Article
Biochemistry & Molecular Biology
Chiharuko Ushimoto, Shigeru Sugiki, Kenshirou Kunii, Shinya Inoue, Eriko Kuroda, Ryoko Akai, Takao Iwawaki, Katsuhito Miyazawa
Summary: Oxidative stress is a significant risk factor for calcium oxalate nephrolithiasis. This study investigates the association between oxidative stress response and stone formation through analyzing the response during different phases and observing the effect on crystal formation in mouse models. The findings suggest that the oxidative stress response via Keap1-Nrf2 pathway may contribute to crystal formation and could be a potential target for preventing and treating nephrolithiasis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Daniel Turudic, Anja Tea Golubic, Mila Lovric, Marko Bilic, Danko Milosevic
Summary: The research found different risks and important variables in urinary stone development between prepubertal and pubertal/postpubertal children, with citrate and glycosaminoglycans increasingly important in children. J48 classifier confirmed the importance of certain variables for distinguishing between children with urolithiasis and healthy children of the same age and gender.
Review
Nutrition & Dietetics
Joseph J. Crivelli, Tanecia Mitchell, John Knight, Kyle D. Wood, Dean G. Assimos, Ross P. Holmes, Sonia Fargue
Summary: The prevalence of kidney stone disease is on the rise, with calcium oxalate being the most common stone composition. Dietary oxalate intake and endogenous production of oxalate play important roles in the pathophysiology of calcium oxalate stone disease, while oxalate-degrading bacteria in the gut microbiome may mitigate stone risk.
Article
Biotechnology & Applied Microbiology
Zhu Wang, Qiong Deng, Yanli Gu, Min Li, Ying Zhang, Qiyi Hu, Shenping Zhang, Xisheng Wang, Hui Liang
Summary: This study investigated the gene expression changes in the kidney of a rat model with kidney stones. The results showed dysregulated genes related to injury, apoptosis, immune response, solute carriers, transporters, and metabolic factors. These findings contribute to a better understanding of the pathogenesis of nephrolithiasis and could potentially lead to the development of new strategies for prevention and treatment.
Article
Biochemistry & Molecular Biology
Chan Jung Liu, Yau Sheng Tsai, Ho Shiang Huang
Summary: This study demonstrates that statins can suppress hyperlipidemia-induced CaOx nephrolithiasis by restoring the expression of anti-lithic protein, leading to a decrease in renal CaOx stone deposits and a change in the dominant calcium crystal composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Aleksei Rusakov, Maria Kuz'mina, Olga Frank-Kamenetskaya
Summary: The study examines the effect of biofilm medium chemistry on oxalate crystallization, especially the impact of organic acids and environmental ions on the weddellite/whewellite ratio and morphology. Citric acid was found to have a unique effect on promoting weddellite crystallization in the presence of micromicetes, resulting in significant changes in the crystallization ratio.
Review
Crystallography
Ana Petrovic, Tomislav Kizivat, Ines Bilic Curcic, Robert Smolic, Martina Smolic
Summary: Urolithiasis is a multifactorial disease with a high recurrence rate, characterized by solid deposits forming in the urinary tract. The most common type is calcium oxalate stones. In vitro models offer insight into molecular processes leading to renal stone formation and are significant for patient management.
Article
Veterinary Sciences
Osamu Ichii, Kazuhisa Oyamada, Hazuki Mizukawa, Nozomu Yokoyama, Takashi Namba, Yuki Otani, Yaser Hosny Ali Elewa, Noboru Sasaki, Teppei Nakamura, Yasuhiro Kon
Summary: Cats are highly susceptible to urinary organ-related diseases. This study investigated the morphologies of healthy ureters and compared them with surgically resected ureters affected by urolithiasis obstruction. The findings revealed that healthy ureters exhibited a decrease in size, lumen area, and submucosa area from the proximal to middle segment. Diseased ureters showed increased connective tissue, inflammation, and decreased nerves. These findings provide important insights into the pathogenesis of feline ureteral obstruction.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Applied
Peng Sun, Shang-Gao Liao, Rao-Qiong Yang, Chuan-Li Lu, Kai -Long Ji, Dong-Hua Cao, Hua-Bin Hu, Jian-Mei Lu, Xing-Zhen Song, Min Wu, Hui-Zhen Jia, Chun -Fen Xiao, Zhi-Wei Ma, You -Kai Xu
Summary: This study identified a 2.3 kD fructan from Aspidopterys obcordata vine with unique anti-urolithiasis activity, reducing the size of calcium oxalate crystals through multiple mechanisms.
CARBOHYDRATE POLYMERS
(2022)
Review
Health Care Sciences & Services
Kyriaki Stamatelou, David S. Goldfarb
Summary: In the past two decades, there have been no major breakthroughs in the understanding and therapy of kidney stones, which remains a challenging disease for patients, physicians, and healthcare systems. Epidemiological studies play a crucial role in identifying global changes in the prevalence and burden of kidney stones and modifiable risk factors. The expanding knowledge of kidney stone epidemiology significantly enhances the modern management of the disease.
Article
Biology
Muhammad Afzal, Imran Kazmi, Anwarulabedin Mohsin Quazi, Aftab Ahmad, Fahad A. Al-Abaasi, Faisal Imam, Khalid Saad Alharbi, Sami I. Alzarea, Ameeduzzafar Zafar
Summary: The study demonstrated the significant antiurolithic effect of 6-shogaol in rats with experimental urolithiasis, reducing serum levels of BUN, creatinine, and uric acid, and restoring oxidative stress parameters.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Crystallography
Silvija Safranko, Sara Goman, Dominik Goman, Stela Jokic, Ida Delac Marion, Nives Matijakovic Mlinaric, Atida Selmani, Martina Medvidovic-Kosanovic, Anamarija Stankovic
Summary: This study focused on the preparation and structural characterization of calcium oxalate hydrates with the presence of gallic acid (GA). The results indicated that GA inhibited the formation of COM and promoted the formation of COD, while medium pH and the amount of added GA had a significant effect on COD formation. Electrochemical measurements were performed to investigate the interactions and possible adsorption between GA and formed crystals.
Article
Veterinary Sciences
Lucy Kopecny, Carrie A. Palm, Gilad Segev, Jennifer A. Larsen, Jodi L. Westropp
Summary: The proportion of calcium oxalate-containing uroliths in cats has decreased over the years, while the proportion of struvite-containing uroliths has increased. Different types of uroliths have significantly different proportions in the upper urinary tract, and the predispositions based on sex and age are similar to previous reports.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Hao Lu, David Yuen Wah Ng, Ingo Lieberwirth, Tobias Weidner, Mischa Bonn
Summary: This study elucidates the mechanism of the acidic osteopontin (OPN) in inhibiting the formation of kidney stones by interacting with calcium ions and calcium oxalate. The findings provide important insights into understanding the development of kidney stones.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Energy & Fuels
Mohamed Donia, Mohamed Zeineldin, Naglaa Gomaa, Midhat Nassif, Yamen Hegazy, Jose Cedillo Monroy, Edson Brodeli Figueroa Pacheco, Raymundo Rene Rivas-Caceres, Rabiha Seboussi, Mohamed Abdelmegeid
Summary: This study aimed to investigate the association between the colonization of Oxalobacter formigenes and the occurrence of calcium oxalate urolithiasis in cats. The results suggest a protective role of O. formigenes against calcium oxalate urolithiasis only in static chronic kidney disease (CKD) cats.
BIOMASS CONVERSION AND BIOREFINERY
(2022)