Article
Nutrition & Dietetics
Yu-Min Huang, Weu Wang, Po-Pin Hsieh, Hsin-Hung Chen
Summary: The genetic effect of obesity plays a significant role in the development of an obesogenic environment. Genes rs712221 and rs2016520 are associated with obesity and show a synergistic effect, increasing the risk of obesity.
Article
Endocrinology & Metabolism
Yohei Masunaga, Yasuko Fujisawa, Francesco Massart, Claudio Spinelli, Yoshiyuki Kojima, Kentaro Mizuno, Yutaro Hayashi, Isoji Sasagawa, Rie Yoshida, Fumiko Kato, Maki Fukami, Naoyuki Kamatani, Hirotomo Saitsu, Tsutomu Ogata
Summary: The AGATC haplotype is strongly associated with cryptorchidism in Italian boys. The study identified a 2249-bp microdeletion (?ESR1) in boys with the specific haplotype, which is strongly associated with cryptorchidism and hypospadias. This finding suggests that ?ESR1 is the true susceptibility factor for cryptorchidism and hypospadias.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Engineering, Environmental
Wang Luo, You Wu, Xueping Chen, Li Zhang, Li Wang, Dan Bai, Qian Liu, Ting Wang, Hongyan Yu, Yaxing Xie, Yixin Fu, Zhongzhong Wang, Yujun Yang, Junjie Li, Yongcan Guo, Ke Lv, Guoming Xie
Summary: Combinations of statistically related SNPs, known as haplotypes, can provide richer medical and genetic information than isolated SNPs. However, determining whether SNP loci separated by thousands of bases are located on the same chromosome is challenging and time-consuming. This study developed a mathematical logic-based algorithm, using DNA nanotechnology and thermodynamic mechanisms, to simplify the analysis of long-range haplotypes. The results have the potential to contribute to the development of personalized applications of haplotype analysis.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Fisheries
Xin He, Yushan Liao, Zexin Yang, Hongxing Liu, Shi Wang, Yongbo Bao
Summary: The blood clam Tegillarca granosa is a commercially important bivalve species. This study conducted genome-wide association studies and identified 39 SNP markers associated with the growth traits of T. granosa. Additionally, 27 candidate genes potentially involved in T. granosa growth were identified. Enrichment analysis highlighted the role of transmembrane transport, immune system function, protein family metabolism, and JAK-STAT signaling pathways in T. granosa growth.
Article
Plant Sciences
Alejandro Carmona, Josefa Rubio, Teresa Millan, Juan Gil, Jose V. Die, Patricia Castro
Summary: Ascochyta blight, caused by the fungal pathogen Ascochyta rabiei, is a significant threat to chickpea cultivation worldwide. This study identified four genomic regions associated with Ascochyta blight resistance, among which the LOC101507066 gene showed the most potential as a candidate gene.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Oncology
Ning Ma, Ao Jin, Yitong Sun, Yiyao Jin, Yucheng Sun, Qian Xiao, XuanYi Sha, Fengxue Yu, Lei Yang, Wenxuan Liu, Xia Gao, Xiaolin Zhang, Lu Li
Summary: This study focused on the relationship between single nucleotide polymorphisms (SNPs) of MMR genes and hepatocellular carcinoma (HCC) associated with chronic hepatitis B virus (HBV) infection. The findings revealed that 12 SNPs were associated with genetic susceptibility to HCC. Additionally, interactions between genes and the impact of SNPs on genetic susceptibility to HCC were also observed. These findings provide new insights for further exploration of the etiology and pathogenesis of HCC.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Francesca Taranto, Giacomo Mangini, Monica Marilena Miazzi, Piergiorgio Stevanato, Pasquale De Vita
Summary: Studying the genetic basis of polyphenol oxidases (PPO) related traits is crucial for crop genetic improvement. By analyzing a tetraploid wheat collection using 90K wheat SNP iSelect assay, 23 marker-trait associations related to PPO activity were detected, and two haplotypes associated with low and high PPO activity were identified. A reliable marker for marker assisted selection was developed, and genetic divergence between T. turgidum subspecies was evaluated using the detected associations.
Article
Biochemistry & Molecular Biology
David Wragg, Sonia E. Eynard, Benjamin Basso, Kamila Canale-Tabet, Emmanuelle Labarthe, Olivier Bouchez, Kaspar Bienefeld, Malgorzata Bienkowska, Cecilia Costa, Ales Gregorc, Per Kryger, Melanie Parejo, M. Alice Pinto, Jean-Pierre Bidanel, Bertrand Servin, Yves Le Conte, Alain Vignal
Summary: Honey bee subspecies originate from specific geographical areas and have been imported to different regions. To better understand Western European honey bee populations, researchers conducted a genome sequence and SNP genotype analysis.
MOLECULAR ECOLOGY RESOURCES
(2022)
Article
Cardiac & Cardiovascular Systems
Jairo Lumpuy-Castillo, Claudia Vales-Villamarin, Ignacio Mahillo-Fernandez, Iris Perez-Nadador, Leandro Soriano-Guillen, Oscar Lorenzo, Carmen Garces
Summary: This study analyzed the relationship between ACE2 polymorphisms and cardiovascular risk factors in children, and found that certain ACE2 mutations are associated with obesity and hyperlipidemia in females.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Fisheries
Baohua Duan, Tongxu Kang, Haifu Wan, Shumei Mu, Yueqiang Guan, Weibiao Liu, Zejian Li, Yang Tian, Yuqin Ren, Xianjiang Kang
Summary: The SIF gene in the swimming crab (Portunus trituberculatus) was investigated to understand its biological function. The study found that the SIF gene had higher expression in the fast-growing group compared to the slow-growing group, and it was ubiquitously expressed in various tissues, with the highest expression in the heart. Additionally, four SNPs in the SIF gene were found to be significantly associated with growth traits in the swimming crab.
AQUACULTURE REPORTS
(2023)
Article
Plant Sciences
Sven E. Weber, Matthias Frisch, Rod J. Snowdon, Kai P. Voss-Fels
Summary: Genomic selection is the preferred method for selecting superior genotypes in modern plant breeding. Using haplotype blocks can improve prediction accuracy, especially in settings with low marker density. However, the method for constructing haplotype blocks should be adjusted based on the specific dataset.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Zuoxiang Liang, Dzianis Prakapenka, Yang Da
Summary: This study evaluated the accuracy of predicting seven human phenotypes using global epistasis effects and compared it to haplotype genomic prediction. The results showed that haplotype effects were more important for prediction accuracy, but pairwise epistasis effects improved the accuracy for six traits. Integrating epistasis and haplotype effects slightly increased the prediction accuracy, especially for HDL and BMIo traits.
Article
Biotechnology & Applied Microbiology
Seyed Milad Vahedi, Siavash Salek Ardetani, Luiz F. Brito, Karim Karimi, Kian Pahlavan Afshari, Mohammad Hossein Banabazi
Summary: This study evaluates the accuracy and bias of haplotype-based genomic prediction (GP) compared to single nucleotide polymorphism (SNP) based GP in a wild sheep population. The results show that haplotype-based GP improves the prediction accuracy of anti-helminthic antibody traits IgA and IgG compared to SNP-based GP.
Article
Agronomy
Yu Zhang, Yu Wang, Dong Wu, Dong Qu, Xiaomin Sun, Xiaojuan Zhang
Summary: This study examined the SNP and Hd diversity of BnP5CR2 among canola cultivars with different resistance levels to S. sclerotiorum, as well as the expression patterns of BnP5CR2. The results show that gene-CDS-haplotype diversity may have greater power than SNPs for the detection of causal genes for quantitative traits.
Article
Genetics & Heredity
Yang Da, Zuoxiang Liang, Dzianis Prakapenka
Summary: The rapid growth in genomic selection data presents unprecedented opportunities to discover and utilize complex genetic effects for improving phenotypes, but there is a lack of methodology. This study developed multifactorial methods to investigate the contributions of global low-order and local high-order epistasis effects to phenotypic variance and the accuracy of genomic prediction of quantitative traits. These methods provide a capability to evaluate the contributions of complex genetic effects to phenotypic variance and prediction accuracy and discover and utilize complex genetic effects for improving quantitative trait phenotypes.
FRONTIERS IN GENETICS
(2022)
Article
Hematology
Huifeng Hao, Sheng Hu, Qing Wan, Chuansheng Xu, Hong Chen, Liyuan Zhu, Zhenyu Xu, Jian Meng, Richard M. Breyer, Nailin Li, De-Pei Liu, Garret A. FitzGerald, Miao Wang
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Editorial Material
Hematology
Miao Wang, Huifeng Hao, Nicholas J. Leeper, Liyuan Zhu
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Hematology
X. Miao, M. F. -U. Rahman, L. Jiang, Y. Min, S. Tan, H. Xie, L. Lee, M. Wang, R. E. Malmstrom, W. -O. Lui, N. Li
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2018)
Article
Pharmacology & Pharmacy
Lihong Chen, Guangrui Yang, Tingting Jiang, Soon Yew Tang, Tao Wang, Qing Wan, Miao Wang, Garret A. FitzGerald
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2019)
Article
Multidisciplinary Sciences
Liyuan Zhu, Chuansheng Xu, Xingyu Huo, Huifeng Hao, Qing Wan, Hong Chen, Xu Zhang, Richard M. Breyer, Yu Huang, Xuetao Cao, De-Pei Liu, Garret A. FitzGerald, Miao Wang
NATURE COMMUNICATIONS
(2019)
Article
Plant Sciences
Huifeng Hao, Wenjia Tian, Chunshui Pan, Yanna Jiao, Xinxin Deng, Jingyu Fan, Jingyan Han, Shuyan Han, Miao Wang, Pingping Li
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Editorial Material
Hematology
Zekun Peng, Bingyan Shu, Yurong Zhang, Miao Wang
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Review
Hematology
Liyuan Zhu, Yuze Zhang, Ziyi Guo, Miao Wang
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2020)
Article
Hematology
Shuai Tan, Shuijie Li, Yanan Min, Anton Gistera, Noah Moruzzi, Junhao Zhang, Yang Sun, John Andersson, Rickard E. Malmstrom, Miao Wang, Per-Olof Berggren, Susanne Schlisio, Wangjun Liao, Daniel F. J. Ketelhuth, Chunhong Ma, Nailin Li
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2020)
Article
Cell Biology
Huifeng Hao, Xiaoyan Ma, Hong Chen, Liyuan Zhu, Zhenyu Xu, Qiaoling Li, Chuansheng Xu, Yuze Zhang, Zekun Peng, Miao Wang
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Yuze Zhang, Huihui Li, Yonghu Huang, Hong Chen, Haojie Rao, Guoli Yang, Qing Wan, Zekun Peng, John Bertin, Brad Geddes, Michael Reilly, Jean-Luc Tran, Miao Wang
Summary: RIPK1 plays a stage-dependent regulatory role in the development of atherosclerosis, with both pro-atherosclerotic effects and anti-atherosclerotic effects. It is important to consider the impact at different stages during the treatment process.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Qing Wan, Chuansheng Xu, Liyuan Zhu, Yuze Zhang, Zekun Peng, Hong Chen, Haojie Rao, Erli Zhang, Hongyue Wang, Fei Chu, Xuan Ning, Xuejian Yang, Jinqing Yuan, Yongjian Wu, Yu Huang, Shengshou Hu, De-Pei Liu, Miao Wang
Summary: PDE4B plays a critical role in neutrophil inflammation and microvascular obstruction, leading to myocardial ischemia-reperfusion (MI/R) injury.
CIRCULATION RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Qian Yu, Sheng Hu, Wei Li, Lianjuan Yang
Summary: This article describes a case of Green Nail Syndrome (GNS) caused by wearing personal protective equipment for prolonged durations. The case occurred during the outbreak of the SARS-CoV-2 Omicron variant in Shanghai, and the patient was cured with proper treatment.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ying Song, Xiao Fang Tang, Yi Yao, Chen He, Jing Jing Xu, Huan Huan Wang, Zhan Gao, Miao Wang, Jin Qing Yuan
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2017)
Article
Cardiac & Cardiovascular Systems
Huifeng Hao, Sheng Hu, Hong Chen, Dawei Bu, Liyuan Zhu, Chuansheng Xu, Fei Chu, Xingyu Huo, Yue Tang, Xiaogang Sun, Bi-Sen Ding, De-Pei Liu, Shengshou Hu, Miao Wang