Article
Cell Biology
Yu Lan, Wei Zhu, Xiaolu Duan, Tuo Deng, Shujue Li, Yang Liu, Zhou Yang, Yaoan Wen, Lianming Luo, Shankun Zhao, Jiamin Wang, Zhijian Zhao, Wenqi Wu, Guohua Zeng
Summary: The study identified a novel role of glycine in regulating kidney calcium oxalate crystal formation, showing that glycine can attenuate CaOx crystal deposition by decreasing urine oxalate and increasing urine citrate levels. The mechanism involves downregulating Slc26a6 expression to decrease urine oxalate and inhibiting Nadc1 expression to increase urine citrate, with additional regulation of protein expression by miRNA-411-3p. These findings provide a potential target for the treatment of kidney calcium oxalate stones.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Editorial Material
Medicine, General & Internal
A. M. Meyers, S. Naicker
Summary: Treatment of patients with calcium oxalate stones should focus on correcting dietary aberrations, with potassium citrate being the drug of choice for those with hypocitraturia. Avoiding Ceylon tea, which contains excess oxalate, is important.
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2021)
Article
Urology & Nephrology
Vikas Bhatt, Mark D. White, James Listman, Paul J. Feustel, Adam Howe, Barry A. Kogan
Summary: This study found that urinary citrate concentration follows a circadian pattern, while urinary calcium has a diurnal excretion pattern. The calcium to citrate ratio is highest in the early morning, indicating a high-risk time for stone formation. Spot urine samples can identify key times for clinical monitoring that may be missed by 24-hour urine collections.
JOURNAL OF ENDOUROLOGY
(2021)
Article
Chemistry, Applied
Xiao-Chen Liu, Leif H. Skibsted
Summary: The addition of strontium chloride to aqueous suspensions of metastable calcium citrate tetrahydrate was found to increase calcium ion activity without causing a structural transition. The increase in calcium activity was attributed to the lower solubility of strontium citrate pentahydrate compared to calcium citrate tetrahydrate, which increased with temperature. The differences in solution thermodynamics and pH effect on complex formation between calcium and strontium citrate are discussed in relation to biomineralization.
Article
Medicine, General & Internal
Muhammad Fahad Arshad, James McAllister, Azhar Merchant, Edmund Rab, Jacqueline Cook, Richard Eastell, Sabapathy Balasubramanian
Summary: This study aimed to compare urinary calcium values in patients with PHPT and FHH. The results showed that 24-hour urine calcium excretion is more sensitive in diagnosing PHPT, but less specific in ruling out FHH.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Article
Chemistry, Physical
Xiangyue Liu, Hong Chen, Haohao Ren, Bo Wang, Xiaodan Li, Suping Peng, Qiyi Zhang, Yonggang Yan
Summary: In this study, ATP-loaded calcium sulfate hemihydrate/calcium citrate tetrahydrate cement (ATP/CSH/CCT) was successfully prepared for the first time, and the effect of different ATP contents on the structure and properties of ATP/CSH/CCT was studied. The results showed that ATP incorporation did not significantly change the structure but affected the mechanical and degradation properties of the composite cement. ATP release from the cement was controlled, and the composite cement demonstrated good cytoactivity, making it a potential option for bone tissue repair and regeneration.
Article
Medical Laboratory Technology
Paula Calvo, Antonia Costa-Bauza, Felix Grases, Yumaira Hernandez, Pilar Sanchis
Summary: The study developed a test for assessing the risk of UA crystallization (RUAC) and validated its utility in routine clinical practice through urine sample analysis. The test showed high specificity, low false negatives, and reliable discrimination between urine susceptible and resistant to UA crystal formation.
CLINICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Monnaya Chalermnon, Sarocha Cherdchom, Amornpun Sereemaspun, Rojrit Rojanathanes, Tanatorn Khotavivattana
Summary: Twelve derivatives of biguanide-derived 1,3,5-triazines were synthesized and evaluated for anticancer activity, with some derivatives showing promising cytotoxicity. Additionally, the potential use of calcium citrate nanoparticles as a drug delivery system was studied, showing pH-responsive controlled release of drugs under acidic conditions. This study provides valuable insights for the development of 1,3,5-triazine-based anticancer drugs and the incorporation of other drugs into calcium citrate nanoparticles in the future.
Article
Medicine, General & Internal
Fernanda Guedes Rodrigues, Milene Subtil Ormanji, Igor Gouveia Pietrobom, Ana Cristina Carvalho de Matos, Martin H. H. De Borst, Ita Pfeferman Heilberg
Summary: The study investigated the association of urinary calcium with serum sclerostin, bone mineral density, and body composition in stone formers. The results showed that serum sclerostin is associated with urinary calcium levels, suggesting a potential additional role of sclerostin in calcium reabsorption in the kidneys.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Vahid Solak, Mehmet Ilker Gokce, Onder Yaman
Summary: This study found that potassium citrate significantly reduced calcium excretion and increased citrate excretion in patients with calcium oxalate stones and hypercalciuria. At the 12-month follow-up, the K-CIT group had a lower rate of stone recurrence compared to the HCT group.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Food Science & Technology
Hong-Ting Victor Lin, Guan-Wen Chen, Ke-Liang Bruce Chang, Yi-Jun Bo, Wen-Chieh Sung
Summary: This study investigated the effects of fortifying noodles with different calcium salts on their physicochemical properties. Calcium citrate, calcium acetate, and calcium carbonate fortification increased the pH and breaking force of the dried noodles, while calcium citrate made from oyster shells showed no significant influence on color, texture, and overall scores of cooked noodles. Noodles fortified with calcium citrate made from oyster shells exhibited similar performance compared to commercially available calcium citrate, suggesting its potential as a preferred additive for calcium-fortified noodles.
Article
Endocrinology & Metabolism
Anda Mihaela Naciu, Gaia Tabacco, John P. Bilezikian, Assunta Santonati, Daniela Bosco, Giosue Giordano Incognito, Gianluigi Gaspa, Silvia Manfrini, Alberto Falchetti, Pierpaolo Trimboli, Gherardo Mazziotti, Nicola Napoli, Gianfranco Sanson, Roberto Cesareo, Fabio Vescini, Andrea Palermo
Summary: This study evaluated the therapeutic advantage of calcium citrate (Ca-Cit) compared to calcium carbonate (CaCO3) in hypoparathyroidism, and found that Ca-Cit may have a potential beneficial effect on reducing the risk of nephrolithiasis. Additionally, Ca-Cit was associated with less constipation symptoms compared to CaCO3.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jatuporn Chaichana, Manee Khamenkhetkarn, Thanapat Sastraruji, Tawachai Monum, Timothy E. O'Brien, Yutti Amornlertwatana, Churdsak Jaikang
Summary: The study aimed to categorize the CYP2D6 activity score using the urinary amphetamine/methamphetamine ratio. The results showed different activity score ranges for males and females, which can be used to describe the toxicity of methamphetamine in forensic crime scenes and relapse behavior.
Article
Construction & Building Technology
Tom Damion, Piyush Chaunsali
Summary: This article explores the acid resistance of calcium sulfoaluminate (CSA) cement and evaluates the effect of chemical composition on acid resistance using acid neutralisation capacity (ANC) as a measure. The tests reveal that high ye'elimite CSA cement demonstrates better acid resistance compared to other binders.
CEMENT AND CONCRETE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Daniel Turudic, Anja Tea Golubic, Mila Lovric, Marko Bilic, Danko Milosevic
Summary: The research found different risks and important variables in urinary stone development between prepubertal and pubertal/postpubertal children, with citrate and glycosaminoglycans increasingly important in children. J48 classifier confirmed the importance of certain variables for distinguishing between children with urolithiasis and healthy children of the same age and gender.
Article
Urology & Nephrology
Miguel Arrabal-Martin, Antonio Poyatos-Andujar, Maria del Carmen Cano-Garcia, Miguel Quesada-Charneco, Felix Abad-Menor, Maria Sierra Giron Prieto, Tomas de Haro Munoz, Miguel Angel Arrabal-Polo
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2015)
Article
Urology & Nephrology
Miguel Angel Arrabal-Polo, Maria Sierra Giron-Prieto, Maria del Carmen Cano-Garcia, Antonio Poyatos-Andujar, Miguel Quesada-Charneco, Felix Abad-Menor, Salvador Arias-Santiago, Armando Zuluaga-Gomez, Miguel Arrabal-Martin
Article
Urology & Nephrology
Maria Sierra Giron-Prieto, Maria del Carmen Cano-Garcia, Miguel Angel Arrabal-Polo, Antonio Poyatos-Andujar, Miguel Quesada-Charneco, Tomas de Haro-Munoz, Salvador Arias-Santiago, Miguel Arrabal-Martin
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2016)
Article
Urology & Nephrology
Maria Sierra Giron-Prieto, Salvador Arias-Santiago, Maria del Carmen Cano-Garcia, Antonio Poyatos-Andujar, Tomas de Haro-Munoz, Felix Abad-Menor, Miguel Quesada-Charneco, Miguel Angel Arrabal-Polo, Miguel Arrabal-Martin
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2016)
Article
Urology & Nephrology
Maria Sierra Giron-Prieto, Maria del Carmen Cano-Garcia, Antonio Poyatos-Andujar, Salvador Arias-Santiago, Tomas de Haro-Munoz, Miguel Arrabal-Martin, Miguel Angel Arrabal-Polo
Article
Medicine, General & Internal
Susana Garcia, Tomas de Haro, Mercedes Zafra-Ceres, Antonio Poyatos, Jose A. Gomez-Capilla, Carolina Gomez-Llorente
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2014)
Article
Urology & Nephrology
Miguel Angel Arrabal-Polo, Miguel Arrabal-Martin, Maria Sierra Giron-Prieto, Jacinto Orgaz-Molina, Miguel Quesada-Charneco, Adriana Lopez-Ruiz, Antonio Poyatos-Andujar, Armando Zuluaga-Gomez, Salvador Arias-Santiago
Article
Urology & Nephrology
Carmen Garcia-Rabaneda, Margarita Martinez-Atienza, Ana Morales-Garcia, Antonio Poyatos-Andujar, Susana Garcia-Linares, Maria Luz Bellido-Diaz, Irene Arguelles-Toledo, Maria Garcia-Valverde, Juan A. Bravo-Soto, Rafael J. Esteban-de-la-Rosa
Letter
Urology & Nephrology
Mikel Barral-Jueza, Carmen Garcia-Rabaneda, Antonio Miguel Poyatos-Andujar, Margarita Martinez-Atienza, Ana Isabel Morales-Garcia, Sonia Morales-Santana, Maria Luz Bellido-Diaz, Juan Antonio Bravo-Soto, Rafael Jose Esteban-de la Rosa
Article
Genetics & Heredity
Marta Cuadros, Carlos Cano, Sonia Garcia-Rodriguez, Jose Luis Martin, Antonio Poyatos-Andujar, Francisco Ruiz-Cabello, Susana Pedrinaci, Gema Duran, Manuel Benavides, Maria Dolores Bautista-Ojeda, Teresa Pereda, Maria Soledad Benitez-Cantos, Pedro Medina, Armando Blanco, Antonio Gonzalez, Paul Lizardi
Summary: This study found that individuals carrying Lynch Syndrome-associated mutations exhibit high variability in their DNAm age, with a faster acceleration rate compared to controls. There were significant differences in DNAm age between two sisters carrying the same mutation, suggesting potential sensitivity of the epigenetic clock to individual biological aging rates.
BMC MEDICAL GENOMICS
(2022)
Article
Biochemistry & Molecular Biology
Maria Molina-Zayas, Carmen Garrido-Navas, Jose Luis Garcia-Puche, Julian Barwell, Susana Pedrinaci, Margarita Martinez Atienza, Susana Garcia-Linares, Tomas De Haro-Munoz, Jose Antonio Lorente, M. Jose Serrano, Antonio Poyatos-Andujar
Summary: This study assessed the prevalence of germline variants in cancer-predisposing genes in a high-risk Hereditary Breast and Ovarian Cancer (HBOC) cohort using targeted or multigene NGS panel. The results showed increased risk of basal or Her2 breast cancer for BRCA1 and MSH6 pathogenic variants, while reduced risk of basal or luminal A breast cancer for BRCA2 and BRCA1 pathogenic variants. Some individuals underwent risk-reducing prophylactic measures such as mastectomy or oophorectomy.
MOLECULAR GENETICS AND GENOMICS
(2022)
Letter
Urology & Nephrology
Rafael J. Esteban de la Rosa, Antonio Miguel Poyatos Andujar, Ana Isabel Morales Garcia, Luis Martinez Navarro, Maria Garcia Valverde, Juan Antonio Bravo Soto
Article
Medicine, General & Internal
Antonio Miguel Poyatos-Andujar, Susana Garcia-Linares, Pilar Carretero, Olga Ocon, Dolores Fresneda, Laura Gort, Francisa Sonia Molina Garcia
Summary: Clinical exome sequencing is a powerful tool that can help overcome the wide clinical and genetic heterogeneity of mucopolysaccharidosis, providing valuable data for prenatal diagnosis of MPS VII, genetic counseling, and preimplantation genetic testing.
CLINICAL CASE REPORTS
(2021)
Article
Urology & Nephrology
Miguel Arrabal-Martin, Samuel Gonzalez-Torres, Maria del Carmen Cano-Garcia, Antonio Poyatos-Andujar, Felix Abad-Menor, Miguel Angel Arrabal-Polo
ARCHIVOS ESPANOLES DE UROLOGIA
(2016)