Review
Biochemistry & Molecular Biology
Geoffrey Brown
Summary: The origin cell of chronic myeloid leukemia is a hematopoietic stem cell and the hallmark oncogene is BCR-ABLp210, which influences hematopoietic stem and progenitor cells to myeloid fate. Studies have shown that BCR-ABLp210 affects the epigenome, leading to dysregulation of fate choice for hematopoietic stem cells, but the reason why neutrophils are abundantly produced in the disease remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Sophia K. Khaldoyanidi, Antreas Hindoyan, Anthony Stein, Marion Subklewe
Summary: This article discusses the properties of leukemic stem cells in acute myeloid leukemia (AML) and strategies aimed at targeting these cells therapeutically. The authors highlight pathways and targets of interest and summarize information on drugs that could eradicate leukemic stem cells. Future research is needed to fill knowledge gaps and provide evidence for the clinical efficacy of leukemic stem cell-directed therapies to improve cure rates in AML patients.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rafaela G. A. Costa, Suellen L. R. Silva, Ingrid R. S. B. Dias, Maiara de S. Oliveira, Ana Carolina B. da C. Rodrigues, Rosane B. Dias, Daniel P. Bezerra
Summary: Acute myeloid leukemia (AML) is a heterogeneous disease group with various mutations triggering malignant proliferation. AML relapse is mainly caused by leukemic stem cells (LSCs) with self-renewal capacity and resistance to traditional therapies. LSCs have low oxidative stress levels due to low mitochondrial activity and high ROS-removing pathway activity. Targeting oxidative stress could be a potential strategy to eliminate AML LSCs.
Review
Cell Biology
Suzana Tesanovic, Peter W. Krenn, Fritz Aberger
Summary: Despite advances in understanding the genetic alterations and biology of acute myeloid leukemia (AML), the translation into clinical treatment approaches is still in its early stages. A major challenge in AML therapy is the high relapse rates, largely due to the presence of treatment-resistant leukemic stem cells (LSCs). The Hedgehog (HH) signaling pathway has emerged as a therapeutic target in AML, as it plays a crucial role in the development and progression of cancer stem cell driven tumors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell & Tissue Engineering
Paul Jaeger, Stefanie Geyh, Soeren Twarock, Ron-Patrick Cadeddu, Pablo Rabes, Annemarie Koch, Uwe Maus, Tobias Hesper, Christoph Zilkens, Christina Rautenberg, Felix Bormann, Karl Koehrer, Patrick Petzsch, Dagmar Wieczorek, Beate Betz, Harald Surowy, Barbara Hildebrandt, Ulrich Germing, Guido Kobbe, Rainer Haas, Thomas Schroeder
Summary: Studies suggest that leukemic cells induce functional inhibition of healthy CD34+ HSPC, at least in part, through pathways like TGF beta 1, indicating that blocking this pathway may improve hematopoiesis in AML patients.
Article
Immunology
Hyery Kim, Beom Hee Lee, Hyo-Sang Do, Gu-Hwan Kim, Sunghan Kang, Kyung-Nam Koh, Ho Joon Im
Summary: Mevalonic aciduria (MA) is the most severe clinical subtype of mevalonate kinase deficiency (MKD) caused by an inherited defect in the mevalonate pathway. The treatment of MKD focuses on suppressing recurrent hyperinflammatory attacks using anti-inflammatory drugs. Allogeneic hematopoietic stem cell transplantation (HCT) has been shown to successfully ameliorate autoinflammatory attacks in patients with MKD who have MA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Karina Barbosa, Aniruddha J. Deshpande
Summary: One important property of hematopoietic stem cells is their ability to self-renew, which is often exploited in blood cancers. Acute myeloid leukemia (AML) follows a hierarchical arrangement with self-renewing leukemia stem cells (LSCs) giving rise to the bulk of the tumor. LSCs have been found to be responsible for chemotherapy resistance and serve as a reservoir for disease relapse. Understanding the characteristics of LSCs compared to normal stem cells has opened up opportunities for targeted therapies in AML.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Li Xuan, Qifa Liu
Summary: Relapse is still the main reason for treatment failure in AML patients undergoing allo-HSCT. Evidence suggests that maintenance therapy post-transplantation, particularly targeted drugs like hypomethylating agents, FLT3 inhibitors, and isocitrate dehydrogenase inhibitors, could benefit AML patients, especially those at high risk.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Oncology
Stefania Trino, Ilaria Laurenzana, Daniela Lamorte, Giovanni Calice, Angelo De Stradis, Michele Santodirocco, Alessandro Sgambato, Antonella Caivano, Luciana De Luca
Summary: This study reveals that AML cells disrupt the hematopoietic process of HSPCs by releasing EVs, which alter gene expression and affect the phenotype and function of HSPCs. This communication may contribute to the formation of a leukemic niche favorable for leukemia development.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jialan Niu, Danyue Peng, Lingbo Liu
Summary: This review summarizes the resistance mechanisms of leukemia stem cells (LSCs) and the crucial role of the bone marrow microenvironment in LSCs resistance in acute myeloid leukemia (AML), providing better strategies for future research on eradicating LSCs and clinical treatment of AML.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Gongqiang Wu, Shanshan Guo, Qian Luo, Xiaoxia Wang, Wenhai Deng, Guifang Ouyang, Jeffrey J. Pu, Wen Lei, Wenbin Qian
Summary: This study identified anti-CD70 CAR-T cells as a potential new treatment for AML. However, this CAR-T cell therapy did not completely eliminate leukemia in vivo, suggesting the need for further research and development of innovative combinatorial CAR constructs and increased CD70 expression on leukemia cell surface to optimize CAR-T cell responses for AML.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Cindy M. Pabon, Hussein A. Abbas, Marina Konopleva
Summary: As our understanding of the intricate pathophysiology of LSCs continues to grow, it is clear that targeting such heterogenous cells successfully will require a thoughtful and multi-modal approach.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2022)
Article
Pharmacology & Pharmacy
Fahui Li, Congying Gao, Xueming Li, Jiangyun Wang, Yao Zhao, Yu Ke, Ying Liu, Hong-Min Liu, Zhenbo Hu, Liuya Wei, Zhe-Sheng Chen
Summary: The natural compound Jiyuan oridonin A (JOA) has been found to overcome the differentiation blockade in AML cells and leukemic stem-like cells, inhibiting their proliferation and offering a novel therapeutic strategy for AML.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yammy Yung, Emily Lee, Hiu-Tung Chu, Pui-Kwan Yip, Harinder Gill
Summary: Myeloproliferative neoplasms (MPNs) are hematopoietic stem cell disorders characterized by clonal myeloproliferation. Despite effective treatment, complete eradication of CML/MPN stem cells is rare. Novel agents and combination therapy have potential to target abnormal hematopoietic stem cells and the sustaining bone marrow microenvironment in CML and MPNs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Petter S. Woll, Tetsuichi Yoshizato, Eva Hellstrom-Lindberg, Thoas Fioretos, Benjamin L. Ebert, Sten Eirik W. Jacobsen
Summary: The genetic architecture of cancer has been extensively studied, leading to the identification of new therapeutic targets and the development of promising treatment strategies. However, disease progression, relapse, and treatment-related mortality remain challenging in certain types of cancer such as myelodysplastic syndromes and acute myeloid leukemia. The persistence of rare leukemic stem cells following therapy underscores the resistance mechanisms of these cells and their role in relapse. To improve treatment strategies, there is a need to better understand and characterize the stem cells associated with these diseases at the cellular, molecular, and genetic levels.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Edgar-Alfonso Rivera-Leon, Beatriz Palmeros-Sanchez, Iris-Monserrat Llamas-Covarrubias, Socorro Fernandez, Juan Armendariz-Borunda, Mercedes Gonzalez-Hita, Blanca-Estela Bastidas-Ramirez, Abraham Zepeda-Moreno, Sergio Sanchez-Enriquez
ENDOKRYNOLOGIA POLSKA
(2015)
Article
Hematology
Wenwen Wang, Thomas Stiehl, Simon Raffel, Van T. Hoang, Isabel Hoffmann, Laura Poisa-Beiro, Borhan R. Saeed, Rachel Blume, Linda Manta, Volker Eckstein, Tilmann Bochtler, Patrick Wuchter, Marieke Essers, Anna Jauch, Andreas Trumpp, Anna Marciniak-Czochra, Anthony D. Ho, Christoph Lutz
Article
Hematology
Wenwen Wang, Thomas Stiehl, Simon Raffel, Van T. Hoang, Isabel Hoffmann, Laura Poisa-Beiro, Borhan R. Saeed, Rachel Blume, Linda Manta, Volker Eckstein, Tilmann Bochtler, Patrick Wuchter, Marieke Essers, Anna Jauch, Andreas Trumpp, Anna Marciniak-Czochra, Anthony D. Ho, Christoph Lutz
Article
Oncology
Van T. Hoang, Divij Verma, Parimala Sonika Godavarthy, Pablo Llavona, Marlene Steiner, Katharina Gerlach, Birgitta E. Michels, Hanibal Bohnenberger, Astrid Wachter, Thomas Oellerich, Uta Mueller-Kuller, Eva Weissenberger, Jenna M. Voutsinas, Vivian G. Oehler, Henner F. Farin, Martin Zoernig, Daniela S. Krause
Article
Biophysics
Rossina Dominguez-Rios, Dante R. Sanchez-Ramirez, Kassandra Ruiz-Saray, Paola E. Oceguera-Basurto, Mario Almada, Josue Juarez, Abraham Zepeda-Moreno, Alicia del Toro-Arreola, Antonio Topete, Adrian Daneri-Navarro
COLLOIDS AND SURFACES B-BIOINTERFACES
(2019)
Article
Immunology
Luis Jesus Najar-Acosta, Ana Karina Robles-Murillo, Lilia Carolina Leon-Moreno, Maria Fernanda Desentis-Desentis, Jose Antonio Garcia-Espinoza, Juan Pablo Barba-Gutierrez, Ana Guadalupe Romero-Gomez, Alicia Del Toro-Arreola, Adrian Daneri-Navarro, Antonio Topete-Camacho, Ramon Antonio Franco-Topete, Fernando Antonio Sanchez-Zubieta, Abraham Zepeda-Moreno, Jorge David Rivas-Carrillo
TRANSPLANTATION PROCEEDINGS
(2020)
Article
Cell & Tissue Engineering
Van T. Hoang, Quynh-Mai Trinh, Dam Thi Minh Phuong, Hue Thi Hong Bui, Le Minh Hang, Nguyen Thi Hong Ngan, Nguyen Thi Tuyet Anh, Phung Yen Nhi, Trinh Thi Hong Nhung, Ha Thi Lien, Tu Dac Nguyen, Liem Nguyen Thanh, Duc M. Hoang
Summary: The study established a standardized method for expanding MSCs using xeno and serum-free commercial media, demonstrating that MSCs from different sources can be stably expanded and retain their functional characteristics. The results showed that MSCs successfully differentiated into various lineages and met quality standards for therapeutic applications after pilot expansion to clinical scale, highlighting the potential for large-scale application of MSCs in therapy.
Article
Medicine, Research & Experimental
Liem Thanh Nguyen, Thai T. H. Trieu, Hue T. H. Bui, Van T. Hoang, Anh T. T. Nguyen, Nhung T. H. Trinh, Kien T. Nguyen, Duc M. Hoang
JOURNAL OF TRANSLATIONAL MEDICINE
(2020)
Article
Cell & Tissue Engineering
Liem Thanh Nguyen, Duc M. Hoang, Kien T. Nguyen, Duc M. Bui, Hieu T. Nguyen, Hong T. A. Le, Van T. Hoang, Hue T. H. Bui, Phuong T. M. Dam, Xuan T. A. Hoang, Anh T. L. Ngo, Hang M. Le, Nhi Y. Phung, Duc M. Vu, Trung T. Duong, Tu D. Nguyen, Lien T. Ha, Hoa T. P. Bui, Hoa K. Nguyen, Michael Heke, Anh Bui
Summary: The study suggests that autologous administration of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) is safe in patients with type 2 diabetes mellitus (T2DM), with treatment efficacy dependent on the quality of the stem cell population and administration routes. Short-term therapeutic effects were observed in patients with shorter T2DM duration and lower body weight.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gabriela del Carmen Lopez-Armas, Martha Eloisa Ramos-Marquez, Monica Navarro-Meza, Miguel Angel Macias-Islas, Ana Miriam Saldana-Cruz, Abraham Zepeda-Moreno, Fernando Siller-Lopez, Jose Alfonso Cruz-Ramos
Summary: This study evaluated the peripheral blood leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNA-CN) in patients with relapsing-remitting multiple sclerosis (RRMS). The results showed a linear correlation between LTL and mtDNA-CN in mild-moderate disability RRMS patients. Moreover, LTL can predict the severity of disability in RRMS patients, and the prediction accuracy can be improved by combining LTL with age.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Quyen Thi Nguyen, Liem Nguyen Thanh, Van T. T. Hoang, Trang T. K. Phan, Michael Heke, Duc M. M. Hoang
Summary: Bone marrow-derived mononuclear cells (BMMNCs) have been extensively used in the treatment of neurological diseases, but the underlying mechanisms and optimal administration factors are still unclear. This review provides an overview of BMMNCs, including cell harvesting, administration factors, mechanisms of action, and applications in various neurological diseases. Additionally, it discusses the indications, advantages, and limitations of BMMNC therapy for neurological diseases.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Mathematical & Computational Biology
Elizabeth Torres-Anguiano, Itzel Sanchez-Lopez, Angeles Garduno-Robles, Jorge David Rivas-Carrillo, Edgar Alfonso Rivera-Leon, Sergio Sanchez-Enriquez, Luis Fernando Ornelas-Hernandez, Fernando Zazueta Leon-Quintero, Eduardo Narciso Salazar Leon-Quintero, Guillermo Enrique Juarez-Lopez, Fernando Antonio Sanchez-Zubieta, Mariana Ochoa-Bru, Abraham Zepeda-Moreno
Summary: The objective of this study was to determine whether air pollution or changes in SARS-CoV-2 lineages lead to an increase in mortality. Descriptive statistics, RT-PCR, and next-generation sequencing were used to analyze infection rates, viral loads, and SARS-CoV-2 lineages. The results showed that mortality rate was correlated with air pollution indices but not with SARS-CoV-2 lineages.
INFECTIOUS DISEASE MODELLING
(2023)
Review
Nanoscience & Nanotechnology
Luis Fernando Ornelas-Hernandez, Angeles Garduno-Robles, Abraham Zepeda-Moreno
Summary: This article summarizes the synthesis methods and applications of carbon dots (CDs) and silica nanoparticles. It also discusses the combined synthesis techniques of CD-silica nanostructures and their applications in biosensing. Furthermore, it provides an overview of the potential applications of these materials as smart hybrid nanocarriers and theragnostic agents in the field of nanomedicine.
NANOSCALE RESEARCH LETTERS
(2022)
Article
Cell & Tissue Engineering
Minh Quang Nguyen, Hue T. H. Bui, Anh Nguyen Thi Tuyet, Trinh Thi Hong Nhung, Duc M. Hoang, Nguyen Thanh Liem, Van T. Hoang
Summary: In a standardized xeno- and serum-free culture platform, cryopreserved UC-MSCs exhibit similar characteristics to fresh UC-MSCs, showing comparable viability, proliferation capacity, immunophenotype, and differentiation potential. However, culture-rescued cells appear to have a more potent immunosuppressive potential compared to freshly thawed cells.
CELL TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Sergio Sanchez-Enriquez, Isabel Thalia Ballesteros-Gonzalez, Jose Rafael Villafan-Bernal, Sara Pascoe-Gonzalez, Edgar Alfonso Rivera-Leon, Blanca Estela Bastidas-Ramirez, Jorge David Rivas-Carrillo, Juan Luis Alcala-Zermeno, Juan Armendariz-Borunda, Iris Monserrat Llamas-Covarrubias, Abraham Zepeda-Moreno
WORLD JOURNAL OF DIABETES
(2017)
