Journal
BIOTECHNOLOGY LETTERS
Volume 32, Issue 7, Pages 891-895Publisher
SPRINGER
DOI: 10.1007/s10529-010-0246-4
Keywords
Amination; Antitumor; Methylan; Polysaccharide
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Funding
- Korea Research Foundation [331-2007-1-D00144, 2009-0077718]
- National Research Foundation of Korea [2009-0077718] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Methylan polysaccharide derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. Their antitumor activity was investigated and a relationship between structure and activity is suggested. For quaternized DEAE-methylan at only 75 mu g ml(-1), tumor cell proliferation was suppressed by 58-84% in three cell lines tested in the order Colo < Hela < HepG2.
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