Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel

Pediatric acute myeloid leukemia

(2012) Gertjan JL Kaspers   Expert Review of Anticancer Therapy

Effect of gemtuzumab ozogamicin on survival of adult patients with de-novo acute myeloid leukaemia (ALFA-0701): a randomised, open-label, phase 3 study

(2012) Sylvie Castaigne et al.   LANCET

Rasburicase for the treatment of tumor lysis in hematological malignancies

(2012) Giulia Malaguarnera et al.   Expert Review of Hematology

Second induction with high-dose cytarabine and mitoxantrone: different impact on pediatric AML patients with t(8;21) and with inv(16)

(2011) U. Creutzig et al.   BLOOD

Presence of FLT3-ITD and high BAALC expression are independent prognostic markers in childhood acute myeloid leukemia

(2011) A. Staffas et al.   BLOOD

Analysis of GATA1 mutations in Down syndrome transient myeloproliferative disorder and myeloid leukemia

(2011) K. A. Alford et al.   BLOOD

Natural history of transient myeloproliferative disorder clinically diagnosed in Down syndrome neonates: a report from the Children's Oncology Group Study A2971

(2011) A. S. Gamis et al.   BLOOD

Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification

(2011) E. Matutes et al.   BLOOD

Acute leukemia incidence and patient survival among children and adults in the United States, 2001-2007

(2011) G. M. Dores et al.   BLOOD

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern

(2011) I. H. I. M. Hollink et al.   BLOOD

Results of a randomized trial in children with Acute Myeloid Leukaemia: Medical Research Council AML12 trial

(2011) Brenda E. S. Gibson et al.   BRITISH JOURNAL OF HAEMATOLOGY

AAML03P1, a pilot study of the safety of gemtuzumab ozogamicin in combination with chemotherapy for newly diagnosed childhood acute myeloid leukemia

(2011) Todd M. Cooper et al.   CANCER

Clinical Practice Guideline for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer: 2010 Update by the Infectious Diseases Society of America

(2011) Alison G. Freifeld et al.   CLINICAL INFECTIOUS DISEASES

FLT3 inhibitors: a story of the old and the new

(2011) Amir Fathi et al.   CURRENT OPINION IN HEMATOLOGY

Invasive fungal infections in the pediatric population

(2011) Thomas Lehrnbecher et al.   Expert Review of Anti-Infective Therapy

Prognostic impact of white blood cell count in intermediate risk acute myeloid leukemia: relevance of mutated NPM1 and FLT3-ITD

(2011) H. J. M. de Jonge et al.   HAEMATOLOGICA

Integrative analysis of type-I and type-II aberrations underscores the genetic heterogeneity of pediatric acute myeloid leukemia

(2011) B. V. Balgobind et al.   HAEMATOLOGICA

Phase I Pharmacokinetic and Pharmacodynamic Study of the Multikinase Inhibitor Sorafenib in Combination With Clofarabine and Cytarabine in Pediatric Relapsed/Refractory Leukemia

(2011) Hiroto Inaba et al.   JOURNAL OF CLINICAL ONCOLOGY

Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia

(2011) Felicitas Thol et al.   JOURNAL OF CLINICAL ONCOLOGY

Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

(2011) Ching-Hon Pui et al.   JOURNAL OF CLINICAL ONCOLOGY

Impact of Pretransplantation Minimal Residual Disease, As Detected by Multiparametric Flow Cytometry, on Outcome of Myeloablative Hematopoietic Cell Transplantation for Acute Myeloid Leukemia

(2011) Roland B. Walter et al.   JOURNAL OF CLINICAL ONCOLOGY

Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report

(2011) U Creutzig et al.   LEUKEMIA

Low frequency of DNMT3A mutations in pediatric AML and the identification of the OCI-AML3 cell line as an in vitro model

(2011) I H I M Hollink et al.   LEUKEMIA

Prevalence and clinical implications of NRAS mutations in childhood AML: a report from the Children's Oncology Group

(2011) J N Berman et al.   LEUKEMIA

Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10

(2011) M C Béné et al.   LEUKEMIA

Allogeneic stem cell transplant to eliminate germline mutations in the gene for CCAAT-enhancer-binding protein α from hematopoietic cells in a family with AML

(2011) M Stelljes et al.   LEUKEMIA

Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML–BFM and DCOG study groups

(2011) F Damm et al.   LEUKEMIA

Hematopoietic stem cell transplantation for advanced myelodysplastic syndrome in children: results of the EWOG-MDS 98 study

(2011) B Strahm et al.   LEUKEMIA

Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: A report from the Children's Oncology Group

(2011) Phoenix A. Ho et al.   PEDIATRIC BLOOD & CANCER

Acute megakaryoblastic leukemia with a four-way variant translocation originating the RBM15-MKL1 fusion gene

(2011) Lurdes Torres et al.   PEDIATRIC BLOOD & CANCER

CNS irradiation in pediatric acute myleoid leukemia: Equal results by 12 or 18 Gy in studies AML-BFM98 and 2004

(2011) Ursula Creutzig et al.   PEDIATRIC BLOOD & CANCER

Long-term health impacts of hematopoietic stem cell transplantation inform recommendations for follow-up

(2011) Smita Bhatia   Expert Review of Hematology

Impact of Genetic Features on Treatment Decisions in AML

(2011) H. Dohner et al.   Hematology-American Society of Hematology Education Program

Prevalence and prognostic implications of WT1 mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group

(2010) P. A. Ho et al.   BLOOD

A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia

(2010) D. Niewerth et al.   BLOOD

Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as "AML not otherwise specified" (AML-NOS) or "AML with myelodysplasia-related changes" (AML-MRC)

(2010) M. Miesner et al.   BLOOD

Prevalence and prognostic significance of KIT mutations in pediatric patients with core binding factor AML enrolled on serial pediatric cooperative trials for de novo AML

(2010) J. A. Pollard et al.   BLOOD

Independent prognostic variables in acute myeloid leukaemia

(2010) Matthew L. Smith et al.   BLOOD REVIEWS

Cardiotoxicity of anthracycline agents for the treatment of cancer: Systematic review and meta-analysis of randomised controlled trials

(2010) Lesley A Smith et al.   BMC CANCER

Favourable outcome of patients with childhood acute promyelocytic leukaemia after treatment with reduced cumulative anthracycline doses

(2010) Ursula Creutzig et al.   BRITISH JOURNAL OF HAEMATOLOGY

Acute leukaemias of ambiguous lineage in children: characterization, prognosis and therapy recommendations

(2010) Heidrun Gerr et al.   BRITISH JOURNAL OF HAEMATOLOGY

Low frequency of MLL-partial tandem duplications in paediatric acute myeloid leukaemia using MLPA as a novel DNA screenings technique

(2010) Brian V. Balgobind et al.   EUROPEAN JOURNAL OF CANCER

Developmental stage-specific interplay of GATA1 and IGF signaling in fetal megakaryopoiesis and leukemogenesis

(2010) J.-H. Klusmann et al.   GENES & DEVELOPMENT

Evaluation of gene expression signatures predictive of cytogenetic and molecular subtypes of pediatric acute myeloid leukemia

(2010) B. V. Balgobind et al.   HAEMATOLOGICA

Prognosis of children with mixed phenotype acute leukemia treated on the basis of consistent immunophenotypic criteria

(2010) E. Mejstrikova et al.   HAEMATOLOGICA

Mosaic Down syndrome-associated acute myeloid leukemia does not require high-dose cytarabine treatment for induction and consolidation therapy

(2010) Kazuko Kudo et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Impact of Cranial Irradiation Added to Intrathecal Conditioning in Hematopoietic Cell Transplantation in Adult Acute Myeloid Leukemia With Central Nervous System Involvement

(2010) Jyoti S. Mayadev et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Prognostic Impact of Specific Chromosomal Aberrations in a Large Group of Pediatric Patients With Acute Myeloid Leukemia Treated Uniformly According to Trial AML-BFM 98

(2010) Christine von Neuhoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Granulocyte Colony-Stimulating Factor (G-CSF) Treatment of Childhood Acute Myeloid Leukemias That Overexpress the Differentiation-DefectiveG-CSFReceptor Isoform IV Is Associated With a Higher Incidence of Relapse

(2010) Stephanie Ehlers et al.   JOURNAL OF CLINICAL ONCOLOGY

Cytogenetics of Childhood Acute Myeloid Leukemia: United Kingdom Medical Research Council Treatment Trials AML 10 and 12

(2010) Christine J. Harrison et al.   JOURNAL OF CLINICAL ONCOLOGY

Response-Guided Induction Therapy in Pediatric Acute Myeloid Leukemia With Excellent Remission Rate

(2010) Jonas Abrahamsson et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of Patients With Acute Myeloblastic Leukemia Who Benefit From the Addition of Gemtuzumab Ozogamicin: Results of the MRC AML15 Trial

(2010) Alan K. Burnett et al.   JOURNAL OF CLINICAL ONCOLOGY

Minimal residual disease-directed therapy for childhood acute myeloid leukaemia: results of the AML02 multicentre trial

(2010) Jeffrey E Rubnitz et al.   LANCET ONCOLOGY

Clinical significance of flowcytometric minimal residual disease detection in pediatric acute myeloid leukemia patients treated according to the DCOG ANLL97/MRC AML12 protocol

(2010) V H J van der Velden et al.   LEUKEMIA

EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia

(2010) B V Balgobind et al.   LEUKEMIA

Consequent and intensified relapse therapy improved survival in pediatric AML: results of relapse treatment in 379 patients of three consecutive AML-BFM trials

(2010) A Sander et al.   LEUKEMIA

KIAA1524: A novel MLL translocation partner in acute myeloid leukemia

(2010) Eva A. Coenen et al.   LEUKEMIA RESEARCH

DNMT3AMutations in Acute Myeloid Leukemia

(2010) Timothy J. Ley et al.   NEW ENGLAND JOURNAL OF MEDICINE

The open issue of central nervous system disease in pediatric acute myeloid leukemia

(2010) Andrea Pession   PEDIATRIC BLOOD & CANCER

The presence of central nervous system disease at diagnosis in pediatric acute myeloid leukemia does not affect survival: A Children's Oncology Group study

(2010) Donna L. Johnston et al.   PEDIATRIC BLOOD & CANCER

Myeloid Sarcoma

(2009) Cristina Campidelli et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Optimising the conditioning regimen for acute myeloid leukaemia

(2009) Frederick R. Appelbaum   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Prevalence and prognostic implications of CEBPA mutations in pediatric acute myeloid leukemia (AML): a report from the Children's Oncology Group

(2009) P. A. Ho et al.   BLOOD

Single-agent arsenic trioxide in the treatment of children with newly diagnosed acute promyelocytic leukemia

(2009) J. Zhou et al.   BLOOD

Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1, and CBFB-MYH11 acute myeloid leukemias

(2009) H. B. Ommen et al.   BLOOD

Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia

(2009) I. H. I. M. Hollink et al.   BLOOD

Clinical characterization of acute myeloid leukemia with myelodysplasia-related changes as defined by the 2008 WHO classification system

(2009) O. K. Weinberg et al.   BLOOD

Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet

(2009) H. Dohner et al.   BLOOD

Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study

(2009) B. V. Balgobind et al.   BLOOD

The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes

(2009) J. W. Vardiman et al.   BLOOD

High burden of late effects after haematopoietic stem cell transplantation in childhood: a single-centre study

(2009) D Bresters et al.   BONE MARROW TRANSPLANTATION

International variations in infection supportive care practices for paediatric patients with acute myeloid leukaemia

(2009) Thomas Lehrnbecher et al.   BRITISH JOURNAL OF HAEMATOLOGY

Salvage treatment for children with refractory first or second relapse of acute myeloid leukaemia with gemtuzumab ozogamicin: results of a phase II study

(2009) Christian M. Zwaan et al.   BRITISH JOURNAL OF HAEMATOLOGY

Three-way complex translocations in infant acute myeloid leukemia with t(7;12)(q36;p13): The incidence and correlation of a HLXB9 overexpression

(2009) Joonhong Park et al.   CANCER GENETICS AND CYTOGENETICS

Structural and Functional Alterations of FLT3 in Acute Myeloid Leukemia

(2009) S. Meshinchi et al.   CLINICAL CANCER RESEARCH

Phase II Study of Clofarabine in Pediatric Patients With Refractory or Relapsed Acute Myeloid Leukemia

(2009) Sima Jeha et al.   JOURNAL OF CLINICAL ONCOLOGY

Risk-Stratified Therapy and the Intensive Use of Cytarabine Improves the Outcome in Childhood Acute Myeloid Leukemia: The AML99 Trial From the Japanese Childhood AML Cooperative Study Group

(2009) Ichiro Tsukimoto et al.   JOURNAL OF CLINICAL ONCOLOGY

Prospective Minimal Residual Disease Monitoring to Predict Relapse of Acute Promyelocytic Leukemia and to Direct Pre-Emptive Arsenic Trioxide Therapy

(2009) David Grimwade et al.   JOURNAL OF CLINICAL ONCOLOGY

Attempts to Optimize Induction and Consolidation Treatment in Acute Myeloid Leukemia: Results of the MRC AML12 Trial

(2009) Alan K. Burnett et al.   JOURNAL OF CLINICAL ONCOLOGY

Pediatric Therapy-related Myelodysplastic Syndrome/Acute Myeloid Leukemia

(2009) Dolly G. Aguilera et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

A multi-center phase I study of clofarabine, etoposide and cyclophosphamide in combination in pediatric patients with refractory or relapsed acute leukemia

(2009) N Hijiya et al.   LEUKEMIA

Anthracycline Dose Intensification in Acute Myeloid Leukemia

(2009) Hugo F. Fernandez et al.   NEW ENGLAND JOURNAL OF MEDICINE

High-Dose Daunorubicin in Older Patients with Acute Myeloid Leukemia

(2009) Bob Löwenberg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mutation inTET2in Myeloid Cancers

(2009) François Delhommeau et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome

(2009) Elaine R. Mardis et al.   NEW ENGLAND JOURNAL OF MEDICINE

WT1 expression at diagnosis does not predict survival in pediatric aml: A report from the Children's Oncology Group

(2009) Suzie A. Noronha et al.   PEDIATRIC BLOOD & CANCER

Acute promyelocytic leukemia in childhood

(2009) John Gregory et al.   Current Oncology Reports

Treatment and prognostic impact of transient leukemia in neonates with Down syndrome

(2008) J.-H. Klusmann et al.   BLOOD

Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

(2008) M. A. Sanz et al.   BLOOD

Successful outcome of allo-SCT in high-risk pediatric AML using chemotherapy-only conditioning and post transplant immunotherapy

(2008) S Bonnanomi et al.   BONE MARROW TRANSPLANTATION

Clinical and biologic features and treatment outcome of children with newly diagnosed acute myeloid leukemia and hyperleukocytosis

(2008) Hiroto Inaba et al.   CANCER

Prophylactic antibiotics reduce morbidity due to septicemia during intensive treatment for pediatric acute myeloid leukemia

(2008) Beth Kurt et al.   CANCER

Outcome for children with relapsed acute myeloid leukemia in the Netherlands following initial treatment between 1980 and 1998: survival after chemotherapy only?

(2008) B. F. Goemans et al.   HAEMATOLOGICA

Molecular characterization of acute myeloid leukemia

(2008) K. Dohner et al.   HAEMATOLOGICA

Monosomal Karyotype in Acute Myeloid Leukemia: A Better Indicator of Poor Prognosis Than a Complex Karyotype

(2008) Dimitri A. Breems et al.   JOURNAL OF CLINICAL ONCOLOGY

Impact of Disease Risk on Efficacy of Matched Related Bone Marrow Transplantation for Pediatric Acute Myeloid Leukemia: The Children's Oncology Group

(2008) John T. Horan et al.   JOURNAL OF CLINICAL ONCOLOGY

Current management and challenges of malignant disease in the CNS in paediatric leukaemia

(2008) Ching-Hon Pui et al.   LANCET ONCOLOGY

Favorable prognostic impact of NPM1 gene mutations in childhood acute myeloid leukemia, with emphasis on cytogenetically normal AML

(2008) I H I M Hollink et al.   LEUKEMIA

Significance of age in acute myeloid leukemia patients younger than 30 years

(2007) Ursula Creutzig et al.   CANCER