Article
Clinical Neurology
Kenneth Chappell, Romain Colle, Abd El Kader Ait Tayeb, Jerome Bouligand, Khalil El-Asmar, Eric Deflesselle, Bruno Feve, Laurent Becquemont, Emmanuelle Corruble, Celine Verstuyft
Summary: This study found an association between the ERICH3 rs11580409 genetic polymorphism and treatment response following long-term antidepressant medication. The rs11580409 polymorphism may serve as a useful biomarker for treatment response in major depressive disorder.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Article
Biochemistry & Molecular Biology
Kenneth Chappell, Romain Colle, Jerome Bouligand, Severine Trabado, Bruno Feve, Laurent Becquemont, Emmanuelle Corruble, Celine Verstuyft
Summary: Genetic variants in the MAOA and MAOB genes are associated with clinical improvement and plasma 5HIAA/5HT ratio in patients treated with antidepressant drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Beatriz Corte-Real, Rodrigo Saraiva, Catarina Rodrigues Cordeiro, Benicio N. Frey, Flavio Kapczinski, Taiane de Azevedo Cardoso
Summary: The study aimed to investigate whether atypical antipsychotics (AA) can induce mania in mood disorders. A systematic review and meta-analysis showed that AA-induced mania is rare and the use of AA is more effective in preventing the development of mania compared to placebo.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Nicolas A. Nunez, Brandon J. Coombes, Lindsay Melhuish Beaupre, Francisco Romo-Nava, Manuel Gardea-Resendez, Aysegul Ozerdem, Marin Veldic, Balwinder Singh, Jorge A. Sanchez Ruiz, Alfredo Cuellar-Barboza, Jonathan G. Leung, Miguel L. Prieto, Susan L. Mcelroy, Joanna M. Biernacka, Mark A. Frye
Summary: This study reviewed the association between the SLC6A4 5-HTTLPR polymorphism and treatment emergent mania (TEM) in bipolar disorder, and discussed the benefits of developing risk stratification models for guiding the use of antidepressant treatment in bipolar depression. The study found a significant association between the s allele of the 5-HTTLPR polymorphism and TEM. Further genome-wide research is needed to identify other genetic variations that may contribute to TEM.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Molly A. Kwiatkowski, Benjamin Z. Roberts, Jordy van Enkhuizen, Baohu Ji, Xianjin Zhou, Jared W. Young
Summary: Bipolar disorder affects 2% of the global population and current treatments are not completely effective. The disorder is characterized by fluctuations between mania and depression, possibly driven by imbalances in dopamine and acetylcholine.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Byung-Hoon Kim, Seung-Hyun Kim, Changsu Han, Hyun-Ghang Jeong, Moon-Soo Lee, Junhyung Kim
Summary: In this study, altered brain connectivity related to antidepressant-induced mania was observed in panic disorder patients. The patient who developed mania showed decreased connectivity in default mode and frontoparietal networks, and increased connectivity in visual processing network. These findings provide insight into the neurological basis of antidepressant-induced mania.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Miao Li, Ning Yuan, John Nurnberger, Ney Alliey-Rodriguez, Jiaqi Zhou, Fangyuan Duan, Jiacheng Dai, Yu Chen, Jiaqi Lu, Li Xie, Fang Liu, Xuli Yang, Philippe Tapon, Vijay Gorrepati, Xuejun Liu, Chao Chen, Chunyu Liu, Elliot S. Gershon
Summary: Common genetic variants in calcium channel genes are important markers of genetic susceptibility for bipolar disorder (BD). Previous clinical trials have shown that Calcium Channel Blocker (CCB) medication can improve mood stability in some BD patients. In this pilot study, 50 BD patients (39 from China and 11 from the US) hospitalized for manic episodes were given add-on CCB treatment. The study found that certain intronic variants of the Calcium Voltage-Gated Channel Subunit Alpha1 B (CACNA1B) were associated with treatment outcomes for manic patients, suggesting that these variants could be predictors for response to add-on CCB treatment for bipolar mania patients.
PSYCHIATRY RESEARCH
(2023)
Article
Behavioral Sciences
Zackary A. Cope, Johnny A. Kenton, Arpi Minassian, Maureen V. Martin, William Perry, Christoffer Bundgaard, Jorn Arnt, Jordy van Enkhuizen, Mark A. Geyer, Jared W. Young
Summary: The study highlights the different responses of DAT knockdown mice to risperidone and asenapine in mania behavior, pointing out the limitations of current treatment methods, and further emphasizes the necessity of resources and research into DAT-targeting drugs.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Psychiatry
Dogukan Koc, Ecem Ince, Tugba San, Pinar Akan, Ahu Paketci, Ece Bober, Nese Direk Tecirli, Neslihan Inal, Aynur Pekcanlar Akay
Summary: This study aimed to explore the association between thyroid autoimmunity and treatment-emergent mania (ATEM) in pediatric mood disorders. The findings showed that the seroprevalence and titer of anti-thyroid peroxidase antibodies (TPO-abs) were significantly higher in patients with ATEM compared to controls. Logistic regression analysis revealed a significant association between TPO-abs seroprevalence and ATEM even after adjusting for various factors. These findings suggest that TPO-abs could potentially serve as a biomarker for assessing the risk of ATEM in children and adolescents.
PSYCHIATRY RESEARCH
(2022)
Article
Plant Sciences
Ran Li, Zhi-Mei Wang, Yan Wang, Xueqi Dong, Li-Hua Zhang, Tao Wang, Yan Zhu, Xiu-Mei Gao, Hong-Hua Wu, Yan-Tong Xu
Summary: This study systematically investigated the effects of SERT activity in antidepressant effects of Nardostachys jatamansi, including identification of active constituents and their potential mechanisms. The findings provide important insights into the antidepressant potential of this plant extract and fractions enriched with SERT enhancing compounds.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Luis R. Patino, Maxwell J. Tallman, Hongbo Wen, Caleb M. Adler, Jeffrey A. Welge, Melissa P. DelBello
Summary: The objective of this study was to evaluate differences in sustained attention and associated neurofunctional profiles between bipolar disorder type I, attention-deficit/hyperactivity disorder, and healthy comparison youth. Adolescent participants underwent MRI while completing a modified Continuous Performance Task. BD participants displayed deficits in sustained attention and lower activation in brain regions associated with performance and neural integration. These differences were distinct to the BD group and not attributable to ADHD comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Tong Guo, Yuan Yang, Qian Zhao, Lei Zhang, Chee H. Ng, Teris Cheung, Yang Li, Xue-Quan Zhu, Xiao-Hong Li, Yu-Tao Xiang
Summary: The study aimed to assess the clinical phenomenology and characteristics of prodromal symptoms in Chinese patients with bipolar disorder prior to their index mood episode. The findings indicated that identifying prodromal symptoms of BPD may be beneficial for early diagnosis and intervention before the development of full episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Jorge M. Aguiar-Geraldo, Taise Possamai-Della, Samira Menegas, Jefte Peper-Nascimento, Joao Quevedo, Samira S. Valvassori
Summary: This study aimed to evaluate the effects of lithium and folic acid on behavioral changes and oxidative stress parameters in an animal model of mania induced by ouabain. The results showed that ouabain induced mania-like behavior and oxidative stress in rats' brains, but lithium could reverse these alterations. Folic acid did not affect behavior parameters but had an antioxidant effect on the evaluated brain structures.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Martin J. Lan, Francesca Zanderigo, Spiro P. Pantazatos, M. Elizabeth Sublette, Jeffrey Miller, R. Todd Ogden, J. John Mann
Summary: Disturbance of serotonin system function is associated with both the diagnosis of BD and its severity of depression. Pretreatment 5HT1AR binding did not predict SSRI antidepressant outcome.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Letter
Psychiatry
A. Amerio, F. Starace, A. Costanza, G. Serafini, A. Aguglia, A. Odone, S. N. Ghaemi, M. Amore
ACTA PSYCHIATRICA SCANDINAVICA
(2020)
Article
Psychiatry
S. N. Ghaemi
ACTA PSYCHIATRICA SCANDINAVICA
(2020)
Review
Clinical Neurology
Luigi Costantini, Cesira Pasquarella, Anna Odone, Maria Eugenia Colucci, Alessandra Costanza, Gianluca Serafini, Andrea Aguglia, Martino Belvederi Murri, Vlasios Brakoulias, Mario Amore, S. Nassir Ghaemi, Andrea Amerio
Summary: The PHQ-9 has been widely validated and recommended for depression screening in primary care settings in a two-stage process. However, limitations such as the lack of longitudinal studies, small sample sizes, and heterogeneity in primary care environments restrict the generalizability of these results. Longitudinal studies are needed to provide evidence of the long-term effectiveness of screening.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Yin Wu, Brooke Levis, John P. A. Ioannidis, Andrea Benedetti, Brett D. Thombs
PSYCHOTHERAPY AND PSYCHOSOMATICS
(2020)
Review
Clinical Neurology
Michele Fornaro, Federico Manuel Daray, Fernando Hunter, Annalisa Anastasia, Brendon Stubbs, Domenico De Berardis, Jae Il Shin, Muhammad Ishrat Husain, Elena Dragioti, Paolo Fusar-Poli, Marco Solmi, Michael Berk, Eduard Vieta, Andre Ferrer Carvalho
Summary: Research indicates that the comorbidity rates of bipolar disorder (BD) and eating disorders (ED) vary across different diagnostic groups, rather than being determined by the direction between BD and ED. Future studies should focus on the risk, timeline, clinical impact, and management of comorbid BD and ED across different age groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Andrea Amerio, Daniel Russo, Norberto Miletto, Andrea Aguglia, Alessandra Costanza, Beatrice Benatti, Anna Odone, Sergio A. Barroilhet, Vlasios Brakoulias, Bernardo Dell'Osso, Gianluca Serafini, Mario Amore, S. Nassir Ghaemi
Summary: The efficacy of polypharmacy compared to monotherapy in maintenance treatment of bipolar illness is not well established, but the best drug combination identified in the literature review is lithium + valproic acid for preventing manic episodes. More focus should be placed on adequate monotherapy in clinical practice before considering polypharmacy.
ACTA PSYCHIATRICA SCANDINAVICA
(2021)
Article
Psychiatry
Leandro Nicolas Grendas, Luciana Chiapella, Demian Emanuel Rodante, Federico Manuel Daray
Summary: A comparison study between Cox regression models and Random Survival Forest (RSF) was conducted to predict suicidal behavior, and a variant of RSF (RSFElimin) showed better accuracy, sensitivity gAUC, and IBS compared to other methods.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
S. Nassir Ghaemi
Summary: Most psychiatric drugs have short-term effects on improving symptoms and do not provide long-term benefits for underlying diseases. A change in approach is needed in psychopharmacology practice and research, focusing on long-term disease modification.
ACTA PSYCHIATRICA SCANDINAVICA
(2022)
Article
Psychiatry
S. Nassir Ghaemi, Jules Angst, Paul A. Vohringer, Eric A. Youngstrom, James Phelps, Philip B. Mitchell, Roger S. McIntyre, Michael Bauer, Eduard Vieta, Samuel Gershon
Summary: This study proposes the Clinical Research Diagnostic Criteria for Bipolar Illness (CRDC-BP) for use in research studies, aiming to provide guidance for the diagnosis of major mental illnesses in the future.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2022)
Review
Clinical Neurology
Sudan Prasad Neupane, Federico M. Daray, Elizabeth D. Ballard, Hanga Galfalvy, Liat Itzhaky, Aviv Segev, Assaf Shelef, Oren Tene, Mina M. Rizk, J. John Mann, Gil Zalsman
Summary: This study conducted a meta-analysis comparing immune biomarkers between individuals with and without a history of suicidal behavior, finding that suicidal behavior is associated with higher levels of CRP and IL-6, independent of psychiatric disorders.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
S. Nassir Ghaemi, Oleksandr Sverdlov, Joris van Dam, Timothy Campellone, Robert Gerwien
Summary: This study aimed to evaluate the effect of PEAR-004, a smartphone-based digital therapeutic, on improving symptoms of acute psychotic exacerbation in schizophrenia when added to standard treatments. The results showed that PEAR-004 did not demonstrate an effect on the primary outcome of total PANSS scores when compared to a nonspecific digital sham control. There were no notable benefits except for a possible temporary improvement in depressive symptoms.
JMIR FORMATIVE RESEARCH
(2022)
Article
Psychiatry
Demian E. Rodante, Marcela Kaplan, Ramiro Olivera Fedi, Pablo Gagliesi, Agustina Pascali, Paula S. Jose Quintero, Emilio J. Compte, Ana Perez, Melina Weinstein, Luciana C. Chiapella, Federico M. Daray
Summary: This study evaluated the acceptability and preliminary effectiveness of a mobile-health application called CALMA, which is based on dialectical behavioral therapy skills. The results showed that CALMA had good acceptability as an adjunct therapy for reducing suicidal and non-suicidal self-injury behaviors.
ARCHIVES OF SUICIDE RESEARCH
(2022)
Article
Psychology, Clinical
S. Nassir Ghaemi, Elizabeth A. Whitham, Paul A. Vohringer, Sergio A. Barroilhet, Andrea Amerio, Oleksandr Sverdlov, Ashwin A. Patkar
Summary: Citalopram did not show significant clinical benefit compared to placebo in the acute and maintenance treatment of bipolar depression. Acute manic symptoms did not worsen with citalopram, but maintenance treatment led to worsened manic symptoms, especially in subjects with a rapid-cycling course.
JOURNAL OF CLINICAL PSYCHIATRY
(2021)
Article
Psychiatry
Cintia R. Prokopez, Miguel Vallejos, Romina Farinola, German Alberio, Gabriela B. Caporusso, Linda G. Cozzarin, Luciana C. Chiapella, Pamela Fuentes, Federico M. Daray
PSYCHIATRY RESEARCH
(2020)
Review
Psychiatry
Hsiang Huang, Heather Huang, Margaret Spottswood, Nassir Ghaemi
HARVARD REVIEW OF PSYCHIATRY
(2020)
