Article
Environmental Sciences
Alexander N. Larcombe, Melissa G. Papini, Emily K. Chivers, Luke J. Berry, Robyn M. Lucas, Caitlin S. Wyrwoll
Summary: This study shows for the first time that long-term exposure to environmentally relevant levels of CO2 can impact respiratory function in mice, particularly in female mice. Importantly, it suggests that the early life period, when lungs are undergoing rapid growth and development, is particularly sensitive to CO2.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Critical Care Medicine
Geremy Clair, Lisa M. Bramer, Ravi Misra, Matthew D. McGraw, Soumyaroop Bhattacharya, Joseph A. Kitzmiller, Song Feng, Vincent G. Danna, Gautam Bandyopadhyay, Harsh Bhotika, Heidie L. Huyck, Gail H. Deutsch, Thomas J. Mariani, James P. Carson, Jeffrey A. Whitsett, Gloria S. Pryhuber, Joshua N. Adkins, Charles Ansong
Summary: This study provides a comprehensive analysis of the human lung proteome during development, revealing distinct molecular substages of alveolar development and evidence of post-transcriptional control in early postnatal development. The study also supports the extensive remodeling of the lung proteome during development and the concept of immune system maturation as an inherent part of normal lung development.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Pediatrics
Kurt H. Albertine, Mar Janna Dahl, Andrew Rebentisch, Elaine Dawson, Akbar Nabi, Sydney Bowen, Cindy Miers, Zhengming Wang, Haixia Yang, Baifeng Yu, Donald M. Null, Dennis Keefe, J-K Chung, Z. Zhou, Norman Barton, Galen Carey, Robert Ward
Summary: This study used a preterm lamb model to investigate the effect of continuous infusion of recombinant human (rh) IGF-1 bound to binding protein-3 (IGFBP-3) on plasma IGF-1 levels and pulmonary and cardiovascular outcomes. The results showed that three days of continuous infusion of 1.5 mg/kg/day of rhIGF-1/rhIGFBP-3 improved some pulmonary and cardiovascular outcomes without toxicity.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, Research & Experimental
Sheng Xia, Heather L. Menden, Nick Townley, Sherry M. Mabry, Jeffrey Johnston, Michael F. Nyp, Daniel P. Heruth, Thomas Korfhagen, Venkatesh Sampath
Summary: The study reveals the critical role of DLL4 in lung development, as haploinsufficiency of Dll4 may lead to dysmorphic microvascularization, impairing alveolarization.
Article
Allergy
William W. Busse, Stanley J. Szefler, Tmirah Haselkorn, Ahmar Iqbal, Benjamin Ortiz, Bobby Q. Lanier, Bradley E. Chipps
Summary: This study found that patients treated with omalizumab experienced larger increases in ppFEV(1) and FEV1 compared with placebo-treated patients in both pediatric and pooled adolescent/adult populations. In the adolescent/adult population, both exacerbators and nonexacerbators derived similar benefit with omalizumab compared with placebo.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Pediatrics
Matthew Marcelino, Charles L. Cai, Stephen Wadowski, Jacob V. Aranda, Kay D. Beharry
Summary: Early supplementation with fish oil and/or antioxidants in rats exposed to neonatal intermittent hypoxia (IH) improves biomarkers of lung alveolarization and microvascular maturation, and reduces IH-induced lung injury.
PEDIATRIC PULMONOLOGY
(2023)
Article
Cell Biology
Christian Muehlfeld, Henri Schulte, Johanna Christine Jansing, Costanza Casiraghi, Francesca Ricci, Chiara Catozzi, Matthias Ochs, Fabrizio Salomone, Christina Brandenberger
Summary: This study aimed to investigate the pathophysiological characteristics of bronchopulmonary dysplasia (BPD) using a rabbit model in a hyperoxic environment. The results showed that rabbit pups exposed to high oxygen environment had impaired lung function, signs of pulmonary hypertension, decreased alveolar number and area. Additionally, they exhibited thickened alveolar septa, intra-alveolar accumulation of edema fluid and inflammatory cells, as well as thickened walls and smaller lumen in nonparenchymal blood vessels.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Medicine, General & Internal
Thais Ferrari da Cruz, Rogerio Rufino, Agnaldo Lopes, Claudia Henrique Costa
Summary: Three female subjects with alpha-1 antitrypsin deficiency showed changes in nitrogen washout tests despite not having COPD, suggesting the test's sensitivity in detecting early signs of small airways disease.
Article
Physiology
Shailaja Rao, Min Liu, Cristiana Iosef, Carsten Knutsen, Cristina M. Alvira
Summary: This study demonstrates the crucial role of the IKKb signaling pathway in endothelial cells for alveolarization and vascular development in the lung. Loss of IKKb leads to disorganized lung vasculature and decreased alveolar counts. Understanding this pathway may provide new targets for enhancing beneficial angiogenic signaling in lung development and disease.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zixue Jin, Ming-Ming Jiang, Brendan Lee
Summary: Inhaled nitric oxide therapy can improve lung growth in premature newborns, but the mechanisms by which nitric oxide regulates lung development are still not clear. Nitric oxide is produced by three isoforms of nitric oxide synthase enzymes, and mice lacking these isoforms show impaired lung alveolarization, indicating the important role of nitric oxide in lung development. The enzyme argininosuccinate lyase is required for nitric oxide synthesis, and its deficiency is a model for nitric oxide deficiency. In this study, lung alveolarization was decreased in argininosuccinate lyase-deficient mice, and supplementation of nitric oxide partially restored lung alveolarization. Endothelial-specific knockout mice also showed impaired lung alveolarization, further supporting the role of endothelial-derived nitric oxide in promoting lung development.
HUMAN MOLECULAR GENETICS
(2023)
Article
Respiratory System
Emma Satrell, Hege Clemm, Ola Drange Roksund, Karl Ove Hufthammer, Einar Thorsen, Thomas Halvorsen, Maria Vollsaeter
Summary: Pulmonary diffusing capacity in extremely preterm (EP) infants compared to term-born subjects remains reduced during adulthood, with development tracking in parallel to controls, showing no signs of catch-up growth or decline at age 25 years.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Allergy
Nur Sabrina Idrose, E. Haydn Walters, Jingwen Zhang, Don Vicendese, Ed J. Newbigin, Jo A. Douglass, Bircan Erbas, Adrian J. Lowe, Jennifer L. Perret, Caroline J. Lodge, Shyamali C. Dharmage
Summary: Outdoor pollen exposure is associated with type-2 airway inflammation in both the upper and lower airways, with little evidence of lung function changes. Seasonal pollen, eosinophilia, and ECP levels may be related to allergic rhinitis, but results vary between studies. Eosinophilic airway inflammation due to outdoor pollen exposure may increase with age in susceptible individuals with asthma and allergic rhinitis.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Environmental Sciences
Yihan Wu, Hongjin Li, Dong Xu, Huichu Li, Zhe Chen, Yu Cheng, Guanjin Yin, Yue Niu, Cong Liu, Haidong Kan, Dedong Yu, Renjie Chen
Summary: This study found that short-term exposure to PM2.5 is associated with changes in airway inflammation, lung function, and bacterial community diversity in children. Among the PM2.5 constituents, organic carbon, elemental carbon, NO3-, and NH4+ showed the strongest associations with these effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pediatrics
Godwill Azeh Engwa, Chungag Anye, Benedicta Ngwenchi Nkeh-Chungag
Summary: This study found an association between obesity and airway obstruction in South African adolescents of African ancestry, suggesting that obese adolescents are more likely to have impaired lung function.
Article
Medicine, General & Internal
Eva Revilla-Lopez, Victoria Ruiz de Miguel, Manuel Lopez-Meseguer, Cristina Berastegui, Meritxell Boada-Perez, Alberto Mendoza-Valderrey, Marta Arjona-Peris, Marta Zapata-Ortega, Victor Monforte, Carlos Bravo, Antonio Roman, Susana Gomez-Olles, Berta Saez-Gimenez
Summary: The authors examined the diagnostic accuracy of various biomarkers for lymphangioleiomyomatosis (LAM) and found that the combination of MMP-2 and VEGF-D can improve the diagnostic accuracy for LAM.
FRONTIERS IN MEDICINE
(2023)