Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL
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Title
Trisomy 12 and elevated GLI1 and PTCH1 transcript levels are biomarkers for Hedgehog-inhibitor responsiveness in CLL
Authors
Keywords
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Journal
BLOOD
Volume 119, Issue 4, Pages 997-1007
Publisher
American Society of Hematology
Online
2011-12-02
DOI
10.1182/blood-2011-06-359075
References
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Related references
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- (2010) Michael Hallek BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
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- Self-Renewal of Acute Lymphocytic Leukemia Cells Is Limited by the Hedgehog Pathway Inhibitors Cyclopamine and IPI-926
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- Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
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- (2009) Inga Hofmann et al. Cell Stem Cell
- Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)
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- Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia
- (2009) Chen Zhao et al. NATURE
- Molecular and cellular mechanisms of CLL: novel therapeutic approaches
- (2009) Lisa Pleyer et al. Nature Reviews Clinical Oncology
- Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
- (2008) M. Hallek et al. BLOOD
- Expansion of Bcr-Abl-Positive Leukemic Stem Cells Is Dependent on Hedgehog Pathway Activation
- (2008) Christine Dierks et al. CANCER CELL
- Hedgehog-Induced Survival of B-Cell Chronic Lymphocytic Leukemia Cells in a Stromal Cell Microenvironment: A Potential New Therapeutic Target
- (2008) G. V. Hegde et al. MOLECULAR CANCER RESEARCH
- Targeting of sonic hedgehog-GLI signaling: a potential strategy to improve therapy for mantle cell lymphoma
- (2008) Ganapati V. Hegde et al. MOLECULAR CANCER THERAPEUTICS
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