Metabolic engineering for the production of clinically important molecules: Omega-3 fatty acids, artemisinin, and taxol

Differences between Dietary Supplement and Prescription Drug Omega-3 Fatty Acid Formulations: A Legislative and Regulatory Perspective

(2013) Nancy Collins et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content

(2011) Pravej Alam et al.   PLANT CELL REPORTS

Artemisinin Biosynthesis Enhancement in TransgenicArtemisia annuaPlants by Downregulation of theβ-Caryophyllene Synthase Gene

(2011) Jian-Lin Chen et al.   PLANTA MEDICA

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expanding the docosahexaenoic acid food web for sustainable production: engineering lower plant pathways into higher plants

(2011) James R. Petrie et al.   AoB Plants

Dietary intake of stearidonic acid–enriched soybean oil increases the omega-3 index: randomized, double-blind clinical study of efficacy and safety

(2010) Shawna L Lemke et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Tissue engineering for clinical applications

(2010) Sujata K. Bhatia   Biotechnology Journal

Palmitoyl ascorbate-modified liposomes as nanoparticle platform for ascorbate-mediated cytotoxicity and paclitaxel co-delivery

(2010) Rupa R. Sawant et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Artemisinins act through at least two targets in a yeast model

(2010) Catherine M. Moore et al.   FEMS YEAST RESEARCH

Paclitaxel-Loaded Polymeric Micelles Modified with MCF-7 Cell-Specific Phage Protein: Enhanced Binding to Target Cancer Cells and Increased Cytotoxicity

(2010) Tao Wang et al.   MOLECULAR PHARMACEUTICS

The production of artemisinin precursors in tobacco

(2010) Yansheng Zhang et al.   PLANT BIOTECHNOLOGY JOURNAL

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors

(2010) Teun W. J. M. van Herpen et al.   PLoS One

Safety assessment of EPA-rich oil produced from yeast: Results of a 90-day subchronic toxicity study

(2010) Susan A. MacKenzie et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Safety assessment of EPA-rich triglyceride oil produced from yeast: Genotoxicity and 28-day oral toxicity in rats

(2010) Leigh A. Belcher et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Manufacturing Molecules Through Metabolic Engineering

(2010) J. D. Keasling   SCIENCE

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annuaThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) Keat H. Teoh et al.   Botany

A Critical Appraisal of the Safety and Efficacy of Drug-Eluting Stents

(2009) G Maluenda et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Medicinal Chemistry of Paclitaxel and its Analogues

(2009) Y. Fu et al.   CURRENT MEDICINAL CHEMISTRY

Paclitaxel and immune system

(2009) Aqeel Javeed et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Anticancer activities of artemisinin and its bioactive derivatives

(2009) Gary L. Firestone et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

The synthesis and accumulation of stearidonic acid in transgenic plants: a novel source of ‘heart-healthy’ omega-3 fatty acids

(2009) Noemí Ruiz-López et al.   PLANT BIOTECHNOLOGY JOURNAL

Overexpression of the HMG‐CoA Reductase Gene Leads to Enhanced Artemisinin Biosynthesis in TransgenicArtemisia annuaPlants

(2009) Samina Aquil et al.   PLANTA MEDICA

High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

(2009) Hiroko Tsuruta et al.   PLoS One

Dietary reference intakes for DHA and EPA

(2009) Penny M. Kris-Etherton et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Specificity of the N-benzoyl transferase responsible for the last step of Taxol biosynthesis

(2008) Robert M. Long et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS)

(2008) Yasushi Saito et al.   ATHEROSCLEROSIS

Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing

(2008) Ling Zhang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Metabolic engineering of microorganisms: general strategies and drug production

(2008) Sang Yup Lee et al.   DRUG DISCOVERY TODAY

Contaminants in fish tissue from US lakes and reservoirs: a national probabilistic study

(2008) Leanne L. Stahl et al.   ENVIRONMENTAL MONITORING AND ASSESSMENT

The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin inArtemisia annua

(2008) Yansheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dietary Stearidonic Acid Is a Long Chain (n-3) Polyunsaturated Fatty Acid with Potential Health Benefits

(2008) Jay Whelan   JOURNAL OF NUTRITION

Stearidonic Acid-Enriched Soybean Oil Increased the Omega-3 Index, an Emerging Cardiovascular Risk Marker

(2008) William S. Harris et al.   LIPIDS

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

(2008) Benedikt Engels et al.   METABOLIC ENGINEERING

Enhancing Plant Seed Oils for Human Nutrition

(2008) H. G. Damude et al.   PLANT PHYSIOLOGY

Qinghaosu (Artemisinin): The Price of Success

(2008) N. J. White   SCIENCE

Reduction in the Recurrence of Stroke by Eicosapentaenoic Acid for Hypercholesterolemic Patients

(2008) Kortaro Tanaka et al.   STROKE