Review
Environmental Sciences
Jiezhang Mo, Doris Wai-Ting Au, Jiahua Guo, Christoph Winkler, Richard Yuen-Chong Kong, Frauke Seemann
Summary: Research indicates that environmental exposure to benzo[a]pyrene may cause osteotoxicity, which could be transgenerationally inherited. Genetic and epigenetic factors play important roles in regulating bone metabolism, and researchers propose two possible epigenetic regulatory circuits in relation to bone miRNAs and genes.
CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Environmental
Zuotao Zhang, Jiao Sun, Xiaoqiang Gong, Chongyang Wang, Hui Wang
Summary: A new sulfate-reducing bacterium, Desulforamulus aquiferis strain DSA, was found to degrade high molecular weight polycyclic aromatic hydrocarbons (HMW-PAHs) pyrene and benzo[a]pyrene, while reducing sulfate to sulfide. The metabolic processes for anaerobic pyrene and benzo[a]pyrene degradation were proposed based on detecting intermediates and analyzing the genome. This study provides new guidance for anaerobic HMW-PAHs degradation under sulfate-reducing conditions.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Angela L. Caipa L. Garcia, Jill E. E. Kucab, Halh Al-Serori, Rebekah S. S. Beck, Franziska Fischer, Matthias Hufnagel, Andrea Hartwig, Andrew Floeder, Silvia Balbo, Hayley Francies, Mathew Garnett, Meritxell Huch, Jarno Drost, Matthias Zilbauer, Volker M. M. Arlt, David H. H. Phillips
Summary: Human organoids derived from different tissues have the ability to metabolize the environmental carcinogen benzo[a]pyrene. The response and metabolite formation of the organoids varied between tissue types. This study demonstrates the potential of organoids for studying environmental carcinogenesis and genetic toxicology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Xiaoxue Zhang, Xiaomin Wang, Yan Li, Guohui Ning, Qian Zhang, Xuena Zhang, Wei Zheng, Zhixin Yang
Summary: This study compared the biosorption, transmembrane transport, and biodegradation of Pyr and BaP by Bacillus sp. strain M1. The results showed that BaP had a higher biosorption efficiency and reached peak adsorption efficiency faster than Pyr. Both Pyr and BaP entered the cells by passive transport. In terms of biodegradation, BaP had a significantly higher efficiency than Pyr around days 5-7 of culture. Key enzymes involved in BaP and Pyr degradation were identified.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Chemistry, Medicinal
Miki Tanaka, Yukako Komaki, Tatsushi Toyooka, Yuko Ibuki
Summary: HDAC inhibitors enhance the metabolic activation of BaP and increase DNA damage, possibly through excessive DNA adducts or oxidative DNA damage.
CHEMICAL RESEARCH IN TOXICOLOGY
(2022)
Article
Engineering, Environmental
Pengfei Cheng, Zhipeng Lin, Xuqiang Zhao, Michael Gatheru Waigi, Galina K. Vasilyeva, Yanzheng Gao
Summary: This study investigates the transformation of benzo(a)pyrene using different types of manganese oxides and their Fe(III)-modified analogues. The results show that Fe(III) modification greatly enhances the transformation capability of manganese oxides towards benzo(a)pyrene, attributed to the high Fe(III) content and abundant active free radicals. Fe(III) modification also increases the surface adsorbed water and oxygen, promoting the generation of active free radicals.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Jingnan Jin, Yahui Shi, Baozhong Zhang, Dongjin Wan, Qingye Zhang, Ying Li
Summary: In this study, a BaP-degrading strain Pannonibacter sp. JPA3 was isolated from oil well production water, which could remove 80% of BaP at an initial concentration of 100 mg L-1 after 35 days of culture. The metabolites BaP-4,5-dihydrodiol, BaP-4,5-epoxide, 5-hydroxychrysene, and 2-hydroxy-1-naphthoic acid were identified in the biodegradation process. A dioxygenase model was built and molecular docking was performed to investigate the interaction mechanism between BaP and dioxygenase. A hypothesis for the progressive degradation mechanism of BaP by this strain was proposed based on the identification of downstream metabolites. In conclusion, this study provided an efficient BaP degrader and a comprehensive reference for the study of degradation mechanisms at the molecular level.
Article
Engineering, Environmental
Ning Sun, Jinhu Wang, Huijian Shi, Xiangxiang Li, Shuqi Guo, Yaoyue Wang, Shaoyang Hu, Rutao Liu, Canzhu Gao
Summary: Through combined experimental and simulation studies, it was found that polystyrene nanoplastics (PS NPs) and benzo[a]pyrene (BaP) exhibit synergistic toxicity in inducing oxidative stress. The cellular reactive oxygen species (ROS) levels were higher under co-exposure of PS NPs and BaP compared to individual exposure. Furthermore, BaP and PS NPs inhibited the decomposition of H2O2 by affecting the structure of the enzyme CAT, exacerbating oxidative stress. This study provides a new perspective and approach for understanding the toxicity of combined pollutants.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Marie Usal, Sylvie Veyrenc, Marie Darracq--Ghitalla-Ciock, Christophe Regnault, Sophie Sroda, Jean-Baptiste Fini, Cecile Canlet, Marie Tremblay-Franco, Muriel Raveton, Stephane Reynaud
Summary: This study demonstrates that exposure to endocrine disruptor benzo[a]pyrene can induce delayed metamorphosis, fatty liver, and disrupted metabolism in F2 offspring of Xenopus tropicalis, ultimately leading to population collapse. These findings suggest a potential transgenerational impact of endocrine disruptors on metabolism in amphibians, supporting the link between environmental endocrine disruptors and metabolic diseases in humans.
ENVIRONMENTAL POLLUTION
(2021)
Article
Environmental Sciences
Jisheng Nie, Yu Zhang, Lijun Ning, Zhiwei Yan, Lei Duan, Huaxing Xi, Qiao Niu, Qunwei Zhang
Summary: The study demonstrates that Benzo[a]pyrene (B[a]P) induces neuronal apoptosis through a dose- and time-dependent manner, and the Cdk5/p53 signaling pathway may play a role in this process. The use of roscovitine, a specific Cdk5 inhibitor, shows potential in alleviating B[a]P-induced neuronal apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Xue Zhang, Zihan Sun, Jinxia Liu, Tao Wang, Bolin Zhang, Hongfei Zhao
Summary: The aim of this study was to investigate the influence of bovine serum albumin (BSA) on the Lactobacillus-strain-mediated removal of benzo[a]pyrene (BaP). Combination of BSA with bacterial cells had varying levels of BaP removal for different strains. BSA enhanced the affinity between the bacterial cells and BaP, with its stability and surface properties affecting the binding process.
Article
Multidisciplinary Sciences
Alexis Nzila, Musa M. Musa, Saravanan Sankara, Marwan Al-Momani, Lei Xiang, Qing X. Li
Summary: This study presents a halophilic bacterial strain 10SBZ1A capable of degrading PAHs, particularly BaP, in petroleum waste effluent and removing BaP from soil. This strain demonstrates potential for bioremediation of oil-contaminated environments with high salinity levels.
Article
Environmental Sciences
Bin Chen, Jiang Xu, Huijie Lu, Lizhong Zhu
Summary: This study aimed to remove benzo[a]pyrene (BaP) contamination by combining moderate chemical oxidation with microbial degradation. Different types and dosages of oxidants were compared, and the results showed that a moderate dose of potassium permanganate (KMnO4) had the highest removal efficiency of BaP in loam clay and sandy soils. Additionally, this approach minimized disturbances to soil pH and organic carbon (OC), and the dominant microorganisms Burkholderiaceae, Enterobacteriaceae, Alicyclobacillaceae, and Oxalobacteraceae played a key role in BaP removal through the expression of the polycyclic aromatic hydrocarbon-ring hydroxylated dioxygenase gene. Overall, this combined technique of moderate chemical oxidation and microbial degradation is a promising method for remediation of BaP-contaminated soils.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Yunxia Han, Xueli Wang, Xiaoxiao He, Menghui Jia, Haifeng Pan, Jinquan Chen
Summary: In this study, the excited state dynamics of benzo[a]pyrene were investigated using time-resolved fluorescence and transient absorption spectroscopy. It was found that benzo[a]pyrene in its singlet excited state can react with oxygen, leading to fluorescence quenching. Furthermore, efficient intersystem crossing from singlet state to triplet state was observed. Additionally, the interaction between benzo[a]pyrene and ct-DNA were directly observed, and charge transfer between the two may be the reason. These findings provide a foundation for understanding the carcinogenic mechanism of benzo[a]pyrene and the photo-degradation mechanism of this molecule.
Article
Chemistry, Multidisciplinary
Yongyi Wei, Hainan Sun, Bing Yan
Summary: Environmental carbon nanomaterials, such as multi-walled carbon nanotubes and graphene oxides, interact with aromatic hydrocarbon pollutants, resulting in adverse effects on ecosystems and human health. The combined toxicity of carbon nanomaterials and benzo[a]pyrene is still unknown. Among the investigated carbon nanomaterials, MWCNTs-NH2, p-GO, and GO-COOH showed some alleviation of the cytotoxicity induced by benzo[a]pyrene, with GO-COOH exhibiting the strongest inhibitory effect. Mechanistically, GO-COOH reduced benzo[a]pyrene-induced cell apoptosis and cytotoxicity by regulating apoptotic proteins and maintaining mitochondrial membrane potential. These findings highlight the importance of the physicochemical properties of carbon nanomaterials in modulating the cytotoxicity of benzo[a]pyrene.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
