Article
Pharmacology & Pharmacy
Huiru Liu, Wenwen Meng, Dongsheng Zhao, Zhihui Ma, Wenguang Zhang, Zhi Chen, Zhengguo Li, Pan Zhao
Summary: The objective of this study was to investigate the effects and molecular mechanisms of total flavonoids from Cortex Juglandis Mandshuricae (TFC) on preventing alcohol-induced chronic liver injury and regulating gut microbiota in mice. The results showed that oral administration of TFC significantly attenuated alcoholic liver injury in mice. TFC improved lipid accumulation in mice with chronic alcoholic liver injury through activation of the AMPK/PPAR alpha pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Mengge Ma, Lin Chen, Zhishu Tang, Zhongxing Song, Xin Kong
Summary: This study evaluated the hepatoprotective effect of Carthamus tinctorius L. leaf extract on chronic liver injury and found that it may exert its effects through antioxidation, anti-inflammation, and modulation of TLRs/NF-kappa B and PI3K/AKT pathways.
Article
Medicine, Research & Experimental
Tomislav Kostic, Dejan Popovic, Zoran Perisic, Dragana Stanojevic, Sonja Dakic, Sandra Saric, Danijela Djordjevic Radojkovic, Svetlana Apostolovic, Nenad Bozinovic, Snezana Ciric Zdravkovic, Stefan Milutinovic, Bojan Maricic, Nikola Zivkovic, Mladjan Golubovic, Miodrag Djordjevic, Radomir Damjanovic, Abraham Bell, Boris Dindic
Summary: The study demonstrates that aminoguanidine has a significant hepatoprotective effect in acute liver damage induced by CCl4, attributed to its antioxidant effects, inhibition of pro-oxidative and pro-inflammatory mediators, and induction of damaged hepatocytes into apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Darya Pon'kina, Sergey Kuranov, Mikhail Khvostov, Nataliya Zhukova, Yulia Meshkova, Mariya Marenina, Olga Luzina, Tatyana Tolstikova, Nariman Salakhutdinov
Summary: In this study, the compound QS-528, previously discovered as an agonist of FFAR1, was found to have a hepatoprotective effect against CCl4-induced liver injury. It reduced the levels of liver enzymes, improved liver tissue degeneration and necrosis, and promoted liver regeneration.
Article
Medicine, Research & Experimental
Neelum Iqbal, Hafiz Muhammad Zubair, Mikhlid H. Almutairi, Muhammad Abbas, Muhammad Furqan Akhtar, Lotfi Aleya, Mohamed Kamel, Ammara Saleem, Qaiser Jabeen, Sobia Noreen, Mirza Muhammad Faran Ashraf Baig, Mohamed M. Abdel-Daim
Summary: Cordia rothii Roem. & Schult. possesses strong antioxidant and hepatoprotective activities, which may involve the Nrf2-NF kappa B pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Food Science & Technology
Ya-Ting Chen, Chao-Wen Tu, Chih-Yao Hou, Yu-An Chen, Ruo-Qi Xu, Chia-Hung Kuo, Chih-Chung Wu, Shu-Ling Hsieh
Summary: The study investigated the hepatoprotective effect of egg protein hydrolysate (EWH) by regulating antioxidant enzyme expression using in vitro and in vivo models. The results showed that EWH enhanced antioxidant activity in HepG2 cells and alleviated hepatotoxicity in rats induced by carbon tetrachloride. EWH also ameliorated liver tissue injuries and had the highest glutamic acid content in its amino acid composition.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Chemistry, Applied
Mamdouh Nabil Samy, Ashraf Nageeb Elsayed Hamed, Basma Khalaf Mahmoud, Eman Zekry Attia, Usama Ramadan Abdelmohsen, Michael Atef Fawzy, Mina Ezzat Attya, Mohamed Salah Kamel
Summary: The chemical profiling of Bignonia binata leaves revealed the presence of various secondary metabolites, and the EtOAc fraction showed the highest potency in improving CCl4-induced alterations in rats. Additionally, EtOAc and aqueous fractions exhibited the most inhibition of inflammatory mediators and improving the histopathological structures of the liver and kidney.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Xiaomin Chen, Hui Wang, Xiaojun Huang, Shengkun Xia, Chunhua Chen, Qixing Nie, Shaoping Nie
Summary: This study developed an effective method for enriching kale flavonoids using resins. By optimizing the resin selection and enrichment conditions, the purified extract obtained from NKA-9 resin exhibited strong antioxidant activity and potential applications across various industries.
Article
Medicine, Research & Experimental
Muhammed Amanat, Md Sharif Reza, Md Sadikur Rahman Shuvo, Khondoker Shahin Ahmed, Hemayet Hossain, Muhammad Tawhid, Md Saifuzzaman, Mohammad Shariful Islam, Tanoy Mazumder, Md Amirul Islam, A. F. M. Shahid Ud Daula
Summary: The study evaluated the hepatoprotective effects of Zingiber roseum rhizome extract in CCl4 induced hepatotoxicity in mice. Seven phenolic compounds in the extract showed potential for inhibiting ROS production and displayed various biological activities, including antioxidant and hepato-protective activities.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Engineering, Chemical
Ruixue Liu, Xiuling Chu, Jianqing Su, Xiang Fu, Qibin Kan, Xiaoya Wang, Xinyu Zhang
Summary: The aim of this work was to investigate enzyme-assisted ultrasonic extraction of A. senticosus flavonoids and their enrichment and antioxidant properties. An effective extraction and enrichment procedure was found, with the highest flavonoid, polyphenol, saponin contents in the 1-butanol fraction, and the highest polysaccharide content in the water fraction.
Article
Food Science & Technology
Nashi K. Alqahtani, Hisham A. Mohamed, Mahmoud E. Moawad, Nancy S. Younis, Maged E. Mohamed
Summary: This study aimed to optimize the extraction method for two cultivars of date palm fruits and investigate their protective effect against CCl4-induced liver toxicity. The optimized extracts showed enhanced antioxidant capacity, reduced inflammation and apoptosis, and improved DNA integrity, thus mitigating liver damage caused by CCl4.
Article
Plant Sciences
Cheng Wang, Cheng Ma, Ke Fu, Yanfang Liu, Lihong Gong, Cheng Peng, Yunxia Li
Summary: The study shows that phillygenin in Forsythiae fructus has hepatoprotective, anti-inflammatory, and antioxidant effects. By modulating gut microbiota and metabolites, phillygenin can mitigate carbon tetrachloride-induced liver fibrosis and improve intestinal barrier function.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
E. S. Said, A. H. Mohammed, H. M. Ali, A. Y. Babiker, R. Alnughaymishi, N. Z. Althaqeel, A. S. Ahmed
Summary: The protective effects of sodium copper chlorophyllin and nebivolol were evaluated in a mice model of CCL4 induced hepatotoxicity. Co-administration of either silymarin, nebivolol, or sodium copper chlorophyllin with CCl4 ameliorated hepatic injury through their anti-inflammatory and antioxidant activities.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qinge Ma, Yang Guan, Zhipei Sang, Jianghong Dong, Rongrui Wei
Summary: This study isolated several compounds with hepatoprotective and hypolipidemic properties from the fruits of Hippophae rhamnoides L. using a bioassay-guided approach. The structures and activities of these compounds were extensively analyzed and discussed.
Article
Chemistry, Multidisciplinary
Shameenii A. P. P. Thanebal, Senty Vun-Sang, Mohammad Iqbal
Summary: The study demonstrated that Pandanus amaryllifolius has antioxidant properties and can protect rats from acute hepatic damage caused by carbon tetrachloride. The extract contains various phytochemical constituents, showing significant antioxidant enzyme activity and reducing the extent of liver damage.
ARABIAN JOURNAL OF CHEMISTRY
(2021)