Article
Cell Biology
Hajime Sasaki, Takayuki Hirose, Tetsu Oura, Ryo Otsuka, Ivy Rosales, David Ma, Grace Lassiter, Ahmad Karadagi, Toshihide Tomosugi, Abbas Dehnadi, Masatoshi Matsunami, Susan Raju Paul, Patrick M. Reeves, Isabel Hanekamp, Samuel Schwartz, Robert B. Colvin, Hang Lee, Thomas R. Spitzer, A. Benedict Cosimi, Pietro E. Cippa, Thomas Fehr, Tatsuo Kawai
Summary: Hematopoietic stem cell transplantation (HSCT) has potential applications beyond current standard indications. Selective inhibition of B cell lymphoma 2 (Bcl-2) shows promise in promoting hematopoietic chimerism without myelosuppression and making HSCT more feasible for a variety of clinical indications.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Neetha Nanoth Vellichirammal, Sahil Sethi, Nagavardhini Avuthu, Stephen Y. Y. Wise, Alana D. D. Carpenter, Oluseyi O. O. Fatanmi, Chittibabu Guda, Vijay K. K. Singh
Summary: The development of advanced molecular biodosimetry methods, such as transcriptomics, is crucial for screening radiation-exposed victims. This study exposed nonhuman primates to different radiation doses and treatment with a potential radiation medical countermeasure. It identified common pathways activated by radiation and sex-specific differences in response.
Article
Multidisciplinary Sciences
Seyed A. Hassani, Adam Neumann, Jason Russell, Carrie K. Jones, Thilo Womelsdorf
Summary: The positive allosteric modulator of M1 mAChRs, VU0453595, enhances cognitive flexibility by improving flexible learning performance, reducing latency inhibition, and reducing response perseveration. However, the acetylcholinesterase inhibitor donepezil only improves attention during visual search without affecting cognitive flexibility. Therefore, M1 mAChR positive allosteric modulators have versatile applications in enhancing cognitive flexibility.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Microbiology
Raj Kalkeri, Kevin Walters, William Van der Pol, Braden C. McFarland, Nathan Fisher, Fusataka Koide, Casey D. Morrow, Vijay K. Singh
Summary: The study reveals substantial alterations in the gut microbiome of nonhuman primates following high-dose radiation exposure, with significant differences in microbiome composition after irradiation compared to baseline. Animals experiencing diarrhea post-irradiation showed specific changes in microbiome composition which may be associated with differential susceptibility to radiation-induced diarrhea.
Article
Biotechnology & Applied Microbiology
Bishnu P. De, Jonathan B. Rosenberg, Nithya Selvan, Isabelle Wilson, Nadir Yusufzai, Alessandria Greco, Stephen M. Kaminsky, Linda A. Heier, Rodolfo J. Ricart Arbona, Ileana C. Miranda, Sebastien Monette, Anju Nair, Richie Khanna, Ronald G. Crystal, Dolan Sondhi
Summary: CLN2 disease is a childhood genetic disorder caused by mutations in the CLN2 gene, resulting in neurodegeneration. The study found that intracisternal delivery of AAVrh.10hCLN2 can safely distribute therapeutic TPP-1 throughout the brain and cerebrospinal fluid at potentially therapeutic levels.
HUMAN GENE THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Ernesto A. Salegio, Mira Cukrov, Rachel Lortz, Abigail Green, Emily Lambert, Summer Copeland, Marc Gonzalez, Diane E. Stockinger, Jeremy M. Yeung, Granger G. C. Hwa
Summary: This study demonstrated the distribution and transport of AAV5-GFP in the nonhuman primate cerebellum using a single convection-enhanced delivery infusion. The results showed a large volume of distribution and distal transport of the vector. The level of transgene expression was negatively correlated with the antibody titer against the GFP construct.
HUMAN GENE THERAPY
(2022)
Article
Chemistry, Medicinal
Hiroki Matsumoto, Tadashi Watabe, Chika Igarashi, Tomoko Tachibana, Fukiko Hihara, Atsuo Waki, Ming-Rong Zhang, Hideaki Tashima, Taiga Yamaya, Kazuhiro Ooe, Eku Shimosegawa, Jun Hatazawa, Sei Yoshida, Kenichiro Naito, Hiroaki Kurihara, Makoto Ueno, Kimiteru Ito, Tatsuya Higashi, Yukie Yoshii
Summary: To improve the prognosis of pancreatic cancer, a new PET imaging method was developed to detect tumor lesions smaller than 1 cm, showing promising results in mouse and monkey experiments.
Article
Pharmacology & Pharmacy
Vijay K. Singh, Alana D. Carpenter, Brianna L. Janocha, Sarah A. Petrus, Oluseyi O. Fatanmi, Stephen Y. Wise, Thomas M. Seed
Summary: Animal models are crucial for developing radiation medical countermeasures. Nonhuman primates play a significant role in obtaining regulatory approval for such agents. It is important to thoroughly characterize these animal models.
EXPERT OPINION ON DRUG DISCOVERY
(2023)
Review
Geriatrics & Gerontology
George W. Schaaf, Jamie N. Justice, Ellen E. Quillen, J. Mark Cline
Summary: The Wake Forest nonhuman primate (NHP) Radiation Late Effects Cohort (RLEC) is a vital population that helps us understand the late effects of radiation exposure. This cohort has evaluated over 250 previously irradiated rhesus macaques, providing valuable insights on resilience and biological aging. By considering individual differences in response to radiation, we can develop strategies to manage late radiation effects and understand mechanisms underlying resilience and aging.
Article
Materials Science, Biomaterials
Matthew J. Haney, Hong Yuan, Steven T. Shipley, Zhanhong Wu, Yuling Zhao, Kelly Pate, Jonathan E. Frank, Nicole Massoud, Paul W. Stewart, Joel S. Perlmutter, Elena Batrakova
Summary: This study investigated the biodistribution and brain retention of PBMCs and EVs in adult rhesus macaques using PET/MRI imaging. The route of administration had a significant impact on brain retention of the carriers, with PBMCs showing higher brain retention when administered intrathecally. EVs demonstrated superior brain accumulation when administered intraperitoneally and intravenously, respectively. No cytotoxic effects were observed for either carrier in blood samples. Overall, living cells and EVs have great potential for drug delivery to the brain, and the route of administration plays a crucial role in CNS drug delivery.
Article
Materials Science, Biomaterials
Juho Lee, Murtada A. Oshi, Dongmin Kwak, Hyunwoo Kim, Jihyun Kim, Shwe Phyu Hlaing, Aruzhan Saparbayeva, Seonghwan Hwang, Yunjin Jung, Jin-Wook Yoo
Summary: In this study, an on-demand reconstitutable drug delivery system for ulcerative colitis (UC) treatment was developed. The system successfully addressed the issue of premature drug release and systemic absorption by incorporating hyaluronic acid (HA)-doped drug microcrystals into a protective layer. The system demonstrated potent anti-inflammatory effects in a colitis model without causing systemic toxicity.
BIOMATERIALS SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Annie Tanenhaus, Timothy Stowe, Andrew Young, John McLaughlin, Rangoli Aeran, I. Winnie Lin, Jianmin Li, Raghavendra Hosur, Ming Chen, Jennifer Leedy, Tiffany Chou, Sirika Pillay, Maria Candida Vila, Jennifer A. Kearney, Martin Moorhead, Archana Belle, Stephanie Tagliatela
Summary: This study tested a gene therapy targeting SCN1A gene to treat Dravet syndrome. By upregulating SCN1A expression in inhibitory neurons, the therapy corrected the genetic defect and significantly reduced seizure occurrence, extending the lifespan of mice with the syndrome.
HUMAN GENE THERAPY
(2022)
Article
Multidisciplinary Sciences
Sourish Chakravarty, Jacob Donoghue, Ayan S. Waite, Meredith Mahnke, Indie C. Garwood, Sebastian Gallo, Earl K. Miller, Emery N. Brown
Summary: Research has shown that unconsciousness under general anesthesia can be reliably tracked using real-time electroencephalogram processing. To aid patient management during surgery, a closed-loop anesthesia delivery system was implemented in nonhuman primates, which accurately controlled the level of unconsciousness. The system demonstrated superior performance and established critical steps for designing and testing closed-loop anesthesia delivery systems in humans.
Review
Biochemistry & Molecular Biology
Veronika I. Ivanova-Radkevich
Summary: Photodynamic therapy relies on the selective accumulation of photosensitizers in tumor tissues for the treatment of malignant neoplasms. Various mechanisms, including binding to blood proteins, uptake by macrophages, and better solubility at low pH, contribute to the selectivity of photosensitizers for tumor tissues. Targeted delivery strategies take advantage of the differences in metabolism and gene expression profiles between tumor cells and healthy cells, resulting in improved efficiency of photodynamic therapy.
BIOCHEMISTRY-MOSCOW
(2022)
Article
Engineering, Biomedical
Natalia Gorbatova, Ella Gasanova, Sergei Zolotov, Anatoly Sirotkin, Gennady Kuzmin, Alexander Tertychny, Natalia Stankova, Maria Remennicova, Oleg Tikhonevich
Summary: The selectivity of laser radiation with a wavelength of 525 nm on hemoglobin-containing tissues has been confirmed in experimental studies, showing promise for the selective photothermolysis of pathological subepithelial capillary structures with minimal damage to skin tissues.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Hematology
Elahe A. Mostaghel, Paul S. Martin, Stephen Mongovin, Shani Frayo, Ailin Zhang, Kerstin L. Edlefsen, Oliver W. Press, Ajay K. Gopal
EXPERIMENTAL HEMATOLOGY
(2017)
Article
Hematology
Yolanda D. Tseng, Philip A. Stevenson, Ryan D. Cassaday, Andrew Cowan, Brian G. Till, Mazyar Shadman, Solomon A. Graf, Ralph Ermoian, Stephen D. Smith, Leona A. Holmberg, Oliver W. Press, Ajay K. Gopal
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Hematology
Victor A. Chow, Mazyar Shadman, Ajay K. Gopal
Article
Oncology
Radhakrishnan Ramchandren, Ranjana H. Advani, Stephen M. Ansell, Nancy L. Bartlett, Robert Chen, Joseph M. Connors, Tatyana Feldman, Andres Forero-Torres, Jonathan W. Friedberg, Ajay K. Gopal, Leo I. Gordon, John Kuruvilla, Kerry J. Savage, Anas Younes, Gerald Engley, Thomas J. Manley, Keenan Fenton, David J. Straus
CLINICAL CANCER RESEARCH
(2019)
Letter
Hematology
Victor A. Chow, Ajay K. Gopal, David G. Maloney, Cameron J. Turtle, Stephen D. Smith, Chaitra S. Ujjani, Mazyar Shadman, Ryan D. Cassaday, Brian G. Till, Yolanda D. Tseng, Edus H. Warren, Andrei R. Shustov, Manoj P. Menon, Sandra Bhark, Utkarsh H. Acharya, Erin Mullane, Lindsay M. Hannan, Jenna M. Voutsinas, Ted A. Gooley, Ryan C. Lynch
AMERICAN JOURNAL OF HEMATOLOGY
(2019)
Article
Oncology
Ajay K. Gopal, Ronald Levy, Roch Houot, Sandip P. Patel, Leslie Popplewell, Caron Jacobson, Xinmeng J. Mu, Shibing Deng, Keith A. Ching, Ying Chen, Craig B. Davis, Bo Huang, Kolette D. Fly, Aron Thall, Adrian Woolfson, Nancy L. Bartlett
CLINICAL CANCER RESEARCH
(2020)
Letter
Hematology
Victor A. Chow, Paul S. Martin, Stephen D. Smith, Brian G. Till, Solomon A. Graf, Kerstin L. Edlefsen, Lindsay M. Hannan, Elahe A. Mostaghel, Ajay K. Gopal
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Article
Hematology
Victor A. Chow, Ajay K. Gopal, Jordan Gauthier, Yolanda D. Tseng, Cameron J. Turtle, David G. Maloney, Mazyar Shadman
Editorial Material
Oncology
Stephen D. Smith, Ajay K. Gopal
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Filippo Figini, Cholenahaly N. Manjunath, Budanur C. Srinivas, Kanvar Sarat Sadananda, Madhu Sreedharan, Louie Fischer, Ramakrishna Pillai, Kiron Varghese, Ajay K. Gopal, Chamarajnagar Mahadevappa Nagesh, Imad Sheiban
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2018)
Article
Hematology
Damian J. Green, Shyril O'Steen, Yukang Lin, Melissa L. Comstock, Aimee L. Kenoyer, Donald K. Hamlin, D. Scott Wilbur, Darrell R. Fisher, Margaret Nartea, Mark D. Hylarides, Ajay K. Gopal, Theodore A. Gooley, Johnnie J. Orozco, Brian G. Till, Kelly D. Orcutt, K. Dane Wittrup, Oliver W. Press
Article
Oncology
A. K. Gopal, M. A. Fanale, C. H. Moskowitz, A. R. Shustov, S. Mitra, W. Ye, A. Younes, A. J. Moskowitz
ANNALS OF ONCOLOGY
(2017)
Article
Hematology
Ang Li, Chris Davis, Qian Wu, Shan Li, Madeline F. Kesten, Leona A. Holmberg, Ajay K. Gopal, David A. Garcia
Article
Hematology
Andrew J. Cowan, Phillip A. Stevenson, Ted A. Gooley, Shani L. Frayo, George R. Oliveira, Stephen D. Smith, Damian J. Green, Jennifer E. Roden, John M. Pagel, Brent L. Wood, Oliver W. Press, Ajay K. Gopal
BRITISH JOURNAL OF HAEMATOLOGY
(2017)
Review
Hematology
D. Alan Potts, Jonathan R. Fromm, Ajay K. Gopal, Ryan D. Cassaday
CASE REPORTS IN HEMATOLOGY
(2017)