Article
Pharmacology & Pharmacy
Fei Ren, Hongmei Ning, Yaming Ge, Zhihong Yin, Lingli Chen, Dongfang Hu, Shanshan Shen, Xinrui Wang, Siting Wang, Rongbo Li, Junping He
Summary: This study investigated the effects of Bisphenol A (BPA) on embryonic development and the involved signaling pathways and protein-protein interactions. Results showed that BPA affected multiple embryonic development pathways, and the c-Abl/YAP(Y357)/p73 pathway played a key role in apoptosis induction in response to DNA damage.
Article
Toxicology
Benjamin D. McMichael, M. Chiara Perego, Caitlin L. Darling, Rebekah L. Perry, Sarah C. Coleman, Lisa J. Bain
Summary: Chronic exposure to low levels of arsenic may delay neuronal differentiation and maintain pluripotency, as indicated by increased expression of pluripotency markers and decreased expression of differentiation markers throughout the study period.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Gil Lola Oreff, Barbara Maurer, Ahmed N. ELKhamary, Iris Gerner, Veronika Sexl, Florien Jenner
Summary: An immortalized cell line was established using Ink4a/Arf deficient mice tenocytes, which has similar characteristics and proliferation potential as wild-type cells. These Ink4a/Arf(-/-) tenocytes can be a valuable tool for in vitro tendon research and an alternative to animal experiments.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Ikuko Kakizaki, Takayasu Kobayashi, Shinri Tamura, Hiroshi Akagi, Keiichi Takagaki
Summary: This study found that chondroitin sulfate E and heparin can upregulate neural specific markers during neural differentiation, with chondroitin sulfate E shown to play a role in spheroid formation, while a hyaluronan oligosaccharide mixture downregulated the expressions of myelin specific markers.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Susov Dhakal, Shahar Rotem-Bamberger, Josilyn R. Sejd, Meyrav Sebbagh, Nathan Ronin, Ruth A. Frey, Mya Beitsch, Megan Batty, Kineret Taler, Jennifer F. Blackerby, Adi Inbal, Deborah L. Stenkamp
Summary: The study on zebrafish embryos revealed that the depletion of vascular endothelial cells resulted in disorganized retinal layers and cell death, while the lack of blood flow led to reduced proliferation and differentiation in the retina. These findings emphasize the importance of vascular endothelial cells in retinal development and suggest distinct roles for them compared to circulating factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell & Tissue Engineering
Arup R. Chakraborty, Alex Vassilev, Sushil K. Jaiswal, Constandina E. O'Connell, John F. Ahrens, Barbara S. Mallon, Martin F. Pera, Melvin L. DePamphilis
Summary: PIKfyve inhibitors selectively kill pluripotent stem cells while maintaining the viability of differentiated cells.
Article
Biotechnology & Applied Microbiology
Yaqi Tang, Lu Yin, Shuai Gao, Xiaojing Long, Zhanhui Du, Yingchao Zhou, Shuiyan Zhao, Yue Cao, Silin Pan
Summary: Combining synthetic polymers and biomacromolecules can prevent thrombosis and intimal hyperplasia in small-diameter vascular grafts (SDVGs). In this study, a bi-layered scaffold using electrospinning poly (L)-lactic acid (PLLA) is developed to promote the capture and differentiation of endothelial colony-forming cells (ECFCs) and prevent thrombosis after implantation. The scaffold consists of an outer PLLA scaffold and an inner PLLA biomimetic membrane containing heparin, the peptide Gly-Gly-Gly-Arg-Glu-Asp-Val (GGG-REDV), and vascular endothelial growth factor (VEGF). The modified SDVGs showed improved hemocompatibility and successful capture and differentiation of ECFCs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell & Tissue Engineering
XiaoLing Cui, XiaoTan Wang, Jie Wen, Xiao Li, Nan Li, XuXiao Hao, BaoXiang Zhao, Xunwei Wu, JunYing Miao
Summary: This study demonstrates that the small chemical molecule CPP can effectively induce the differentiation of human dermal fibroblasts (HDFs) into vascular endothelial cells (VECs). The results show that CPP treatment leads to morphological changes in HDFs and upregulation of VEC markers. Additionally, in vitro and in vivo experiments confirm that CPP-induced HDFs possess the functions of VECs. The induction of VEC differentiation by CPP is associated with the increased expression of pro-angiogenic factors.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell Biology
Fangyu Wang, Xuan Liu, Shaowen Li, Chen Zhao, Yumei Sun, Kuan Tian, Junbao Wang, Wei Li, Lichao Xu, Jing Jing, Juan Wang, Sylvia M. Evans, Zhiqiang Li, Ying Liu, Yan Zhou
Summary: The possibility of trans-differentiation of GBM cells into vascular cells is unlikely to occur during gliomagenesis, according to the study. The findings advance the understanding of cell lineage dynamics during gliomagenesis and have implications for targeted treatment of GBMs.
Review
Cell Biology
Jan K. Hennigs, Christiane Matuszcak, Martin Trepel, Jakob Koerbelin
Summary: Endothelial cells play crucial roles in facilitating physiological processes throughout the body, demonstrating tremendous cellular diversity. Different endothelial cell populations adapt to the specific needs of various organs and tissues, influencing vascular tone, blood coagulation, and cellular adhesion.
Article
Cell & Tissue Engineering
Arseniy Lobov, Polina Kuchur, Aigul Khizhina, Anastasia Kotova, Andrei Ivashkin, Daria Kostina, Polina Klausen, Evgeniia Khokhlova, Egor Repkin, Kseniia Postnikova, Daria Perepletchikova, Evgeny Denisov, Tatiana Gerashchenko, Rashid Tikhilov, Svetlana Bozhkova, Andrey Sereda, Vitaliy Karelkin, Natella Enukashvily, Anna Malashicheva
Summary: In this study, we conducted a comparative analysis of mesenchymal cell primary cultures from various sources and found differences in their ability to undergo osteogenic differentiation and produce extracellular matrix. Based on the analysis of secretome, proteome, and transcriptome, we classified them into dental stem cells, mesenchymal stem cells, and fetal stem cells. Although they have differences, mesenchymal cells from all sources secreted core bone extracellular matrix-associated proteins. These findings shed light on the distinctive characteristics of mesenchymal stem cells and provide insights into their potential applications in regenerative medicine and the inherent diversity of mesenchymal cells in vivo.
Review
Nutrition & Dietetics
Hanxu Zhang, Shuang Zhou, Minxue Sun, Manqi Hua, Zhiyan Liu, Guangyan Mu, Zhe Wang, Qian Xiang, Yimin Cui
Summary: The review discusses the role of ferroptosis in endothelial cells in vascular diseases and explores potential therapeutic strategies for treating ferroptosis.
Article
Pathology
Nida S. Safdar, Jennifer N. Stall, Robert H. Young
Summary: This study describes the clinical and pathological characteristics of 100 cases of ovarian malignant mixed germ cell tumors occurring in patients of different ages. The most common tumor type was yolk sac tumor, with frequent mixtures including dysgerminoma and yolk sac tumor, immature teratoma and yolk sac tumor, among others.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Cell Biology
German Atzin Mora-Roldan, Dalia Ramirez-Ramirez, Rosana Pelayo, Karlen Gazarian
Summary: This study compared the effects of 2D and 3D culture formats on the hematopoietic differentiation of human pluripotent stem cells, demonstrating that under the same conditions, the 3D format better supports the differentiation of stem cells into primitive hematopoietic cells, while the 2D format performs poorly.
Article
Nutrition & Dietetics
Tays Amanda Felisberto Goncalves, Viviane Silva Lima, Arthur Jose Pontes Oliveira de Almeida, Alinne Villar de Arruda, Ana Caroline Meneses Ferreira Veras, Thais Trajano Lima, Evyllen Myllena Cardoso Soares, Adhonias Correia dos Santos, Maria Eduarda Costa de Vasconcelos, Mathania Silva de Almeida Feitosa, Robson Cavalcante Veras, Isac Almeida de Medeiros
Summary: This study demonstrated the regulatory effects of carvacrol on endothelial repair in spontaneously hypertensive rats. Results showed that carvacrol promoted the migration and proliferation of endothelial progenitor cells, increased eNOS expression and activity, reduced reactive oxygen species production and cellular senescence, and improved vascular function.
