Plzf drives MLL-fusion-mediated leukemogenesis specifically in long-term hematopoietic stem cells

EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs

(2012) E. M. J. Bindels et al.   BLOOD

Functional Crosstalk between Bmi1 and MLL/Hoxa9 Axis in Establishment of Normal Hematopoietic and Leukemic Stem Cells

(2011) Lan-Lan Smith et al.   Cell Stem Cell

MLL partner genes drive distinct gene expression profiles and genomic alterations in pediatric acute myeloid leukemia: an AIEOP study

(2011) M Pigazzi et al.   LEUKEMIA

Evi-1 is a transcriptional target of mixed-lineage leukemia oncoproteins in hematopoietic stem cells

(2010) S. Arai et al.   BLOOD

Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia

(2010) B. V. Balgobind et al.   HAEMATOLOGICA

Therapeutic targeting of MLL

(2009) M. Liedtke et al.   BLOOD

PLZF is a regulator of homeostatic and cytokine-induced myeloid development

(2009) S. Doulatov et al.   GENES & DEVELOPMENT

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

(2009) H. Boukarabila et al.   GENES & DEVELOPMENT

Mixed-lineage-leukemia (MLL) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation

(2009) R Ono et al.   LEUKEMIA

Malignant Transformation Initiated by Mll-AF9: Gene Dosage and Critical Target Cells

(2008) Weili Chen et al.   CANCER CELL

The Transcription Factor PLZF Directs the Effector Program of the NKT Cell Lineage

(2008) Adam K. Savage et al.   IMMUNITY