Review
Oncology
Chunyu Zhang, Jiao Hu, Huihuang Li, Hongzhi Ma, Belaydi Othmane, Wenbiao Ren, Zhenglin Yi, Dongxu Qiu, Zhenyu Ou, Jinbo Chen, Xiongbing Zu
Summary: Early detection of lymph node metastasis is crucial for improving prognosis and overall survival in bladder cancer patients, but current diagnostic methods are limited. Non-coding RNA and m6A have been reported to be abnormally expressed in bladder cancer related to lymph node metastasis, offering potential for more accurate diagnostic methods in future clinical applications.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Zijian Tian, Lingfeng Meng, Xin Wang, Tongxiang Diao, Maolin Hu, Miao Wang, Yaqun Zhang, Ming Liu
Summary: This study identified clinicopathological factors associated with lymph node metastasis in bladder cancer and developed a nomogram for predicting prognosis. The nomogram showed high accuracy in predicting LNM, assisting in optimal treatment selection for patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Surgery
Yukinori Sakao, Kenji Suzuki, Sadanori Takeo, Akihioro Hayashi, Masanori Tsuchida, Tatsuhiko Hirono, Yuichi Saito, Hideaki Miyamoto
Summary: This study aimed to discuss the underlying oncological issues in staging of mediastinal lymph node metastasis in patients with left lung cancer who underwent extended radical lymphadenectomy. The results showed that cN status and adjuvant chemotherapy were significant prognostic factors for left lung cancer with mediastinal lymph node metastasis, rather than pN status. These findings broaden the discussion of oncological issues in the staging of mediastinal lymph node metastasis of left lung cancer.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
B. H. E. Jansen, Y. J. L. Bodar, G. J. C. Zwezerijnen, D. Meijer, J. P. van der Voorn, J. A. Nieuwenhuijzen, M. Wondergem, T. A. Roeleveld, R. Boellaard, O. S. Hoekstra, R. J. A. van Moorselaar, D. E. Oprea-Lager, A. N. Vis
Summary: The study found that F-18-DCFPyL PET/CT has high specificity but limited sensitivity for detecting pelvic lymph-node metastases in primary prostate cancer patients. Therefore, current PSMA PET/CT imaging cannot fully replace diagnostic ePLND. Further research is needed to determine the exact role of PSMA PET/CT imaging in the primary staging of prostate cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Junpeng Wu, Hao Wang, Xin Yin, Xibo Wang, Yufei Wang, Zhanfei Lu, Jiaqi Zhang, Yao Zhang, Yingwei Xue
Summary: This study examined a new hybrid lymph node staging system to enhance the predictive ability for patients with gastric cancer. The results showed that the new staging system outperformed the traditional pathological lymph node staging system in terms of prognostic performance.
Article
Multidisciplinary Sciences
Xiaodong Wang, Ying Chen, Yunshu Gao, Huiqing Zhang, Zehui Guan, Zhou Dong, Yuxuan Zheng, Jiarui Jiang, Haoqing Yang, Liming Wang, Xianming Huang, Lirong Ai, Wenlong Yu, Hongwei Li, Changsheng Dong, Zhou Zhou, Xiyang Liu, Guanzhen Yu
Summary: The study proposes a deep-learning framework to analyze lymph node whole-slide images, identifying lymph nodes and tumor regions, and revealing the importance of the tumor-area-to-MLN-area ratio (T/MLN) in predicting the prognosis of gastric cancer patients.
NATURE COMMUNICATIONS
(2021)
Article
Urology & Nephrology
Eva Gresser, Piotr Woznicki, Katharina Messmer, Andrea Schreier, Wolfgang Gerhard Kunz, Michael Ingrisch, Christian Stief, Jens Ricke, Dominik Noerenberg, Alexander Buchner, Gerald Bastian Schulz
Summary: This study aimed to evaluate the performance of quantitative radiomics signatures in the detection of lymph node metastases in bladder cancer. By analyzing 1354 patients who underwent radical cystectomy, it was found that the diagnostic efficacy of radiologist-evaluated CT imaging studies is limited. The results showed that radiomics signatures can accurately discriminate lymph node metastases.
EUROPEAN UROLOGY FOCUS
(2023)
Review
Medicine, Research & Experimental
Jiajing Sun, Sikai Wu, Zixian Jin, Sijia Ren, William C. Cho, Chengchu Zhu, Jianfei Shen
Summary: Lung cancer has high morbidity and mortality rates, with tumor metastasis being a significant risk factor for death. Even after complete removal of a tumor at an early stage, there is still a risk of recurrence. Lymph node micrometastasis has been found to be associated with poor prognosis, but predicting prognosis and choosing the appropriate surgical and postoperative adjuvant chemotherapy options remain challenging for clinicians.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Zhenghao Chen, Chuan Qin, Gang Wang, Donghao Shang, Ye Tian, Lushun Yuan, Rui Cao
Summary: This study developed a nomogram that included an StrLNM signature to predict the lymph node metastasis status in bladder cancer patients. The nomogram showed good performance in prediction and was validated in multiple independent cohorts.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Bartosz Malkiewicz, Diana Jedrzejuk, Adam Gurwin, Karol Wilk, Klaudia Knecht-Gurwin, Pawel Kielb, Wojciech Krajewski, Marek Bolanowski, Agnieszka Halon, Tomasz Szydelko
Summary: This study aimed to investigate the reliability of radio-guided sentinel node (SLN) detection in the perioperative localisation of potential lymphatic metastasis during cystectomy for bladder cancer treatment. The results showed that the SLN technique detected lymph node metastasis in 40.7% of patients, with a sensitivity of 66.66%, specificity of 4.16%, positive predictive value of 28.57%, and false-negative rate of 33.33%.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Kai Yao, Yue Chen, Yunlin Ye, Zhiming Wu, Dong Chen, Hui Han, Zaishang Li, Zhuowei Liu, Yanjun Wang, Zike Qin, Yonghong Li, Zhiyong Li, Fangjian Zhou
Summary: The study provides a detailed map of pelvic lymph node metastasis in patients with penile carcinoma, showing that the external iliac and obturator packages are most commonly involved. Pelvic lymph node metastasis is associated with advanced T-stage. Some patients have crossover metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Maximilian Pallauf, David D'Andrea, Frederik Koenig, Ekaterina Laukhtina, Takafumi Yanagisawa, Morgan Roupret, Siamak Daneshmand, Hooman Djaladat, Alireza Ghoreifi, Francesco Soria, Kazutoshi Fujita, Stephen A. Boorjian, Aaron M. Potretzke, Andrea Mari, Mathieu Roumiguie, Alessandro Antonelli, Alberto Bianchi, Zine-Eddine Khene, John P. Sfakianos, Marcus Jamil, Joost L. Boormans, Jay D. Raman, Nico C. Grossmann, Alberto Breda, Axel Heidenreich, Francesco Del Giudice, Nirmish Singla, Shahrokh F. Shariat, Benjamin Pradere
Summary: This study evaluated the diagnostic accuracy of conventional cross-sectional imaging for lymph node staging in upper tract urothelial cancer and found low sensitivity. Therefore, lymph node dissection should be performed during surgery to obtain accurate staging information.
JOURNAL OF UROLOGY
(2023)
Article
Critical Care Medicine
Hyungjin Kim, Hyewon Choi, Kyung Hee Lee, Sukki Cho, Chang Min Park, Young Tae Kim, Jin Mo Goo
Summary: Three robust definitions for central lung cancer that are associated with occult nodal metastasis were identified, but selecting candidates for invasive mediastinal staging solely based on tumor location is suboptimal.
Article
Health Care Sciences & Services
Martijn P. A. Starmans, Li Shen Ho, Fokko Smits, Nick Beije, Inge de Kruijff, Joep J. de Jong, Diederik M. Somford, Egbert R. Boeve, Ed Te Slaa, Evelyne C. C. Cauberg, Sjoerd Klaver, Antoine G. van der Heijden, Carl J. Wijburg, Addy C. M. van de Luijtgaarden, Harm H. E. van Melick, Ella Cauffman, Peter de Vries, Rens Jacobs, Wiro J. Niessen, Jacob J. Visser, Stefan Klein, Joost L. Boormans, Astrid A. M. van der Veldt
Summary: The study aimed to evaluate the ability of CT-based radiomics to differentiate between pN+ and pN0 disease in patients with clinical stage cT2-T4aN0-N1M0 MIBC. The results showed that radiomics features did not significantly differentiate between pN+ and pN0 disease, and the radiomics models performed no better than random guessing.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Yadong Guo, Zongtai Zheng, Wentao Zhang, Shiyu Mao, Fuhan Yang, Wei Li, Yang Yan, Xudong Yao
Summary: The effect of gender and metastasis sites on the prognosis of bladder cancer is assessed in this study. A gender-associated signature is identified and validated, and a radiomics signature is developed for predicting the gender-associated signature. These results provide additional evidence for individualized treatment in bladder cancer.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)