Review
Engineering, Biomedical
Jacob S. Brenner, Samir Mitragotri, Vladimir R. Muzykantov
Summary: Red blood cell hitchhiking is a drug delivery method that increases drug concentration in target organs by adsorbing drug-loaded nanoparticles onto red blood cells. This method has been successfully demonstrated in multiple species and organs, highlighting its versatility and potential clinical applications in various preclinical disease models.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021
(2021)
Article
Cell Biology
Xiaoya An, Guoliang Wang, Mengyi Jin, Xiaoping Zhou, Shubin Gao, Jingyao Chen, Peter S. Reinach, Zuguo Liu, Yuhua Xue, Cheng Li
Summary: The novel 6C medium developed in this study contains six different signaling pathway modulators to control the proliferative activity of mouse corneal epithelial cells, which helps expedite the healing of epithelial wounds in experimental animal models. By inhibiting specific markers of epithelial mesenchymal transdifferentiation, this medium facilitates the procurement of epithelial progenitor cells in a feeder-free system, ultimately improving cell fate determination and potentially enhancing outcomes in corneal regenerative medicine.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
He N. Xu, Sarah Gourmaud, Allison Podsednik, Xiaofan Li, Huaqing Zhao, Frances E. Jensen, Delia M. Talos, Lin Z. Li
Summary: The translation above discusses a study on the decline in NAD levels in brain tissue of Alzheimer's disease models and the use of optical redox imaging to explore new biomarkers for AD. The study found that NADH, Fp, and the redox ratio were associated with AD, and suggested that ORI could be used to conveniently study the metabolism of freshly dissected brain tissues.
Article
Immunology
Takuya Yamaguchi, Ikumi Katano, Iyo Otsuka, Ryoji Ito, Misa Mochizuki, Motohito Goto, Takeshi Takahashi
Summary: This study investigated the role of mouse complement C3 in eliminating human red blood cells, by developing a novel mouse model with a truncated version of the murine C3 gene. Results showed that genetic deletion of C3 prolonged the survival of transfused human red blood cells, potentially paving the way for further research on human diseases associated with red blood cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Noppawan Phumala Morales, Supot Rodrat, Pannaree Piromkraipak, Paveena Yamanont, Kittiphong Paiboonsukwong, Suthat Fucharoen
Summary: Treatment with deferiprone significantly improved the oxidative status in β-thalassemia/hemoglobin E patients, reducing the risk of oxidative-related complications and improving red blood cell quality. This improvement may partially be attributed to the reduction of redox active iron and enhancement of antioxidant enzyme activity.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Environmental Sciences
Periklis Vardakas, Zoi Skaperda, Fotios Tekos, Aikaterini-Flora Trompeta, Aristidis Tsatsakis, Constantinos A. Charitidis, Demetrios Kouretas
Summary: Nanotechnology has become a forefront of research and industrial interest in recent decades, but concerns have been raised about the impacts of nanomaterials on human health and safety. Scientific data suggest that oxidative stress induced by Reactive Oxygen Species (ROS) may be the main mechanism of toxicity, although some nanomaterials also exhibit antioxidant properties. An integrated approach using translational biomarkers and reliable protocols is recommended for the assessment of redox-related activities of nanomaterials at different biological levels.
ENVIRONMENTAL RESEARCH
(2021)
Article
Cell Biology
Lichen Zhang, Wushan Li, Zhuangzhuang Liu, Yang Liu, Zhilong Liu, Yanrong Gu, Le He, Binhui Zhou, Tianhan Li, Tianzhu Chao, Yinming Liang, Liaoxun Lu
Summary: This study demonstrates the feasibility of establishing sgRNA knock-in mice and their use in crossing with Cas9 constitutively expressing mice for complete deletion of target genes. sgRNA knock-in provides an alternative approach for in vivo genetic modification, facilitating the maintenance of genetically modified animals and obtaining genetically modified animals with diverse genomic backgrounds.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Energy & Fuels
Robert Bock, Bjorn Kleinsteinberg, Bjorn Selnes-Volseth, Odne Stokke Burheim
Summary: In order to replace fossil fuels with renewable energies, large-scale and cost-effective energy storage solutions are necessary. By utilizing aqueous iron chloride in a concentration flow cell with a hydrocarbon-based membrane separating two compartments, energy can be stored through redox reactions.
Article
Biochemistry & Molecular Biology
Maria Ancin, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Luis Larraya, Alicia Fernandez-San Millan, Jon Veramendi, Inmaculada Farran
Summary: Post-translational redox modifications, particularly mediated by thioredoxins (Trxs), play a crucial role in controlling cellular processes. In this study, a new in vivo approach was developed to identify potential targets of Trx f, Trx m, and NTRC. The results revealed new insights into the specificity and function of these proteins in various cellular processes.
Article
Multidisciplinary Sciences
Johannes C. van der Mijn, Kristian B. Laursen, Leiping Fu, Francesca Khani, Lukas E. Dow, Dawid G. Nowak, Qiuying Chen, Steven S. Gross, David M. Nanus, Lorraine J. Gudas
Summary: Genetically engineered mouse models (GEMMs) are important for cancer research and therapy development. In this study, researchers developed two GEMMs using inducible CRISPR-Cas9 systems to simulate common chromosome deletions in kidney cancer. The models induced somatic mutations in the kidneys but did not cause tissue transformation. Further research is needed.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Glauco Caon, Lucas Feistauer, Daniel Sganzerla, Jose C. F. Moreira
Summary: Moderate beer consumption can have beneficial effects against chronic diseases, but does not protect against CCl4-induced liver injury. Imperial red ale exhibits higher antioxidant properties and a silymarin-like effect, suggesting it may increase enzymatic and non-enzymatic redox status after liver insult.
Article
Biochemistry & Molecular Biology
Norikazu Koyasu, Fuminori Hyodo, Ryota Iwasaki, Hinako Eto, Abdelazim Elsayed Elhelaly, Hiroyuki Tomita, Shinichi Shoda, Masaki Takasu, Takashi Mori, Masaharu Murata, Akira Hara, Yoshifumi Noda, Hiroki Kato, Masayuki Matsuo
Summary: In this study, the usefulness of spatiotemporal redox status as an early imaging biomarker of tumor response after irradiation using in vivo DNP-MRI was demonstrated. The results showed that in vivo DNP-MRI/CmP allowed faster and earlier visualization of tumor redox status responses compared to the verification of morphological changes observed with 1.5 T MRI and cancer metabolism obtained by hyperpolarized C-13 pyruvate MRS. The early assessment of redox status alterations with in vivo DNP-MRI/CmP probe may provide efficient information regarding the effectiveness of subsequent radiation treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Enrique Recuero, Sara Lazaro, Corina Lorz, Ana Belen Enguita, Ramon Garcia-Escudero, Mirentxu Santos
Summary: In this study, new transplantable cell lines derived from primary mouse LCNEC and SCLC tumors were generated and analyzed. These cell line tools retain important features of their human counterparts, allowing further research and testing of new treatment strategies for SCLC and LCNEC, and addressing the lack of LCNEC disease models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Elie Hatem, Nadine El Banna, Amelie Heneman-Masurel, Dorothee Baille, Laurence Vernis, Sylvie Riquier, Marie-Pierre Golinelli-Cohen, Olivier Guittet, Cindy Vallieres, Jean-Michel Camadro, Xue Qiu, Niko Hildebrandt, Michel Lepoivre, Meng-Er Huang
Summary: Auranofin (AUF) is a gold complex that has shown potential as a repurposed therapy for multiple diseases, including cancer. The main anticancer mechanism of AUF is the inhibition of thioredoxin reductase (TrxR), but other complex and multifaceted modes of action have also been observed. This study found that AUF had variable cytotoxicity in different triple-negative breast cancer cell lines and that TrxR inhibition alone may not be sufficient to induce cell death. Cytotoxic doses of AUF caused oxidative stress and affected various pathways related to cell proliferation, cell cycle, cell-cell adhesion, and cytoskeleton structure. These findings provide new insights into the redox-based mechanisms of AUF as an anticancer molecule.
Article
Biophysics
Ruixue Zhu, Tatiana Avsievich, Alexey Popov, Alexander Bykov, Igor Meglinski
Summary: Biosensors based on nanotechnology have vital positions in various fields. The potential health risks of novel nano-materials lack comprehensive assessment. RBC-mediated in vivo delivery strategies have wide applications in bio-imaging, medical diagnostics, and analysis of biomolecules and cellular activities.
BIOSENSORS & BIOELECTRONICS
(2021)
