Article
Medicine, General & Internal
Weixi Liu, Zhicheng Yang, Yan Chen, Haoyu Yang, Xiaoxian Wan, Xindie Zhou, Ruiping Liu, Yunkun Zhang
Summary: The study found that the CTLA-4 rs231775 gene polymorphism decreased the risk of RA, while the CTLA-4 rs16840252 and CD86 rs17281995 gene polymorphisms were not associated with RA susceptibility. Stratification analyses revealed significant associations for CTLA-4 rs231775 and rs16840252 gene polymorphisms in RF-positive and RF-negative groups. The meta-analysis of CTLA-4 gene polymorphisms indicated that CTLA-4 rs231775 and rs3087243 gene polymorphisms decreased the risk of RA. Additional clinical cases should be investigated in further studies to confirm these findings.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Jun Zhu, Takenori Inomata, Masahiro Nakamura, Keiichi Fujimoto, Yasutsugu Akasaki, Kenta Fujio, Ai Yanagawa, Koichiro Uchida, Jaemyoung Sung, Naoko Negishi, Ken Nagino, Yuichi Okumura, Maria Miura, Hurramhon Shokirova, Mizu Kuwahara, Kunihiko Hirosawa, Akie Midorikawa-Inomata, Atsuko Eguchi, Tianxiang Huang, Hideo Yagita, Sonoko Habu, Ko Okumura, Akira Murakami
Summary: We investigated the effects of anti-CD80/86 antibodies in a murine high-risk corneal transplantation rejection model. The results showed that anti-CD80/86 antibodies significantly reduced T-cell proliferation and inflammatory response, thereby prolonging the survival of corneal grafts.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Yikong Lin, Di Zhang, Yangyang Li, Yunyun Li, Bin Li, Meirong Du
Summary: This study revealed a crucial role of NR2F2 in regulating maternal-fetal immune tolerance through promoting Th2 differentiation of decidual CD4(+)T cells, with decreased NR2F2 expression associated with unexplained recurrent spontaneous abortion. The interaction between GATA-3 and NR2F2 was confirmed, suggesting GATA-3 may play an important role in the immunoregulatory process mediated by NR2F2, providing a potential biomarker for prediction and prevention of clinical unexplained RSA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Murat Tekguc, James Badger Wing, Motonao Osaki, Jia Long, Shimon Sakaguchi
Summary: Regulatory T cells reduce the expression of CD80/CD86 on antigen-presenting cells through CTLA-4-dependent trogocytosis, inhibiting T cell immune responses. This mechanism can have dual suppressive effects, limiting CD80/CD86 costimulation to naive T cells and increasing free PD-L1 available for the inhibition of PD-1-expressing effector T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Giorgia Fanelli, Marco Romano, Estefania Nova-Lamperti, Mariana Werner Sunderland, Alessandra Nerviani, Cristiano Scotta, Michele Bombardieri, Sergio A. Quezada, Steven H. Sacks, Randolph J. Noelle, Costantino Pitzalis, Robert I. Lechler, Giovanna Lombardi, Pablo D. Becker
Summary: PD-L1 signaling on memory T cells can induce their conversion into highly suppressive T cells, with reduced ERK phosphorylation and weakened AKT/mTOR/S6 signaling. However, T cells from rheumatoid arthritis patients may be refractory to down modulation of these pathways following PD-L1 cross-linking.
Article
Immunology
David Martinez-Mendez, Luis Mendoza, Carlos Villarreal, Leonor Huerta
Summary: During the activation of T CD4+ cells, the balance between oxidative phosphorylation and glycolysis is regulated by the nutrient sensor adenosine monophosphate-activated protein kinase (AMPK), which plays a crucial role in cell metabolism regulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel A. Michelson, Christophe Benoist, Diane Mathis
Summary: Medullary thymic epithelial cells (mTECs) are crucial for T cell central tolerance. In addition to the transcription factor Aire, we found that mTECs express the inhibitory receptor CTLA-4. CTLA-4(+) mTECs have a distinct gene signature associated with antigen presentation and interferon-gamma signaling, complementing the role of Aire.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Surgery
Sharad K. Mittal, WonKyung Cho, Elsayed Elbasiony, Yilin Guan, William Foulsham, Sunil K. Chauhan
Summary: The study showed that CD80 in MSCs plays a crucial role in modulating Treg function. In vitro and in vivo experiments, as well as a mouse transplantation model, demonstrated the impact of CD80 on Tregs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Victoria Gorbacheva, Ran Fan, Satoshi Miyairi, Robert L. Fairchild, William M. Baldwin III, Anna Valujskikh
Summary: Antibodies reactive to self-antigens are important in posttransplant immune responses. This study identifies DNA topoisomerase I as a novel self-antigen in transplant settings and demonstrates that autoantibodies enhance activation of donor-reactive T cells following renal transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Fabienne Mazerolles, Frederic Rieux-Laucat
Summary: The expression of co-signalling receptors on T cells plays a crucial role in regulating T cell responses, and an imbalance between activating and inhibitory signals may lead to autoimmunity. Research showed that activated TEFFs and TREGs express different co-signalling receptors, and the expression of PD-L1 on activated TEFFs is correlated with their proliferation.
Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Tao-Zhen Lu, Xun Liu, Chang-Song Wu, Zi-You Ma, Yang Wang, Yong-An Zhang, Xu-Jie Zhang
Summary: This study identifies the genes CD80/86, CD28, and CD152 in grass carp and shows that CD80/86 can interact with both CD28 and CD152. The expression patterns suggest that teleost fish may regulate T cell activation through the differential expression of CD28 and CD152. The study provides insights into the evolution of costimulatory signals across vertebrates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Jonathan Aldridge, Kerstin Andersson, Inger Gjertsson, Anna-Karin Hultgard Ekwall, Magnus Hallstrom, Ronald van Vollenhoven, Anna-Carin Lundell, Anna Rudin
Summary: This study found that the proportions of PD-1(+)TFh and CTLA-4(+) conventional CD4(+) T cells in circulation at baseline may serve as predictive biomarkers for remission in early RA after CTLA-4Ig treatment.
Article
Hematology
Reiner K. Mailer, Sandra Konrath, Lydia Zhan, Hanna Thode, Manu Beerens, Maike Frye, Daniel F. J. Ketelhuth, Thomas Renne, Goeran K. Hansson
Summary: Inflammation caused by LDL deposition in the arterial wall leads to atherosclerosis. Regulatory T cells inhibit vascular inflammation by inducing immune tolerance towards LDL-related antigens. However, the mechanisms that promote the generation of LDL-specific regulatory T cells in vivo are still unclear.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Immunology
Luis Weitbrecht, Daniel Berchtold, Tian Zhang, Sandra Jagdmann, Claudia Dames, Katarzyna Winek, Christian Meisel, Andreas Meisel
Summary: The study revealed that CD4(+) T cells play a crucial role in facilitating delayed B cell infiltration into the ischemic brain post-stroke, highlighting the long-lasting impact of lymphocyte infiltration on immune response. Depletion of CD4 T cells improved cognitive functions, suggesting the potential of specific immune modulating therapies for treating post-stroke cognitive impairment.
BRAIN BEHAVIOR AND IMMUNITY
(2021)