Article
Immunology
Sofie C. M. Tops, Eva Kolwijck, Evert L. Koldewijn, Diederik M. Somford, Filip J. M. Delaere, Menno A. van Leeuwen, Anthonius J. Breeuwsma, Thijn F. de Vocht, Hans J. H. P. Broos, Rob A. Schipper, Martijn G. Steffens, Steven Teerenstra, Marjolijn C. A. Wegdam-Blans, Els de Brauwer, Wouter van den Bijllaardt, Alexander C. A. P. Leenders, J. P. Michiel Sedelaar, Heiman F. L. Wertheim
Summary: This study compared the impact of empirical ciprofloxacin prophylaxis and culture-based prophylaxis on infectious complication rates after transrectal prostate biopsy. The results showed that culture-based prophylaxis can reduce the occurrence of infectious complications. However, infections can still occur even with adequate prophylaxis.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Tim Du, Kelly B. Choi, Anada Silva, George R. Golding, Linda Pelude, Romeo Hizon, Ghada N. Al-Rawahi, James Brooks, Blanda Chow, Jun C. Collet, Jeannette L. Comeau, Ian Davis, Gerald A. Evans, Charles Frenette, Guanghong Han, Jennie Johnstone, Pamela Kibsey, Kevin C. Katz, Joanne M. Langley, Bonita E. Lee, Yves Longtin, Dominik Mertz, Jessica Minion, Michelle Science, Jocelyn A. Srigley, Paula Stagg, Kathryn N. Suh, Nisha Thampi, Alice Wong, Susy S. Hota
Summary: We investigated the epidemiology and molecular characteristics of healthcare-associated and community-associated Clostridioides difficile infection (CDI) in adult patients in Canadian hospitals. Our study found higher mortality rate associated with healthcare-associated CDI, and a decrease in both healthcare-associated and community-associated CDI rates from 2015 to 2019. Certain ribotypes were more commonly associated with CDI-related deaths.
EMERGING INFECTIOUS DISEASES
(2022)
Review
Microbiology
Flora Cruz-Lopez, Adrian Martinez-Melendez, Elvira Garza-Gonzalez
Summary: Healthcare-associated infections (HAIs) are a global public health concern and are associated with high mortality and antimicrobial resistance. The hospital environment serves as a potential reservoir for pathogenic microbial strains, which can persist on medical equipment surfaces, patient surroundings, and patient and healthcare worker surfaces. Understanding the hospital microbiota can provide knowledge on the relationship between commensal and pathogenic microorganisms, their role in HAI development, and the environmental conditions that promote their proliferation.
Review
Infectious Diseases
Jessica L. Fraser, Athman Mwatondo, Yewande H. Alimi, Jay K. Varma, Victor J. Del Rio Vilas
Summary: In Africa, there is a significant under-detection and under-reporting of healthcare-associated infection outbreaks over the 10-year period. The quality and timeliness of reporting need to be improved to ensure changes in public health practice.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Nicolas Francisco Fernandez-Martinez, Mario Rivera-Izquierdo, Rocio Ortiz-Gonzalez-Serna, Virginia Martinez-Ruiz, Pablo Lardelli-Claret, Adrian Hugo Aginagalde-Llorente, Maria del Carmen Valero-Ubierna, Maria Auxiliadora Vergara-Diaz, Nicola Lorusso
Summary: This study indicates that social factors should be considered when investigating healthcare-associated infections caused by multidrug-resistant bacteria. The heterogeneity in the incidence of cases between municipalities in Andalusia may be explained by social determinants of health, as well as under-notification.
Article
Multidisciplinary Sciences
Mariachiara Carestia, Massimo Andreoni, Ersilia Buonomo, Fausto Ciccacci, Luigi De Angelis, Gerardo De Carolis, Patrizia De Filippis, Daniele Di Giovanni, Leonardo Emberti Gialloreti, Carla Fontana, Luca Guarente, Andrea Magrini, Marco Mattei, Stefania Moramarco, Laura Morciano, Claudia Mosconi, Stefano Orlando, Giuseppe Quintavalle, Fabio Riccardi, Viviana Santoro, Leonardo Palombi
Summary: In Italy, the integration of microbiology laboratory data with electronic health records (EHRs) has provided a valuable tool for evaluating healthcare-associated infections (HAIs) and antimicrobial resistance (AMR). This study successfully established a management system that accurately assessed the burden of HAIs and the impact of AMR. Despite a low percentage of HAIs caused by antimicrobial resistant bacteria, the contribution of AMR to increased mortality risk was significant.
Review
Urology & Nephrology
Truls E. Bjerklund Johansen, Ekaterina Kulchavenya, Gretchen M. Lentz, David M. Livermore, J. Curtis Nickel, George Zhanel, Gernot Bonkat
Summary: Fosfomycin trometamol is considered an appropriate candidate for antimicrobial prophylaxis in transrectal ultrasound-guided prostate biopsy (TRPB) due to its low resistance rates, good safety profile, sufficient prostate concentrations, and demonstrated efficacy in reducing the risk of infectious complications.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Medicine, General & Internal
Ender Siyez
Summary: This study aimed to compare the incidence of febrile infectious complications after transrectal ultrasound-guided prostate biopsy in men receiving ciprofloxacin prophylaxis alone versus ciprofloxacin with povidone-iodine transrectal injection. The results showed a lower rate of febrile infectious complications in patients who received both ciprofloxacin and povidone-iodine prophylaxis compared to those who only received ciprofloxacin.
Article
Infectious Diseases
Xin Fang, Noleen Bennett, Courtney Ierano, Rodney James, Karin Thursky
Summary: The National Antimicrobial Prescribing Survey (NAPS) is a widely adopted tool in Australian healthcare facilities to evaluate the reasons, quantity, and quality of antimicrobial prescribing. The study shows that inappropriate prescribing of antimicrobials is common in both hospital and aged care settings.
Review
Immunology
Ayman Elbehiry, Eman Marzouk, Adil Abalkhail, Yasmine El-Garawany, Sulaiman Anagreyyah, Yaser Alnafea, Abdulaziz M. Almuzaini, Waleed Alwarhi, Mohammed Rawway, Abdelmaged Draz
Summary: The growing risk of antimicrobial resistance (AMR) has negative impacts on the healthcare system, calling for the development of quick diagnostic tools and new treatment approaches to combat multidrug-resistant pathogens in healthcare-associated infections (HAIs).
Article
Immunology
Richard E. Nelson, Kelly M. Hatfield, Hannah Wolford, Matthew H. Samore, R. Douglas Scott, Sujan C. Reddy, Babatunde Olubajo, Prabasaj Paul, John A. Jernigan, James Baggs
Summary: This study estimated the healthcare costs associated with infections due to multidrug-resistant bacteria in the United States, revealing that these infections resulted in substantial healthcare costs.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Health Care Sciences & Services
Simona Di Giambenedetto, Alberto Borghetti, Lorena Quagliozzi, Valeria Gallucci, Francesca Lombardi, Arturo Ciccullo, Anna Fagotti, Enrica Tamburrini, Giovanni Scambia
Summary: Healthcare-associated infections (HCAIs) in gynecologic cancer patients can be effectively managed through personalized treatment and multidisciplinary antimicrobial stewardship programs. This retrospective study evaluated 27 patients and found that all patients achieved clinical cure, with low mortality rates, and outpatient antimicrobial therapy reduced hospital stays.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Infectious Diseases
Gabriele Tulone, Sofia Giannone, Piero Mannone, Alessio Tognarelli, Tommaso Di Vico, Rosa Giaimo, Alessandro Zucchi, Marta Rossanese, Alberto Abrate, Nicola Pavan, Francesco Claps, Vincenzo Ficarra, Riccardo Bartoletti, Alchiede Simonato
Summary: This study aimed to compare the incidence of infective complications after transrectal ultrasound-guided prostate biopsy (TRUSBx) when using different antimicrobial prophylaxis regimens. The results showed that fluoroquinolone and trimethoprim/sulfamethoxazole regimens were significantly associated with a lower risk of infective complications.
Article
Infectious Diseases
Daniel J. G. Thirion, Jean-Alexandre Caissy, Florence Poulin, Camille S. H. Lanfranchi, Albin Deda, Armen Aprikian, Charles Frenette, Sero Andonian
Summary: The study compared the impact of augmented prophylaxis (ciprofloxacin with an aminoglycoside) and empirical prophylaxis (ciprofloxacin alone) on post-prostate biopsy infectious complication rates. A total of 2835 patients were evaluated in a retrospective cohort study, and the results showed that augmented prophylaxis was associated with significantly lower rates of infectious complications compared to empirical prophylaxis. Risk factors such as recent fluoroquinolone use and previous urinary tract infection also had a significant impact on infection rates.
Article
Public, Environmental & Occupational Health
Susan E. Coffin, Francisca Abanyie, Kristina Bryant, Joseph Cantey, Anthony Fiore, Stephanie Fritz, Judith Guzman-Cottrill, Adam L. Hersh, W. Charles Huskins, Larry K. Kociolek, Matthew Kronman, Ebbing Lautenbach, Grace Lee, Matthew Linam, Latania K. Logan, Aaron Milstone, Jason Newland, A. Christine Nyquist, Debra L. Palazzi, Sameer Patel, Karen Puopolo, Sujan C. Reddy, Lisa Saiman, Thomas Sandora, Andi L. Shane, Michael Smith, Pranita D. Tamma, Theoklis Zaoutis, Danielle Zerr, Jeffrey S. Gerber
Summary: Through expert recommendations and the Delphi approach, this study identified 12 high-priority research topics in pediatric healthcare-associated infections and antimicrobial stewardship. These topics include judicious testing for infections, CHG bathing, monitoring and prevention of multidrug-resistant infections, as well as allergy de-labeling and antibiotic therapy conversion in antimicrobial stewardship.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Deepak Batura, Eve Boakes, Tumaj Hashemzehi, Priya Khanna
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2021)
Review
Urology & Nephrology
Vasileios Bonatsos, Deepak Batura
Summary: Introduction of foreign bodies into the urethra is common in clinical practice, with various contributing factors. Treatment of urethral foreign bodies can be challenging, with potential need for open surgical or blind procedures if endoscopic removal fails. Psychiatric assessment is crucial for prevention of repeat incidents.
AFRICAN JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Jason Mavrotas, Akash Gandhi, Vasiliki Kalogianni, Vikash Patel, Deepak Batura
Summary: Acute urinary retention is a common presentation in UK emergency departments, leading to significant hospital admissions. Timely bladder decompression by catheterisation is crucial for preventing complications. Variations in patient presentation determine long-term management and prognosis.
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2022)
Article
Medicine, General & Internal
Samsara Bachoo, Deepak Batura
Summary: Penile fracture is typically caused by traumatic injury during sexual activity, presenting with detumescence, swelling, ecchymosis and deviation of the penis. Surgical management is the mainstay of treatment, and urethral repair may be necessary.
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2021)
Letter
Urology & Nephrology
Vasileios Bonatsos, Deepak Batura
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Review
Urology & Nephrology
Rajeev Desai, Deepak Batura
Summary: This study conducted a meta-analysis to assess the impact of risk factors and treatment choices on outcomes in emphysematous pyelonephritis (EPN). The results showed that conservative and minimally invasive treatment strategies had lower mortality risks. Shock, thrombocytopenia, confusion, hyponatremia, and emergency nephrectomy were significantly associated with mortality.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Urology & Nephrology
Deepak Batura, Iqbal Sahibzada, Wade Gayed
Summary: A 75-year-old man with lower urinary tract symptoms underwent re-do transurethral resection of the prostate (TURP) and stone removal. It was found that a metal staple from a previous hernia repair had migrated into the bladder, causing stone formation. The patient developed intestinal obstruction, possibly due to other migrated staples. This case highlights the importance of being aware of delayed complications and damage from metallic hernia staples.
LUTS-LOWER URINARY TRACT SYMPTOMS
(2023)
Article
Urology & Nephrology
Deepak Batura, Akash Gandhi, Paul Bassett
Summary: This study provides information to hospitals, surgeons, patient advocacy groups, and insurance companies that the morbidity and mortality risks of non-supra major elective urological surgery in patients aged 80 and over are not disproportionately high.
Review
Urology & Nephrology
Rajeev Desai, Deepak Batura
Summary: Fournier's gangrene is a necrotizing infection mainly seen in males, affecting the external genitalia, perineal or perianal regions. Early diagnosis and management are crucial due to its aggressive nature and high mortality rate of 20%-30%. Although a simplified Fournier Gangrene Severity Index (sFGSI) has been proposed, timely diagnosis, supportive medical management and complete surgical debridement remain essential.
Article
Urology & Nephrology
Deepak Batura, Anish Patel, Akash Gandhi, Ameena Pradhan, Samsara Bachoo, Alina Alexandra Tetea, Paul Bassett, Giles Hellawell
Summary: This study examines the differences between ethnicities in prostate cancer presentation, progression risk, and PSA testing use. The results show that black men are diagnosed at a younger age, while South Asian patients have the highest proportion of advanced disease. Most ethnicities have a high risk of disease progression, with South Asians having the least PSA test-detected cases.
WORLD JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
O. D. Baek, D. Batura, A. W. Thorpe, F. M. Maqboul, D. K. Rindorf, E. D. L. Dehlholm-Lambertsen, J. V. Vangsgaard, J. P. Patterson
Letter
Urology & Nephrology
Deepak Batura
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Tumaj Hashemzehi, Szabolcs Bertok, Malwina Julia Figaszewska, Deepak Batura
Summary: This case illustrates the various manifestations of SCD and the potentially severe consequences it can lead to. It serves as a reminder to be aware of the complications that may arise from sickle cell disease.
Article
Medicine, General & Internal
Peter de Souza, Chun Wah So, Deepak Batura, Wade Gayed, Eirini Vrentzou
Article
Urology & Nephrology
A. Habib, J. Noel, D. Batura, G. Hellawell
JOURNAL OF CLINICAL UROLOGY
(2020)