Article
Psychiatry
Dogukan Koc, Ecem Ince, Tugba San, Pinar Akan, Ahu Paketci, Ece Bober, Nese Direk Tecirli, Neslihan Inal, Aynur Pekcanlar Akay
Summary: This study aimed to explore the association between thyroid autoimmunity and treatment-emergent mania (ATEM) in pediatric mood disorders. The findings showed that the seroprevalence and titer of anti-thyroid peroxidase antibodies (TPO-abs) were significantly higher in patients with ATEM compared to controls. Logistic regression analysis revealed a significant association between TPO-abs seroprevalence and ATEM even after adjusting for various factors. These findings suggest that TPO-abs could potentially serve as a biomarker for assessing the risk of ATEM in children and adolescents.
PSYCHIATRY RESEARCH
(2022)
Article
Psychiatry
Jane E. Persons, Paul Lodder, William H. Coryell, John Nurnberger, Jess G. Fiedorowicz
Summary: This study found that manic and anxiety symptoms did not significantly contribute to suicidal ideation and behavior in individuals with bipolar disorder during a depressive state, with the main risk factor being severe depressive symptoms. The limitations of small sample size and measurement tools may have influenced these findings, suggesting future studies would benefit from larger samples and more rigorous assessments.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Ole Kohler-Forsberg, Louisa G. Sylvia, Vicki Fung, Lindsay Overhage, Michael Thase, Joseph R. Calabrese, Thilo Deckersbach, Mauricio Tohen, Charles L. Bowden, Melvin McInnis, James H. Kocsis, Edward S. Friedman, Terence A. Ketter, Susan L. McElroy, Richard C. Shelton, Michael J. Ostacher, Dan V. Iosifescu, Andrew A. Nierenberg
Summary: In this study, adjunctive antidepressant treatment was not associated with lower depressive symptoms or higher mania symptoms in outpatients with bipolar disorder. There were no differences in treatment effects on mania scales, and potential biases due to nonrandomized design complicated causal interpretations, with no evidence suggesting better treatment effects of adjunctive antidepressants.
DEPRESSION AND ANXIETY
(2021)
Review
Clinical Neurology
L. Roosen, P. Sienaert
Summary: This paper provides an overview of evidence-based treatment options for rapid cycling in bipolar disorder, highlighting medications such as aripiprazole, olanzapine, quetiapine, valproate, and lamotrigine. However, evidence regarding the treatment of rapid cycling remains scarce, indicating the need for future research to further validate the efficacy of these treatment methods.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Lorenza Lucidi, Mauro Pettorruso, Federica Vellante, Francesco Di Carlo, Franca Ceci, Maria Chiara Santovito, Ilenia Di Muzio, Michele Fornaro, Antonio Ventriglio, Carmine Tomasetti, Alessandro Valchera, Alessandro Gentile, Yong-Ku Kim, Giovanni Martinotti, Silvia Fraticelli, Massimo Di Giannantonio, Domenico De Berardis
Summary: The gut microbiota plays a crucial role in maintaining homeostasis, growth, and digestive processes. It also influences the intercommunication system between the gut and the brain, potentially impacting the pathogenesis and clinical management of Bipolar Disorder. Current literature suggests a relationship between compositional alterations in the gut microbiota and BD, with potential benefits in treating BD symptoms through modifications in the microbiota composition. Further research is needed to explore the potential of correcting gut microbiota alterations as a novel strategy in BD management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Ana Lucia Ramos, Henrique Salgado, Miguel Braganca
Summary: Bipolar disorder is characterized by persistent mood changes between depressive and manic states, with rapid cycling being a common yet often overlooked condition that worsens prognosis. Treatment for bipolar depression lacks evidence-supported options, and there are few references in the literature to cases of manic switch induced by lamotrigine.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Pharmacology & Pharmacy
Nicolas A. Nunez, Brandon J. Coombes, Lindsay Melhuish Beaupre, Francisco Romo-Nava, Manuel Gardea-Resendez, Aysegul Ozerdem, Marin Veldic, Balwinder Singh, Jorge A. Sanchez Ruiz, Alfredo Cuellar-Barboza, Jonathan G. Leung, Miguel L. Prieto, Susan L. Mcelroy, Joanna M. Biernacka, Mark A. Frye
Summary: This study reviewed the association between the SLC6A4 5-HTTLPR polymorphism and treatment emergent mania (TEM) in bipolar disorder, and discussed the benefits of developing risk stratification models for guiding the use of antidepressant treatment in bipolar depression. The study found a significant association between the s allele of the 5-HTTLPR polymorphism and TEM. Further genome-wide research is needed to identify other genetic variations that may contribute to TEM.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Christopher B. Morrow, Jared T. Hinkle, Joseph Seemiller, Kelly A. Mills, Gregory M. Pontone
Summary: This study found overlapping symptoms between impulse control disorders (ICD) in Parkinson's disease (PD) and hypomanic episodes of bipolar disorder, suggesting a shared neurobiology. Antidepressant therapy may be associated with ICD, and the severity of affective symptoms in on and off dopamine states is also associated with ICD.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Psychiatry
Haniya J. Halim, Bradley G. Burk, Rachel E. Fargason, Badari Birur
Summary: Research on psychedelic substances as treatment options for neuropsychiatric conditions is increasing. Psilocybin, a psychedelic drug, has gained interest as an effective treatment for treatment-resistant depression, depression associated with terminal conditions, certain substance use disorders, and obsessive-compulsive disorder. However, there is limited data on the effects of psilocybin on patients at risk for mania, largely due to exclusion from studies. This case study describes a 21-year-old male with bipolar II disorder who experienced a manic episode after ingesting psilocybin.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Clinical Neurology
Jay D. Amsterdam, Colin Xu
Summary: This study analyzed the data from trials of bipolar II depression and found that compared to lithium monotherapy, antidepressant monotherapy is more effective in reducing symptoms without causing treatment-emergent hypomanic symptoms.
Article
Clinical Neurology
Luis R. Patino, Maxwell J. Tallman, Hongbo Wen, Caleb M. Adler, Jeffrey A. Welge, Melissa P. DelBello
Summary: The objective of this study was to evaluate differences in sustained attention and associated neurofunctional profiles between bipolar disorder type I, attention-deficit/hyperactivity disorder, and healthy comparison youth. Adolescent participants underwent MRI while completing a modified Continuous Performance Task. BD participants displayed deficits in sustained attention and lower activation in brain regions associated with performance and neural integration. These differences were distinct to the BD group and not attributable to ADHD comorbidity.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Tong Guo, Yuan Yang, Qian Zhao, Lei Zhang, Chee H. Ng, Teris Cheung, Yang Li, Xue-Quan Zhu, Xiao-Hong Li, Yu-Tao Xiang
Summary: The study aimed to assess the clinical phenomenology and characteristics of prodromal symptoms in Chinese patients with bipolar disorder prior to their index mood episode. The findings indicated that identifying prodromal symptoms of BPD may be beneficial for early diagnosis and intervention before the development of full episodes.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Psychiatry
Subho Chakrabarti, Amal J. Jolly, Pranshu Singh, Nidhi Yadhav
Summary: Rapid-cycling bipolar disorder (RCBD) is a common subtype of bipolar disorder characterized by greater severity and disability, with limited efficacy of conventional pharmacotherapy. There is a lack of robust evidence regarding optimal treatment strategies for RCBD, especially nonpharmacological interventions. However, preliminary studies suggest that adjunctive electroconvulsive therapy and chronotherapeutic treatments may be beneficial for RCBD management.
WORLD JOURNAL OF PSYCHIATRY
(2023)
Review
Psychiatry
Gao Zhihan, Sun Fengli, Lv Wangqiang, Shen Dong, Jin Weidong
Summary: The combination of lithium and lamotrigine has shown to be effective in improving mental symptoms and increasing response rates in patients with rapid-cycling bipolar disorder.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
F. Pacchioni, F. Casoni, A. Sarzetto, F. Attanasio, B. Barbini, M. Locatelli, C. Colombo, M. C. Cavallini, L. Fregna
Summary: Sleep plays a crucial role in the development and manifestation of mood disorders, but few studies have examined sleep architecture during manic episodes of Bipolar Disorder (BD) and changes in sleep parameters. This study investigated 21 BD patients in the manic phase and found that their sleep quantity and quality improved during hospitalization, accompanied by clinical improvement. The study also revealed an increase in REM sleep. These findings suggest that changes in sleep architecture can serve as sensitive markers for clinical variations during manic phases of Bipolar Disorder.
PSYCHIATRY RESEARCH
(2023)