Notch and PI3K: how is the road traveled?

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCR -selected mouse thymocytes

(2012) G. W. Wong et al.   BLOOD

Vital roles of mTOR complex 2 in Notch-driven thymocyte differentiation and leukemia

(2012) Keunwook Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling

(2011) Hind Medyouf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation

(2010) Agnieszka A. Wendorff et al.   IMMUNITY

Targeting the Notch1 and mTOR pathways in a mouse T-ALL model

(2009) K. Cullion et al.   BLOOD

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss

(2009) H. Medyouf et al.   BLOOD

CSL–MAML-dependent Notch1 signaling controls T lineage–specific IL-7Rα gene expression in early human thymopoiesis and leukemia

(2009) Sara González-García et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical roles of the PI3K/Akt signaling pathway in T cell development

(2008) Marisa M. Juntilla et al.   IMMUNOLOGY LETTERS