Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia
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Title
Posttranscriptional deregulation of MYC via PTEN constitutes a major alternative pathway of MYC activation in T-cell acute lymphoblastic leukemia
Authors
Keywords
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Journal
BLOOD
Volume 117, Issue 24, Pages 6650-6659
Publisher
American Society of Hematology
Online
2011-04-29
DOI
10.1182/blood-2011-02-336842
References
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Related references
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- Conditional expression and oncogenicity of c-myc linked to a CD2 gene dominant control region
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- NOTCH1 and/or FBXW7 mutations predict for initial good prednisone response but not for improved outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on DCOG or COALL protocols
- (2010) L Zuurbier et al. LEUKEMIA
- Subtle variations in Pten dose determine cancer susceptibility
- (2010) Andrea Alimonti et al. NATURE GENETICS
- Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss
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- High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia
- (2009) A. Gutierrez et al. BLOOD
- FBXW7andNOTCH1mutations in childhood T cell acute lymphoblastic leukaemia and T cell non-Hodgkin lymphoma
- (2009) Myoung-Ja Park et al. BRITISH JOURNAL OF HAEMATOLOGY
- The ups and downs of Myc biology
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- Regulation of PTEN by CK2 and Notch1 in primary T-cell acute lymphoblastic leukemia: rationale for combined use of CK2- and -secretase inhibitors
- (2009) A. Silva et al. HAEMATOLOGICA
- The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group
- (2009) A Larson Gedman et al. LEUKEMIA
- NOTCH1/FBXW7 mutation identifies a large subgroup with favorable outcome in adult T-cell acute lymphoblastic leukemia (T-ALL): a Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) study
- (2008) V. Asnafi et al. BLOOD
- Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia
- (2008) Pieter Van Vlierberghe et al. BRITISH JOURNAL OF HAEMATOLOGY
- Oncogenic NOTCH1 Control of MYC and PI3K: Challenges and Opportunities for Anti-NOTCH1 Therapy in T-Cell Acute Lymphoblastic Leukemias and Lymphomas
- (2008) T. Palomero et al. CLINICAL CANCER RESEARCH
- Dynamic regulation ofc-Myc proto-oncogene expression during lymphocyte development revealed by aGFP-c-Myc knock-in mouse
- (2008) Ching-Yu Huang et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- PTEN posttranslational inactivation and hyperactivation of the PI3K/Akt pathway sustain primary T cell leukemia viability
- (2008) Ana Silva et al. JOURNAL OF CLINICAL INVESTIGATION
- Oncogenesis of T-ALL and nonmalignant consequences of overexpressing intracellular NOTCH1
- (2008) Xiaoyu Li et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
- (2008) Wei Guo et al. NATURE
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