Article
Psychiatry
Xiuhua Song, Yufang Feng, Lei Yi, Baoliang Zhong, Yi Li
Summary: The objective of this case-control study is to determine whether the blood thyroid hormone levels in bipolar disorder patients are associated with different types of first onset. The study found that thyroid dysfunction may be involved in the disease progression of bipolar disorder and correlated with the clinical symptoms in patients with depression or mania as the first episode.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Luis R. Patino, Maxwell J. Tallman, Hongbo Wen, Caleb M. Adler, Jeffrey A. Welge, Melissa P. DelBello
Summary: The objective of this study was to evaluate differences in sustained attention and associated neurofunctional profiles between bipolar disorder type I, attention-deficit/hyperactivity disorder, and healthy comparison youth. Adolescent participants underwent MRI while completing a modified Continuous Performance Task. BD participants displayed deficits in sustained attention and lower activation in brain regions associated with performance and neural integration. These differences were distinct to the BD group and not attributable to ADHD comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
F. Pacchioni, F. Casoni, A. Sarzetto, F. Attanasio, B. Barbini, M. Locatelli, C. Colombo, M. C. Cavallini, L. Fregna
Summary: Sleep plays a crucial role in the development and manifestation of mood disorders, but few studies have examined sleep architecture during manic episodes of Bipolar Disorder (BD) and changes in sleep parameters. This study investigated 21 BD patients in the manic phase and found that their sleep quantity and quality improved during hospitalization, accompanied by clinical improvement. The study also revealed an increase in REM sleep. These findings suggest that changes in sleep architecture can serve as sensitive markers for clinical variations during manic phases of Bipolar Disorder.
PSYCHIATRY RESEARCH
(2023)
Article
Psychiatry
Mahdieh Saeidi, Tara Rezvankhah, Victor Pereira-Sanchez, Maryam Rafieian, Behnam Shariati, Soode Tajik Esmaeeli, Maziar Emamikhah, Kaveh Alavi, Amir Shabani, Shiva Soraya, Fatemeh Kashaninasab, Fatemeh Sadat Mirfazeli
Summary: A case series study was conducted to document the clinical presentations, family aggregation patterns, and brain imaging correlates of patients with manic episodes shortly after COVID-19 infections. The study found that a family history of bipolar disorder and the use of corticosteroids may be factors to focus on in further research.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Christoph Born, Heinz Grunze, Robert M. Post, Lori L. Altshuler, Ralph Kupka, Susan L. McElroy, Mark A. Frye, Trisha Suppes, Paul E. Keck, Willem A. Nolen, Lars Schaerer
Summary: This study analyzed the presence of depressive symptoms in bipolar disorder patients and found that (hypo)manic states are associated with a higher burden of depression compared to non-(hypo)manic states. Female patients were more likely to exhibit depressive symptoms, and mania and depression were shown to complement each other rather than being opposing poles.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2021)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Hua-Meng Shi, De-Guo Jiang
Summary: This study found that mood-incongruent psychosis during the first manic episode of bipolar disorder appears to predict an increased likelihood of persistent psychotic symptoms over the subsequent 24 months. This persistence of psychosis is associated with a worse overall course of illness.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Review
Clinical Neurology
Guido Cereda, Paolo Enrico, Valentina Ciappolino, Giuseppe Delvecchio, Paolo Brambilla
Summary: Most studies found no significant differences in vitamin D levels between bipolar disorder patients and other psychiatric disorders, with the average values in the bipolar population being sub-threshold for deficiency. Although an association between vitamin D levels and clinical symptoms was observed, it is not a specific marker for bipolar disorder but a common characteristic shared with other psychiatric disorders. Additionally, vitamin D supplementation was linked to a reduction in depressive and manic symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Cuirong Zeng, Yan Qiu, Sujuan Li, Ziwei Teng, Hui Xiang, Jindong Chen, Xiangxin Wu, Ting Cao, Shuangyang Zhang, Qian Chen, Haishan Wu, HuaLin Cai
Summary: This study aimed to investigate the effects of probiotic supplementation on oxidative stress biomarkers and clinical symptoms in patients with bipolar disorder. The results showed that probiotics had advantageous effects on specific clinical symptoms, especially manic symptoms, in these patients. The changes in plasma oxidative stress biomarkers may serve as prognostic indexes for bipolar patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Leonid Braverman, Camil Fuchs, Abraham Weizman, Michael Poyurovsky
Summary: Evidence suggests a higher comorbidity rate of obsessive-compulsive disorder (OCD) in bipolar disorder (BD) patients, particularly in those experiencing bipolar depression (BP-D). A study found 26% of BD patients with their first depressive episode also had OCD, while 23.2% met criteria for subthreshold OCD. No differences in demographic and clinical variables were observed between BD patients with and without OCD. Further research is needed to explore the longitudinal course, treatment approaches, and outcomes of comorbid BP-D/OCD.
PSYCHIATRY RESEARCH
(2021)
Article
Psychiatry
Catarina Rodrigues Cordeiro, Beatriz Romao Corte-Real, Rodrigo Saraiva, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: This systematic review aimed to identify triggers of acute mood episodes in bipolar disorder (BD). The review found that pharmacotherapy, particularly the use of antidepressants, was the trigger with the strongest evidence for manic/hypomanic relapse. Other identified triggers for mania included brain stimulation, energy drinks, acetyl-lcarnitine, St. John's wort, seasonal changes, hormonal changes, and viral infections. However, there is a lack of evidence regarding triggers for depressive relapses in BD, highlighting the need for further research in this area.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Rebecca E. Easter, Kelly A. Ryan, Ryne Estabrook, David F. Marshall, Melvin G. McInnis, Scott A. Langenecker
Summary: This study found that cognitive performance is largely unrelated to depressive and manic symptoms in patients with bipolar disorder. The results suggest that cognitive dysfunction is stable in BD and is not dependent on mood state. Future research could investigate how treatment affects the relationship between cognition and mood.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
Marta Migo, Kendra Simpson, Amy Peters, Kristen K. Ellard, Tina Chou, Andrew A. Nierenberg, Darin D. Dougherty, Thilo Deckersbach
Summary: By dimensionally analyzing symptom severity in patients with bipolar disorder, more accurate differences in neural responses to emotional stimuli can be captured. There is a correlation between symptom severity and brain activation, with depression severity associated with increased activation in various brain regions and mania severity associated with both increased and decreased activation.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Jess G. Fiedorowicz, Jane E. Persons, Shervin Assari, Michael J. Ostacher, Fernando S. Goes, John Nurnberger, William H. Coryell
Summary: Depressive symptoms are strongly linked to suicidal ideation and behavior, serving as important risk factors for suicide. However, manic symptoms show no clear association with suicide risk, and mixed symptoms do not convey a greater risk of suicidal ideation or behavior than depressive symptoms alone.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Clinical
Jan Stochl, Emma Soneson, Freya Stuart, Jessica Fritz, Annabel E. L. Walsh, Tim Croudace, Joanne Hodgekins, Ushma Patel, Debra A. Russo, Clare Knight, Peter B. Jones, Jesus Perez
Summary: Female, younger, more functionally impaired, and socioeconomically disadvantaged individuals tend to have higher baseline severity of depression and anxiety symptoms, while older individuals with less functional impairment and more severe baseline symptoms show more rapid improvement. Therapy intensity and appointment frequency do not seem to affect symptomatic improvement rate, and patients with lower baseline symptom severity, less functional impairment, and older age have a greater likelihood of achieving symptomatic recovery.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Developmental
Gonzalo Salazar de Pablo, Dolores Moreno, Ana Gonzalez-Pinto, Beatriz Paya, Josefina Castro-Fonieles, Inmaculada Baeza, Montserrat Graell, Celso Arango, Marta Rapado-Castro, Carmen Moreno
Summary: The study revealed that in early-onset psychosis (EOP) patients, mania is the most prominent and stable affective dimension, but over time, depression and anxiety may become more predominant. Comprehensive evaluation of affective symptoms' structural dimensions and progression may provide clinical and therapeutic advantages.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Alvaro Andreu-Bernabeu, Covadonga M. Diaz-Caneja, Javier Costas, Lucia De Hoyos, Carol Stella, Xaquin Gurriaran, Clara Alloza, Lourdes Fananas, Julio Bobes, Ana Gonzalez-Pinto, Benedicto Crespo-Facorro, Lourdes Martorell, Elisabet Vilella, Gerard Muntane, Juan Nacher, Maria Dolores Molto, Eduardo Jesus Aguilar, Mara Parellada, Celso Arango, Javier Gonzalez-Penas
Summary: This study demonstrates the contribution of loneliness and social isolation (LNL-ISO) to schizophrenia risk through a polygenic score, showing differential effects in different genders and other mental disorders, and suggesting a plausible bi-directional causal relationship.
NATURE COMMUNICATIONS
(2022)
Article
Psychiatry
Anna Butjosa, Judith Usall, Regina Vila-Badia, Gisela Mezquida, Manuel J. Cuesta, Elisa Rodriguez-Toscano, Silvia Amoretti, Antonio Lobo, Ana Gonzalez-Pinto, Ana Espliego, Iluminada Corripio, Eduard Vieta, Inmaculada Baeza, Dani Berge, Miguel Bernardo
Summary: This study explored traumatic life events (TLEs) in first-episode psychosis (FEP) patients and healthy controls (HC), finding that FEP patients had a higher number of TLEs and a significantly higher proportion of individuals with multiple TLEs. There were no gender or age differences observed. Overall, the number and cumulative TLEs should be taken into account in the detection, epidemiology, and recovery processes of FEP.
INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Albert Martinez-Pinteno, Gisela Mezquida, Miquel Bioque, Jose M. Lopez-Ilundain, Alvaro Andreu-Bernabeu, Inaki Zorrilla, Anna Mane, Roberto Rodriguez-Jimenez, Iluminada Corripio, Salvador Sarro, Angela Ibanez, Judith Usall, Olga Rivero, Patricia Gasso, Juan Carlos Leza, Manuel J. Cuesta, Mara Parellada, Ana Gonzalez-Pinto, Esther Berrocoso, Sergi Mas, Miguel Bernardo, S. Amoretti, C. Moren, E. Urbiola, J. Gonzalez-Penas, A. Roldan, A. Catalan, I Gonzalez-Ortega, A. Toll, T. Legido, L. Sanchez-Pastor, M. Dompablo, E. Pomarol-Clotet, R. Landin-Romero, A. Butjosa, E. Rubio, M. Ribeiro, I Lopez-Torres, L. Leon-Quismondo, J. Nacher, F. Contretas, A. Lobo, M. Gutierrez-Fraile, Pa Saiz
Summary: This study examined the relationship between plasma levels of BDNF/NGF and symptom severity in first-episode schizophrenia patients in remission. The results showed significant correlations between BDNF/NGF levels and symptom severity, but they were not predictive of relapse. These findings suggest that BDNF and NGF may serve as potential biomarkers for long-term severity in schizophrenia.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychology, Clinical
Ana Catalan, Claudia Aymerich, Amaia Bilbao, Borja Pedruzo, Jose Luis Perez, Nerea Aranguren, Gonzalo Salazar de Pablo, Emily Hedges, Patxi Gil, Rafael Segarra, Ana Gonzalez-Pinto, Aranzazu Fernandez-Rivas, Lucia Inchausti, Philip McGuire, Paolo Fusar-Poli, Miguel Angel Gonzalez-Torres
Summary: COVID-19-related mortality and hospitalization rates were higher for patients with pre-existing psychotic disorders, while patients with affective disorders had lower rates.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Miquel Bioque, Gisela Mezquida, Silvia Amoretti, Clemente Garcia-Rizo, Jose M. Lopez-Ilundain, Covadonga M. Diaz-Caneja, Inaki Zorrilla, Anna Mane, Roberto Rodriguez-Jimenez, Iluminada Corripio, Edith Pomarol-Clotet, Angela Ibanez, Judith Usall, Fernando Contreras, Sergi Mas, Javier Vazquez-Bourgon, Manuel J. Cuesta, Mara Parellada, Ana Gonzalez-Pinto, Maria Hidalgo-Figueroa, Miquel Bernardo
Summary: Relapses are common in the early years following a first episode of schizophrenia, and are associated with higher antipsychotic doses, polypharmacy, benzodiazepine use, side effects reports, psychological treatment, and cannabis consumption.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Psychiatry
Laura Pina-Camacho, Kenia Martinez, Covadonga M. Diaz-Caneja, Gisela Mezquida, Manuel J. Cuesta, Carmen Moreno, Silvia Amoretti, Ana Gonzalez-Pinto, Celso Arango, Eduard Vieta, Josefina Castro-Fornieles, Antonio Lobo, David Fraguas, Miguel Bernardo, Joost Janssen, Mara Parellada
Summary: Patients with first-episode psychosis (FEP) show structural brain abnormalities at the first episode. The changes in cortical thickness that follow a FEP are dependent on the age at first episode, with younger patients showing more pronounced cortical thinning in the temporal lobe.
Article
Psychology, Clinical
Alex G. Segura, Gisela Mezquida, Albert Martinez-Pinteno, Patricia Gasso, Natalia Rodriguez, Lucia Moreno-Izco, Silvia Amoretti, Miquel Bioque, Antonio Lobo, Ana Gonzalez-Pinto, Alicia Garcia-Alcon, Alexandra Roldan-Bejarano, Eduard Vieta, Elena de la Serna, Alba Toll, Manuel J. Cuesta, Sergi Mas, Miquel Bernardo
Summary: Early intervention is crucial for preventing the progression of psychotic disorders. This study found that genetic susceptibility related to cognitive performance is associated with an increased risk of first-episode psychosis (FEP) and its clinical and cognitive progression. Additionally, genetic susceptibility for depression is associated with a worsening trajectory of executive function and general cognitive status.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Nursing
Teresa Sufrate-Sorzano, Jesus Perez, Raul Juarez-Vela, MariaElena Garrote-Camara, Regina Ruiz de Vinaspre, Fidel Molina-Luque, Ivan Santolalla-Arnedo
Summary: This umbrella review aimed to determine effective nursing interventions for preventing and managing suicidal behavior. The review found that nursing interventions are common in suicide risk management and have been shown to be effective for individuals with suicidal ideation or suicide attempts. Prevention and treatment of suicidal behavior require coping tools, behavioral interventions, and therapeutic partnerships.
INTERNATIONAL JOURNAL OF NURSING KNOWLEDGE
(2023)
Article
Health Care Sciences & Services
Maria Elena Garrote-Camara, Raul Juarez-Vela, Teresa Sufrate-Sorzano, Angela Durante, Paolo Ferrara, Stefano Terzoni, Jesus Perez, Ivan Santolalla-Arnedo
Summary: This study aims to translate and adapt the NGASR scale for the Spanish population and evaluate its psychometric properties in patients with suicide risk factors. The study will include 165 participants, and psychometric analysis will be conducted using methods such as internal consistency and factor analysis. The study is expected to conclude in the first quarter of 2023.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Public, Environmental & Occupational Health
Piotr Karniej, Jesus Perez, Raul Juarez-Vela, Ivan Santolalla-Arnedo, Vicente Gea-Caballero, Pablo del Pozo-Herce, Anthony Dissen, Michal Czapla
Summary: This study aimed to identify demographic factors and predictors of orthorexia nervosa (ON) among a sample group of Spanish and Polish gay men. The results showed that low BMI and the use of Grindr were the most important predictors of ON in gay men, while daily use of PrEP was associated with lower risk and occasional use was associated with increased risk.
Letter
Psychiatry
Maria Irigoyen-Otinano, Carla Albert-Porcar, Cecilia Borras, Margarita Puigdevall-Ruestes, Ana Gonzalez-Pinto
EUROPEAN JOURNAL OF PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Anne-Marie Burn, Tamsin J. Ford, Jan Stochl, Peter B. Jones, Jesus Perez, Joanna K. Anderson
Summary: Artemis-A is a web app designed for assessing the mental health of secondary school students. It uses computerized adaptive testing technology to shorten the assessment process. Through stakeholder consultations and user testing, the research team improved the user interface design and explored the feasibility and acceptability of the app in schools.
JMIR FORMATIVE RESEARCH
(2022)
Article
Psychology, Clinical
Jan Stochl, Eiko I. Fried, Jessica Fritz, Tim J. Croudace, Debra A. Russo, Clare Knight, Peter B. Jones, Jesus Perez
Summary: This study evaluated the multidimensionality and temporal measurement invariance of common measures of depression and anxiety, showing that while they are multidimensional instruments, sum scores can still be used as measures of severity. Researchers can compare sum scores across different time points with confidence.