Article
Medicine, General & Internal
Julia Ponce, Teresa Cobo, Clara Murillo, Anna Gonce, Nadia Dominguez, Francesca Crovetto, Laura Guirado, Montse Palacio, Mar Bennasar
Summary: Preterm prelabour rupture of membranes (PPROMs) before viability carries significant perinatal mortality and morbidity. Clinical management and prenatal counselling are a challenge, especially in twin pregnancies, due to scarce evidence on how previable PPROM affects this population. This study aimed to describe pregnancy outcomes of twin pregnancies complicated with previable PPROM and evaluate potential prognostic factors that may predict perinatal mortality. The overall survival rate of twin pregnancies complicated with previable PPROM is poor but similar to singletons. No prognostic factors, apart from achieving periviability, were identified as individual predictors of perinatal mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Obstetrics & Gynecology
Pierre Delorme, Elsa Lorthe, Jeanne Sibiude, Gilles Kayem
Summary: Studies on prelabour rupture of membranes (PROM) suggest that expectant management (EM) until 37 weeks of gestation in preterm PROM can reduce overall neonatal morbidity, while active management in term PROM may lead to a shorter birth interval without lowering neonatal infection rates. Induction methods using oxytocin, PGE2, or oral misoprostol have similar maternal and neonatal outcomes.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Review
Obstetrics & Gynecology
Megan Hall, Fiona Challacombe, Ciara Curran, Andrew Shennan, Lisa Story
Summary: Preterm prelabour rupture of the membranes (PPROM) complicates 3% of pregnancies and is associated with an increased risk of maternal and perinatal morbidity and mortality. Patients often resort to the internet for medical information about PPROM, but the information obtained is often low quality, low accuracy, not credible, and difficult to read. The lack of governance online leaves patients at risk of relying on unreliable websites.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Line Rode, Camilla B. Wulff, Charlotte K. Ekelund, Eva Hoseth, Olav B. Petersen, Ann Tabor, Vanessa El-Achi, Jon A. Hyett, Andrew C. McLennan
Summary: This retrospective analysis examined risk factors for preterm prelabour rupture of membranes (PPROM) in early pregnancy and developed a predictive model. The study identified several maternal characteristics, placental biochemical and sonographic features that are predictive of PPROM. The researchers suggest that further validation and additional biomarkers may improve the model's performance.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Review
Obstetrics & Gynecology
Lucia Ramirez-Montesinos, Soo Downe, Annette Ramsden
Summary: This systematic review analyzes and critiques the latest research on the management of term prelabour rupture of membranes, including the effect of vaginal examinations during labour. The review identified three research questions and combined the results from multiple databases. The findings indicate that the management of term prelabour rupture of membranes remains controversial. The overall quality of the studies included in the review was not high, and no prospective studies have investigated interventions to reduce the number of vaginal examinations.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
Laila Ezzat Abdelfattah, Rehab Abdelhamid Aboshama, Amr S. Abdelbadie, Mohamed H. Abulhasan, Mohamed A. Anan, Ibraheem I. Abdelaal
Summary: This study evaluated the efficacy of different azithromycin protocols for the conservative management of preterm prelabor rupture of membranes. The results showed that a higher dose of azithromycin was associated with a longer latency period, higher mean gestational age at delivery, but also increased rates of postpartum endometritis and respiratory distress syndrome.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
A. Vierin, G. Vandenberghe, K. Bloemenkamp, S. Berlage, L. Colmorn, C. Deneux-Tharaux, S. Donati, M. Gissler, M. Knight, J. Langhoff-Roos, P. G. Lindqvist, B. Maier, J. van Roosmalen, J. Zwart, K. Roelens
Summary: This study analyzed atypical cases of uterine rupture, including those occurring in unscarred, preterm or prelabour uteri. The study found that these cases are extremely rare but can result in severe maternal and perinatal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Jing Peng, Ying Chen, Sheng Wan, Tianfan Zhou, Yu-Sin Chang, Xiaobo Zhao, Xiaolin Hua
Summary: This retrospective study aimed to investigate reliable biomarkers for predicting histological chorioamnionitis (HCA) in women with preterm prelabour rupture of membranes (PPROM). The study found that procalcitonin (PCT) could be a reliable biomarker for the early prediction of HCA in women with PPROM within 72 hours of dexamethasone treatment.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ariel Sklar, Jeanelle Sheeder, Anne R. Davis, Carrie Wilson, Stephanie B. Teal
Summary: This study compared maternal morbidity in women with preterm premature rupture of membranes who chose either expectant management or termination of pregnancy. The results showed that women who chose expectant management had higher morbidity rates, with an increased risk of chorioamnionitis and postpartum hemorrhage compared to those who chose termination of pregnancy. Expectant management was also associated with a higher likelihood of admission to the maternal intensive care unit and unplanned hysterectomy. The study suggests that expectant management increases maternal morbidity compared to termination of pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Stefania Ronzoni, Isabelle Boucoiran, Mark H. Yudin, Jillian Coolen, Christy Pylypjuk, Nir Melamed, Ann C. Holden, Graeme Smith, Jon Barrett
Summary: This article provides clear and concise guidelines for the diagnosis and management of preterm prelabour rupture of membranes (PPROM) in patients with less than 37 weeks of gestation. The guidelines are based on a comprehensive review of evidence on diagnosis, management, timing, and method of delivery. The article aims to provide healthcare providers with updated and comprehensive recommendations based on a wide range of research studies.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY CANADA
(2022)
Article
Obstetrics & Gynecology
Sarah W. Freeman, Annalies Denoble, Jeffrey A. Kuller, Sarah Ellestad, Sarah Dotters-Katz
Summary: This article reviews the comparison between immediate delivery and expectant management for patients with late preterm prelabor rupture of membranes (PPROM). The evidence shows that there is no significant difference in neonatal sepsis rates between the two groups. Expectant management increases the likelihood of reaching full term pregnancies while decreasing the rate of cesarean delivery. However, there is an increased risk of antepartum hemorrhage and histologic chorioamnionitis in the expectant management groups.
OBSTETRICAL & GYNECOLOGICAL SURVEY
(2022)
Article
Nutrition & Dietetics
Haoyue Cheng, Peihan Chi, Yan Zhuang, Xialidan Alifu, Haibo Zhou, Yiwen Qiu, Ye Huang, Libi Zhang, Diliyaer Ainiwan, Zhicheng Peng, Shuting Si, Hui Liu, Yunxian Yu
Summary: This study conducted Mendelian randomization (MR) analysis and found no causal relationship between 25-hydroxyvitamin D (25(OH)D) concentrations in the three trimesters and the risk of preterm birth (PTB), premature rupture of membranes (PROM), and preterm premature rupture of membranes (PPROM).
Article
Immunology
Haoning Shi, Lingling Sun, Zhenjie Wang, Aimei Zhang, Huaiming Cao, Wanying Zhao, Hongyu Wang, Xiao Yang, Jing Li
Summary: This study evaluated and compared the predictive accuracy of serum markers for histological chorioamnionitis (HCA) in women with preterm prelabour rupture of membranes (PPROM). The results showed that maternal serum CRP and NLR could be used as predictive biomarkers for HCA in women with PPROM. A prediction model with high predictive value was also developed based on the results.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jana Hutter, Paddy J. Slator, Carla Avena Zampieri, Megan Hall, Mary Rutherford, Lisa Story
Summary: A study using MRI found that preterm premature rupture of membranes can cause a decline in placental function, mainly related to perfusion in the placenta. Multi-modal MRI measurements can be used to assess placental function and are correlated with gestational age at delivery.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Review
Microbiology
Nathalia M. Noda-Nicolau, Ourlad Alzeus G. Tantengco, Jossimara Polettini, Mariana C. Silva, Giovana F. C. Bento, Geovanna C. Cursino, Camila Marconi, Ronald F. Lamont, Brandie D. Taylor, Marcia G. Silva, Daniel Jupiter, Ramkumar Menon
Summary: This study determined the association between genital mycoplasmas and adverse pregnancy outcomes such as preterm labor, preterm birth, and preterm prelabor rupture of membranes. The results showed that women with these adverse pregnancy outcomes had significantly higher odds of presence with genital mycoplasmas compared to women who delivered at term.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Obstetrics & Gynecology
Marie Vincienne, Olivia Anselem, Anne Gaelle Cordier, Camille Le Ray, Vassilis Tsatsaris, Alexandra Benachi, Francois Goffinet
FETAL DIAGNOSIS AND THERAPY
(2018)
Article
Genetics & Heredity
Minh-Tuan Huynh, Lucie Tosca, Francois Petit, Jelena Martinovic, Alexis Proust, Jerome Bouligand, Jeanne Amiel, Elie Azria, Frederic Parisot, Virginie Benoit, Aline Receveur, Loic Drevillon, Gerard Tachdjian, Sophie Brisset
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2018)
Article
Obstetrics & Gynecology
Olivier Poujade, Elie Azria, Pierre-Francois Ceccaldi, Carine Davitian, Carine Khater, Paul Chatel, Emilie Pernin, Nizar Aflak, Martin Koskas, Agnes Bourgeois-Moine, Laurence Hamou-Plotkine, Morgane Valentin, Jean-Paul Renner, Carine Roy, Candice Estellat, Dominique Luton
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2018)
Article
Public, Environmental & Occupational Health
Fabienne El-Khoury, Anne-Laure Sutter-Dallay, Lidia Panico, Marie-Aline Charles, Elie Azria, Judith Van der Waerden, Maria Melchior
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2018)
Article
Immunology
D. S. N'Diaye, O. Launay, O. Picone, V. Tsatsaris, E. Azria, F. Rozenberg, M. Schwarzinger, Y. Yazdanpanah
Article
Public, Environmental & Occupational Health
Pauline Blanc-Petitjean, Bruno Carbonne, Catherine Deneux-Tharaux, Marina Salome, Francois Goffinet, Camille Le Ray
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2019)
Article
Obstetrics & Gynecology
Pauline Blanc-Petitjean, Thomas Schmitz, Marina Salome, Francois Goffinet, Camille Le Ray, Corinne Dupont, Catherine Crenn-Hebert, Adrien Gaudineau, Frederique Perrotte, Pierre Raynal, Elodie Clouqueur, Gael Beucher, Bruno Carbonne, Catherine Deneux-Tharaux, Pierre-Yves Ancel
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2020)
Article
Medicine, General & Internal
Veronique Pierrat, Laetitia Marchand-Martin, Stephane Marret, Catherine Arnaud, Valerie Benhammou, Gilles Cambonie, Thierry Debillon, Marie-Noelle Dufourg, Catherine Gire, Francois Goffinet, Monique Kaminski, Alexandre Lapillonne, Andrei Scott Morgan, Jean-Christophe Roze, Sabrina Twilhaar, Marie-Aline Charles, Pierre-Wes Ancel
Summary: This study aimed to describe neurodevelopment at age 5 among children born preterm. The results showed that rates of neurodevelopment disabilities increased as gestational age decreased and were higher in families with low socioeconomic status. The findings indicate that early interventions and support are crucial for preterm children to optimize their development outcomes.
BMJ-BRITISH MEDICAL JOURNAL
(2021)
Article
Obstetrics & Gynecology
I Monier, A. Ego, A. Benachi, A. Hocquette, B. Blondel, F. Goffinet, J. Zeitlin
Summary: The study compared the performance of different estimated fetal weight (EFW) charts at the third trimester ultrasound, finding significant differences in detecting small- and large-for-gestational age newborns between descriptive and prescriptive charts, with prescriptive charts having higher specificity but lower sensitivity.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Pediatrics
Peter Jones, Laetitia Marchand-Martin, Thomas Desplanches, Caroline Diguisto, Jeanne Fresson, Francois Goffinet, Stephane Dauger, Pierre-Yves Ancel, Andrei Scott Morgan
Summary: Inborn and outborn very preterm children, matched for gestational age and antenatal steroids, showed no difference in survival without moderate-to-severe neurodevelopmental impairment at 5.5 years of age. This suggests the significance of steroids in determining outcomes.
BMJ PAEDIATRICS OPEN
(2022)
Article
Obstetrics & Gynecology
Sophia Braund, Catherine Deneux-Tharaux, Loic Sentilhes, Aurelien Seco, Patrick Rozenberg, Francois Goffinet
Summary: This study investigated the association between induction of labor (IOL) and postpartum hemorrhage (PPH). The results showed a significant positive association between IOL and the risk of PPH, regardless of the method of induction. The quantity of oxytocin administered during labor explained one third of this association.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Obstetrics & Gynecology
Hugo Madar, Loic Sentilhes, Francois Goffinet, Marie-Pierre Bonnet, Patrick Rozenberg, Catherine Deneux-Tharaux
Summary: This study compared postpartum blood loss assessed by quantitative and calculated methods, and analyzed the incidence of abnormal blood loss with each method. It found that quantitative blood loss was lower than calculated blood loss, and the correlation between the two methods was moderate. The difference between them tended to increase with blood loss.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Medicine, Research & Experimental
Antonin Weckel, Thomas Guilbert, Clara Lambert, Celine Plainvert, Francois Goffinet, Claire Poyart, Celine Mehats, Agnes Fouet
Summary: Group A Streptococcus (GAS), a Gram-positive human-specific pathogen, causes a significant number of deaths worldwide, particularly in cases of puerperal fever. Little is known about the factors and mechanisms of GAS invasion and establishment in postpartum infections, but a study in an ex vivo infection model of the human decidua revealed some key findings about GAS behavior and immune response.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Letter
Obstetrics & Gynecology
Morgane Linard, Catherine Deneux-Tharaux, Elie Azria
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2018)
Article
Obstetrics & Gynecology
M. Linard, B. Blondel, C. Estellat, C. Deneux-Tharaux, D. Luton, J. F. Oury, T. Schmitz, L. Mandelbrot, E. Azria
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2018)