Article
Biochemistry & Molecular Biology
Yurong Wang, Yan Wang, Kai Xue, Feng Gao, Chengde Li, Hui Fang
Summary: The study showed that increased expression of Apelin-13 under chronic intermittent hypoxia conditions can reduce renal fibrosis, while inhibition of Apelin expression can exacerbate renal fibrosis. Cell experiments also demonstrated that Apelin-13 treatment can reduce oxidative stress and inflammatory response, and decrease the expression of fibrosis-related proteins.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Engineering, Mechanical
E. R. Sergio, F. V. Antunes, D. Kujawski, D. M. Neto
Summary: This study introduces an additional damage mechanism to predict the effects of micro-void growth, nucleation, and coalescence. By using a non-local damage model, the reverse plastic zone is identified as the fatigue process zone, and a relation is established to calculate its size. The results show that the effect of stress amplitude on fatigue crack growth rate is minimal in the absence of crack closure, but is amplified when considering the contact between crack flanks.
INTERNATIONAL JOURNAL OF FATIGUE
(2023)
Article
Medicine, Research & Experimental
Peng Xiong, Yu-Yun Zheng, Jian-Ming Ouyang
Summary: By studying the Chinese medicine Pocoa (PCPs) with different carboxyl group (-COOH) contents, it was found that PCPs can inhibit oxidative damage and inflammatory response of renal epithelial cells, and this inhibitory effect is enhanced with the increase of carboxyl group content.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Eva Monte-Serrano, Pedro A. A. Lazo
Summary: DNA accessibility to cellular functions requires dynamic regulation of chromatin organization through different epigenetic modifications. Acetylation of histone H4 at lysine 14 (H4K16ac) determines chromatin accessibility to nuclear functions and DNA damage drugs. The epigenetic enzymes Tip60/KAT5 and SIRT2 regulate H4K16ac through acetylation and deacetylation, respectively. VRK1 regulates H4K16 acetylation by activating Tip60, and forms a stable protein complex with SIRT2. VRK1's kinase activity is inhibited by direct interaction with SIRT2, leading to loss of H4K16ac. Inhibition of SIRT2 cooperates with VRK1 in drug accessibility to chromatin in response to DNA damage caused by doxorubicin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Xin Shen, Bo Zhang, Xiaoyu Hu, Jia Li, Miaomiao Wu, Caixia Yan, Yutao Yang, Yan Li
Summary: Periodontitis-associated bacteria may have the potential to inhibit the development of oral squamous cell carcinomas by regulating genome stability and modulating the DNA damage response and inflammatory pathways.
Article
Green & Sustainable Science & Technology
Chao Ren, Yihan Xing
Summary: This paper proposes an efficient active learning Kriging approach called AK-MDAmax for estimating the maximum fatigue damage of wind turbine towers with reduced computational cost. The proposed approach can accurately estimate wind turbine towers' maximum cumulative fatigue damage and requires less computational effort compared to typical simulation approaches.
Article
Biochemistry & Molecular Biology
Meiyuan Jin, Shouying Xu, Bin Cao, Qiang Xu, Ziyi Yan, Qianlei Ren, Chao Lin, Chao Tang
Summary: The study discovered that Hypoxia-Inducible Factor-1 alpha is up-regulated in clinical preeclampsia samples, while Regulator of G Protein Signaling 2 is down-regulated. Mechanistically, Hypoxia-Inducible Factor-1 alpha is induced in response to hypoxia, forming a complex with E1A binding protein P300 that inhibits the transcription of Regulator of G Protein Signaling 2, potentially contributing to the development of preeclampsia.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Oncology
Libin Jiang, Yingxia Li, Yixin He, Dapeng Wei, Lvyin Yan, Hongtao Wen
Summary: IGF2BP3 regulates hypoxia-induced cell migration and angiogenesis in stomach cancer by directly binding to HIF1A mRNA and positively regulating its expression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Huiyi Wang, Xiaoxuan Wang, Li Ma, Xin Huang, Yan Peng, Hantao Huang, Xudong Gao, Yuan Chen, Zhengguo Cao
Summary: The study found that in hypoxic conditions, the expression of hypoxia inducible factor-1 alpha was elevated in apical periodontitis tissues, while PGC-1 alpha expression decreased in periapical lesions. Induced hypoxia suppressed the mineralization ability and mitochondrial biogenesis of cementoblasts, with abnormal mitochondrial morphology observed.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Environmental Sciences
Xiaohui Li, Chen Ling, Qiaoxin Wang, Cui Feng, Xiangzhong Luo, Hang Sha, Guoyu He, Guiwei Zou, Hongwei Liang
Summary: The silver carp, an economically and environmentally important fish, has low tolerance to environmental hypoxia. This study examined the impact of hypoxia on the gills of silver carp at various levels and found that it may use HIF-1 to increase oxygen supply during hypoxic conditions.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Multidisciplinary Sciences
Nader Allam, W. Jeffrey Zabel, Valentin Demidov, Blake Jones, Costel Flueraru, Edward Taylor, I. Alex Vitkin
Summary: Stereotactic body radiotherapy (SBRT) is an emerging cancer treatment that offers logistical and potential therapeutic advantages compared to conventional radiotherapy. This study utilizes longitudinal imaging and quantification of the vascular architecture to investigate the relationship between microvasculature and tumor response kinetics. The results show promise in determining the dose-response relationship for SBRT.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, Research & Experimental
Fangfang Zhu, Jie Gao, Fuling Zeng, Yuling Lai, Xiaofeng Ruan, Gaopi Deng
Summary: This study investigated the protective effects and mechanisms of hyperoside against cyclophosphamide-induced ovarian damage and reduced fertility. The results showed that hyperoside can diminish follicular depletion, prevent excessive hypoxia and autophagy activation, and increase follicular reserve, thereby improving fertility in mice.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Elisabeth Jeanclos, Jan Schloetzer, Kerstin Hadamek, Natalia Yuan-Chen, Mohammad Alwahsh, Robert Hollmann, Stefanie Fratz, Dilan Yesilyurt-Gerhards, Tina Frankenbach, Daria Engelmann, Angelika Keller, Alexandra Kaestner, Werner Schmitz, Martin Neuenschwander, Roland Hergenroeder, Christoph Sotriffer, Jens Peter von Kries, Hermann Schindelin, Antje Gohla
Summary: This study demonstrates the druggability of phosphoglycolate phosphatase and validates an alternative approach to control glycolysis. The compound CP1 inhibits the phosphatase and replicates the effects of cellular PGP-deficiency, providing key insights into effective and precise targeting of PGP.
NATURE COMMUNICATIONS
(2022)
Article
Plant Sciences
Yuying Zheng, Shengchang Yang, Jianchao Si, Yang Zhao, Ming Zhao, Ensheng Ji
Summary: The study suggests that treatment with Shashen-Maidong Decoction can inhibit lung cancer growth under intermittent hypoxia conditions. The antitumor effect may be attributed to attenuated oxidative stress and inflammation through inactivation of the IL-6/JAK2/STAT3 signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Magdalena Zdrowowicz, Paulina Spisz, Aleksandra Hac, Anna Herman-Antosiewicz, Janusz Rak
Summary: This study found that breast and prostate cancer cells are more sensitive to the radiosensitizer 5-bromo-2'-deoxyuridine (BrdU) in a hypoxic environment. BrdU can more effectively induce double-strand breaks in cancer cells under hypoxia, thereby increasing sensitivity to radiotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
