Article
Cardiac & Cardiovascular Systems
Maria A. de Winter, Harry R. Buller, Marc Carrier, Alexander T. Cohen, John-Bjarne Hansen, Karin A. H. Kaasjager, Ajay K. Kakkar, Saskia Middeldorp, Gary E. Raskob, Henrik T. Sorensen, Frank L. J. Visseren, Philip S. Wells, Jannick A. N. Dorresteijn, Mathilde Nijkeuter, VTE PREDICT study Grp
Summary: This study aimed to develop and validate models for predicting 5-year risks of recurrence and bleeding in VTE patients without cancer. The models were derived from patient data and validated externally, showing good agreement between predicted and observed risks for up to 5 years.
EUROPEAN HEART JOURNAL
(2023)
Article
Oncology
Masataka Ikeda, Hiroyuki Uetake, Takayuki Yoshino, Taishi Hata, Mari S. Oba, Atsushi Takita, Tetsuya Kimura
Summary: The impact of venous thromboembolism in Japanese colorectal cancer patients has been investigated in this study. The incidence of venous thromboembolism was low but was associated with increased mortality. Early treatment and effective screening methods may help reduce the risk of venous thromboembolism.
Article
Oncology
Takaki Yoshikawa, Takeshi Sano, Masanori Terashima, Kensei Yamaguchi, Etsuro Bando, Ryohei Kawabata, Hiroshi Yabusaki, Hisashi Shinohara, Mari S. Oba, Tetsuya Kimura, Atsushi Takita, Mitsuru Sasako
Summary: This study is a large-scale, multicenter, prospective registry that aims to investigate the incidence and risk factors of venous thromboembolism (VTE) in adult Japanese patients with solid tumors. The analysis of stomach cancer patients revealed that female sex, age >= 65 years, VTE history, and D-dimer > 1.2 μg/mL were independent risk factors for VTE. Additionally, screening for D-dimer before starting cancer treatment is necessary, even for asymptomatic patients.
Article
Hematology
Yasuo Ohashi, Masataka Ikeda, Hideo Kunitoh, Mitsuru Sasako, Takuji Okusaka, Hirofumi Mukai, Keiichi Fujiwara, Mashio Nakamura, Mari S. Oba, Tetsuya Kimura, Kei Ibusuki, Atsushi Takita, Masato Sakon
Summary: This study aimed to investigate the relationship between solid tumors and venous thromboembolism (VTE) in Japanese patients. The results showed a low incidence of symptomatic VTE, but the presence of symptomatic or asymptomatic VTE at baseline was an important risk factor for developing symptomatic VTE, bleeding events, and death.
THROMBOSIS RESEARCH
(2022)
Editorial Material
Hematology
Anna Falanga, Cinzia Giaccherini
Summary: In this study, the PRISM score was developed as a new risk prediction model for venous thromboembolism prevention in outpatients with multiple myeloma. The abnormal metaphase cytogenetics was identified as a new disease-related risk factor, which contributes to the understanding and treatment of patients with multiple myeloma.
Review
Biochemistry & Molecular Biology
Beata Franczyk, Anna Gluba-Brzozka, Janusz Lawinski, Magdalena Rysz-Gorzynska, Jacek Rysz
Summary: VTE, consisting of DVT and PE, is a major cause of cardiovascular disease. Current diagnosis and treatment guidance for VTE are limited, and there is a lack of understanding of the mechanisms and pathways responsible for the occurrence of observed alterations. The application of metabolomics profiling may play a significant role in early diagnosis and management, but more research is needed to fully understand VTE-related metabolic changes.
Article
Oncology
Deanna Glassman, Nicholas W. Bateman, Sanghoon Lee, Li Zhao, Jun Yao, Yukun Tan, Cristina Ivan, Kelly M. Rangel, Jianhua Zhang, Kelly A. Conrads, Brian L. Hood, Tamara Abulez, P. Andrew Futreal, Nicole D. Fleming, Vahid Afshar-Kharghan, George L. Maxwell, Thomas P. Conrads, Ken Chen, Anil K. Sood
Summary: Ovarian cancer patients with venous thromboembolism (VTE) have molecular differences compared to those without. VTE is associated with upregulated inflammatory and coagulation pathways, and correlated with the expression of platelet-derived growth factor subunit B (PDGFB) and extracellular proteins, namely collagens.
Review
Hematology
Jodi Chiu, Alejandro Lazo-Langner
Summary: Venous thromboembolism (VTE) is a common complication after hematopoietic stem cell transplantation (HSCT), and treatment decisions become challenging due to the complex risk balance between thrombosis and bleeding. Currently, there is a lack of validated risk assessment models and guidelines for thromboprophylaxis and VTE treatment in HSCT patients. This review summarizes the various risk factors for VTE in HSCT patients and discusses current strategies for thromboprophylaxis and VTE management, as well as the development of risk assessment models for targeted intervention in high-risk subgroups.
THROMBOSIS RESEARCH
(2023)
Article
Medicine, General & Internal
Sunjoo Boo, Hyunjin Oh, Kyungjin Hwang, Kyoungwon Jung, Jonghwan Moon
Summary: This study evaluated the incidence and potential predictors of VTE in Korean trauma patients, finding significant associations between VTE occurrence and variables such as VTE history, pelvic-bone fracture, ventilator use, and hospitalization period. Furthermore, the study showed that increased RAP and TESS scores were correlated with increased VTE rate, with an optimal cut-off value of 6 for both scores.
YONSEI MEDICAL JOURNAL
(2021)
Article
Surgery
Ahmed Mohammed Abdelsalam, Ahmed Mohammed Salah Eldeen ElAnsary, Mohammed Abdallah Salman, Sahar Abdelrahman Nassef, Hala Mostafa Elfergany, Hesham Ahmed Abou Aisha
Summary: This study aimed to evaluate the optimal regimen for VTE prophylaxis in bariatric procedures and reduce the incidence of perioperative VTE by using prophylactic anticoagulants. The results showed a significant decrease in postoperative VTE incidence in patients who received postoperative LMWH treatment.
WORLD JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Jin-Sung Yuk, Banghyun Lee, Myoung Hwan Kim, Kidong Kim, Yong-Soo Seo, Sung Ook Hwang, Yong Kyoon Cho, Yong Beom Kim
Summary: This study investigated the incidence and risk factors for VTE in patients with cervical cancer, finding that chemotherapy was associated with the highest incidence of VTE and risk compared to other primary treatments.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ambrogio P. Londero, Serena Bertozzi, Carla Cedolini, Silvia Neri, Michela Bulfoni, Maria Orsaria, Laura Mariuzzi, Alessandro Uzzau, Andrea Risaliti, Giovanni Barillari
Summary: This study aims to assess the occurrence and timing of venous thromboembolism (VTE) over a long follow-up period in breast cancer patients, analyzing correlated factors and overall survival. The presence of invasive breast cancer significantly impacts VTE occurrence and survival, with factors such as chronic hypertension, high BMI, cancer type, and evidence of metastasis being identified as significant risk factors for VTE in women undergoing breast surgery.
Review
Cell Biology
Viktoria Muster, Thomas Gary
Summary: Glioblastoma patients have a high risk of developing venous thromboembolism, making therapeutic anticoagulation challenging with limited data available for this vulnerable patient group.
Article
Cardiac & Cardiovascular Systems
David Smith, Micaela Raices, Carolina Diego, Drago Julian, Juan Montagne, Agustin Dietrich
Summary: VTE and postoperative bleeding are significant complications following pulmonary lobectomy. Adherence to VTE prophylaxis guidelines is crucial, but individual risk assessment for VTE and bleeding is preferred to determine the optimal timing for thromboprophylaxis.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2021)
Article
Multidisciplinary Sciences
Kuo Zhao, Junzhe Zhang, Junyong Li, Hongyu Meng, Zhiyong Hou, Yingze Zhang
Summary: This study aimed to investigate the incidence of and risk factors for postoperative new-onset deep venous thrombosis (PNO-DVT) following intertrochanteric fracture surgery. Results showed a high incidence of PNO-DVT in inpatients after surgery, with a significant number of cases diagnosed within 8 days post-surgery. Routine DVT examinations for patients after surgery are recommended based on the findings.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Mitchell S. von Itzstein, Elda Railey, Mary L. Smith, Carol B. White, George W. Sledge, John R. Howell, Wendy Lawton, Donna M. Marinucci, Nisha Unni, David E. Gerber
Article
Oncology
David E. Gerber, D. Ross Camidge, Daniel Morgensztern, Jeremey Cetnar, Ronan J. Kelly, Suresh S. Ramalingam, David R. Spigel, Woondong Jeong, Pier P. Scaglioni, Song Zhang, Marilyn Li, David T. Weaver, Louis Vaikus, Mitchell Keegan, Joanna C. Horobin, Timothy F. Burns
Article
Oncology
David E. Gerber, William C. Putnam, Farjana J. Fattah, Kemp H. Kernstine, Rolf A. Brekken, Ivan Pedrosa, Rachael Skelton, Jessica M. Saltarski, Robert E. Lenkinski, Richard D. Leff, Chul Ahn, Chyndhri Padmanabhan, Vaidehi Chembukar, Sahba Kasiri, Raja Reddy Kallem, Indhumathy Subramaniyan, Qing Yuan, Quyen N. Do, Yin Xi, Scott Reznik, Lorraine Pelosof, Brandon Faubert, Ralph J. DeBerardinis, James Kim
CLINICAL CANCER RESEARCH
(2020)
Editorial Material
Oncology
Mitchell S. von Itzstein, David E. Gerber, John D. Minna
Summary: The study by Dagnino and colleagues identified CDCP1 as a potential biomarker for distinguishing patients with or without lung cancer, and demonstrated that combining CDCP1 blood levels with smoking history can be a predictive tool for lung cancer screening. Analysis of transcripts in peripheral blood cells suggested a Wnt/b-catenin signaling-based mechanism for CDCP1 in tumorigenesis, providing biological plausibility.
Article
Oncology
Sandi L. Pruitt, David E. Gerber, Hong Zhu, Daniel F. Heitjan, Bhumika Maddineni, Danyi Xiong, Amit G. Singal, Anna Tavakkoli, Ethan A. Halm, Caitlin C. Murphy
Summary: The study found that patients with previous cancer have worse overall survival but superior CRC-specific survival. Patients with previous melanoma had overall survival equivalent to those with no previous cancer. It is recommended that patients with previous melanoma and those with stage IV CRC with any type of previous cancer should be eligible to participate in clinical trials.
Editorial Material
Oncology
Erin L. Williams, Desiree L. Pierre, Mary E. Martin, Muhammad S. Beg, David E. Gerber
JCO ONCOLOGY PRACTICE
(2021)
Article
Oncology
David E. Gerber, Valerie L. Clark, Thomas Y. Sheffield, M. Shaalan Beg, Yang Xie, M. E. Blair Holbein, Celette Sugg Skinner, Simon J. Craddock Lee, Erin L. Williams
Summary: The COVID-19 pandemic has brought about significant changes in clinical research, such as remote consent, telehealth, and remote study monitoring. A survey conducted among cancer research professionals showed that perceptions of these adjustments remained favorable over time, and individuals with experience were more likely to recommend the continuation of these changes in the future.
JCO ONCOLOGY PRACTICE
(2022)
Article
Multidisciplinary Sciences
Ke Gong, Gao Guo, Nicole A. Beckley, Xiaoyao Yang, Yue Zhang, David E. Gerber, John D. Minna, Sandeep Burma, Dawen Zhao, Esra A. Akbay, Amyn A. Habib
Summary: The study explored the efficacy of broad versus focused targeting of resistance to EGFR inhibition in NSCLC, finding that a broad inhibitor of inflammation, prednisone, is the most effective in suppressing inflammatory signals and resistance mechanisms.
NATURE COMMUNICATIONS
(2021)
Letter
Oncology
Erin F. Williams, David E. Gerber
JCO ONCOLOGY PRACTICE
(2022)
Article
Oncology
Mitchell S. von Itzstein, Amrit S. Gonugunta, Thomas Sheffield, Jade Homsi, Jonathan E. Dowell, Andrew Y. Koh, Prithvi Raj, Farjana Fattah, Yiqing Wang, Vijay S. Basava, Shaheen Khan, Jason Y. Park, Vinita Popat, Jessica M. Saltarski, Yvonne Gloria-McCutchen, David Hsiehchen, Jared Ostmeyer, Yang Xie, Quan-Zhen Li, Edward K. Wakeland, David E. Gerber
Summary: Patients treated with antibiotics have worse outcomes from cancer immunotherapy, potentially due to the impact of antibiotics on the gut microbiome. This study found significant differences in immune parameters, including antibodies and cytokines, according to antibiotic exposure.
Editorial Material
Oncology
Christa Braun-Inglis, Erin L. Williams, Alyssa Macchiaroli, Andrea Denicoff, David E. Gerber
JCO ONCOLOGY PRACTICE
(2022)
Article
Oncology
Amrit S. Gonugunta, Mitchell S. Von Itzstein, David Hsiehchen, Tri Le, Sawsan Rashdan, Hui Yang, Christopher Selby, Carlos Alvarez, David E. Gerber
Summary: Antibiotic exposure is more common in lung cancer and melanoma patients, especially in lung cancer patients. These observations may have implications for clinical practice and health policies.
CLINICAL LUNG CANCER
(2022)
Editorial Material
Oncology
Sherry Fu, David E. E. Gerber, Muhammad Shaalan Beg
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Alexis C. Boulter, Barry J. Maurer, Meredith Pogue, Min H. Kang, Hwangeui Cho, Amanda Knight, C. Patrick Reynolds, Donald Quick, Sanjay Awasthi, David E. Gerber
Summary: This study is a clinical trial of the combination therapy of synthetic retinoid 4-HPR and a variant dihydroceramide precursor. The results show that this combination therapy has limited efficacy in refractory solid tumors.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Editorial Material
Oncology
David E. Gerber
JOURNAL OF CLINICAL ONCOLOGY
(2023)