Journal
BIOTECHNOLOGY LETTERS
Volume 34, Issue 9, Pages 1637-1642Publisher
SPRINGER
DOI: 10.1007/s10529-012-0948-x
Keywords
Detoxification; Furfural; Furfuryl alcohol; Furoic acid; Trichosporon fermentans
Categories
Funding
- National Natural Science Foundation of China [31071559, 21072065]
- New Century Excellent Talents in University [NCET-11-0161, NCET-10-0367]
- Doctoral Program of Higher Education [20090172110019]
- Major State Basic Research Development Program '973' [2010CB732201]
- State Key Laboratory of Pulp and Paper Engineering, SCUT [201138]
- Fundamental Research Funds for the Central Universities [2012ZP0009]
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In vivo detoxification of furfural by the oleaginous yeast, Trichosporon fermentans, under lipid-producing (i.e., nitrogen-limited) conditions was evaluated for the first time. During the initial fermentation phase, furfural was rapidly reduced to furfuryl alcohol, which is more toxic to T. fermentans than furfural. Furfuryl alcohol was subsequently oxidized to furoic acid which has low toxicity to T. fermentans and is the end product of the in vivo detoxification of furfural in this organism. These observations explain how T. fermentans can grow and accumulate lipids in medium containing furfural. They also indicate that strategies to minimize the transient production of furfuryl alcohol could further improve the capacity of the strain to produce lipids from furfural-containing lignocellulosic hydrolysates.
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