Article
Nutrition & Dietetics
Marco Tretola, Giuseppe Bee, Paolo Silacci
Summary: The study revealed that GA influences intestinal uptake of cationic amino acids at low concentrations and decreases the intestinal-cell barrier function at high concentrations. Similarities were observed between in vitro and ex vivo models, but differences in treatment times and structures must be taken into consideration.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Julian Friebel, Katina Schinnerling, Kathleen Weigt, Claudia Heldt, Anja Fromm, Christian Bojarski, Britta Siegmund, Hans-Joerg Epple, Judith Kikhney, Annette Moter, Thomas Schneider, Joerg D. Schulzke, Verena Moos, Michael Schumann
Summary: Tropheryma whipplei (TW) can enter intestinal epithelial cells via an actin-, dynamin-, caveolin-, and Ras-Rac1-dependent endocytosis mechanism, leading to apoptosis and barrier defect. TW may also enter intestinal macrophages through phagocytic uptake. These findings are important for understanding the mechanisms of TW crossing the intestinal epithelial barrier and causing gastroenteritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Andre Barany, Milagrosa Oliva, Silvia Filipa Gregorio, Gonzalo Martinez-Rodriguez, Juan Miguel Mancera, Juan Fuentes
Summary: This study investigated the physiological effects of Aflatoxin B1 (AFB1) on the gastrointestinal system of seabream through in vitro and in vivo experiments, as well as molecular analysis. Results showed dose-related effects on ion transport, changes in Na+/K+-ATPase and H+-ATPase activities, and alterations in intestinal barrier proteins expression. These findings suggest that AFB1 may be the underlying cause of growth impairment in fish reported previously.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Samuel Blake Mitchell, Yu-Han Hung, Trista Lee Thorn, Jiaqi Zou, Filiz Baser, Sukru Gulec, Celeste Cheung, Tolunay Beker Aydemir
Summary: This study aims to investigate the impact of high sucrose consumption on zinc homeostasis and intestinal permeability, and its correlation with the development of chronic diseases.
FRONTIERS IN NUTRITION
(2023)
Review
Medicine, General & Internal
Katrin Sommer, Maximilian Wiendl, Tanja M. Mueller, Karin Heidbreder, Caroline Voskens, Markus F. Neurath, Sebastian Zundler
Summary: The intestinal epithelial barrier plays a crucial role in regulating the entry of substances and nutrients, as well as maintaining the integrity of the host. Dysfunction of this barrier is associated with inflammatory bowel disease, with intestinal mucosal wounds and repair involving complex interactions among various cellular mediators. Understanding the crosstalk between epithelial and immune cells during intestinal wound repair is essential for developing improved therapies.
FRONTIERS IN MEDICINE
(2021)
Article
Agriculture, Dairy & Animal Science
Alexandra Rath, Silke Rautenschlein, Janina Rzeznitzeck, Gerhard Breves, Marion Hewicker-Trautwein, Karl-Heinz Waldmann, Alexandra von Altrock
Summary: Campylobacteriosis is a common food-borne zoonotic disease in humans, mainly characterized by watery to bloody diarrhoea. This study focused on the clinical impact of mono- and co-colonisation of C. coli and C. jejuni on weaned piglets and their influence on transepithelial transport processes in the jejunum and caecum. The results showed that mono-infection with C. jejuni had an impact on ion transport processes in the caecum.
Article
Agriculture, Dairy & Animal Science
Marco Tretola, Paolo Silacci, Raquel Sousa, Francesca Colombo, Sara Panseri, Matteo Ottoboni, Luciano Pinotti, Giuseppe Bee
Summary: Polyphenols interact with protein fractions in feed ingredients, affecting digestibility. This study found that tannin-rich chestnut extract decreased the digestibility of soy-based feeds and demonstrated protective effects on intestinal epithelium in vitro.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2022)
Article
Microbiology
Chunru Liu, Stoffel Matjeke Radebe, Hang Zhang, Junpeng Jia, Shuang Xie, Miaolei Shi, Qinghua Yu
Summary: This study found that Bacillus coagulans can maintain the intestinal mucosal barrier by improving the intestinal flora, enhancing innate immunity, and promoting intestinal epithelial proliferation.
VETERINARY MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Zhongyang Guo, Xiaoling Chen, Zhiqing Huang, Daiwen Chen, Jie Yu, Hui Yan, Hong Chen, Jun He, Ping Zheng, Yuheng Luo, Bing Yu
Summary: Apple polyphenols have significant effects on barrier function, antioxidant capacity, and immune-inflammatory response in weaning piglets. They improve jejunal barrier function, increase antioxidant enzyme activities, modulate protein expressions, and decrease inflammation-related gene expressions.
ANIMAL SCIENCE JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Henrique Rodrigues Marcelino, Audrey Solgadi, Monique Cheron, Eryvaldo Socrates Tabosa do Egito, Gilles Ponchel
Summary: This study aimed to explore the effects of different aggregation states of AmB in nanocarriers and their influence on jejunal permeability. Physicochemical characterization revealed different degrees of AmB aggregation states. However, although this approach had an impact on the toxicity of AmB, its effect on permeability was not significant enough.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Marine & Freshwater Biology
Marine Pyl, Angus Taylor, Francois Oberhansli, Peter Swarzenski, Leila Hussamy, Marc Besson, Bruno Danis, Marc Metian
Summary: The present study demonstrates the ability of marine microplastics to cross the intestinal wall of sea urchins and enter the coelomic fluid. The size-dependence of microplastic translocation across the intestinal wall is also highlighted.
AQUATIC TOXICOLOGY
(2022)
Article
Food Science & Technology
Ng'Andwe Kalungwana, Lisa Marshall, Alan Mackie, Christine Boesch
Summary: To accurately assess the absorption of nutrients in food, it is important to simulate human digestion using model settings. This study compared the uptake and transportation of dietary carotenoids using two different models. The results showed that the mouse intestinal tissue had a higher uptake and absorption efficiency than the Caco-2 cells. These findings demonstrate the usefulness of physiologically relevant models for studying human intestinal absorption.
FOOD RESEARCH INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Kazuya Maeda
Summary: The prediction of intestinal absorption of drugs is crucial in the development of oral drugs, but is challenging due to various factors influencing drug absorption and the differences between animal and human bioavailability. Traditionally, Caco-2 cell transcellular transport assay has been used for screening drug absorption properties, but its predictability is limited. Recently, novel in vitro experimental systems, such as human-derived intestinal samples and differentiated epithelial cells from intestinal stem cells, have been proposed. Crypt-derived differentiated epithelial cells show advantages in characterizing species and regional differences in drug absorption.
DRUG METABOLISM AND DISPOSITION
(2023)
Article
Pharmacology & Pharmacy
Jiemei Chen, Mingchao Wang, Peng Zhang, Hui Li, Kai Qu, Ruiming Xu, Na Guo, Haibo Zhu
Summary: Cordycepin has been found to alleviate metabolic inflammation and improve obesity-related symptoms through regulating intestinal barrier function and intestinal flora.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Daniel H. M. Watanabe, John Doelman, Michael A. Steele, Le L. Guan, Dave J. Seymour, Gregory B. Penner
Summary: This study evaluated the effects of Ca-gluconate relative to butyrate on gastrointestinal tract function in beef heifers. The results showed that only Ca-butyrate was able to stimulate ruminal short-chain fatty acid absorption in growing beef heifers.
JOURNAL OF ANIMAL SCIENCE
(2023)
