Article
Oncology
Tobias Burkard, Martina Herrero San Juan, Caroline Dreis, Anastasiia Kiprina, Dmitry Namgaladze, Kai Siebenbrodt, Sebastian Luger, Christian Foerch, Josef M. Pfeilschifter, Andreas Weigert, Heinfried H. Radeke
Summary: Functionally distinct cytotoxic T lymphocytes can be identified based on their expression of CD8, playing opposing roles in the tumor microenvironment and autoimmune diseases such as multiple sclerosis. The presence of CD8(Low) T cells correlated with poor prognosis and enhanced cancer progression, while a reduced frequency of these cells was found in relapse multiple sclerosis patients compared to healthy subjects during immune cell starvation in vitro.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Hematology
Alan H. Lazarus, John W. Semple
Summary: A study found that patients with chronic ITP have clonal expansions of a specific subset of CD8 T cells called terminally differentiated effector memory (TEMRA) T cells. These cells persist over the course of the disease, are more prominent in refractory ITP, and are more prevalent when the platelet count is low.
Article
Immunology
Ashley A. Brate, Alexander W. Boyden, Isaac J. Jensen, Vladimir P. Badovinac, Nitin J. Karandikar
Summary: This study identifies a disease-suppressing subset of CD8 T cells with unique phenotypic properties, including a CXCR3(+) subpopulation and increased degranulation and coproduction of IFN-gamma and IL-10. Understanding the functional characteristics of this regulatory subset provides insights into potential novel immunotherapeutic approaches for MS.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Carolina Lyon De Ana, Anukul T. Shenoy, Kimberly A. Barker, Emad I. Arafa, Neelou S. Etesami, Filiz T. Korkmaz, Alicia M. Soucy, Michael P. Breen, Ian M. C. Martin, Brian R. Tilton, Priyadharshini Devarajan, Nicholas A. Crossland, Riley M. F. Pihl, Wesley N. Goltry, Anna C. Belkina, Matthew R. Jones, Lee J. Quinton, Joseph P. Mizgerd
Summary: Streptococcus pneumoniae is a common bacterial pathogen that causes pneumonia, leading to significant mortality in children and the elderly worldwide. This study identifies a unique subset of CD4+ TRM cells in the lungs that play a crucial role in lung immunity during pneumococcal infections. These cells exhibit distinct functional characteristics compared to other subsets, suggesting their importance in protecting against reinfection.
MUCOSAL IMMUNOLOGY
(2023)
Article
Oncology
Marija Mojic, Kiyomi Shitaoka, Chikako Ohshima, Sisca Ucche, Fulian Lyu, Hiroshi Hamana, Hideaki Tahara, Hiroyuki Kishi, Yoshihiro Hayakawa
Summary: By analyzing the immunological status of tumor antigen-specific CD8(+) T cells during tumor progression, it was found that NKG2D can control the fate and TOX expression of tumor-reacting CD8(+) T cells.
Article
Biology
Agnese Losurdo, Caterina Scirgolea, Giorgia Alvisi, Jolanda Brummelman, Valentina Errico, Luca Di Tommaso, Karolina Pilipow, Federico Simone Colombo, Bethania Fernandes, Clelia Peano, Alberto Testori, Corrado Tinterri, Massimo Roncalli, Armando Santoro, Emilia Maria Cristina Mazza, Enrico Lugli
Summary: By analyzing breast cancer-infiltrating T cells using high-dimensional single-cell technologies, researchers found that a small subset of tissue-resident memory CD8+ T cells with enhanced degranulation capacity is associated with positive prognosis in luminal-like breast cancer, highlighting the potential importance of specific T cell immune microenvironment.
COMMUNICATIONS BIOLOGY
(2021)
Article
Hematology
Wenbin Xiao, Alexander Chan, Michael R. Waarts, Tanmay Mishra, Ying Liu, Sheng F. Cai, Jinjuan Yao, Qi Gao, Robert L. Bowman, Richard P. Koche, Isabelle S. Csete, Nicole L. DelGaudio, Andriy Derkach, Jeeyeon Baik, Sophia Yanis, Christopher A. Famulare, Minal Patel, Maria E. Arcila, Maximilian Stahl, Raajit K. Rampal, Martin S. Tallman, Yanming Zhang, Ahmet Dogan, Aaron D. Goldberg, Mikhail Roshal, Ross L. Levine
Summary: Plasmacytoid dendritic cell expansion in acute myeloid leukemia is poorly studied, and pDC-AML patients often have adverse risk stratification with RUNX1 mutations. CD123 targeting represents a potential treatment approach for pDC-AML.
Article
Immunology
Sara Quon, Bingfei Yu, Brendan E. Russ, Kirill Tsyganov, Hongtuyet Nguyen, Clara Toma, Maximilian Heeg, James D. Hocker, J. Justin Milner, Shane Crotty, Matthew E. Pipkin, Stephen J. Turner, Ananda W. Goldrath
Summary: Using the Hi-C technique, we investigated the relationship between genome configuration and CD8+ T cell differentiation. We found that CTCF mutations can affect the expression of terminal-effector genes, indicating that CTCF not only participates in genome organization, but also regulates the diversity of effector CD8+ T cells by altering interactions that regulate the transcription factor landscape and transcriptome.
Article
Biochemistry & Molecular Biology
Hongbo M. Xie, Kathrin M. Bernt
Summary: Angiosarcoma is a rare and deadly malignancy, with 33% of patients showing recurrent amplifications of HOXA-cluster genes. The amplifications typically affect multiple pro-angiogenic HOXA genes and commonly co-occur with CD36 and KDR amplifications, with a low overall mutation rate.
Article
Immunology
Alsya J. Affandi, Katarzyna Olesek, Joanna Grabowska, Maarten K. Nijen Twilhaar, Ernesto Rodriguez, Anno Saris, Eline S. Zwart, Esther J. Nossent, Hakan Kalay, Michael de Kok, Geert Kazemier, Johannes Stockl, Alfons J. M. van den Eertwegh, Tanja D. de Gruijl, Juan J. Garcia-Vallejo, Gert Storm, Yvette van Kooyk, Joke M. M. den Haan
Summary: CD169(+) monocytes are activated monocytes with enhanced capacity to stimulate CD8(+) T cells. They are present in various diseases, including viral infections and cancers, and emerge as an interesting target in nanovaccine strategies. The study also showed that two CD169-targeting nanovaccine platforms efficiently presented tumor-associated peptides to antigen-specific CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jasper Norenberg, Pal Jakso, Aliz Barakonyi
Summary: The study showed that during pregnancy, the proportion of CD56+ gamma delta T cells increases while maintaining potential cytotoxicity, although the cytotoxic strength is reduced, and PD-1 expression increases. Highly cytotoxic CD56+ gamma delta T cells tend to express PD-1, which may allow the inhibition of these cells after binding its ligand in the placenta.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Romain Ballet, Melissa Lajevic, Noelle Huskey-Mullin, Rachel Roach, Kevin Brulois, Ying Huang, Muhammad A. Saeed, Ha X. Dang, Russell K. Pachynski, Elizabeth Wilson, Eugene C. Butcher, Brian A. Zabel
Summary: This study reveals the role of chemerin:CMKLR1 in defining a specialized NK-like CD8 T cell and suggests the use of chemerin-dependent modalities to target effector CMKLR1-expressing T cells to the tumor microenvironment for immunotherapeutic purposes. In an experimental prostate tumor mouse model, chemerin expression is downregulated in the tumor microenvironment, which is associated with few tumor-infiltrating CD8+ T cells.
Article
Biochemistry & Molecular Biology
Huafeng Zhang, Jincheng Liu, Zhuoshun Yang, Liping Zeng, Keke Wei, Liyan Zhu, Liang Tang, Dianheng Wang, Yabo Zhou, Jiadi Lv, Nannan Zhou, Ke Tang, Jingwei Ma, Bo Huang
Summary: Glycolysis plays a crucial role in the recall response of CD8(+) memory T cells. This study reveals that intracellular glycogen serves as the major carbon source for the early recall response, and TCR signaling regulates this process through the phosphorylation of PYGB. This discovery highlights the specific dependence of memory T cell activation on glycogen and its potential therapeutic implications.
Article
Multidisciplinary Sciences
Wei Liao, Yong Liu, Chaoyu Ma, Liwen Wang, Guo Li, Shruti Mishra, Saranya Srinivasan, Kenneth Ka-Ho Fan, Haijing Wu, Qianwen Li, Ming Zhao, Xun Liu, Erika L. Demel, Xin Zhang, Yuanzheng Qiu, Qianjin Lu, Nu Zhang
Summary: The stepwise induction of CD69 and CD103 distinguishes different differentiation stages of mucosal Trms, while the majority of non-mucosal Trm do not have CD103 expression. CD69 expression alone is not sufficient to accurately define Trm cells in highly vascularized non-mucosal tissues, such as the kidney. The downregulation of IL-18 receptor (IL-18R) is associated with tissue residency, with IL-18R(lo) exclusively identifying tissue-resident cells and IL-18R(hi) population containing both tissue-resident and migratory cells. Additionally, local cytokines and transcription factors play essential roles in regulating the downregulation of IL-18R during kidney Trm differentiation, allowing for the identification of kidney-resident CD8(+) T cells and the underlying molecular mechanisms.
Article
Immunology
Diana Martin, Pedro Perdiguero, Esther Morel, Irene Soleto, J. German Herranz-Jusdado, Luis A. Ramon, Beatriz Abos, Tiehui Wang, Patricia Diaz-Rosales, Carolina Tafalla
Summary: CD38 has diverse expressions in different species, with high levels in mouse B cell subsets and transient expression on early lymphocyte precursors in humans while consistently expressed on terminally differentiated plasma cells.
FRONTIERS IN IMMUNOLOGY
(2021)
