Article
Peripheral Vascular Disease
Piotr Sobieraj, Peter M. Nilsson, Thomas Kahan
Summary: The SPRINT study demonstrated that intensive blood pressure lowering not only reduced heart failure events, but also significantly decreased the risk of cardiovascular events, supporting the use of a more intensive treatment strategy for high-risk hypertensive patients.
Article
Biochemistry & Molecular Biology
Jiang-Ming Chen, Wei-Jian Zhu, Jie Liu, Gui-Zhen Wang, Xiao-Qin Chen, Yun Tan, Wei-Wei Xu, Li-Wei Qu, Jin-Yan Li, Huan-Ju Yang, Lan Huang, Ning Cai, Wei-Da Wang, Ken Huang, Jian-Quan Xu, Guo-Hui Li, Sheng He, Tian-Ying Luo, Yi Huang, Song-Hua Liu, Wen-Qiang Wu, Qi-Yang Lu, Mei-Guang Zhou, Shu-Ying Chen, Rong-Lan Li, Mei-Ling Hu, Ying Huang, Jin-Hua Wei, Jun-Min Li, Sai-Juan Chen, Guang-Biao Zhou
Summary: The study demonstrates that thalidomide is effective in patients with transfusion-dependent beta-thalassemia (TDT), showing a significant increase in hemoglobin concentration within 12 weeks and a reduction in the need for blood transfusions. However, patients treated with thalidomide were more likely to experience adverse events compared to those on placebo.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Multidisciplinary Sciences
Zahid Ali, Mohammad Ismail, Inayat Ur Rehman, Gulab Fatima Rani, Muhammad Ali, Muhammad Tariq Masood Khan
Summary: This single-arm, non-randomized clinical trial aimed to explore the long-term safety and efficacy of thalidomide in hydroxyurea refractory transfusion-dependent beta-thalassemia patients. The study found that thalidomide treatment can significantly increase hemoglobin level, reduce transfusion frequency, lower serum ferritin level, and improve liver and spleen size. The results suggest that thalidomide is an effective and well-tolerated drug for improving hemoglobin levels and reducing transfusion burden in TDT patients.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Zhimin Chen, Liran Chen, Huafang Chen
Summary: The COVID-19 pandemic has caused various changes in the implementation of drug clinical trials, leading to increased workload, deviations from protocol, and heightened anxiety among subjects. While measures such as online meetings and remote follow-up can ensure the progress of clinical trials to a certain extent, they cannot fully guarantee the quality as before.
Article
Genetics & Heredity
Michael T. Eadon, Marc B. Rosenman, Pengyue Zhang, Cathy R. Fulton, John T. Callaghan, Ann M. Holmes, Kenneth D. Levy, Samir K. Gupta, David M. Haas, Raj Vuppalanchi, Eric A. Benson, Rolf P. Kreutz, Emma M. Tillman, Tyler Shugg, Rebecca C. Pierson, Brandon T. Gufford, Victoria M. Pratt, Yong Zang, Zeruesenay Desta, Paul R. Dexter, Todd C. Skaar
Summary: This study evaluated the impact of pharmacogenetic testing on the occurrence of adverse drug events (ADEs) in individuals receiving pharmacogenetic-actionable drugs. The results showed no significant reduction in overall ADEs, but a decrease in serious ADEs and death was observed in individuals who underwent pharmacogenotyping for specific drugs.
PHARMACOGENOMICS JOURNAL
(2023)
Article
Hematology
Sindy N. Escobar Alvarez, Elizabeth R. Myers
Summary: The Doris Duke Charitable Foundation provided funding for sickle cell disease (SCD) research through the Innovations in Clinical Research Awards program, resulting in substantial advancements in diagnosis and treatment of the disease. The research investment showed substantial financial return and led to significant innovations in the field.
Article
Clinical Neurology
Iris Lettow, Maerit Jensen, Eckhard Schlemm, Florent Boutitie, Fanny Quandt, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Vincent Thijs, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Christian Gerloff, Gotz Thomalla
Summary: This study analyzed the impact of serious adverse events (SAE) on functional outcomes in patients with acute ischemic stroke, as well as predictors of SAE occurrence. Results showed that approximately one in five patients experienced SAE, with older age and male sex being predictive factors for SAE. These findings may help in assessing the risk of SAE in future stroke trials and raising awareness of severe complications after stroke in clinical practice.
Article
Cardiac & Cardiovascular Systems
Georg M. Wieselthaler, Liviu Klein, Anson W. Cheung, Matthew R. Danter, Martin Strueber, Claudius Mahr, Nahush A. Mokadam, Simon Maltais, Edwin C. McGee
Summary: The two-year follow-up of the LATERAL trial demonstrated a favorable morbidity profile in HVAD system-supported patients, with higher AE rates occurring within the first 30 days postimplant but significantly reduced overall AE rates after 6 months. Importantly, the 2-year freedom from disabling stroke was 95%. These findings further support the improving AE profile in long-term HVAD-supported patients.
CIRCULATION-HEART FAILURE
(2021)
Article
Hematology
Wally R. Smith, Donna K. McClish, Richard Lottenberg, India Y. Sisler, Daniel Sop, Shirley Johnson, Anthony Villella, Darla Liles, Elizabeth Yang, Ian Chen
Summary: Patients eligible for hydroxyurea treatment who were exposed to patient navigators showed improvements in starting hydroxyurea treatment and adherence, but there were no significant differences in hematological parameters between the experimental and control groups at 12 months.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Clinical Neurology
David S. Liebeskind, Hamidreza Saber, Parita Bhuva, Bin Xiang, Albert J. Yoo, Ashutosh P. Jadhav, Diogo C. Haussen, Ronald F. Budzik, Alain Bonafe, Dileep R. Yavagal, Ricardo A. Hanel, Marc Ribo, Christophe Cognard, Cathy Sila, Ameer E. Hassan, Wade S. Smith, Jeffrey L. Saver, Raul G. Nogueira, Tudor G. Jovin
Summary: In the DAWN trial, baseline ASPECTS and 24-hour ASPECTS were influenced by different factors, with age and medical history affecting the former and endovascular therapy, glucose levels, and stroke scale affecting the latter. A significant portion (8%) of patients had extensive infarct evolution.
Article
Cardiac & Cardiovascular Systems
Eric L. Eisenstein, Shelly Sapp, Tina Harding, Amanda Harrington, Eric J. Velazquez, Robert J. Mentz, Stephen J. Greene, Vandana Sachdev, Dong-Yun Kim, Kevin . Anstrom
Summary: There is substantial agreement between deaths identified by a centralized call center and the National Death Index (NDI). However, the call center has a significantly shorter time between a death event and its identification.
JOURNAL OF CARDIAC FAILURE
(2022)
Article
Hematology
Shehu U. Abdullahi, Surayya Sunusi, Mohammed Sani Abba, Saifuddeen Sani, Hauwau Aminu Inuwa, Safiya Gambo, Awwal Gambo, Bilya Musa, Brittany V. Covert Greene, Adetola A. Kassim, Mark Rodeghier, Nafiu Hussaini, Mariana Ciobanu, Muktar H. Aliyu, Lori C. Jordan, Michael R. DeBaun
Summary: This study investigated the effectiveness of fixed oral moderate-dose hydroxyurea compared with fixed oral low-dose hydroxyurea for secondary stroke prevention in children with sickle cell anemia. The results showed that there was no evidence to support the superiority of moderate-dose hydroxyurea in reducing the risk of stroke or death compared to low-dose hydroxyurea.
Article
Cardiac & Cardiovascular Systems
Tineke H. Pinxterhuis, Eline H. Ploumen, Paolo Zocca, Carine J. M. Doggen, Carl E. Schotborgh, Rutger L. Anthonio, Ariel Roguin, Peter W. Danse, Edouard Benit, Adel Aminian, Martin G. Stoel, Gerard C. M. Linssen, Robert H. Geelkerken, Clemens von Birgelen
Summary: Patients with PADs who undergo PCI have a higher risk of bleeding compared to those without PADs. Additionally, bleeding in PADs patients is associated with increased mortality and adverse cardiac events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Psychology, Multidisciplinary
Desiree N. Williford, Emily A. McTate, Anna M. Hood, Steven K. Reader, Aimee K. Hildenbrand, Kim Smith-Whitley, Susan E. Creary, Alexis A. Thompson, Rogelle Hackworth, Jean L. Raphael, Lori E. Crosby
Summary: Psychologists have the responsibility to improve health care experiences for racialized families, such as those with sickle cell disease. This article discusses the application of antiracism and participatory strategies in a clinical trial for pediatric patients with SCD, including the development of research questions promoting justice, addressing imbalances through shared decision-making, involving stakeholders through community participatory approaches, and considering contextual factors like COVID-19 and racism pandemics. The intersectionality lens is applied, considering the primary caregivers of children with SCD who are Black women. Implications for psychologists working to advance health equity in medical settings are also discussed.
AMERICAN PSYCHOLOGIST
(2023)
Article
Medicine, General & Internal
Seth M. Noar, Nisha C. Gottfredson, Talia Kieu, Jacob A. Rohde, Marissa G. Hall, Haijing Ma, Nicholas J. Fendinger, Noel T. Brewer
Summary: This study found that vaping prevention advertisements from the FDA Real Cost campaign reduced adolescent susceptibility to vaping and had positive spillover effects on cigarette smoking outcomes.
Article
Allergy
Sasha Taylor, Brigitte Borg, Caroline Gao, David Brown, Ryan Hoy, Annie Makar, Tom McCrabb, Jillian F. Ikin, Bruce R. Thompson, Michael J. Abramson
Summary: In 2014, a fire at an open cut coal mine in South-eastern Australia burned for about 6 weeks. This study aimed to investigate potential long-term impacts of short-term exposure to coal mine fire smoke on asthma. The results showed that after 3 and a half years of exposure, coal mine fire smoke did not appear to be associated with more severe asthma symptoms or worse lung function but might be associated with poorer asthma control.
Review
Pharmacology & Pharmacy
Wenyao Yang, Bruce Thompson, Faith A. A. Kwa
Summary: Friedreich's ataxia is caused by an intronic GAA trinucleotide expansion in the gene, leading to frataxin protein deficiency. Current management focuses on symptomatic relief as there are no treatments to prevent disease progression, highlighting the importance of targeting molecular pathways to alter the course of the condition.
DRUG DISCOVERY TODAY
(2022)
Article
Respiratory System
Sanja Stanojevic, David A. Kaminsky, Martin R. Miller, Bruce Thompson, Andrea Aliverti, Igor Barjaktarevic, Brendan G. Cooper, Bruce Culver, Eric Derom, Graham L. Hall, Teal S. Hallstrand, Joerg D. Leuppi, Neil MacIntyre, Meredith McCormack, Margaret Rosenfeld, Erik R. Swenson
Summary: This article emphasizes the importance of accurately interpreting pulmonary function test results and updates the new standards and strategies for interpreting pulmonary function tests. It is necessary to combine clinical expertise and biological variability for interpretation to ensure an accurate understanding of individual pulmonary function measurements.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Rehabilitation
Benjamin J. Tarrant, Elizabeth Quinn, Rebecca Robinson, Megan Poulsen, Louise Fuller, Greg Snell, Bruce R. Thompson, Brenda M. Button, Anne E. Holland
Summary: This study aimed to establish the feasibility and safety of intensive acute physiotherapy post-lung transplantation. The results showed that acute, intensive physiotherapy was feasible and safe, with no intervention-related adverse events observed.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Critical Care Medicine
Shyamali C. Dharmage, Dinh S. Bui, Eugene H. Walters, Adrian J. Lowe, Bruce Thompson, Gayan Bowatte, Paul Thomas, Judith Garcia-Aymerich, Debbie Jarvis, Garun S. Hamilton, David P. Johns, Peter Frith, Chamara Senaratna, Nur S. Idrose, Richard R. Wood -Baker, John Hopper, Lyle Gurrin, Bircan Erbas, George R. Washko, Rosa Faner, Alvar Agusti, Michael J. Abramson, Caroline J. Lodge, Jennifer L. Perret
Summary: This study is the first to characterize lifetime phenotypes of obstruction and restriction simultaneously using objective data-driven techniques. Early interventions might be beneficial for individuals with mixed and obstructive-only patterns, while those with restrictive-only pattern are at increased risk of true lung restriction and multiple morbidities in middle age.
LANCET RESPIRATORY MEDICINE
(2023)
Letter
Respiratory System
Martin R. Miller, Sanja Stanojevic, David A. Kaminsky, Bruce R. Thompson
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Fakir M. Amirul Islam, Mohammad Ariful Islam, Mohammad Arzan Hosen, Elisabeth A. Lambert, Ralph Maddison, Gavin W. Lambert, Bruce R. Thompson
Summary: Engaging in high physical activity and having a positive attitude towards physical activity are associated with lower blood pressure levels in rural Bangladesh. Awareness programs should be implemented to promote the benefits of physical activity and increase participation in high physical activity.
Letter
Respiratory System
Sanja Stanojevic, David A. Kaminsky, Martin Miller, Bruce Thompson
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Physiology
G. Kim Prisk, Sandra Rutting, Jack Bozier, Cindy Thamrin, Paul D. Robinson, Bruce R. Thompson
Summary: Sensor errors in commercial multiple-breath washout (MBW) devices result in elevated N2 concentration, leading to erroneous values of functional residual capacity (FRC), lung clearance index (LCI), Scond, and Sacin. The mechanism behind these errors and the appropriateness of the algorithm used to calculate these indices need further exploration.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Letter
Pediatrics
Shivanthan Shanthikumar, Katherine Chen, Victoria X. Soriano, Lily Nguyen, Jennifer J. Koplin, Mimi L. K. Tang, Adrian J. Lowe, Caroline J. Lodge, Nur Sabrina Idrose, Sarath Ranganathan, Bruce Thompson, Shyamali C. Dharmage, Rachel L. Peters
PEDIATRIC PULMONOLOGY
(2023)
Review
Medicine, General & Internal
Chuan T. T. Foo, David Langton, Bruce R. R. Thompson, Francis Thien
Summary: Respiratory diseases are a major cause of death and disability worldwide. Current diagnostic tools lack sensitivity and invasiveness, making early diagnosis difficult. This article reviews emerging techniques such as hyperpolarised gas MRI and other novel imaging techniques to overcome these challenges and evaluate lung function and microstructure in clinically focused ways.
FRONTIERS IN MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Faith A. A. Kwa, Bang V. Bui, Bruce R. Thompson, Lauren N. Ayton
Summary: Vision loss has a significant impact on individuals and communities, both financially and emotionally. Age-related macular degeneration, diabetic retinopathy, glaucoma, and retinitis pigmentosa are common causes of vision loss. As the global population grows and ages, it is crucial to develop therapies that can prevent early pathological events. This review outlines the preclinical research on sulforaphane, a compound derived from broccoli, in ocular diseases and discusses its potential for future clinical testing.
DRUG DISCOVERY TODAY
(2023)
Proceedings Paper
Engineering, Marine
Daniel K. Freeman, Stephen Lynch, Jonathan D. Anderson, Richard Teal, Matthew Bernasconi, Michael Rickley, Philip Bailey, Jimmy Nguyen, Bruce Thompson, Mihai Ibanescu, Graeme Knox, Alexander Stolyarov, Andrew March, Livia Racz
Summary: This article introduces a long-length fiber sensing array that can continuously monitor ocean characteristics, and describes the process of fabricating the fibers and integrating electronics into them. An ASIC is used to handle long-distance communication along the fiber.
2022 OCEANS HAMPTON ROADS
(2022)
Meeting Abstract
Respiratory System
C. O'Sullivan, G. K. Prisk, K. Nilsen, R. Mcintyre, B. Pontre, D. Dubowitz, B. Thompson
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Respiratory System
Shivonne Prasad, Caroline X. Gao, Brigitte Borg, Jonathan Broder, David Brown, Jillian F. Ikin, Annie Makar, Tom McCrabb, Ryan Hoy, Bruce Thompson, Michael J. Abramson
Summary: This study investigates the impact of exposure to high concentrations of PM2.5 from the Hazelwood fire on chronic obstructive pulmonary disease (COPD). The study found a dose-response association between PM2.5 exposure from the fire and COPD in nonsmokers. These findings are important for informing policy decisions during future sustained smoke events.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
