Article
Multidisciplinary Sciences
R. C. Nayak, K. H. Chang, A. K. Singh, M. Kotliar, M. Desai, A. M. Wellendorf, M. Wunderlich, J. Bartram, B. Mizukawa, M. Cuadrado, P. Dexheimer, A. Barski, X. R. Bustelo, N. N. Nassar, J. A. Cancelas
Summary: This study investigates the function of leukemic VAV3 in Ph+ and Ph-like B-ALL and reveals that nuclear VAV3 controls repressive transcriptional activity through the AKT/PHLPP2-BMI1 pathway. The findings highlight the importance of non-canonical nuclear Rho GTPase signaling in leukemogenesis.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Aysha S. Ansari, K. C. Remant, Xiaoyan Jiang, Hasan Uludag
Summary: This study examined the characteristics and therapeutic efficacy of high cholesterol-substituted low molecular weight (MW) polyethylenimine (PEI) in CML treatment, demonstrating their potential to be potent RNAi agents. The modified polymer complexes showed smaller size, higher cationic charge, and significant interaction with heparan sulfate proteoglycans on cell surfaces, leading to effective gene silencing and colony formation inhibition in K562 cells.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Article
Medicine, Research & Experimental
Mansi Shah, Harish Kumar, Shaowei Qiu, Hui Li, Mason Harris, Jianbo He, Ajay Abraham, David K. Crossman, Andrew Paterson, Robert S. Welner, Ravi Bhatia
Summary: In chronic myeloid leukemia (CML), LT-HSCs expressing low c-KIT levels are primitive, quiescent, and drug-resistant leukemia-initiating cells, representing a critical target for eliminating disease persistence.
Article
Biotechnology & Applied Microbiology
Minori Tamai, Shinichi Fujisawa, Thao T. T. Nguyen, Chiaki Komatsu, Keiko Kagami, Kenji Kamimoto, Kohei Omachi, Shin Kasai, Daisuke Harama, Atsushi Watanabe, Koshi Akahane, Kumiko Goi, Kazuhito Naka, Tadashi Kaname, Takanori Teshima, Takeshi Inukai
Summary: The Philadelphia chromosome, generated by aberrant ligation between the BCR and ABL1 genes, is the first translocation identified in leukemia. Simultaneous double-strand breaks at the breakpoints of these genes have been found to be the initiation events for Ph+ leukemia and lead to the fusion of BCR and ABL1.
CANCER GENE THERAPY
(2023)
Article
Oncology
Daniel F. Liefwalker, Meital Ryan, Zhichao Wang, Khyatiben V. Pathak, Seema Plaisier, Vidhi Shah, Bobby Babra, Gabrielle S. Dewson, Ian K. Lai, Adriane R. Mosley, Patrick T. Fueger, Stephanie C. Casey, Lei Jiang, Patrick Pirrotte, Srividya Swaminathan, Rosalie C. Sears
Summary: The study demonstrates that de novo lipogenesis is a shared feature of several lymphoma subtypes, and inhibition of lipogenesis can induce cell death in tumor cells without affecting normal cells. This suggests that de novo lipogenesis may be a common survival strategy for many lymphoid malignancies and may be a clinically exploitable metabolic liability.
CANCER & METABOLISM
(2021)
Article
Medicine, General & Internal
Ihda Kartika Syamsuddin, Paulus Budiono Notopuro
Summary: Chronic myeloid leukemia (CML) in pediatric patients is a rare blood disorder that can lead to hearing loss. This article presents the case of a 10-year-old patient with bilateral hearing loss, diagnosed with juvenile CML. Unfortunately, the patient passed away before the hearing loss could be treated.
INTERNATIONAL MEDICAL CASE REPORTS JOURNAL
(2022)
Review
Hematology
Vaidehi Krishnan, Dennis Dong Hwan Kim, Timothy P. Hughes, Susan Branford, S. Tiong Ong
Summary: Cancer treatment is evolving towards personalized approaches. In chronic myeloid leukemia (CML), there is a need for biomarkers to predict treatment outcomes and improve management. Gene expression (GE) profiling studies have evaluated the clinical relevance of GE signatures, but challenges exist in interpreting genomic data.
Article
Biochemistry & Molecular Biology
Prisca Brauns-Schubert, Florian Schubert, Manuela Wissler, Martina Weiss, Lisa Schlicher, Simon Bessler, Mariam Safavi, Cornelius Miething, Christoph Borner, Tilman Brummer, Ulrich Maurer
Article
Cell Biology
Alessandro Prestipino, Alica J. Emhardt, Konrad Aumann, David O'Sullivan, Sivahari P. Gorantla, Sandra Duquesne, Wolfgang Melchinger, Lukas Braun, Slavica Vuckovic, Melanie Boerries, Hauke Busch, Sebastian Halbach, Sandra Pennisi, Teresa Poggio, Petya Apostolova, Pia Veratti, Michael Hettich, Gabriele Niedermann, Mark Bartholomae, Khalid Shoumariyeh, Jonas S. Jutzi, Julius Wehrle, Christine Dierks, Heiko Becker, Annette Schmitt-Graeff, Marie Follo, Dietmar Pfeifer, Jan Rohr, Sebastian Fuchs, Stephan Ehl, Frederike A. Hartl, Susana Minguet, Cornelius Miething, Florian H. Heidel, Nicolaus Kroeger, Ioanna Triviai, Tilman Brummer, Jurgen Finke, Anna L. Illert, Eliana Ruggiero, Chiara Bonini, Justus Duyster, Heike L. Pahl, Steven W. Lane, Geoffrey R. Hill, Bruce R. Blazar, Nikolas von Bubnoff, Erika L. Pearce, Robert Zeiser
SCIENCE TRANSLATIONAL MEDICINE
(2018)
Article
Medicine, Research & Experimental
Jung-Rok Lee, Iris Appelmann, Cornelius Miething, Tyler O. Shultz, Daniel Ruderman, Dokyoon Kim, Parag Mallick, Scott W. Lowe, Shan X. Wang
Article
Hematology
Chuanjiang Yu, Sivahari P. Gorantla, Alina Mueller-Rudorf, Tony A. Mueller, Stefanie Kreutmair, Corinna Albers, Lena Jakob, Lena J. Lippert, Zhenyu Yue, Monika Engelhardt, Marie Follo, Robert Zeiser, Tobias B. Huber, Justus Duyster, Anna L. Illert
Article
Oncology
M. Janning, J. Sueptitz, C. Albers-Leischner, P. Delpy, A. Tufman, J-L Velthaus-Rusik, M. Reck, A. Jung, D. Kauffmann-Guerrero, I Bonzheim, S. Braendlein, H-D Hummel, M. Wiesweg, H-U Schildhaus, J. A. Stratmann, M. Sebastian, J. Alt, J. Buth, I Esposito, J. Berger, L. Toegel, F. C. Saalfeld, M. Wermke, S. Merkelbach-Bruse, A. M. Hillmer, F. Klauschen, C. Bokemeyer, R. Buettner, J. Wolf, S. Loges
Summary: This retrospective multicenter study investigated the response of atypical EGFR mutations in different systemic treatments. The study found that uncommon mutations responded well to EGFR-TKI, while exon 20 insertions were insensitive to EGFR-TKI. Very rare point and compound mutations also showed sensitivity to TKI, but treatment responses varied greatly. Co-occurring TP53 mutations may have a detrimental effect on treatment outcome in certain cases.
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
Stefanie Kreutmair, Lena Johanna Lippert, Cathrin Klingeberg, Corinna Albers-Leischner, Salome Yacob, Valeria Shlyakhto, Tony Mueller, Alina Mueller-Rudorf, Chuanjiang Yu, Sivahari Prasad Gorantla, Cornelius Miething, Justus Duyster, Anna Lena Illert
Summary: This study identifies NIPA as a crucial player in NPM-ALK-driven ALCL-like disease in clinically relevant murine and cell-based models. Deletion of Nipa inhibits tumorigenesis and prolongs survival in NPM-ALK-positive cells, indicating the potential therapeutic value of targeting NIPA in ALCL.
FRONTIERS IN ONCOLOGY
(2022)
Meeting Abstract
Oncology
L. Phely, P. Veratti, J. Mitschke, S. Ehrenfeld, D. Redhaber, K. Shoumariyeh, J. Duyster, C. Miething
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Meeting Abstract
Oncology
D. M. Redhaber, L. Phely, S. Ehrenfeld, P. Veratti, S. Schaefer, J. Mitschke, J. Beckert, K. Shoumariyeh, C. Miething
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Meeting Abstract
Oncology
R. Hoefflin, A-L Geissler, R. Fritsch, R. Claus, J. Wehrle, P. Metzger, M. Reiser, L. Mehmed, L. Fauth, D. H. Heiland, T. Erbes, F. Stock, A. Csanadi, C. Miething, B. Weddeling, F. Meiss, D. von Bubnoff, C. Dierks, I Ge, V Brass, S. Heeg, H-E Schaefer, M. Boeker, J. Rawluk, E. M. Botzenhart, G. Kayser, S. Hettmer, H. Busch, C. Peters, M. Werner, J. Duyster, T. Brummer, M. Boerries, S. Lassmann, N. von Bubnoff
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Meeting Abstract
Oncology
S. Ehrenfeld, R. Khan, D. Redhaber, K. Shoumariyeh, P. Veratti, M. Auer, M. Speicher, J. Duyster, C. Miething
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Meeting Abstract
Oncology
M. Engelhardt, K. Kieselbach, M. Szymaniak-Vits, S. Ajayi, M. Naegele, C. Kiote-Schmidt, C. Greil, C. Miething, H. Reinhardt, R. Waesch
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Meeting Abstract
Oncology
M. Engelhardt, K. Kieselbach, S. Ajayi, M. Szymaniak-Vits, M. Naegele, C. Kiote-Schmidt, W. Kuehn, C. Greil, C. Miething, H. Reinhardt, R. Waesch
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Meeting Abstract
Oncology
C. Dierks, C. Miething, N. von Bubnoff, J. Duyster, O. Thomusch
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Meeting Abstract
Oncology
S. M. Dold, I Bartsch, D. Wider, V. C. Riebl, S. J. Mueller, M. Pantic, C. Miething, C. Kiote-Schmidt, M. Zlei, A. K. Azab, M. Binder, J. Rawluk, D. Ewerth, Duyste, R. Zeiser, R. Waesch, M. Engelhardt
ONCOLOGY RESEARCH AND TREATMENT
(2018)
Meeting Abstract
Oncology
D. M. Redhaber, S. Ehrenfeld, P. Veratti, S. M. Schafer, J. Mitschke, K. Shoumariyeh, C. Miething
ONCOLOGY RESEARCH AND TREATMENT
(2017)