2011) M. Kalos et al.   Science Translational Medicine

Relapse of renal cell carcinoma with disappearance of HLA class I following hTERT peptide vaccination

(2010) M. Yasukawa et al.   ANNALS OF ONCOLOGY

Combination immunotherapy using adoptive T-cell transfer and tumor antigen vaccination on the basis of hTERT and survivin after ASCT for myeloma

(2010) A. P. Rapoport et al.   BLOOD

Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study

(2010) M. Hishizawa et al.   BLOOD

Telomere/telomerase interplay in virus-driven and virus-independent lymphomagenesis: pathogenic and clinical implications

(2010) Riccardo Dolcetti et al.   MEDICINAL RESEARCH REVIEWS

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

(2010) Gavin M Bendle et al.   NATURE MEDICINE

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

Improved Expression and Reactivity of Transduced Tumor-Specific TCRs in Human Lymphocytes by Specific Silencing of Endogenous TCR

(2009) S. Okamoto et al.   CANCER RESEARCH

HBZ is an immunogenic protein, but not a target antigen for human T-cell leukemia virus type 1-specific cytotoxic T lymphocytes

(2009) K. Suemori et al.   JOURNAL OF GENERAL VIROLOGY

Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells

(2008) M. Bellon et al.   BLOOD

Aurora-A kinase: a novel target of cellular immunotherapy for leukemia

(2008) T. Ochi et al.   BLOOD

Role of human T-cell leukemia virus type I Tax in expression of thehuman telomerase reverse transcriptase(hTERT) gene in human T-cells

(2008) Toshifumi Hara et al.   CANCER SCIENCE

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

(2008) Martin A Pule et al.   NATURE MEDICINE