Review
Psychiatry
Haiqing Liu, Longhuo Wu
Summary: Bilingualism significantly delays the onset of dementia and protects against cognitive decline, acting as a pharmacological intervention with no side effects. However, further research is needed to investigate the pharmacological parameters of bilingualism.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Guanqun Chen, Mingyan Zhao, Kun Yang, Hua Lin, Chunlei Han, Xiaoni Wang, Ying Han
Summary: The study found that education has a positive effect on cognition in individuals with subjective cognitive decline (SCD) and cognitive impairment (CI). This effect is particularly strong in individuals with low education levels. High educational attainment may also delay cognitive decline in individuals with SCD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Psychology, Multidisciplinary
Luca Kleineidam, Steffen Wolfsgruber, Anne-Sophie Weyrauch, Linn E. Zulka, Simon Forstmeier, Sandra Roeske, Hendrik van den Bussche, Hanna Kaduszkiewicz, Birgitt Wiese, Siegfried Weyerer, Jochen Werle, Angela Fuchs, Michael Pentzek, Christian Brettschneider, Hans-Helmut Konig, Dagmar Weeg, Horst Bickel, Melanie Luppa, Francisca S. Rodriguez, Silka Dawn Freiesleben, Selin Erdogan, Chantal Unterfeld, Oliver Peters, Eike J. Spruth, Slawek Altenstein, Andrea Lohse, Josef Priller, Klaus Fliessbach, Xenia Kobeleva, Anja Schneider, Claudia Bartels, Bjoern H. Schott, Jens Wiltfang, Franziska Maier, Wenzel Glanz, Enise I. Incesoy, Michaela Butryn, Emrah Duezel, Katharina Buerger, Daniel Janowitz, Michael Ewers, Boris-Stephan Rauchmann, Robert Perneczky, Ingo Kilimann, Doreen Goerss, Stefan Teipel, Christoph Laske, Matthias H. J. Munk, Annika Spottke, Nina Roy, Frederic Brosseron, Michael T. Heneka, Alfredo Ramirez, Renat Yakupov, Martin Scherer, Wolfgang Maier, Frank Jessen, Steffi G. Riedel-Heller, Michael Wagner
Summary: This study explores the relationship between occupation, cognitive abilities, and brain health throughout a person's lifetime. It suggests that engaging in complex and stimulating work environments can enhance the resistance to pathological changes and reduce the risk of Alzheimer's disease.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Endocrinology & Metabolism
Sivaniya Subramaniapillai, Anne Almey, M. Natasha Rajah, Gillian Einstein
Summary: The literature review identified gender differences in cognitive/brain reserve contributors in relation to Alzheimer's disease risk, suggesting that greater reserve may be more beneficial in lowering risk for women. However, further research is needed in this area to fully understand the impact of cognitive reserve on AD risk in women.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Review
Neurosciences
Mahesh S. Joshi, James E. Galvin
Summary: With the expected rise in Alzheimer's disease and related dementias (ADRD) in the coming decades, there is a need for preventive strategies that tap into resilience parameters. This review discusses the various resilience strategies, including genetics, socioeconomic status, lifestyle modifications, behavioral changes, and management of comorbid diseases. The focus of research has shifted towards disease resistance and resilience, identifying potential therapeutic targets and quantifying resilience through genetic variants and neuroimaging analyses. Additionally, studying resilience in caregivers of persons with dementia may have direct and indirect impacts on care quality and patient outcomes.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Tomohiko Sato, Haruo Hanyu, Yumi Koyama, Haruka Horita, Toshinori Aoki, Kentaro Hirao, Hidekazu Kanetaka, Soichiro Shimizu
Summary: The discrepancy between cognitive and imaging findings in AD patients is associated with cognitive reserve, measured by a combination of leisure activity and education levels, indicating that lifestyle interventions may be able to delay clinical symptoms of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Thanaphong Phongpreecha, Dana Godrich, Eloise Berson, Camilo Espinosa, Yeasul Kim, Brenna Cholerton, Alan L. Chang, Samson Mataraso, Syed A. Bukhari, Amalia Perna, Koya Yakabi, Kathleen S. Montine, Kathleen L. Poston, Elizabeth Mormino, Lon White, Gary Beecham, Nima Aghaeepour, Thomas J. Montine
Summary: The study proposes a framework for defining cognitive resilience (CR) as a continuous variable for each neuropsychological test, aiming to address discrepancies and shortcomings of the current CR definition. The framework clarifies the relationship between CR and closely related terms and provides insights into the underlying mechanisms of CR.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Sara Mondini, Veronica Pucci, Sonia Montemurro, Raffaella Ida Rumiati
Summary: This study highlights the importance of education and occupation in predicting cognitive performance in older adults, with higher levels of education and occupation associated with better resistance to cognitive decline. Cognitive reserve plays a crucial role in predicting performance across different levels of cognitive ability.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Patricia A. Boyle, Tianhao Wang, Lei Yu, Robert S. Wilson, Robert Dawe, Konstantinos Arfanakis, Julie A. Schneider, Todd Beck, Kumar B. Rajan, Denis Evans, David A. Bennett
Summary: The cognitive clock, a novel indicator of brain health, is a better predictor than chronological age for adverse outcomes such as Alzheimer's disease dementia, mild cognitive impairment, and mortality. It offers person-specific estimates of cognitive age and is strongly associated with neuropathology and brain atrophy, making it a useful biomarker in aging research.
ALZHEIMERS & DEMENTIA
(2021)
Article
Medicine, General & Internal
Hyung Jin Choi, Minjung Seo, Ahro Kim, Seol Hoon Park
Summary: The study aimed to evaluate the role of cognitive reserve in patients with Alzheimer's disease by assessing the metabolic status of cerebral cortex regions. The study found that FDG PET was significantly correlated with neuropsychological test results and not influenced by education level. Therefore, FDG PET could be a reliable tool for evaluating cognitive decline in Alzheimer's disease.
MEDICINA-LITHUANIA
(2023)
Review
Cell Biology
Sonia Turrini, Bonnie Wong, Mark Eldaief, Daniel Z. Press, David A. Sinclair, Giacomo Koch, Alessio Avenanti, Emiliano Santarnecchi
Summary: As the global population ages, understanding healthy brain aging is vital for preserving cognitive abilities. This review provides a comprehensive look at anatomical changes in the aging brain, as well as modifiable risk factors for healthy aging. It also examines the cognitive profile of healthy older adults, discussing the decline in four cognitive factors and their neural substrate. Different cognitive trajectories in Alzheimer's Disease and successful agers with high cognitive reserve are explored. Effective interventions and strategies to promote cognitive reserve and delay cognitive decline are reviewed and proposed.
AGEING RESEARCH REVIEWS
(2023)
Article
Geriatrics & Gerontology
Jessica M. Collins, Edward Hill, Aidan Bindoff, Anna E. King, Jane Alty, Mathew J. Summers, James C. Vickers
Summary: This study found that both early and mid-life education significantly influenced serum BDNF levels. Serum BDNF levels decreased with age, were lower in males compared to females, and the impact of the BDNF Val66Met genotype was small and non-significant.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Sandra L. Kletzel, Pallavi Sood, Ahmed Negm, Patricia C. Heyn, Shilpa Krishnan, Joseph Machtinger, Xiaolei Hu, Hannes Devos
Summary: This study conducted a systematic review and meta-analysis on the effects of brain gaming interventions for improving cognitive functions in older adults with cognitive impairments. The findings suggest that brain gaming did not show significant improvements in standardized cognitive tests compared to control interventions.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Clinical Neurology
Leslie Grasset, Vincent Planche, Vincent Bouteloup, Chabha Azouani, Bruno Dubois, Frederic Blanc, Claire Paquet, Renaud David, Catherine Belin, Therese Jonveaux, Adrien Julian, Jeremie Pariente, Jean-Francois Mangin, Genevieve Chene, Carole Dufouil, Memento Cohort Study Grp
Summary: This study examines whether physical activity can moderate the association between biomarkers of brain pathologies and dementia risk. The results show that individuals who engage in high-intensity physical activity have weaker associations with brain pathologies and a lower risk of developing dementia.
ALZHEIMERS & DEMENTIA
(2023)
Review
Cell Biology
Israel Contador, Patricia Alzola, Yaakov Stern, Alejandro de la Torre-Luque, Felix Bermejo-Pareja, Bernardino Fernandez-Calvo
Summary: This study conducted a systematic review and meta-analyses to examine the effect of socio-behavioral cognitive reserve proxies on cognitive decline after stroke. The findings showed that high education is associated with a decreased rate of post-stroke dementia, and other CR proxies demonstrate a protective effect against non-dementia cognitive decline after stroke. The results suggest that CR may prevent cognitive decline after stroke, but this effect can be influenced by different factors such as the CR proxy and individual characteristics.
AGEING RESEARCH REVIEWS
(2023)
Article
Psychology, Clinical
Yllza Xerxa, Leslie A. Rescorla, Lilly Shanahan, Henning Tiemeier, William E. Copeland
Summary: This study found that childhood loneliness is associated with anxiety and depressive disorders in young adults, suggesting that loneliness may have long-term effects on mental health. The study highlights the importance of early intervention to prevent loneliness and its consequences.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Developmental
Sara Sammallahti, Elisa Holmlund-Suila, Runyu Zou, Saara Valkama, Jenni Rosendahl, Maria Enlund-Cerullo, Helena Hauta-Alus, Marius Lahti-Pulkkinen, Hanan El Marroun, Henning Tiemeier, Outi Makitie, Sture Andersson, Katri Raikkonen, Kati Heinonen
Summary: Higher maternal vitamin D concentration during pregnancy is associated with better child mental health, particularly in relation to negative affectivity, a trait indicating increased risk of psychopathology. The study found that higher maternal early/mid-pregnancy vitamin D levels were associated with lower negative affectivity in infants, while cord blood vitamin D levels showed less clear associations. These findings suggest that maternal vitamin D status during early- and mid-pregnancy may play a role in the behavioral development of offspring.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Scott W. Delaney, Yllza Xerxa, Ryan L. Muetzel, Tonya White, Sebastien Haneuse, Kerry J. Ressler, Henning Tiemeier, Laura D. Kubzansky
Summary: The study suggests that positive prenatal family environments may have lasting benefits on white matter neurodevelopment in preadolescence, which can reduce the risk of behavior problems.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Pediatrics
Jonathan S. Litt, Samantha Johnson, Neil Marlow, Henning Tiemeier
Summary: This study aimed to investigate whether poor childhood pulmonary function explains the association between extremely preterm birth and attention-deficit/hyperactivity disorder symptoms in young adulthood. The results showed that extremely preterm individuals had a higher risk of inattention compared to term-born peers, and this risk may be related to poor pulmonary function.
Article
Public, Environmental & Occupational Health
Elizabeth W. Diemer, Alexandra Havdahl, Ole A. Andreassen, Marcus R. Munafo, Pal R. Njolstad, Henning Tiemeier, Luisa Zuccolo, Sonja A. Swanson
Summary: In this study, the researchers computed nonparametric bounds for the causal risk difference derived from multiple proposed instruments in a Mendelian randomisation study. The results showed that when proposing multiple instruments, bounds can provide a reasonable range and direction of the expected effects.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Psychology, Clinical
Wei-Chen Wang, Ming Ding, Susanne Strohmaier, Eva Schernhammer, Qi Sun, Jorge E. Chavarro, Henning Tiemeier
Summary: This study found an association between maternal healthy lifestyles and offspring depressive symptoms, which was mediated by offspring's healthy lifestyles.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Koen Bolhuis, Lisa R. Steenkamp, Henning Tiemeier, Laura Blanken, Jean-Baptiste Pingault, Charlotte A. M. Cecil, Hanan El Marroun
Summary: This study found that there is an association between maternal childhood adversity and offspring childhood adversity, and offspring childhood adversity further mediates the relationship between maternal childhood adversity and offspring hallucinations and delusions.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychology, Developmental
Iryna Culpin, Gemma Hammerton, Alan Stein, Marc H. Bornstein, Henning Tiemeier, Tim Cadman, Eivor Fredriksen, Jonathan Evans, Tina Miller, Esther Dermott, Jon Heron, Hannah M. Sallis, Rebecca M. Pearson
Summary: The present study suggests that the adverse effects of maternal postnatal depression on child development cannot be explained by various aspects of paternal involvement. Only father-child conflict has been identified as a risk factor for adverse child development and as a mediator in the association between maternal postnatal depression and child development. If found causal, interventions that reduce father-child conflict may improve developmental outcomes of children of mothers with postnatal depression.
DEVELOPMENTAL PSYCHOLOGY
(2023)
Editorial Material
Psychology, Developmental
Henning Tiemeier
Summary: In their study on the stability of psychopathology using longitudinal population surveys, Oldehinkel and Ormel emphasize the importance of not only comparing groups but also focusing on within-person variability. They suggest that adopting a within-person approach can enhance our understanding of emotional and behavioral problems and potentially improve intervention research.
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY
(2023)
Article
Psychology, Developmental
Sara Sammallahti, Fadila Serdarevic, Henning Tiemeier
Summary: Excessive crying and irritability in infancy are associated with behavioral problems and amygdala volume among children and adolescents.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Correction
Public, Environmental & Occupational Health
Bethany Kotlar, Emily Michelle Gerson, Sophia Petrillo, Ana Langer, Henning Tiemeier
REPRODUCTIVE HEALTH
(2023)
Review
Endocrinology & Metabolism
Federica Sileo, Joris A. J. Osinga, W. Edward Visser, Toyah A. Jansen, Wichor M. Bramer, Arash Derakhshan, Valeria Citterio, Henning Tiemeier, Luca Persani, Tim I. M. Korevaar
Summary: Postpartum depression (PPD) has a significant impact on maternal and offspring well-being. This study found no association between thyroid function/TPOAb positivity and PPD through a population-based prospective cohort study, systematic literature review, and meta-analysis.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tessa A. Mulder, Purdey J. Campbell, Peter N. Taylor, Robin P. Peeters, Scott G. Wilson, Marco Medici, Colin Dayan, Vincent V. W. Jaddoe, John P. Walsh, Nicholas G. Martin, Henning Tiemeier, Tim I. M. Korevaar
Summary: This study found that the effects of many known thyroid function-related genes are already apparent in childhood, and some genes have a greater impact on children compared to adults. These findings provide new insights into the genetic regulation of thyroid function in early life.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Psychiatry
Fernando Estevez-Lopez, Hannah H. H. Kim, Monica Lopez-Vicente, Jeroen S. S. Legerstee, Manon H. J. Hillegers, Henning Tiemeier, Ryan L. L. Muetzel
Summary: Physical symptoms are symptoms for which no sufficient underlying root cause can be found through medical examinations. This study found a negative association between physical symptoms and surface area of the prefrontal cortex, suggesting a potential link between physical symptoms and brain morphology. Further research is needed to understand the longitudinal relationship between physical symptoms and brain changes.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
A. Tsompanidis, L. Blanken, Z. A. Broere-Brown, B. B. van Rijn, S. Baron-Cohen, H. Tiemeier
Summary: Autism is more prevalent in males, and males on average score higher on measures of autistic traits. Placental function is significantly affected by the sex of the fetus. It is unclear if sex differences in placental function are associated with sex differences in the occurrence of autistic traits postnatally.
TRANSLATIONAL PSYCHIATRY
(2023)
