Review
Immunology
Virginia Perez-Carrasco, Ana Soriano-Lerma, Miguel Soriano, Jose Gutierrez-Fernandez, Jose A. Garcia-Salcedo
Summary: The application of next generation sequencing techniques has revealed that the urinary tract is not sterile, contrary to previous beliefs. Microbial communities in the urinary tract play a crucial role in maintaining health and are associated with various urinary pathologies. Understanding the urinary microbiome in health and disease could lead to the development of new therapeutic strategies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Robin Patel, Christopher R. Polage, Jennifer Dien Bard, Larissa May, Francesca M. Lee, Valeria Fabre, Mary K. Hayden, Sarah D. B. Doernberg, David A. Haake, Barbara W. Trautner, Larissa Grigoryan, Ephraim L. Tsalik, Kimberly E. Hanson
Summary: Urinary tract infections (UTIs) are common bacterial infections in the United States and contribute significantly to antibiotic use in healthcare settings. Novel UTI diagnostics have the potential to improve healthcare delivery, patient outcomes, and antibiotic use.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Masayuki Hashimoto, Bin-Hsu Mao, Chien-Shun Chiou, Wen-Chun Huang, Ida Bagus Nyoman Putra Dwija, Shuen-Lin Jeng, Jiunn-Jong Wu, Ming-Cheng Wang, Wei-Hung Lin, Chin -Chung Tseng, Ching-Hao Teng
Summary: This study focuses on Escherichia coli, which is the main pathogen of urinary tract infections, and investigates its relationship with the gut microbiota.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2022)
Review
Medicine, General & Internal
Dong Soo Kim, Jeong Woo Lee
Summary: Urinary tract infection is a common bacterial infection that can have significant consequences for individuals and society as a whole. Advances in sequencing and culture techniques have revealed a dynamic urinary tract microbiome, challenging the previously held belief that the urinary tract is sterile. Research has identified the normal core microbiota and explored changes in microbial communities due to factors such as sex and age. The pathogenesis of recurrent urinary tract infections and antibiotic resistance has also been studied, and new therapeutic options are being investigated. However, further research is needed to fully understand the implications of the urinary microbiome in urinary tract infections.
Article
Medicine, General & Internal
Adam Halinski, Kamran Hassan Bhatti, Luca Boeri, Jonathan Cloutier, Kaloyan Davidoff, Ayman Elqady, Goran Fryad, Mohamed Gadelmoula, Hongyi Hui, Kremena Petkova, Elenko Popov, Bapir Rawa, Iliya Saltirov, Francisco Rodolfo Spivacow, Belthangady Monu Zeeshan Hameed, Katarzyna Arkusz, Alberto Trinchieri, Noor Buchholz
Summary: The rate of infection stones and urine cultures were evaluated in a multi-center study. Data from charts of adult urinary stone patients were collected. The study included 1204 renal stone formers from 10 countries and found that 4.6% had struvite stones. The highest frequency of struvite stones was observed in India and Pakistan, while lower rates were reported in Canada, China, Argentina, Iraq, Italy, and Poland, and intermediate rates in Egypt and Bulgaria. Urine cultures showed that patients with struvite stones had a higher rate of positive cultures compared to patients with other types of stones.
Review
Infectious Diseases
Yveline Ansaldi, Begona Martinez de Tejada Weber
Summary: Urinary tract infections (UTIs) during pregnancy can have significant consequences for both the mother and the baby. Treating asymptomatic bacteriuria (ASB) can reduce the risk of low birth weight and preterm birth. Further research is needed to understand the complications of ASB and to explore preventive measures.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Microbiology
Meital Elbaz, Amanda Chikly, Ronnie Meilik, Ronen Ben-Ami
Summary: The urinary tract is an uncommon source of Candida bloodstream infection (CBSI), but the frequency of U-CBSI may be increasing. Patients with U-CBSI are typically older with a higher incidence of dementia, and risk factors include bladder catheterization and urologic procedures. U-CBSI tends to occur earlier and have a lower mortality rate compared to CBSI of undetermined origin.
Article
Biology
Nikos Stratakis, Alexandros P. Siskos, Eleni Papadopoulou, Anh N. Nguyen, Yinqi Zhao, Katerina Margetaki, Chung-Ho E. Lau, Muireann Coen, Lea Maitre, Silvia Fernandez-Barres, Lydiane Agier, Sandra Andrusaityte, Xavier Basagana, Anne Lise Brantsaeter, Maribel Casas, Serena Fossati, Regina Grazuleviciene, Barbara Heude, Rosemary R. C. McEachan, Helle Margrete Meltzer, Christopher Millett, Fernanda Rauber, Oliver Robinson, Theano Roumeliotaki, Eva Borras, Eduard Sabido, Jose Urquiza, Marina Vafeiadi, Paolo Vineis, Trudy Voortman, John Wright, David Conti, Martine Vrijheid, Hector C. Keun, Leda Chatzi
Summary: Urinary metabolic profiling is a promising tool to evaluate diet quality in European children, and it is associated with markers of insulin resistance. This method can help study diet quality and identify biological pathways related to metabolic diseases.
Article
Medicine, General & Internal
Jung Ki Jo, Dong Seob Kim, Younghun Sim, Soorack Ryu, Kyu Shik Kim
Summary: The study found that the severity of UTI is higher in patients with catheters, and the infecting strains vary depending on the presence of a catheter. Fosfomycin has a success rate of over 50% in treating UTIs, even in patients with catheters.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Moataz M. Hanafy, Jeremie Z. Lindeque, Shohda A. El-Maraghy, Abdel-Hamid Z. Abdel-Hamid, Nancy N. Shahin
Summary: This study monitored the metabolic profile of diabetic rats using metabolomics and identified urinary metabolic biomarkers to better understand the metabolic disturbances in diabetes, emphasizing the need for additional markers beyond glucose levels for disease prognosis.
Article
Immunology
Fengping Liu, Lei Hu, Jiayi Sheng, Yifan Sun, Qiang Xia, Yifan Tang, Peng Jiang, Shichao Wei, Jialin Hu, Hao Lin, Zhenyi Xu, Wei Guo, Yifeng Gu, Ninghan Feng
Summary: This study investigated the effects of antibiotic administration via gavage and/or urinary catheterisation on the urinary microbiota in rats. The results showed that antibiotic treatment via urinary catheterisation for 1 week can alter the urinary microbial community. However, antibiotic treatment via gavage did not significantly affect the microbial composition in the urine. Furthermore, it was observed that urinary catheterisation did not induce infections or injuries to the bladder and kidney tissues.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anna Kawalec, Danuta Zwolinska
Summary: The urinary tract microbiome is crucial for maintaining health and preventing urinary tract infections. However, the characteristics and role of the urobiome in children, as well as strategies for treating pediatric patients with recurrent urinary tract infections, are still not completely understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Michael W. Dunne, Steven Aronin, Anita F. Das, Karthik Akinapelli, Michael T. Zelasky, Sailaja Puttagunta, Helen W. Boucher
Summary: This study demonstrates that sulopenem is an effective alternative for the treatment of urinary tract infections, with superiority in infections caused by resistant pathogens.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Silvia Colussi, Paolo Pastorino, Marino Prearo, Simona Sciuto, Fabio Bondavalli, Pier Luigi Acutis, Elena Bozzetta, Francesco Amisano, Angelo Salerno
Summary: This paper reports the first human urinary tract infection caused by Lactococcus petauri, highlighting the expected increase in human L. petauri infections and calling for further investigations to understand their role as pathogens and zoonotic agents.
Article
Public, Environmental & Occupational Health
Renee Lehane, Catherine Svensson, Jennifer A. Ormsby, Jenny Chan Yuen, Gregory P. Priebe, Thomas J. Sandora, Ana M. Vaughan-Malloy
Summary: The study implemented hospital-wide urinary catheter K-card rounding, which significantly improved the reliability of catheter maintenance bundle and reduced the CAUTI rates.
AMERICAN JOURNAL OF INFECTION CONTROL
(2023)
Article
Ophthalmology
Somnath De, Sandeep Saxena, Apjit Kaur, Abbas A. Mahdi, Arvind Misra, Malvika Singh, Carsten H. Meyer, Levent Akduman
Summary: The study showed that anti-VEGF therapy restores the barrier effect of ELM, causing ELM to restore first followed by EZ restoration in diabetic macular oedema (DMO).
Article
Orthopedics
Varsha Shukla, Siddharth Kumar Das, Abbas Ali Mahdi, Shweta Agarwal, Ragini Alok, Jamal Akhtar Ansari, Sukhanshi Khandpur
Summary: This study found that levels of oxidative stress markers were significantly higher in FMS patients, while essential metals were significantly lower, and these were closely related to the severity of the disease.
JOURNAL OF BACK AND MUSCULOSKELETAL REHABILITATION
(2021)
Article
Biochemistry & Molecular Biology
Jyoti Yadav, Anoop Kumar Verma, Md. Kaleem Ahmad, Ravindra K. Garg, Shiuli, Abbas Ali Mahdi, Shrikant Srivastava
Summary: Alzheimer's disease patients showed higher levels of non-essential metals and lower levels of essential biometals in their blood. Up-regulation of target genes was observed in AD patients, but there was no significant correlation found between metals dyshomeostasis and gene expressions in this study.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Neurosciences
Mohammad Rumman, Shivani Pandey, Babita Singh, Mrinal Gupta, Saba Ubaid, Abbas Ali Mahdi
Summary: The study demonstrated that GE can ameliorate hypoxia-induced cognitive dysfunction in mice by reducing oxidative stress, suppressing neuroinflammation, and enhancing the expression of neuroprotective genes in the hippocampus.
NEUROTOXICITY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Babita Singh, Shivani Pandey, Mohammad Rumman, Shashank Kumar, Prem Prakash Kushwaha, Rajesh Verma, Abbas Ali Mahdi
Summary: The study showed that Bacopa monnieri extract has neuroprotective and neurorescue effects against MPTP-induced degeneration of dopaminergic neurons, potentially slowing down disease progression and delaying neurodegeneration in Parkinson's disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohd Zahid, Pushkar Singh Rawat, Shalini Singh, Akshay Kumar Gupta, Rumana Ahmad, Abbas Ali Mahdi, Md Kaleem Ahmad, Sudhir Mehrotra
Summary: The study found that curcumin and quercetin have a beneficial impact on lead toxicity, possibly due to their antioxidant properties that can counteract the oxidative stress induced by lead exposure. Therefore, the combination of curcumin and quercetin may serve as a useful supplement in the appropriate management of lead poisoning.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2022)
Review
Pharmacology & Pharmacy
Esha Sarkar, Aparna Misra, Abbas Ali Mahdi, Anchal Trivedi, Afreen Khan
Summary: Chemoresistance is a major obstacle in cancer treatment, and various strategies have been discovered to overcome this issue, such as novel agents, drug carriers, and combination treatment targeting different pathways simultaneously.
CURRENT DRUG THERAPY
(2021)
Article
Environmental Sciences
Naina Dwivedi, Abbas Ali Mahdi, Sujata Deo, Mohammad Kaleem Ahmad, Durgesh Kumar
Summary: The study aimed to assess the correlation between transplacental transfer of xenobiotics and resulting biochemical alterations in pregnant women in North India. The results showed higher organo-chlorine pesticides levels in preterm maternal blood, along with increased genotoxicity and oxidative stress effects. The findings suggest a potential link between pesticides exposure and adverse pregnancy outcomes, highlighting the importance of early detection and stricter guidelines for pesticide use.
ENVIRONMENTAL RESEARCH
(2022)
Article
Genetics & Heredity
Ravi Shanker Yadav, Surya Kant, Prashant Mani Tripathi, Anumesh K. Pathak, Abbas Ali Mahdi
Summary: The study found that mRNA levels of IL-1 beta, IL-8, and NF-kappa B were significantly higher in COPD patients compared to healthy controls; smokers with COPD had significantly higher mRNA expression levels of IL-1 beta, IL-8, and NF-kappa B than non-smokers; increasing pack-years of smoking correlated with worsening COPD severity.
Article
Biochemistry & Molecular Biology
Abbas Ali Mahdi, Jamal Akhtar Ansari, Priyanka Chaurasia, Mohammad Kaleem Ahmad, Shipra Kunwar, Sally McClean, Pratheepan Yogarajah
Summary: This study investigated the blood lead levels in pregnant women and umbilical cord blood, finding elevated lead levels in both groups. There was a strong positive correlation between the maternal and umbilical cord blood lead levels. Factors such as recent home painting and close proximity to traffic congestion were significantly associated with higher maternal blood lead levels. Education, mother age, fuel, and water sources did not show a significant association. Screening of blood lead levels and stricter regulations on lead-based products are recommended to reduce the exposure to lead in high-risk women and the general population.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2023)
Article
Environmental Sciences
Naina Dwivedi, Abbas Ali Mahdi, Sujata Deo
Summary: The present study aimed to assess the safety of infants in North India in relation to the presence of persistent organochlorine pesticides (OCPs) in breast milk, which could transfer endocrine-disrupting chemicals to newborns. Samples of colostrum and breast milk were collected and analyzed for pesticide concentration. Results showed that OCPs concentration was higher in breast milk compared to colostrum, indicating an increase in pesticides contamination over lactation. The study also found that women consuming non-vegetarian food had higher exposure to OCPs, and factors such as mother's age, gestational age, and infant birth weight were associated with OCPs levels in colostrum and breast milk. The study highlights the need for regulation and further research on the relationship between pesticide residues in breast milk and maternal and child health.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ajay Kumar Verma, Anuj Kumar Pandey, Arpita Singh, Surya Kant, Abbas Ali Mahdi, Ved Prakash, Kausar Mahmood Ansari, Rakesh Kumar Dixit, Shyam Chand Chaudhary
Summary: This study found that serum levels of MMP-9, COX-2, and PGE-2 are correlated with GOLD grade, CAT score, and clinical history in the COPD group, serving as potential indicators for understanding disease progression.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Shalini Gupta, Kumud Nigam, Ratnesh Kumar Srivastav, Md. Kaleem Ahmad, Abbas Ali Mahdi, Somali Sanyal
Summary: The study found a significant association between SNPs of TNF-alpha and TNF-beta genes with oral pre-cancerous lesions and oral squamous cell carcinoma. Specifically, the GA genotype of TNF-alpha and the AG heterozygote of TNF-beta were associated with an increased risk of oral diseases.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2022)
Article
Biochemistry & Molecular Biology
Raza Abbas Mahdi, Israr Ahmad, Talha Jilani, Jamal Akhtar Ansari, Farzana Mahdi, Abbas Ali Mahdi, Tabrez Jafar
Summary: The study investigated dopamine gene polymorphism, biochemical and oxidative stress parameters in elderly patients with and without depression. Changes in levels of various markers including dopamine, antioxidants and oxidative stress markers were observed in depressed individuals compared to controls, suggesting a possible association between these factors and depression in the aging population.
INDIAN JOURNAL OF CLINICAL BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Sonal Sachan, Sucheta Pathania, Abbas Ali Mahdi, Swastika Suvirya, Atin Singhai
Summary: Long-term ingestion of high concentrations of arsenic can lead to arsenicosis, which is common in India and Bangladesh due to contamination of groundwater with naturally occurring high concentrations of arsenic in the earth's crust. Skin and internal organ involvement in arsenic endemic regions should be given special attention.
JOURNAL OF HEALTH AND POLLUTION
(2021)