Article
Chemistry, Multidisciplinary
Simone Adorinni, Giulio Goti, Lorenzo Rizzo, Federica Grassi, Slavko Kralj, Fatima Matroodi, Mirco Natali, Rita De Zorzi, Silvia Marchesan, Luca Dell'Amico
Summary: The conjugation of photoactive benzophenone with diphenylalanine resulted in a self-assembling photocatalyst, which was investigated in the E -> Z photoisomerization of stilbene derivatives.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Maria Cristina Cringoli, Silvia Marchesan
Summary: Cysteine redox chemistry is used in nature for protein assembly and has inspired the design of self-assembling peptides. This review focuses on recent advancements in using Cys thiol-disulfide redox chemistry to modulate hydrogelation of various peptide classes.
Article
Nanoscience & Nanotechnology
Deepika Gupta, Varun Gupta, Debasish Nath, Chirag Miglani, Dipankar Mandal, Asish Pal
Summary: Supramolecular assemblies can mimic natural biomaterials and the introduction of redox-stimuli responsive ferrocene moiety can control peptide nanostructures and mechanical properties, as well as enable a piezoelectric response.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Physics, Applied
Cheong Hoon Kwon, Minchul Kang, Minseong Kwon, Donghyeon Nam, Yongkwon Song, Euiju Yong, Min-Kyu Oh, Yongju Kim, Bongjun Yeom, Jun Hyuk Moon, Seung Woo Lee, Jinhan Cho
Summary: This study demonstrates the use of a unique amphiphilic assembly method to generate hybrid biofuel cells with high power output and good operational stability. The assembled biofuel cell exhibits remarkably high power output (7.3 mW cm(-2)) and good operational durability.
APPLIED PHYSICS REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Jolien Bertouille, Sandor Kasas, Charlotte Martin, Ulrich Hennecke, Steven Ballet, Ronnie G. G. Willaert
Summary: Peptide-based hydrogels have potential applications in wound healing, drug delivery, and tissue engineering. The physical properties of these materials depend on their gel network morphology, but the self-assembly mechanism of peptides leading to different network shapes is still debated.
Article
Chemistry, Multidisciplinary
Priscila Cardoso, Samuel Appiah Danso, Andrew Hung, Chaitali Dekiwadia, Nimish Pradhan, Jamie Strachan, Brody McDonald, Kate Firipis, Jacinta F. White, Arturo Aburto-Medina, Charlotte E. Conn, Celine Valery
Summary: Microbial resistance to antibiotics is becoming a major crisis, and antimicrobial peptides (AMPs) are being explored as an alternative. This study reports the design of Fmoc-peptides with dual functionality, as antimicrobial agents and hydrogelators. Molecular dynamics simulations predicted the self-assembly of Priscilicidin into nanostructures in water, and experimental results confirmed its antimicrobial activity and hydrogel-forming capacity, including against multidrug resistant strains.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Physical
Haiyang Cui, Lingling Zhang, Dominik Soeder, Xiaomei Tang, Mehdi D. Davari, Ulrich Schwaneberg
Summary: MetRich plays a crucial role in the rapid immobilization of CueO on electrodes, showing high affinity to carbon nanotubes through the synergistic effect of pi-pi stacking and hydrophobic interactions. Fusion of MetRich with CotA enables CotA to rapidly and selectively adsorb on electrode surfaces.
Article
Chemistry, Multidisciplinary
Tyler D. Jorgenson, Hadi M. Zareie, Mehmet Sarikaya, Rene M. Overney
Summary: The spontaneous co-organization of distinct biomolecules at interfaces enables many of Nature's hierarchical organizations. Binary peptide assembly at graphite surfaces can fabricate biomolecular nano-mosaics with predictable structures. The ability to tune such structures facilitates the bottom up fabrication of high-density, multifunctional interfaces for nanotechnology.
Article
Chemistry, Multidisciplinary
Patrick Bitterwolf, Ahmed E. Zoheir, Julian Hertel, Sandra Kroll, Kersten S. Rabe, Christof M. Niemeyer
Summary: An intracellular approach to produce all-enzyme hydrogel particles has been developed, enabling efficient and sustainable biocatalysis. By using gene engineering, the researchers were able to simplify the construction of biocatalytic reactors and improve the stability and continuity of the reactions. This study provides a novel method for optimizing sustainable biocatalytic processes.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Review
Pharmacology & Pharmacy
Matthew J. Webber, E. Thomas Pashuck
Summary: Hydrogels prepared via self-assembly offer scalable and tunable platforms for drug delivery applications. Peptides are widely used as building blocks for self-assembly, while stimuli-responsive self-assembly provides opportunities for more precise drug action. Double-network hydrogels combine the beneficial properties of both self-assembled and covalent networks.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Johannes Strobl, Fanny Kozak, Meder Kamalov, Daniela Reichinger, Dennis Kurzbach, Christian F. W. Becker
Summary: The article discusses the limitations of mimicking biological materials and introduces a peptide library that enables the design of biomimetic materials. It explains that the formation of biomaterials is governed by self-assembling precursors, and these precursors can be manipulated to control the morphology of silica particles. The study uses residue-resolved real-time NMR spectroscopy and molecular dynamics simulations to understand the atomistic details of the templates.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiaoyan Mao, Xinqi Ding, Qi Wang, Xiping Sun, Lei Qin, Fei Huang, Luhong Wen, Xingwei Xiang
Summary: This study reports an oriented super-assembly strategy to construct micro-scale metal-organic frameworks (MOFs) superstructure through molecular self-assembly. By utilizing the strong intermolecular interactions between zirconium-oxygen (ZrO) cluster and glutamic acid, flexible nanoribbons can self-assemble into pumpkin-like microspheres. The confined effect between water-flexible building blocks and crosslinked hydrogen networks of the superstructures achieved a mismatch transformation of MOFs powders into homogeneous hydrogels. Experimental results and theoretical calculations demonstrate that the MOFs anisotropic superstructure exhibits dynamic double networks with superior water harvesting capacity and strong mechanical strength.
Article
Chemistry, Multidisciplinary
Nilan J. B. Kamathewatta, Tyler M. Nguyen, Rachel Lietz, Talisa Hughes, Banu Taktak Karaca, Dwight O. Deay, Mark L. Richter, Candan Tamerler, Cindy L. Berrie
Summary: Controlling the orientation and location of enzymes on surfaces is crucial for their successful implementation in various applications, with solid binding peptides offering versatility for immobilization on different materials. The use of a gold binding peptide, PutOx-AuBP, allows for self-assembly of enzymes on gold substrates, with material-selective binding and orientation control demonstrated on TSG substrates. The study provides insight into material-selective enzymatic assembly, highlighting significant variations in enzyme-surface interactions and surface-bound enzymatic activities.
Article
Biotechnology & Applied Microbiology
Shiyan Wang, Lingxuan Duan, Liang Jiang, Kailong Liu, Shizhen Wang
Summary: A new strategy for assembling amino acid dehydrogenase with peptide linker onto metal-organic framework (MOF) ZIF-8 has been successfully developed, leading to improved enzyme activity and stability. The catalytic efficiency of PheDH_1D02/ZIF-8 is significantly higher than other controls, demonstrating that this method is simple, cost-effective, and efficient for enhancing enzyme stability.
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Wendi Luo, Xiaocui Fang, Chen Wang, Yanlian Yang, Bin Tu, Qiaojun Fang
Summary: Peptide-modified delivery systems have great potential in improving targeting specificity, biocompatibility, and stability. However, designing a peptide-decorated surface with specific function remains challenging due to a lack of understanding of the interactions between surface-bound peptide ligands and their receptors.
Article
Materials Science, Multidisciplinary
Cem Ornek, Bilgehan M. Sesen, Mustafa K. Urgen
Summary: This paper investigates the mechanism of hydrogen-microstructure-strain interactions in a finely-grained 25Cr-7Ni super duplex stainless steel subjected to dynamic tensile loading. It reveals that hydrogen affects the properties of austenite and ferrite, leading to the occurrence of hydrogen-induced cracks, with the hydrogen absorption capacity of austenite playing a decisive role in hydrogen embrittlement susceptibility.
METALS AND MATERIALS INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Mubashir Mansoor, Mehya Mansoor, Maryam Mansoor, Ammar Aksoy, Sinem Nergiz Seyhan, Betul Yildirim, Ahmet Tahiri, Nuri Solak, Kursat Kazmanli, Zuhal Er, Kamil Czelej, Mustafa Urgen
Summary: This study investigates the formation energy and equilibrium state of point defects in diamond through theoretical calculations. Monolithic-Kroger-Vink diagrams are plotted to represent the relationship between defect concentrations and heat treatment parameters. The method successfully predicts experimental data and provides new insights for the heat treatment of diamond and other materials.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Environmental Sciences
K. Malci, G. Kurt-Gur, C. Tamerler, A. Yazgan-Karatas
Summary: This study evaluated the performance of recombinant laccase Pslcc2 from Pycnoporus sanguineus in decolorizing and detoxifying hazardous textile dyes. The results showed that Pslcc2, when coupled with appropriate mediators, had a high potential for decolorization and could transform toxic dyes into non-toxic products. The study demonstrated that Pslcc2/mediator systems could be eco-friendly solutions for the bioremediation of toxic textile dyes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cagatay Yelkarasi, Nina Recek, Kursat Kazmanli, Janez Kovac, Miran Mozetic, Mustafa Urgen, Ita Junkar
Summary: This study presents a unique process for the preparation of nanopatterned surfaces on cardiovascular stents using magnetron sputtering and anodization. The nanopatterned surfaces were found to stimulate endothelial cell proliferation while reducing the proliferation of smooth muscle cells. Plasma treatment further enhanced the proliferation of endothelial cells and prevented platelet activation on the surfaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Coatings & Films
Erkan Kacar, Mustafa Urgen
Summary: The coating-diffusion method based on CA-PVD allows controlled production of titanium carbide (TiC) on steel substrates, forming Fe-Ti compounds during initial diffusion stages, which release iron and are carried to the TiC layer surface by macro particles.
SURFACE ENGINEERING
(2022)
Article
Chemistry, Physical
Nourhan Mohamed, Cem Ornek, Servet Timur, Mustafa Uergen
Summary: This study investigated the electrochemical behavior of pure nickel in sub-molten KOH at 200 degrees C and the structure of surface films formed at different anodic polarization potentials. The results showed that the thickness and structure of the surface films varied depending on the polarization potential. A thick and defective layer of NiO formed in the active region, while a thick and flaky adlayer of potassium-intercalated gamma-NiOOH formed in the far passive region. The high dissolution rate of nickel and the high viscosity of the sub-molten KOH contributed to the formation of micrometer thick surface films.
SURFACES AND INTERFACES
(2022)
Article
Engineering, Biomedical
Kenda Sabouni, Yetkin Ozturk, Erkan Kacar, Gamze Torun Kose, Fatma Nese Kok, Muhammet Kursat Kazmanli, Mustafa Kamil Urgen, Sakip Onder
Summary: In this study, the effect of (Ti, Mg)N thin film coated Ti6Al4V plates and screws on mineralization/osseointegration was investigated. The results showed that the Mg-containing coatings enhanced mineralization, cell attachment, and hydroxyapatite growth, leading to increased attachment at the implant tissue interface.
BIO-MEDICAL MATERIALS AND ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Aya K. Cloyd, Kyle Boone, Qiang Ye, Malcolm L. Snead, Paulette Spencer, Candan Tamerler
Summary: Overcoming the short lifespan of current dental adhesives is a significant clinical need. Adhesives rely on the hybrid layer formation to adhere to dentin, but complete enclosure of demineralized collagen fibrils is currently unattainable. The use of peptide-based approach enables collagen intrafibrillar mineralization, providing a promising route for improving the long-term prospects of composite resins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Coatings & Films
Mehran Karimzadehkhoei, Erkan Kacar, Servet Timur, Mustafa Urgen, Guldem Kartal Sireli
Summary: This study presents an alternative approach for producing a hard TiB2/TiC multilayer on M2 high-speed steel by combining cathodic arc physical vapor deposition (CA-PVD) and cathodic reduction and thermal diffusion-based boriding (CRTD-Bor). The effects of boriding parameters on multilayer growth were examined, and empirical equations for estimating the thicknesses of TiB2 and TiC layers were derived. The multilayer coating exhibited enhanced hardness and wear resistance under dry sliding conditions.
JOURNAL OF VACUUM SCIENCE & TECHNOLOGY A
(2023)
Article
Materials Science, Multidisciplinary
Burcak Avci, Kursat Kazmanli, Burak Evren, Mustafa Urgen
Summary: We investigated the impact of nitride-based physical vapor deposition (PVD) hard coatings, including TiN, TiAlN, and CrN deposited on inert substrates by cathodic arc PVD method (CA-PVD), on the galvanic corrosion of carbon steel. The contribution of these coatings was evaluated using zero-resistance ammeter (ZRA) and electrochemical impedance spectroscopy (EIS) in 3.5 wt.% NaCl at pH 2 and 6, with and without aeration. The results showed that the type of coating and the coupling environment played a significant role in the generated galvanic currents. Immersion tests visually confirmed these results for TiN-, TiAlN-, and CrN-coated steel cross-sections. The contribution of galvanic corrosion was prominent in environments where oxygen reduction was the dominant cathodic reaction, but minimal in deaerated acidic solutions due to the high bonding strength of adsorbed intermediates to the coating surfaces.
MATERIALS AND CORROSION-WERKSTOFFE UND KORROSION
(2023)
Article
Biochemistry & Molecular Biology
Romana Jarosova, Sarah K. Woolfolk, Noraida Martinez-Rivera, Mathew W. Jaeschke, Eduardo Rosa-Molinar, Candan Tamerler, Michael A. Johnson
Summary: The zebrafish is used to study metal ion mechanisms in the brain, particularly zinc which plays a critical role in neurodegenerative diseases. A nanoprobe based on engineered fluorescence protein was developed to detect zinc in living zebrafish brain tissue. The nanoprobe showed stability and specificity, allowing for the study of imbalances in zinc regulation and contributing to the understanding of neurological diseases.
Article
Chemistry, Multidisciplinary
Kyle Boone, Aya Kirahm Cloyd, Emina Derakovic, Paulette Spencer, Candan Tamerler
Summary: Collagen is essential for various health functions and potential therapies. Short peptides targeting collagen are attractive for designing modular systems for targeted delivery of bioactive agents. We developed a hydropathy-based free energy estimation tool that allows quick evaluation of collagen-binding peptides. Our design tool enables exploration of peptide-protein binding properties across multiple pH conditions and we successfully engineered a collagen-binding peptide with enhanced properties. The predicted peptide showed improved collagen binding in validation assays. Overall, the free-energy-based tool provides an alternative computational screening approach for protein interaction search methods.
APPLIED SCIENCES-BASEL
(2023)
Article
Materials Science, Biomaterials
Deniz T. Yucesoy, Hanson Fong, John Hamann, Eric Hall, Sami Dogan, Mehmet Sarikaya
Summary: Exposure of dentin tubules due to loss of protective enamel and cementum has been the leading cause of dentin hypersensitivity. Current treatments provide short-lived effects, and there is no permanent solution available. This study describes a biomimetic treatment using a mineralization directing peptide to promote dentin repair and form an infiltrating mineral layer. The remineralized dentin showed similar composition to hydroxyapatite and exhibited higher mechanical properties than demineralized dentin.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Electrochemistry
Dilan Er, Burcak Avci, Mustafa Uergen
Summary: In this study, interconnected self-standing tin nanowire electrocatalysts were produced using a specially designed aluminum anodic oxide template technique for CO2 reduction toward formate. These electrodes showed higher formate production and longer stability compared to flat tin sheets.
Article
Materials Science, Multidisciplinary
Cem Ornek, Beste Payam, Andrei Gloskovskii, Kursat Kazmanli, Nourhan Mohamed, Bora Derin, Mustafa Urgen, Chin-En Chou, Hung-Wei Yen, Burcak Avci, Steve Ooi
Summary: We investigated the passive behavior of Hybrid steel in sulfuric acid and sodium chloride solutions, finding that it possesses stainless steel characteristics and excellent corrosion resistance. The presence of Al and Ni enhances the role of Cr in forming a protective surface film, leading to the exceptional corrosion resistance. This work demonstrates the potential for designing sustainable stainless steel with high-strength properties without requiring the conventional Cr threshold concentration of 10.5 per cent.
NPJ MATERIALS DEGRADATION
(2023)