Article
Plant Sciences
Shuai Liu, Kefan Li, Yanfen Zhao, Wenbo Wang, Jie Bao, Xinxin Wang, Liwen Shi, Lei Zhou, Qiang Fu
Summary: In this study, the effect of fermented or unfermented G. officinalis root extract on diabetes mellitus-induced erectile dysfunction (DMED) and the potential mechanisms were investigated. The results showed that fermentation increased the composition of main active ingredients in G. officinalis and enhanced its role in DMED. Fermented G. officinalis has potential therapeutic application for treating DMED.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Biology
Leticia Perticarrara Ferezin, Cezar Kayzuka, Vitoria Carolina Rondon Pereira, Murilo Ferreira de Andrade, Carlos Augusto Fernandes Molina, Silvio Tucci Jr, Jose Eduardo Tanus-Santos, Riccardo Lacchini
Summary: As men age, the risk for developing erectile dysfunction (ED) increases. ED can be a sign of cardiovascular diseases and is related to mental disorders such as depression. This study investigated the relationship between a gene variant related to cardiovascular balance and the risk and severity of ED. The findings suggest that this gene variant may be associated with a worse degree of ED.
Review
Cell Biology
Mohammad Sheibani, Mehdi Ghasemi, Ahmad Reza Dehpour
Summary: Lithium has been a main therapy for bipolar disorders, but it can cause adverse effects such as sexual and erectile dysfunction. The mechanisms underlying these side effects involve both central and peripheral pathways. Understanding these mechanisms may lead to improved therapies for sexual dysfunction and better patient adherence.
Article
Pharmacology & Pharmacy
Zheyi Yan, Xiaoming Cao, Chunfang Wang, Sha Liu, Yanjie Li, Gan Lu, Wenjun Yan, Rui Guo, Dajun Zhao, Jimin Cao, Yong Xu
Summary: CTRP3 improves vasodilation of microvasculature in diabetes by enhancing endothelial cell function through the AMPK/eNOS/NO. signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Doaa R. R. Adam, Manal M. M. Alem
Summary: Erectile dysfunction is a global public health concern associated with cardiovascular risk factors, and is considered a clinical marker for future adverse events.
Article
Biochemistry & Molecular Biology
Ayokunle O. Ademosun, Ganiyu Oboh, Adeniyi A. Adebayo, Tosin A. Olasehinde, Olamide W. Fasakin
Summary: Grapefruit peel extract has the potential to enhance erectile function and protect against erectile dysfunction induced by paroxetine.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Paolo Severino, Andrea D'Amato, Massimo Mancone, Alberto Palazzuoli, Marco Valerio Mariani, Silvia Prosperi, Vincenzo Myftari, Carlo Lavalle, Giovanni Battista Forleo, Lucia Ilaria Birtolo, Viviana Caputo, Fabio Miraldi, Cristina Chimenti, Roberto Badagliacca, Viviana Maestrini, Raffaele Palmirotta, Carmine Dario Vizza, Francesco Fedele
Summary: This study investigated the association between single nucleotide polymorphisms (SNPs) of genes involved in coronary blood flow regulation and ischemic heart disease (IHD). The results showed a significant association between specific SNPs of certain genes and coronary artery disease (CAD) and coronary microvascular dysfunction (CMD) in healthy individuals. Additionally, the co-presence of specific SNPs was found to be an independent protective factor against IHD, regardless of cardiovascular risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Shuhan Bu, Hien C. Nguyen, Sepideh Nikfarjam, David C. R. Michels, Berk Rasheed, Sauraish Maheshkumar, Shweta Singh, Krishna K. Singh
Summary: The endothelium maintains vascular homeostasis by balancing vasorelaxation and vasoconstriction through regulating Nitric Oxide (NO) availability. Endothelial nitric oxide synthase (eNOS) is involved in this process and regulates endothelial function such as cell proliferation, migration, and tube formation. Inhibition of eNOS through genetic or pharmacologic methods has shown differential effects on endothelial cell behavior, suggesting a more complex mechanism behind eNOS regulation.
Article
Medicine, General & Internal
Alex Konstantinovsky, Nina Kuchersky, Khalaf Kridin, Arnon Blum
Summary: The purpose of this research was to explore the mechanistic protective cardiovascular effects of phosphodiesterase-5 inhibitors in males with erectile dysfunction. The study showed that PDE5-Is improved endothelial function and erectile dysfunction, leading to a reduction in cardiovascular events and death risk.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ya-Ping Liu, Guang Hai Zhou, Xin Song, Yu-Hao Wang, Feng Zhang, Qi-Qi Chen, Kyung Woo Cho, Song Nan Jin, Jin Fu Wen
Summary: This study aimed to investigate the effects of emodin on Hcy-induced cardiac dysfunction and its molecular mechanisms. The results showed that emodin significantly alleviated myocardial structural damage and cardiac dysfunction in HHcy rats. Emodin prevented apoptosis and mitochondrial membrane potential collapse in Hcy-treated H9C2 cells by inhibiting oxidative stress via the MAPK and Akt/eNOS/NO signaling pathways.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Felice Crocetto, Vittoria Cuomo, Ciro Santoro, Ludovica Fiorillo, Biagio Barone, Davide Arcaniolo, Teresa Fedele, Ciro Imbimbo, Roberta Esposito
Summary: This study aims to investigate whether long-acting PDE5i tadalafil can improve diastolic function assessed by cardiac ultrasound. The results show that tadalafil treatment can improve the E/e' ratio and peak velocity of the TR jet.
APPLIED SCIENCES-BASEL
(2022)
Article
Multidisciplinary Sciences
Ravi Varma Aithabathula, Naveed Pervaiz, Ishita Kathuria, Mallory Swanson, Udai P. Singh, Santosh Kumar, Frank Park, Bhupesh Singla
Summary: This study demonstrates the potential role of H2S donor NaHS in promoting lymphatic vessel formation, suggesting its potential for treating lymphatic dysfunction-related disorders.
Article
Biochemistry & Molecular Biology
Carolina Nunes da Silva, Kenia Nunes Pedrosa, Grazielle Caroline da Silva, Pricila da Silva Cunha, Thiago F. Diniz, Luisa Michette S. Maia, Flavia De Marco Almeida, Ricardo Santiago Gomez, Virginia S. Lemos, Dawidson Assis Gomes, Maria Elena de Lima
Summary: PnPP-19 peptide potentiates erectile function through nitric oxide activation, with a key role of endothelial nitric oxide synthase, and inducible nitric oxide synthase enhancing its effect on erectile function.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Naris Thengchaisri, Lih Kuo, Travis W. Hein
Summary: In diabetes, the increased activity of the enzyme arginase competes with endothelial nitric oxide synthase (eNOS) for their common substrate L-arginine, leading to compromised vasodilation mediated by nitric oxide (NO). However, eNOS uncoupling in diabetes may result in the production of superoxide and compensatory hydrogen peroxide (H2O2) formation to restore NO deficiency. This study found that in early type 1 diabetes, the vasodilation response in coronary arterioles was partially impaired due to reduced availability of L-arginine as a result of upregulated arginase activity. Nevertheless, the increased production of H2O2 during eNOS uncoupling and PI3K activation seemed to compensate for the NO deficiency and mask the disturbance caused by arginase activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Computer Science, Interdisciplinary Applications
Mojtaba Barzegari, Bahman Vahidi, Mohammad Reza Safarinejad, Mahtab Ebad
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2020)
Article
Immunology
Maryam Ghaffari Rahbar, Mohsen Nafar, Alireza Khoshdel, Nooshin Dalili, Alireza Abrishami, Ahmad Firouzan, Fatemeh Poorrezagholi, Fariba Samadian, Shadi Ziaie, Somayeh Fatemizadeh, Shiva Samavat
TRANSPLANT INFECTIOUS DISEASE
(2020)
Article
Hematology
Tahereh Rostami, Seyed Mostafa Monzavi, Hossein Poustchi, Ali Reza Khoshdel, Maryam Behfar, Amir Ali Hamidieh
Summary: This study analyzed liver fibrosis progression in ex-thalassemic patients after undergoing allogeneic hematopoietic stem cell transplantation. Results showed that significant increases in liver fibrosis were seen in patients with post-transplant iron overload or hepatic graft-vs-host disease. Control of these complications and adequate iron depletion post-transplantation can preserve hepatic status in thalassemia patients.
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2021)
Article
Clinical Neurology
Hamidreza Ghodsi, Mohammad Ali Abouei Mehrizi, Ali Reza Khoshdel, Babak Shekarchi
Summary: This study found that ASPECTS < 7, MPV, and other platelet indices can independently predict poor function and mortality in AIS patients, and combining ASPECTS with all platelet indices provides a more robust prediction for 1-year poor function and mortality.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Ali Reza Khoshdel, Omid Emami Aleagha, Alireza Shahriary, Hossein Aghamollaei, Farshad Najjar Asiabani
Summary: This study aimed to analyze the effects of NAC and Dox on inflammatory and angiogenic factors in alkali-burned corneas. The combined NAC and Dox treatment increased SOD enzyme activity and reduced the expression of inflammatory factors, while Dox alone decreased corneal neovascularization levels.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Review
Public, Environmental & Occupational Health
Hassan Shahmiri Barzoki, Mohammadreza Ebrahimi, Alireza Khoshdel, Ahmad Ali Noorbala, Amir Mohsen Rahnejat, Lababeh Avarzamani, Haleh Shahed Hagh Ghadam, Farhad Avakh
Summary: War as a stressful and unpleasant phenomenon can lead to psychiatric disorders, such as Post-Traumatic Stress Disorder (PTSD). This study aimed to estimate the prevalence of PTSD in combatants, veterans, and freed soldiers of the Iran-Iraq war. The results showed a higher incidence of PTSD compared to previous studies, which may be due to longer exposure, more in-the-field missions, multiple traumas, and higher combat exposure rates.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Review
Psychology, Multidisciplinary
Amir Mohsen Rahnejat, Mohammadreza Ebrahimi, Alireza Khoshdel, Ahmad Ali Noorbala, Hassan Shahmiri Barzoki, Lababeh Avarzamani, Farhad Avakh, Arsia Taghva
Summary: This study aimed to estimate the prevalence of depression among Iranian veterans, former POWs, and military personnel in the Iran-Iraq war. The estimated prevalence of depression among Iranian veterans and POWs was much higher than reported for military personnel. Effective policies and strategies are needed for prevention and treatment of depression and related psychiatric complications among veterans and former POWs.
INTERNATIONAL JOURNAL OF PSYCHOLOGY
(2022)
Retraction
Endocrinology & Metabolism
Mohammad Reza Safarinejad, Kamran Azma, Ali Asgar Kolahi
JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Psychiatry
Arsia Taghva, Ahmad Ali Noorbala, Mojgan Khademi, Alireza Shahriari, Mahdi Nasr Esfahani, Ali Asadi, Jafar Mohsenifar, Ali Yousefifard, Moussa Abolhassani, Jafar Bolhari, Ahmad Hajebi, Amir Mohsen Rahnejat, Haleh Shahed-Haghghadam
Summary: This study aims to investigate the clergy's perspective on the impact of mental health workshops in reducing stigma. The results demonstrated that training sessions can enhance the clergy's awareness and attitude towards mental health.
FRONTIERS IN PSYCHIATRY
(2022)
Retraction
Pediatrics
S. A. Asgari, M. R. Safarinejad, F. Poorreza, A. Safaei Asl, M. Mansour Ghanaie, E. Shahab
JOURNAL OF PEDIATRIC UROLOGY
(2022)
Retraction
Neurosciences
Mohammad R. Safarinejad
NEUROPSYCHOPHARMACOLOGY
(2023)
Retraction
Pharmacology & Pharmacy
M. R. Safarinejad
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2022)
Retraction
Pharmacology & Pharmacy
M. R. Safarinejad
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2022)
Retraction
Pharmacology & Pharmacy
M. R. Safarinejad
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2022)
Article
Urology & Nephrology
Sara Keshtkari, Bahareh Hajibaratali, Mohammad Parsa Mahjoob, Nooshin Dalili, Shiva Samavat, Pedram Ahmadpoor, Sadra Ashrafi, Mostafa Shahrezaei, Ali Reza Khoshdel
Summary: The study showed that BP response to HD is a significant independent determinant of mortality, with significant relationships with factors such as heart rate and augmentation index. It was also found that arterial stiffness and intradialytic BP can predict changes in Ejection Fraction.
IRANIAN JOURNAL OF KIDNEY DISEASES
(2021)