Article
Biology
Eric Mandela, Christopher J. Stubenrauch, David Ryoo, Hyea Hwang, Eli J. Cohen, Von L. Torres, Pankaj Deo, Chaille T. Webb, Cheng Huang, Ralf B. Schittenhelm, Morgan Beeby, J. C. Gumbart, Trevor Lithgow, Iain D. Hay
Summary: The cell envelope of Gram-negative bacteria is composed of two membranes and plays a crucial role in spatial constraints and load-bearing forces. This study focuses on the mechanism behind spatial constraints in Escherichia coli, specifically the role of the coiled-coil lipoprotein Lpp. The findings demonstrate that E. coli can accommodate elongated Lpp through various factors and genetic adaptations, highlighting the importance of maintaining spatial constraints in bacterial cell envelopes.
Article
Biochemistry & Molecular Biology
Margherita Burattini, Robrecht Lippens, Nicolas Baleine, Melanie Gerard, Joeri Van Meerssche, Chloe Geeroms, Jeremy Odent, Jean-Marie Raquez, Sandra Van Vlierberghe, Lieven Thorrez
Summary: In this study, Gelatin Methacryloyl (GelMA) is modified with hydrophilic 2-acryloxyethyltrimethylammonium chloride (AETA) and 3-sulfopropyl acrylate potassium (SPA) ionic comonomers to create a piezoionic hydrogel. The modified GelMA exhibits increased ionic conductivity and electrical response to mechanical stress, making it suitable for tissue engineering of skeletal muscles. The viability of murine myoblasts on the piezoionic hydrogels confirms their biocompatibility and the potential for utilizing piezo-effects in tissue engineering.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Multidisciplinary Sciences
Sarah Fausett, Nausicaa Poullet, Clotilde Gimond, Anne Vielle, Michele Bellone, Christian Braendle
Summary: Exposure to various environmentally relevant stressors in the natural habitat of Caenorhabditis elegans increases germline apoptosis, contributing to maintaining offspring fitness. Eliminating the core apoptotic machinery leads to reduced embryonic survival under environmental stress, highlighting the essential role of germ cell apoptosis in adverse conditions. The central genes of the apoptosis pathway play a key role in maintaining gamete quality and offspring fitness under ecologically relevant environmental conditions.
Article
Multidisciplinary Sciences
Bo Ding, Ying Liu, Zhiheng Liu, Lina Zheng, Ping Xu, Zhao Chen, Peiyao Wu, Ying Zhao, Qian Pan, Yu Guo, Wensheng Wei, Wei Wang
Summary: This study revealed the structural importance of noncoding loci that are not associated with any functional element, providing a previously unknown mechanistic understanding of disease-associated genetic variations (GVs). Additionally, it suggests a potential approach for developing therapeutics targeting disease-specific noncoding regions essential for disease cell survival.
Review
Oncology
Marjorie C. Delahaye, Kaoutar-Insaf Salem, Jeoffrey Pelletier, Michel Aurrand-Lions, Stephane J. C. Mancini
Summary: B-cell acute lymphoblastic leukemia (B-ALL) is a common malignancy in children, and new chemotherapy combinations have improved outcomes for young patients. The interaction between leukemic cells and their microenvironment plays a crucial role in the prognosis of B-ALL patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zhaoming Wang, Michael S. Chimenti, Christopher Strouse, George J. Weiner
Summary: The study found that T cell help, mainly mediated by local production of IL2, plays a significant role in enhancing NK cell-mediated antibody-dependent cellular cytotoxicity and viability. Activating T cells can improve the efficacy of anti-CD20 and other mAb therapies, particularly when NK-mediated antibody-dependent cellular cytotoxicity is the primary mechanism of action.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ian A. Mellis, Hailey Edelstein, Rachel Truitt, Yogesh Goyal, Lauren E. Beck, Orsolya Symmons, Margaret C. Dunagin, Ricardo A. Linares Saldana, Parisha P. Shah, Juan A. Perez-Bermejo, Arun Padmanabhan, Wenli Yang, Rajan Jain, Arjun Raj
Summary: Identifying transcription factors that maintain cell type in vitro through perturbation-induced transcriptional responses can help manipulate and control cell types effectively.
Article
Multidisciplinary Sciences
Jani Huuhtanen, Dipabarna Bhattacharya, Tapio Lonnberg, Matti Kankainen, Cassandra Kerr, Jason Theodoropoulos, Hanna Rajala, Carmelo Gurnari, Tiina Kasanen, Till Braun, Antonella Teramo, Renato Zambello, Marco Herling, Fumihiro Ishida, Toru Kawakami, Marko Salmi, Thomas Loughran, Jaroslaw P. Maciejewski, Harri Lahdesmaki, Tiina Kelkka, Satu Mustjoki
Summary: In T cell large granular lymphocytic leukemia (T-LGLL), the non-leukemic immune system is interconnected with the T-LGLL clonotype(s) and exhibits a more mature, cytotoxic, and clonally restricted T cell repertoire compared to other cancers and autoimmune disorders. Moreover, the T-LGLL clonotypes are more cytotoxic and exhausted than healthy reactive clonotypes, and they actively communicate with non-leukemic immune cells through various mechanisms. 72% of the leukemic T-LGLL clonotypes share T cell receptor similarities with their non-leukemic repertoire, suggesting possible common target antigens.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Industrial
Tadeusz Sawik, Bartosz Sawik
Summary: This paper applies stochastic optimisation of CVaR to maintain risk-averse viability and improve resilience of a supply chain under propagated disruptions. Two stochastic optimisation models are developed with conflicting objectives, and a stochastic mixed integer quadratic programming model is used to select a risk-averse viable production trajectory. The proposed approach is applied to smartphone manufacturing, and the findings show that more risk-aversive decision-making leads to a larger viability space and higher resilience of the supply chain. Single-objective decision-making may reduce supply chain viability.
INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH
(2023)
Editorial Material
Hematology
Daniela S. Krause
Summary: Yu et al. discovered a novel signaling pathway that leads to resistance to venetoclax, an increase in stem cell features, and a decrease in apoptosis in acute myeloid leukemia (AML).
Article
Engineering, Industrial
Tadeusz Sawik
Summary: “This paper presents a novel quantitative approach and stochastic quadratic optimisation model to maintain supply chain viability under the ripple effect. Instead of viability kernel commonly used in the viability theory, this paper establishes the boundaries on acceptable production states for which the production can be continued under the ripple effect, with no severe losses. The findings indicate that for the extreme values of the weight factor, the viable production trajectory is inclined toward the corresponding boundary trajectory and remains in-between the two boundaries, when both objectives are equally important. Keeping production trajectory in-between the two boundaries makes the supply chain more resilient to disruption risks, while the supply chain resilience diminishes as the production trajectory approaches a boundary trajectory. Then a more severe disruption may push the production outside the viability region and cause greater losses.”
INTERNATIONAL JOURNAL OF PRODUCTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Lars Velten, Benjamin A. Story, Pablo Hernandez-Malmierca, Simon Raffel, Daniel R. Leonce, Jennifer Milbank, Malte Paulsen, Aykut Demir, Chelsea Szu-Tu, Robert Fromel, Christoph Lutz, Daniel Nowak, Johann-Christoph Jann, Caroline Pabst, Tobias Boch, Wolf-Karsten Hofmann, Carsten Muller-Tidow, Andreas Trumpp, Simon Haas, Lars M. Steinmetz
Summary: This study successfully identified and molecularly profiled LSCs, HSCs, and pre-leukemic stem cells in AML by combining single-cell transcriptomics and lineage tracing techniques.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Xiuchuan (Lucas) Hu, Wenfeng Xiao, Yuxian Lei, Adam Green, Xinyi Lee, Muralidhara Rao Maradana, Yajing Gao, Xueru Xie, Rui Wang, George Chennell, M. Albert Basson, Pete Kille, Wolfgang Maret, Gavin A. Bewick, Yufeng Zhou, Christer Hogstrand
Summary: This study discovered that dietary supplementation with zinc and activation of the aryl hydrocarbon receptor (AHR) pathway through plant-derived ligands can improve intestinal epithelial barrier function and prevent inflammatory bowel disease. Activation of AHR increases cellular zinc levels and upregulates tight junction proteins through transcription of zinc importer genes, leading to improved gut barrier function. Combined supplementation with AHR ligands and zinc in the diet may be effective in preventing inflammatory gut disorders.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Vidya C. Sinha, Amanda L. Rinkenbaugh, Mingchu Xu, Xinhui Zhou, Xiaomei Zhang, Sabrina Jeter-Jones, Jiansu Shao, Yuan Qi, John A. Zebala, Dean Y. Maeda, Florencia McAllister, Helen Piwnica-Worms
Summary: The aggressive and indolent breast tumor cells are functionally indistinguishable once isolated from their local niche, suggesting the involvement of non-tumor collaborators in determining aggressiveness. Aggressive lesions are characterized by fewer total but more suppressed-like T cells, elevated tumor-promoting neutrophils, and IL-17 signaling, disruption of which can increase tumor latency and reduce the number of aggressive lesions.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Lucia Ichino, Colette L. Picard, Jaewon Yun, Meera Chotai, Shuya Wang, Evan K. Lin, Ranjith K. Papareddy, Yan Xue, Steven E. Jacobsen
Summary: Silencing of transposable elements is crucial for chromatin compaction in pollen vegetative cells, and MBD5/6 and SILENZIO act as important silencers in this process. Other mechanisms are involved in silencing in other cell types. Loss of MBD5/6 leads to derepression of transposable elements in leaves with decondensed chromatin.
