Revisiting the differentiation paradigm in acute promyelocytic leukemia

Dimer-tetramer transition controls RUNX1/ETO leukemogenic activity

(2010) C. Wichmann et al.   BLOOD

PML-RARα/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia

(2010) Joost H.A. Martens et al.   CANCER CELL

PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3

(2010) Marion Jeanne et al.   CANCER CELL

PML-RAR  and Dnmt3a1 Cooperate in vivo to Promote Acute Promyelocytic Leukemia

(2010) D. Subramanyam et al.   CANCER RESEARCH

The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

(2010) P. Drane et al.   GENES & DEVELOPMENT

Single-Agent Arsenic Trioxide in the Treatment of Newly Diagnosed Acute Promyelocytic Leukemia: Long-Term Follow-Up Data

(2010) Vikram Mathews et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia

(2010) Hiba El Hajj et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Arsenic Trioxide Controls the Fate of the PML-RAR  Oncoprotein by Directly Binding PML

(2010) X. W. Zhang et al.   SCIENCE

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia

(2009) F. C. Guibal et al.   BLOOD

Comprehensive genomic screens identify a role for PLZF-RAR  as a positive regulator of cell proliferation via direct regulation of c-MYC

(2009) K. L. Rice et al.   BLOOD

Curing APL: Differentiation or Destruction?

(2009) Scott C. Kogan   CANCER CELL

Differentiation therapy of acute myeloid leukemia: past, present and future

(2009) Kevin Petrie et al.   CURRENT OPINION IN HEMATOLOGY

The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation

(2009) H. Boukarabila et al.   GENES & DEVELOPMENT

PML–RARα initiates leukemia by conferring properties of self-renewal to committed promyelocytic progenitors

(2009) S Wojiski et al.   LEUKEMIA

Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells

(2009) Andrea Viale et al.   NATURE

The tumor suppressor Pml regulates cell fate in the developing neocortex

(2009) Tarik Regad et al.   NATURE NEUROSCIENCE

Acute Promyelocytic Leukemia — Weapons of Mass Differentiation

(2009) Jonathan D. Licht   NEW ENGLAND JOURNAL OF MEDICINE

Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia

(2009) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RUNX1/AML1 DNA-binding domain and ETO/MTG8 NHR2-dimerization domain are critical to AML1-ETO9a leukemogenesis

(2008) M. Yan et al.   BLOOD

Acute promyelocytic leukemia: from highly fatal to highly curable

(2008) Z.-Y. Wang et al.   BLOOD

Stem cell regulation by polycomb repressors: postponing commitment

(2008) Alexandra M Pietersen et al.   CURRENT OPINION IN CELL BIOLOGY

PML targeting eradicates quiescent leukaemia-initiating cells

(2008) Keisuke Ito et al.   NATURE

RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

(2008) Michael H. Tatham et al.   NATURE CELL BIOLOGY

Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

(2008) Valérie Lallemand-Breitenbach et al.   NATURE CELL BIOLOGY

Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

(2008) Rihab Nasr et al.   NATURE MEDICINE

Regulation of apoptosis by PML and the PML-NBs

(2008) R Bernardi et al.   ONCOGENE