Article
Medicine, General & Internal
H. Dean Hosgood, Meghan Davitt, Richard Cawthon, Stephanie J. Weinstein, Batel Blechter, Jason Y. Y. Wong, Mohammad L. Rahman, Wei Hu, Satu Mannisto, Demetrius Albanes, Nathaniel Rothman, Qing Lan
Summary: This study suggests that a higher fraction of mitochondrial DNA with breaks is associated with an increased risk of non-Hodgkin lymphoma (NHL).
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: Many studies have found associations between neighborhood deprivation and disease, emphasizing the importance of social determinants of health. However, when studying diseases with long latency periods such as cancers, considering the timing of exposures for deprivation becomes more important.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Joseph Boyle, Mary H. Ward, James R. Cerhan, Nathaniel Rothman, David C. Wheeler
Summary: This study assessed the association between historic environmental pollutant emissions and chemical mixtures in house dust with non-Hodgkin lymphoma (NHL). The results showed a significant positive association between RSEI scores and NHL in long-term residents in Detroit, while significant inverse associations were found in two other study centers. These findings highlight the importance of considering historic and cumulative environmental exposures and using residential histories for diseases with long latency periods like NHL.
ENVIRONMENTAL RESEARCH
(2023)
Article
Immunology
Laura E. Martinez, Larry I. Magpantay, Yu Guo, Priya Hegde, Roger Detels, Shehnaz K. Hussain, Marta Epeldegui
Summary: The study revealed significantly higher levels of EVs bearing PD-L1, CD40, TNF-RII, and/or IL-6R alpha in AIDS-NHL cases compared to controls. EVs carrying these molecules were found to be significantly and positively associated with AIDS-NHL risk, suggesting their potential as biomarkers for early detection of NHL in PLWH.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Terry Boyle, Geffen Kleinstern, Paige M. Bracci, James R. Cerhan, Yolanda Benavente, Delphine Casabonne, Brian C-H Chiu, Thomas M. Habermann, Elizabeth A. Holly, Mark Liebow, Aaron Norman, Ora Paltiel, Dennis Robinson, Nathaniel Rothman, Rania Abu Seir, Susan L. Slager, Paul J. Villeneuve, Sophia S. Wang, Dennis D. Weisenburger, John J. Spinelli
Summary: This study, which pooled data from nine case-control studies, found that moderate-to-vigorous intensity physical activity can reduce the risk of non-Hodgkin lymphoma.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
James Yarmolinsky, Christopher I. Amos, Rayjean J. Hung, Victor Moreno, Kimberley Burrows, Karl Smith-Byrne, Joshua R. Atkins, Paul Brennan, James D. McKay, Richard M. Martin, George Davey Smith
Summary: Deucravacitinib, a selective TYK2 inhibitor, is being reviewed for the treatment of psoriasis. However, there are concerns about the safety of TYK2 inhibition due to the increased risk of lung cancer and non-Hodgkin lymphoma associated with similar medications. Genetic analysis using a loss-of-function variant in TYK2 showed an increased risk of lung cancer and non-Hodgkin lymphoma with therapeutic TYK2 inhibition. These findings have important implications for the safety assessment of deucravacitinib and other TYK2 inhibitors.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Mark Liebow, Melissa C. Larson, Carrie A. Thompson, Grzegorz S. Nowakowski, Timothy G. Call, William R. Macon, Neil E. Kay, Thomas M. Habermann, Susan L. Slager, James R. Cerhan
Summary: The study found that regular use of low-dose aspirin may reduce the risk of non-Hodgkin lymphoma, while other NSAIDs and statins showed no association with NHL risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Shuyan Yao, Zhili Jin, Lingbo He, Ruoxi Zhang, Menghan Liu, Zhengjie Hua, Zhao Wang, Yini Wang
Summary: The study showed significant differences in pathological types, clinical characteristics, and prognosis between lymphoma patients with or without LAHS. Age, platelet count, IPI, history of lymphoma, and lack of HLH remission were identified as independent risk factors for the prognosis of NHL-LAHS patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Dennis A. Eichenauer, Horst Muller, Leonard Elger, Helen Goergen, Michael Fuchs, Stefanie Kreissl, Boris Boll, Volker Diehl, Bastian von Tresckow, Peter Borchmann, Andreas Engert
Summary: NHL after cHL is a rare event that primarily affects older individuals, with a five-year event-free survival and overall survival estimates of 36.9% and 44.2% respectively.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Allini Mafra, Mathieu Laversanne, Mary Gospodarowicz, Paulo Klinger, Neimar De Paula Silva, Marion Pineros, Eva Steliarova-Foucher, Freddie Bray, Ariana Znaor
Summary: Global patterns of non-Hodgkin lymphoma (NHL) in 2020 were evaluated using the GLOBOCAN 2020 database. The study found that Eastern Asia, Northern America, and South-Central Asia had the highest number of NHL cases. Incidence rates were higher in men than in women, with the highest rates in Australia, New Zealand, Northern America, Northern Europe, and Western Europe. The highest mortality rates were found in regions in Africa, Western Asia, and Oceania.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Hematology
Simone de Vries, Inge M. Krul, Michael Schaapveld, Cecile P. M. Janus, Saskia E. Rademakers, Judith M. Roesink, Marten R. Nijziel, Berthe M. P. Aleman, Flora E. van Leeuwen
Summary: Male survivors of Hodgkin lymphoma who received chest radiotherapy have a significantly increased risk of breast cancer. The risk is higher for those who received chest radiotherapy and alkylating chemotherapy compared to those who only received chest radiotherapy.
Review
Hematology
Zhumei Zhan, Wei Guo, Xin Wan, Ou Bai
Summary: With advancements in NHL therapeutics, long-term survival of NHL patients has increased. However, the concern for SPMs as a long-term complication for NHL survivors has grown. The factors leading to SPMs are multifactorial and include germline alterations, immune dysregulation, and external factors such as lifestyle and exposure to certain agents. Targeted therapies may reduce the incidence of t-MNs in indolent B-cell NHL.
ANNALS OF HEMATOLOGY
(2023)
Review
Medicine, General & Internal
Pauline Brice, Eric de Kerviler, Jonathan W. Friedberg
Summary: Classical Hodgkin lymphoma is a relatively common lymphoma that is generally considered highly curable with standard first-line chemotherapy and radiotherapy, although some patients may not be cured or may experience late toxic effects leading to premature death. Recent changes in the gold standard of chemotherapy, now often including immunotherapy in relapse settings, have further impacted treatment outcomes.
Article
Health Care Sciences & Services
Sonia Guadalupe Barreno-Rocha, Sandra Guzman-Silahua, Ernesto German Cardona-Munoz, Maria Guadalupe Zavala-Cerna, David Eduardo Munoz Gaytan, Carlos Riebeling-Navarro, Benjamin Rubio-Jurado, Arnulfo Hernan Nava-Zavala
Summary: A retrospective cohort study was performed on patients diagnosed with Non-Hodgkin Lymphoma. The presence of autoantibodies was observed in 30 out of 39 patients, while 9 patients did not have autoantibodies. However, there were no statistically significant differences between the two groups in terms of clinical, demographic, staging, and prognosis characteristics. Further research on a broader panel of autoantibodies is needed to explore the relationship between their presence and the clinical outcome of patients.
Article
Oncology
Alexander M. Newman, Masood Zaka, Peixun Zhou, Alex E. Blain, Amy Erhorn, Amy Barnard, Rachel E. Crossland, Sarah Wilkinson, Amir Enshaei, Julian De Zordi, Fiona Harding, Mary Taj, Katrina M. Wood, Despina Televantou, Suzanne D. Turner, G. A. Amos Burke, Christine J. Harrison, Simon Bomken, Chris M. Bacon, Vikki Rand
Summary: Research shows that TP53 gene abnormalities are associated with inferior survival rates in children with B-cell non-Hodgkin lymphoma, especially in high-risk patients. These findings provide a novel molecular risk stratifier for more personalized treatment protocols.
Editorial Material
Pediatrics
Paula L. Hedley, Marie Baekvad-Hansen, Gitte Hedermann, Henrik Hjalgrim, David M. Hougaard, Mads Melbye, Morten Breindahl, Lone Krebs, Anders Hviid, Ulrik Lausten-Thomsen, Michael Christiansen
Article
Public, Environmental & Occupational Health
Christian Erikstrup, Erik Sorensen, Kaspar R. Nielsen, Mie T. Bruun, Mikkel S. Petersen, Klaus Rostgaard, Lise W. Thorner, Margit Larsen, Susan Mikkelsen, Khoa M. Dinh, Michael Schwinn, Andreas S. Rigas, Maria Didriksen, Joseph Dowsett, Jakob H. von Stemann, Thorsten Brodersen, Isabella W. Paulsen, Lotte Hindhede, Susanne G. Saekmose, Kathrine A. Kaspersen, Jens K. Boldsen, Bertram Kjerulff, Thomas Werge, Soren Brunak, Karina Banasik, Thomas F. Hansen, Henrik Ullum, Henrik Hjalgrim, Sisse R. Ostrowski, Ole B. Pedersen
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Infectious Diseases
Bertram Kjerulff, Kathrine A. Kaspersen, Khoa M. Dinh, Jens Boldsen, Susan Mikkelsen, Lise T. Erikstrup, Erik Sorensen, Kaspar R. Nielsen, Mie T. Bruun, Henrik Hjalgrim, Ole B. Pedersen, Lise W. Thorner, Henrik Ullum, Sisse R. Ostrowski, Klaus Rostgaard, Carsten B. Pedersen, Torben Sigsgaard, Christian Erikstrup
Summary: Through a study of more than 120,000 Danish blood donors, it was found that smoking is closely related to an increased risk of infection, especially respiratory tract infection, abscesses, and skin infection. These findings indicate that we should pay more attention to the infection risk among smokers.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Endocrinology & Metabolism
Arvid Engstroem, Viktor Wintzell, Mads Melbye, Anders Hviid, Bjoern Eliasson, Soffia Gudbjoernsdottir, Kristian Hveem, Christian Jonasson, Henrik Svanstroem, Bjoern Pasternak, Peter Ueda
Summary: Using nationwide registers data from Denmark, Norway, and Sweden, this study demonstrates an association between the use of SGLT2 inhibitors and the risk of new-onset atrial fibrillation. Compared to GLP-1 receptor agonists, SGLT2 inhibitors are associated with a modestly reduced risk of new-onset atrial fibrillation.
Article
Public, Environmental & Occupational Health
Signe Holst Soegaard, Maria Spanggaard, Klaus Rostgaard, Mads Kamper-Jorgensen, Lone Graff Stensballe, Kjeld Schmiegelow, Henrik Hjalgrim
Summary: Early childcare enrolment is associated with a modest increase in the cumulative number of antimicrobial-treated infections throughout childhood and adolescence, and this increase is not compensated by lower infection risk later in life.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Hematology
Thorsten Brodersen, Klaus Rostgaard, Cathrine Juel Lau, Knud Juel, Christian Erikstrup, Kasper Rene Nielsen, Sisse Rye Ostrowski, Kjell Titlestad, Susanne G. Saekmose, Ole B. Pedersen, Henrik Hjalgrim
Summary: This study found that blood donors were more likely to participate in health surveys, indicating the presence of the healthy donor effect. Furthermore, blood donation was associated with better self-reported health and healthier lifestyles.
Article
Medicine, General & Internal
Anders Husby, Jan Wohlfahrt, Mads Melbye
Summary: A Danish study found that there is a link between gestational age at birth and cognitive outcomes. Children born before 34 weeks showed lower academic performance in language and mathematics, while those born between 34-39 weeks did not differ significantly from full-term babies. This study provides important insights into the development of preterm babies.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Hematology
Emelie Curovic Rotbain, Cristine Allmer, Klaus Rostgaard, Michael Asger Andersen, Noomi Vainer, Caspar da Cunha-Bang, Sameer A. Parikh, Kari G. Rabe, Henrik Hjalgrim, Henrik Frederiksen, Susan L. Slager, Carsten Utoft Niemann
Summary: Age-related comorbid conditions, such as type 2 diabetes, are common in patients with chronic lymphocytic leukemia (CLL). This study analyzed two separate cohorts to assess the impact of type 2 diabetes on CLL patient outcomes. The results showed that CLL patients with type 2 diabetes had shorter overall survival, were less likely to receive treatment, and had an increased risk of death due to infections. These findings highlight the need for additional interventions and research to address the treatment needs of CLL patients with co-occurring type 2 diabetes.
AMERICAN JOURNAL OF HEMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Arnor Sigurdsson, Ioannis Louloudis, Karina Banasik, David Westergaard, Ole Winther, Ole Lund, Sisse Rye Ostrowski, Christian Erikstrup, Ole Birger Vesterager Pedersen, Mette Nyegaard, Soren Brunak, Bjarni J. Vilhjalmsson, Simon Rasmussen
Summary: We developed a deep learning framework for polygenic risk score (PRS) prediction that can handle large-scale genomics data, support multi-task learning, and automatically integrate clinical and biochemical data. The framework demonstrated competitive performance and improved predictions for complex genetic relationships and non-additive genetic effects and epistasis. The model also outperformed traditional linear PRS methods for Type 1 Diabetes.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Victoria de Knegt, Paula Hedley, Gitte N. Hedermann, Casper Wilstrup, Marie Baekvad-Hansen, Ida Thagaard, Henrik M. Hjalgrim, Jorgen Kanters, Mads Melbye, David Hougaard, Anders Hviid, Lone Krebs, Morten Breindahl, Ulrik Lausten-Thomsen, Michael Christiansen
Summary: A nationwide COVID-19 lockdown in Denmark resulted in a reduced prevalence of extremely preterm or extremely low birthweight births. This study aimed to investigate the impact of the lockdown on term birthweights in Denmark. The findings showed a small but significant increase in birthweight during the lockdown period, primarily driven by an increase in birthweight in gestational weeks 40 and 41. Additionally, the proportion of infants with a large-for-gestational-age (LGA) increased during the lockdown.
Article
Multidisciplinary Sciences
Klaus Rostgaard
Summary: This article develops an approximate Bayesian factor method applicable in any bio-statistical settings, which converts p-values into evidence using parameter estimates and covariance. It is more flexible, intuitive, and versatile than previous techniques, while still being easy to calculate.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Giulia Corn, Mads Melbye, Mark A. Hlatky, Jan Wohlfahrt, Marie Lund
Summary: A study found that low to moderate-intensity statins are more effective in reducing LDL-C levels in older adults compared to younger individuals, suggesting that they may be a more appealing initial treatment option for the elderly.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Niklas Worm Andersson, Giulia Corn, Tine Lovso Dohlmann, Mads Melbye, Jan Wohlfahrt, Marie Lund
Summary: Reducing LDL cholesterol through lipid-lowering therapy has been shown to effectively lower the risk of cardiovascular disease in individuals under 70 years old, but the evidence is less clear for older individuals. This study compared the clinical effectiveness of lowering LDL cholesterol through lipid-lowering therapy for primary prevention of cardiovascular disease in older and younger individuals, and found that the risk reduction effect was similar between the two age groups.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Hematology
Louise Ornskov Drechsler, Jens Kjaergaard Boldsen, Lotte Hindhede, Bitten Aagaard, Lene Holm Harritshoj, Christina Mikkelsen, Thorsten Brodersen, Nanna Brons, Michael Schwinn, Henrik Hjalgrim, Klaus Rostgaard, Mie Topholm Bruun, Sisse Rye Ostrowski, Ole Birger Pedersen, Susan Mikkelsen, Christian Erikstrup
Summary: This study examines the effects of ferritin-guided iron supplementation on Danish female first-time blood donors. The intervention resulted in a significant decrease in the risk of low hemoglobin levels and an increase in the number of donations per donor.
Article
Clinical Neurology
Nete Munk Nielsen, Morten Frisch, Sanne Gortz, Egon Stenager, Kristin Skogstrand, David M. Hougaard, Alberto Ascherio, Klaus Rostgaard, Henrik Hjalgrim
Summary: This study found that smoking during pregnancy increases the risk of developing multiple sclerosis in offspring. These findings further support the association between smoking and the development of multiple sclerosis.
MULTIPLE SCLEROSIS JOURNAL
(2023)
