Article
Toxicology
Xiaozhuan Liu, Yuwei Zhang, Lijun Shen, Zhidong He, Yao Chen, Ning Li, Xiuli Zhang, Tingting Zhang, Suhua Gao, Haodi Yue, Zhitao Li, Zengli Yu
Summary: Treatment with all-trans retinoic acid (atRA) promotes the upregulation of Meg3 in mouse embryonic palate mesenchymal (MEPM) cells, leading to a suppression of cell proliferation potentially through interacting with Smad2 protein to inhibit Smad signaling.
TOXICOLOGY LETTERS
(2021)
Article
Oncology
Zhiqiang Sun, Tengfeng Yan, Hongxiang Jiang, Jiayang Cai, Xiwei Zhu, Qianxue Chen
Summary: In this study, the role of Claudin-3 (CLDN3) in the pathogenesis and progression of glioblastoma multiforme (GBM) was investigated. It was found that CLDN3 was upregulated in GBM and could promote tumor cell growth and epithelial-mesenchymal transition (EMT). Furthermore, CLDN3 was involved in the tumorigenic effects of transforming growth factor-beta (TGF-beta). Developing specific inhibitors of CLDN3 could potentially be a promising new approach for treating GBM.
Article
Biochemistry & Molecular Biology
Fang Chen, Qi Gao, Ai Wei, Xingren Chen, Yujun Shi, Hongwei Wang, Wangsen Cao
Summary: The study reveals that aberrant HDAC3 induction and subsequent Klotho suppression play a crucial role in promoting renal fibrogenesis. The selective HDAC3 inhibitor RGFP966 shows significant efficacy in mitigating renal fibrotic injuries.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
Bei Pu, Xu Zhang, Tengfeng Yan, Yuntao Li, Baohui Liu, Zhihong Jian, Omer Kamal Mahgoub, Lijuan Gu, Xiaoxing Xiong, Ning Zou
Summary: Recent studies have shown that MICAL2 plays a role in promoting proliferation and migration of glioblastoma through the TGF-beta/p-Smad2/EMT-like signaling pathway. Knockdown of MICAL2 can inhibit the growth and invasion abilities of glioblastoma cells. High MICAL2 expression predicts poor prognosis in GBM patients, making it a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Panyu Yang, Yanyan Yang, Pin Sun, Yu Tian, Fang Gao, Chen Wang, Tingyu Zong, Min Li, Ying Zhang, Tao Yu, Zhirong Jiang
Summary: Beta II spectrin plays crucial roles in the development of various organs and regulates multiple cellular functions. Dysfunction of beta II spectrin is associated with diseases, highlighting the potential therapeutic targets for future research. Understanding the regulatory mechanism of beta II spectrin signal inactivation and recovery may offer hope for the treatment of related diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Reproductive Biology
Zengli Yu, Guoxu Wang, Shuaixing Song, Yaxin Zhang, Yang Wu, Yuwei Zhang, Wenjing Duan, Xiaozhuan Liu
Summary: This study found that atRA suppressed MEPM cell proliferation, upregulated Meg3 expression, and reduced the phosphorylation levels of Smad2 and Tgfβ2. RNA immunoprecipitation experiments confirmed that Meg3 directly targets the TgfβI receptor, suggesting that atRA-induced cleft palate may be mediated through the Tgfβ/Smad signaling pathway.
REPRODUCTIVE TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoshuang Wang, Mei Feng, Tengfei Xiao, Baosen Guo, Danyang Liu, Chenglong Liu, Jinpeng Pei, Qiaofeng Liu, Yi Xiao, Rina Rosin-Arbesfeld, Ying Shi, Yang Zhou, Mengxuan Yang, Yu-Xiong Feng, Yizhou Jiang, Zhimin Shao, Ker Yu, Di Zhu
Summary: The expression of BCL9 and BCL9L is correlated with malignancy in TNBC patient tumors, and they promote tumor cell growth, migration, and metastasis. Inhibition of BCL9/BCL9L and TGF-beta suppresses Treg activity, while TGF-beta signaling increases tumor infiltration of cytotoxic CD8 (+) T cells. Inhibiting BCL9/BCL9L synergizes with PD-1/L1 antibodies to inhibit tumor growth.
Review
Biochemistry & Molecular Biology
Hong-Lian Wang, Li Wang, Chang-Ying Zhao, Hui-Yao Lan
Summary: Research has shown that TGF-beta signaling plays diverse roles in beta cell development, function, proliferation, and apoptosis, with Smad3 identified as a key mediator and ideal therapeutic target for type-2 diabetes. However, the effects of Smad7 on beta cell proliferation and glucose homeostasis remain controversial. Overexpression of Tgfb1 has been found to prevent beta cells from autoimmune destruction without affecting beta cell function. These findings highlight the complex regulatory roles of TGF-beta signaling in beta cell biology.
Article
Cell Biology
Weiwei Sheng, Jingtong Tang, Rongxian Cao, Xiaoyang Shi, Yuteng Ma, Ming Dong
Summary: The isoform-specific function of Numb in cancers, particularly in the initiation of epithelial-to-mesenchymal transition (EMT), is still controversial. Our study focused on the Numb-PRRL isoform in activated EMT of pancreatic ductal adenocarcinoma (PC), showing that Numb-PRRL promotes TGF-beta 1- and EGF-induced EMT in PC by regulating TGF-beta 1-Smad2/3-Snail and EGF-induced EGFR-ERK/MAPK signaling pathways.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Qianqian Ju, Maorong Jiang, Wenxin Huang, Qingbo Yang, Zhenghong Luo, Hui Shi
Summary: This study investigated the mechanisms underlying the biological activity of CtBP2 in esophageal squamous cell carcinoma (ESCC) and demonstrated that CtBP2 interacts with TGIF and promotes the malignant progression of ESCC through the Wnt/beta-catenin pathway.
Article
Oncology
Abhilasha Srivastava, Harshita Sharma, Simran Khanna, Tejasvini Sadhu Balasundaram, Shibasish Chowdhury, Rajdeep Chowdhury, Sudeshna Mukherjee
Summary: HCC is associated with inflammation, and IL-6 and TGF-beta are enriched in HCC. IL-6 promotes proliferation by acting on NFkB, while TGF-beta induces mesenchymal transition and growth arrest. Combining IL-6 and TGF-beta weakens IL-6-induced proliferation but has little impact on mesenchymal transition. TGF-beta attenuates IL-6 effects by regulating receptor levels, downstream signaling, and the epigenome.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Pedro Garcia-Gomez, Irene Golan, Mahsa S. Dadras, Artur Mezheyeuski, Claudia Bellomo, Kalliopi Tzavlaki, Anita Moren, Jordi Carreras-Puigvert, Laia Caja
Summary: This study investigates the crucial roles of TGF beta and ROS in GSC biology, revealing the key regulatory function of NOX4 in GSCs.
MOLECULAR ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Siqi Liu, Bingyu Shen, Juan J. Loor, Qianming Jiang, Yang Yuan, Yezi Kong, Panpan Tan, Fangyuan Zeng, Chenxu Zhao, Xiaoyan Zhu, Jianguo Wang
Summary: The present study evaluated the effects of strontium on the proliferation and differentiation of chondrocytes. It was found that strontium promotes cell proliferation and inhibits cell differentiation by directing TGF beta signaling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jiangcheng Shu, Lizhi Hu, Yichen Wu, Long Chen, Kai Huang, Zhaohui Wang, Minglu Liang
Summary: This study reveals that daidzein has an anti-fibrotic effect in myocardial fibrosis by reducing the activation of cardiac fibroblasts induced by TGF-beta 1, partially through regulating the TGF-beta 1/SMAD2/3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andi Shi, Michele M. G. Hillege, Rob C. Wust, Gang Wu, Richard T. Jaspers
Summary: The study demonstrates that TGF-beta 1 and TGF-beta 3 have different effects on gene expression in C2C12 myoblasts and myotubes, promoting collagen production in differentiating myoblasts but with less impact in myotubes. TGF-beta 3 does not effectively counteract TGF-beta 1-induced collagen production in muscle cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)