Article
Surgery
Viniyendra Pamecha, Nilesh Sadashiv Patil, Kumaraswamy Parthasarathy, Piyush Kumar Sinha, Nihar Mohapatra, Archana Rastogi, Karthika Rudrakumar, Amar Mukund, Ashok Chaudhary, Uma Kanal
Summary: This study examines the feasibility of live liver donation in potential donors with non-alcoholic steatohepatitis (NASH) after successful donor optimization. The results suggest that with careful selection and optimization, NASH patients can become live liver donors, expanding the organ pool for liver transplantation. However, post-operative recovery may take longer for these donors.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Immunology
Hillary J. Braun, Jennifer L. Dodge, Joshua D. Grab, Marisa E. Schwab, Iris H. Liu, Alexa C. Glencer, Peter G. Stock, Ryutaro Hirose, John P. Roberts, Nancy L. Ascher
Summary: The implementation of Share 35 policy led to an increase in LDLT volume, largely due to increased LDLT volume at centers with experience in LDLT, and corresponded to significant geographic variation in LDLT utilization.
Article
Physiology
Rosa G. M. Lammerts, Lisanne M. Lagendijk, Gesa Tiller, Wendy A. Dam, Harriet L. Lancaster, Mohamed R. Daha, Marc A. Seelen, Bouke G. Hepkema, Robert A. Pol, Henri G. D. Leuvenink, Grietje Molema, Jacob van den Born, Stefan P. Berger
Summary: Renal endothelial cells play important roles in renal diseases, and a new method of isolating ECs from the perfusate of donor kidneys has been described in this study, demonstrating potential diagnostic value in HLA antibody-specific cross-matching tests and further applications in renal endothelial research.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Surgery
Suk Kyun Hong, Sunho Choe, Nam-Joon Yi, Aesun Shin, Eun Kyung Choe, Kyung Chul Yoon, Kwang-Woong Lee, Kyung-Suk Suh
Summary: The study evaluated the long-term mortality of Korean live liver donors by comparing it with the mortality of the general population, finding that liver donors have slightly higher long-term mortality rates. The most common causes of death were suicide, cancer, and traffic accidents.
Article
Immunology
Jiri Fronek, Libor Janousek, Jakub Kristek, Jaroslav Chlupac, Marek Pluta, Robert Novotny, Jana Maluskova, Michael Olausson
Summary: This study reported the first live birth after a deceased donor uterus transplant in Europe, demonstrating that nulliparous uteri may be a suitable source of uterine grafts for transplantation. Stenting appears to be a feasible treatment for vaginal anastomotic stenosis.
Review
Immunology
Mohamed Eftal Bin Mohamed Ebrahim, Animesh Singla, Jinna Yao, Jerome Martin Laurence, Germaine Wong, Howard Lau, Taina Lee, Lawrence Yuen, Wai H. Lim, Henry Pleass
Summary: This systematic review aimed to assess the clinical outcomes of kidney donors with a prior history of nephrolithiasis. After searching electronic databases, 14 studies comprising 432 live donors were included. The results showed that donors with a history of nephrolithiasis did not have significant post-donation complications or decline in renal function.
TRANSPLANTATION REVIEWS
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Sunit-Preet Chaudhry, Varun Sundaram, Samer Najjar
Summary: Heart transplantation in the United States is commonly performed using donors after brain death. Brain death accounts for 2% of adult inhospital deaths in the country and can cause physiological and hemodynamic changes that may negatively affect the donor heart.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Surgery
F. Villanego, L. A. Vigara, J. M. Cazorla, J. Naranjo, L. Atienza, A. M. Garcia, M. E. Montero, M. C. Minguez, T. Garcia, A. Mazuecos
Summary: This study examined the utility of preimplantation biopsies and KDPI scores in predicting kidney transplant survival from expanded criteria donors (ECD). It found that lower KDPI quartiles were associated with better survival rates, while higher KDPI and greater histological injuries in preimplantation biopsies were linked to higher rates of kidney transplant loss from ECD donors.
TRANSPLANT INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Jongman Kim, Jae Heon Kim, Hyun Jung Kim
Summary: This study found that living liver donors have a significantly higher incidence of liver and thyroid cancer compared to a matched healthy control group. The findings suggest the need for medical surveillance, especially for liver cancer, among living liver donors.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Health Care Sciences & Services
Hui-Ying Lin, Cheng-Maw Ho, Pei-Yin Hsieh, Min-Heuy Lin, Yao-Ming Wu, Ming-Chih Ho, Po-Huang Lee, Rey-Heng Hu
Summary: The study retrospectively reviewed the time and risk factors associated with interruptions in the live donor liver transplantation (LDLT) process, finding that patients with hepatitis B virus, encephalopathy, hypertension, and increased total bilirubin were at higher risk of not undergoing LDLT. Major barriers included patients' critical illnesses, donors' physical conditions, motivation for live donation, and stability on the waiting list.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Medicine, Research & Experimental
Puja H. Nambiar, Brianna Doby, Aaron A. R. Tobian, Dorry L. Segev, Christine M. Durand
Summary: The implementation of the HOPE Act has enabled HIV+ organ transplantation, with successful deceased donor transplants and the first living donor kidney transplants. However, reaching the full potential of HIV+ donors requires overcoming challenges at various levels in the community, organ procurement organizations, and transplant centers. Multiple ongoing clinical trials will provide further data to expand knowledge in this field.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Article
Biology
Slavica Pusica, Borko Stojanovic, Marko Bencic, Marta Bizic, Tatjana Atanasijevic, Miroslav L. Djordjevic
Summary: Preserved penile tissues can be used for live-donor penile transplantation in feminizing gender affirmation surgery. A study on 41 patients showed that microvascular penile dissection followed by gender-affirming vaginoplasty was simple and safe, with satisfactory results reported by all patients.
Review
Gastroenterology & Hepatology
Pankaj Puri, Abhinav Kumar, Mohd Qaleem
Summary: Donor evaluation is a critical step in both deceased and living donor liver transplantation. The selection of a healthy graft and prevention of infection and malignancy transmission are crucial for successful transplantation. Donor safety is also important in living donor transplantation.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2024)
Article
Hematology
Rohtesh S. Mehta, David Marin, Amin Alousi, Christopher G. Kanakry, Richard E. Champlin, Katayoun Rezvani, Elizabeth J. Shpall, Kristin Page, Shahinaz M. Gadalla, Daniel Weisdorf, Partow Kebriaei
Summary: In adult patients with acute lymphoblastic leukemia, younger haploidentical donors have better overall survival compared to older HLA-matched unrelated donors. Donor age is a prognostic factor for survival in hematopoietic cell transplantation.
Article
Surgery
Zhihao Li, Ashwin Rammohan, Vasanthakumar Gunasekaran, Suyoung Hong, Itsuko Chih-Yi Chen, Jongman Kim, Kris Ann Hervera Marquez, Shih Chao Hsu, Elvan Onur Kirimker, Nobuhisa Akamatsu, Oren Shaked, Michele Finotti, Marcus Yeow, Lara Genedy, Philipp Dutkowski, Silvio Nadalin, Markus U. Boehnert, Wojciech G. Polak, Glenn K. Bonney, Abhishek Mathur, Benjamin Samstein, Jean C. Emond, Giuliano Testa, Kim M. Olthoff, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Tiffany CL. Wong, Chung-Mau Lo, Kiyoshi Hasegawa, Deniz Balci, Mark Cattral, Gonzalo Sapisochin, Nazia Selzner, Long Bin Jeng, Dieter Broering, Jae-Won Joh, Chao-Long Chen, Kyung-Suh Suk, Mohamed Rela, Pierre-Alain Clavien
Summary: This study aims to establish benchmark values for adult-to-adult living-donor liver transplantation (LDLT). By analyzing data from 15 high-volume centers, it was found that benchmark LDLT can reduce waitlist mortality, with Asian centers outperforming others and non-benchmark low-volume centers displaying inferior outcomes.
Article
Transplantation
Mark K. Tiong, Edward R. Smith, Elaine M. Pascoe, Grahame J. Elder, Nicole M. Lioufas, Eugenia Pedagogos, Carmel M. Hawley, Andrea Valks, Stephen G. Holt, Tim D. Hewitson, Nigel D. Toussaint
Summary: This study investigated the impact of lanthanum carbonate on serum calciprotein particles (CPP) in patients with early-stage chronic kidney disease (CKD). The results suggest that lanthanum carbonate is not effective in reducing CPP levels at 96 weeks compared with placebo.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Ashik Hayat, David W. Johnson, Carmel M. Hawley, Lauren R. Jaffrey, Usman Mahmood, Sarah Saw Yu Mon, Yeoungjee Cho
Summary: This study aimed to compare the associations, microbiologic profiles, and outcomes between pre-training peritonitis (PTP) and post-training peritonitis in patients with kidney failure. The results showed that PTP was closely associated with prior exit-site infection, often had culture-negative peritonitis, and was associated with worse outcomes of hemodialysis transfer or death.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Health Policy & Services
Dharmenaan Palamuthusingam, Elaine M. Pascoe, Carmel M. Hawley, David W. Johnson, Gishan Ratnayake, Stephen McDonald, Neil Boudville, Matthew Jose, Magid Fahim
Summary: This study assessed the concordance between comorbidities recorded in the Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry and those in state-based hospital admission datasets. The results showed that the accuracy of diabetes mellitus recording was the highest, while the accuracy of cerebrovascular disease recording was the lowest.
HEALTH INFORMATION MANAGEMENT JOURNAL
(2023)
Article
Urology & Nephrology
Wai H. Lim, Jenny H. C. Chen, Kimberley Minas, David W. Johnson, Maleeka Ladhani, Esther Ooi, Neil Boudville, Carmel Hawley, Andrea K. Viecelli, Matthew Roberts, Kate Wyburn, Rachael Walker, Monique Borlace, Helen Pilmore, Christopher E. Davies, Charmaine E. Lok, Armando Teixeira-Pinto, Germaine Wong
Summary: This study investigates the cause-specific mortality rates between male and female dialysis patients in Australia and New Zealand from 1998 to 2018. It found that female patients had a higher risk of all-cause mortality in the first 5 years after dialysis initiation, primarily due to mortality from infections and dialysis withdrawals.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Urology & Nephrology
Sibel G. Bek, Simone Marschner, Kamal Sud, David W. Johnson, Clara K. Chow, Carmel Hawley, Helen Pilmore, Germaine Wong, Wai Lim, Vincent W. Lee
Summary: This study found that smoking is associated with increased rates of all-cause mortality, cardiovascular mortality, respiratory failure, chronic lung disease, and malignancy in dialysis patients. It also increases the risk of non-skin cancers, de novo vascular disease, and chronic lung disease.
Article
Pediatrics
Chandana Guha, Rabia Khalid, Anita van Zwieten, Anna Francis, Carmel M. Hawley, Allison Jaure, Armando Teixeira-Pinto, Alistair R. Mallard, Amelie Bernier-Jean, David W. Johnson, Deirdre Hahn, Donna Reidlinger, Elaine M. Pascoe, Elizabeth G. Ryan, Fiona Mackie, Hugh J. McCarthy, Jonathan C. Craig, Julie Varghese, Charani Kiriwandeniya, Kirsten Howard, Nicholas G. Larkins, Luke Macauley, Amanda Walker, Martin Howell, Michelle Irving, Patrina H. Y. Caldwell, Reginald Woodleigh, Shilpanjali Jesudason, Simon A. Carter, Sean E. Kennedy, Stephen Alexander, Steven McTaggart, Germaine Wong
Summary: This study aims to evaluate the effectiveness of a patient navigator program in children with chronic kidney disease. A total of 162 patients were enrolled and randomized into immediate intervention and waitlisted groups. The results of the study will be completed by October 2022.
PEDIATRIC NEPHROLOGY
(2023)
Review
Urology & Nephrology
Ashik Hayat, Rachael C. Walker, Andrea K. Viecelli, Karine E. Manera, Allison Jaure, Rathika Krishnasamy, Elaine M. Pascoe, Yeoungjee Cho, David W. Johnson
Summary: This study assessed the range and consistency of gastrointestinal (GI) outcomes reported in contemporary peritoneal dialysis (PD) trials. It found that only 19% of PD trials reported GI outcomes, with nausea, diarrhea, vomiting, constipation, and abdominal pain being the most frequently reported outcomes. The majority of GI outcomes were patient-reported adverse events with no defined metrics.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Urology & Nephrology
Ryan Gately, Elasma Milanzi, Wai Lim, Armando Teixeira-Pinto, Phil Clayton, Nicole Isbel, David W. Johnson, Carmel Hawley, Scott Campbell, Germaine Wong
Summary: BK polyomavirus-associated nephropathy (BKPyVAN) is associated with an increased risk of graft dysfunction and loss in kidney transplant recipients. This cohort study in Australia and New Zealand found that BKPyVAN occurred in 3% of recipients and was linked to higher rates of graft loss, rejection, and death. Changes in immunosuppression, such as reducing tacrolimus and mycophenolate doses, were commonly made after BKPyVAN. Several factors, including gender, age, blood group, donor characteristics, transplantation era, immunosuppression use, and transplant center volume, were associated with the development of BKPyVAN. The study also found that BKPyVAN increased the risk of graft loss but not mortality. It highlights the need for interventional trials to evaluate strategies for reducing immunosuppression and minimizing adverse outcomes associated with BKPyVAN.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Katharine Hegerty, Allison Jaure, Nicole Scholes-Robertson, Kirsten Howard, Angela Ju, Nicole Evangelidis, Martin Wolley, Amanda Baumgart, David W. Johnson, Carmel M. Hawley, Donna Reidlinger, Laura Hickey, Alyssa Welch, Yeoungjee Cho, Peter G. Kerr, Matthew A. Roberts, Jenny I. Shen, Jonathan Craig, Rathika Krishnasamy, Andrea K. Viecelli
Summary: This study aimed to explore patients' perspectives on incremental hemodialysis (HD) and their priorities and concerns regarding HD. The study found that patients with kidney failure preferred incremental initiation of HD to minimize disruption to daily living and improve quality of life. The top prioritized outcomes were quality of life, residual kidney function, and mortality.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Transplantation
Gregory J. Wilson, Kim Van, Emma O'Lone, Allison Tong, Jonathan C. Craig, Benedicte Sautenet, Klemens Budde, Derek Forfang, John Gill, William G. Herrington, Tazeen H. Jafar, David W. Johnson, Vera Krane, Adeera Levin, Jolanta Malyszko, Patrick Rossignol, Deirdre Sawinski, Nicole Scholes-Robertons, Giovanni Strippoli, Angela Wang, Wolfgang C. Winkelmayer, Carmel M. Hawley, Andrea K. Viecelli
Summary: This study aimed to assess the range and consistency of cardiovascular outcomes reported by contemporary trials in kidney transplant recipients, revealing substantial heterogeneity in cardiovascular outcome reporting.
TRANSPLANTATION DIRECT
(2023)
Article
Urology & Nephrology
Ashik Hayat, Yeoungjee Cho, Carmel M. Hawley, Htay Htay, Rathika Krishnasamy, Elaine Pascoe, Isaac Teitelbaum, Marliene Varnfield, David W. Johnson
Summary: Comparing with full-dose PD start, incremental PD start shows similar declines in RKF and UV.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
B. Logan, A. K. Viecelli, D. W. Johnson, E. M. Aquino, J. Bailey, T. A. Comans, L. C. Gray, C. M. Hawley, L. E. Hickey, M. Janda, A. Jaure, M. D. Jose, E. Kalaw, C. Kiriwandeniya, M. Matsuyama, G. Mihala, K. H. Nguyen, E. Pascoe, J. D. Pole, K. R. Polkinghorne, D. Pond, R. Raj, D. M. Reidlinger, N. Scholes-Robertson, J. Varghese, G. Wong, R. E. Hubbard
Summary: This study aims to evaluate the clinical utility and cost-effectiveness of comprehensive geriatric assessment (CGA) for frail older people living with chronic kidney disease (CKD). The study compares the attainment of self-identified goals between participants receiving CGA and those receiving standard care. The study will help improve the survival and quality of life of patients with CKD.
Article
Urology & Nephrology
Yeoungjee Cho, Kai-Ming Chow, Philip Kam-Tao Li, Naomi Runnegar, David W. Johnson
Summary: Peritoneal dialysis is an important treatment option for patients with kidney failure, providing various benefits such as enhanced participation in daily activities, flexibility in schedules, cost savings, and improved quality of life. However, the utilization of peritoneal dialysis has remained static or declining in certain regions due to concerns about PD-related infections. This review aims to provide an overview of the definition, epidemiology, risk factors, prevention, and treatment of PD-related infections based on current evidence.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Yu-Hui Zhang, Xiao Xu, Hai-Chen Pi, Zhi-Kai Yang, David W. Johnson, Jie Dong
Summary: This study aimed to examine the effects of vitamin D supplementation on the risk of PD-related peritonitis. The results showed that oral natural vitamin D supplementation can increase serum 25(OH)D levels in PD patients, without affecting the occurrence or outcome of peritonitis. The study suggests that conducting this type of randomized controlled trial is feasible and safe.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)